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10 Things You Need To Know
About Hemp-Derived CBD
Presented by: AimĂŠe Shunney, ND
10 Things You Need To Know
About Hemp-Derived CBD
1.Semantics
2.History
3.Balance is
Everything
4.Utility
5.Grow Practices
6.Source
7.Whole Plant
Synergy
8.Research
9.Safety
10.Legal Questions
1. Know Your Definitions
Cannabis Sativa,
Agricultural Hemp,
Medical Cannabis,
CBD & THC
Words Matter
•Cannabis Sativa L.
– Source of medical cannabis and agricultural hemp
– Contains 60-100 constituents
– THC: psychoactive
– CBD: not-psychotoxic
•Medical Cannabis (MC) - cannabis for medical
purposes
– Marijuana (MJ) - cannabis for recreational purposes
•Agricultural Hemp (AH) – until recently referred to the
commercial use of the cannabis stalk and seed
– less than 0.3% THC by dry weight
2. History of Cannabis
Use & Safety
History of Cannabis
• First reported as medicine > 5000 years
• Introduced into Western medicine in
1840s by Dr. W.B. O’Shaughnessy
• Cannabis extract from cannabis plants
was the medicine of choice in the early
1930s
• Promoted as analgesic, sedative, anti-
inflammatory, antispasmotic, and
anticonvulsant properties
• Available in 1906 Mfg by Eli Lilly, Wyeth
Park-Davis, Sharp & Dohme
3. The Endocannabinoid
System (ECS)
Balance is Everything
Master Control System (ECS)
•Endocannabinoids are “messengers”, isolated from
brain and peripheral tissues that communicate via
cannabinoid receptors
–Anandamide and 2AG
–Main Receptors: CB1 and CB2
•Involved in the direct regulation of appetite, metabolic
health, pain/inflammation, thermoregulation, intra-
ocular pressure, sensation, muscle control,
motivation/reward, mood, and memory
•Involved in learning and synaptic plasticity
Balance is Everything
•ECS tone requires CB1 and CB2 balance as well as
‘optimal’ CB1 activation
•Optimal CB1 activity decreases anxiety, reduces pain,
decreases inflammation, controls sensory perception,
memory and cognitive function
•Anandamide binds to CB1 as does THC which can over
stimulate CB1
–Stress will increase Anandamide
–Anandamide derived from Omega6
•Overstimulation of CB1 has many negative effects
WHY SHOULD WE CARE
ABOUT ECS TONE?
Source: http://eurheartjsupp.oxfordjournals.org/content/10/suppl_B/B34/F1.expansion
Master Control System (ECS)
“…Science has linked the ECS with
complex processes from anxiety to
immunity…This research bonanza is
revealing more and more about the ECS
master control system and it’s shining
star, cannabidiol.”
4. Potential Uses of CBD
GW PHARMACEUTICALS:
BEST CANNABIS PLAY AND A
RENEWED BUY AFTER Q4
RESULTS
READ THIS NEW
BOOK:
“The Medicinal Powers
Of Cannabis”
By John Hicks, MD
Available At
GreenHealthCube.com
5. Environmental and Health
Impact of Grow Practices
Agricultural Hemp vs
Medical Cannabis
Comparing Hemp to Medical Cannabis
Indoor Grown Medical Cannabis
• Enormous Carbon Foot Print
• Environmentally Harmful
• Wasteful Water Demands
• Huge Strain on Power Grid
• Consequences of Fungicides, Pesticides
and Fertilizers
• Unsustainable
Outdoor Grown Agricultural Hemp
• Sequesters CO2
• Environmentally Helpful
• Requires 80% less water
• Sun Powered Outdoor Grow
– No artificial light Sources required
• Zero Fungicides, Pesticides and Fertilizers
• Textbook Sustainability
December 3, 2015
2014
6. Does Source of CBD Matter?
NO! Source Does Not Matter
• CBD is CBD
• CBD from AH or high-CBD strain MC act
the same in our bodies
• CBD from AH affords a non-
psychoactive option
And…Agricultural Hemp is Amazing!
• Non-psychotoxic
–Supports health and balance without a ‘high’
• Whole Plant Incredibly Useful
–Food, fiber, building materials, fuels – 25K uses!
• Nutrient-rich
– EFAs, amino acids, vitamin E, phosphorus, potassium,
sodium, magnesium, sulfur, calcium, iron, zinc
• Eco-friendly
– Sequesters CO2
– No herbicides
– Repletes soil
7. The Entourage Effect
Whole Plant Synergy
•Entourage Effect – refers to the idea that different
constituents of cannabis work synergistically
–Overstates the importance of THC
–Ignores the benefits from all the other parts of the plant not
used when only ingesting flowers
•Hemptourage Effect – refers to the idea that you
get superior synergistic benefit from ingesting the
over 500 components found in the whole plant
–Minimal THC
TOTAL PLANT COMPLEX – GREEN FORMULA
GOLD FORMULA
8. State of the Research
Why Don’t We Have More Research?
• Cannabis is listed as a Schedule 1 drug, making it
difficult to conduct research over certain limits
• CBD is not directly scheduled, there is no reference of CBD in
the Federal Acts
• AH not a controlled substance
• Only allowed to be grown under research oversight and
illegal to commercially grow and extract in US
• Good source material for phytocannabinoids is difficult
to obtain.
• Issues with growing, selling, and transporting across state
lines.
• Can be imported
9. Safety Data
CBD’s Remarkable Safety Profile
•Studies showing CBD as non-toxic
–Does not induce changes on food intake, does not induce
catalepsy, does not affect physiological parameters (heart
rate, blood pressure and body temperature)
– Does not affect gastrointestinal transit nor alter psychomotor
or psychological functions.
– Chronic use and high doses up to 1,500 mg/day of CBD are
reportedly well tolerated in humans.
•Conclusion: Based on recent advances in cannabinoid
administration in humans, CBD shows safety in humans
and animals
10. State of Legal Issues
Remember:
• Hemp is not defined as “marijuana” under the Controlled
Substances Act (CSA)
• Expressly and intentionally excludes: mature stalks, fiber from stalks,
oil or cake made from seeds, any other compound, manufacture,
salt, derivative, mixture, or preparation of such mature stalks (except
resin extracted therefrom), fiber, oil, or cake, or the sterilized seed of
such plant which is incapable of germination.
• Naturally occurring cannabinoids in agricultural hemp foods,
including oils, were never scheduled under the CSA.
• Agricultural hemp fiber, stalk, seed, and oils can be lawfully
imported into the United States and these portions of the hemp
plant may enter into US commerce
In order to make the
highest quality CBD
products, we believe it
is imperative to be a
part of every step of
the supply chain
process.
FULL TRACEABILITY
FROM SEED TO SHELF™
THE DIFFERENCE
BETWEEN OUR OILS
The raw oil is a total plant CO2 extract from agricultural hemp, imported from Europe. Cannabidiolic Acid, or
CBDA, comprises a significant proportion of the extracted cannabinoids in the raw oil. CBDA is an acidic
cannabinoid, the naturally-occurring raw form of CBD that is produced directly in the plant, and contains many
beneficial properties distinct from CBD.
RAW
DECARBOXYLATION
DISTILLED
TOTAL PLANT COMPLEX
GOLD FORMULA
Our Gold Formula is the ultimate step in refining our oil, where excess plant material is distilled from our
decarboxylated oil in a solvent-free process, rendering the oil gold in color. The final oil comprises only of CBD,
minor cannabinoids, and plant-derived fatty acids. Our Gold Formula oil is the highest-concentrated form of
CBD oil that we offer.
The raw oil undergoes a process called decarboxylation (a gentle heating process), in which most of the
remaining CBDA is converted into CBD to maximize the concentration of CBD.
For example, if the raw oil consisted of 100 milligrams of CBDA and 100 milligrams of CBD, the decarb oil will
contain a sum of 200 milligrams of CBD after decarboxylation, along with many of the cannabinoids, terpenes,
plant sterols, vitamin E and other natural plant material that comprises our Total Plant Complex.
TOTAL PLANT COMPLEX
GOLD FORMULA
PlusCBD Oil™
Balm
2-10 sprays = 1mg-5mg CBD
PlusCBD Oil™
1oz 100mg Spray
Unflavored
Peppermint
Vanill
a
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Natural Vanilla Flavor,
Stevia Leaf Extract, Potassium Sorbate
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Peppermint Oil (Mentha
Piperita), Stevia Leaf Extract, Potassium
Sorbate
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Stevia Leaf Extract,
Potassium Sorbate
PlusCBD Oil™
2oz 200mg Spray
2-10 sprays = 1mg-5mg CBD
Unflavored
Peppermint
Vanilla Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Natural Vanilla Flavor,
Stevia Leaf Extract, Potassium Sorbate
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Peppermint Oil (Mentha
Piperita), Stevia Leaf Extract, Potassium
Sorbate
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Stevia Leaf Extract,
Potassium Sorbate
2-10 sprays = 3mg-15mg
CBD
PlusCBD Oil™
2oz 500mg Spray
Unflavored
Peppermint
Vanill
a
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Natural Vanilla Flavor,
Stevia Leaf Extract, Potassium Sorbate
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Peppermint Oil
(Mentha Piperita), Stevia Leaf Extract,
Potassium Sorbate
Other Ingredients: Glycerin (Kosher),
Purified Water, Polysorbate 80 (Kosher),
Sunflower Lecithin, Stevia Leaf Extract,
Potassium Sorbate
Applicator use: Place 0.25mL on spoon.
Place in mouth and swallow. Adjust dose as
needed.
PlusCBD Oil™
1g Green Applicator
Other Ingredients: none
Applicator use: Place 0.25mL on spoon.
Place in mouth and swallow. Adjust dose as
needed.
PlusCBD Oil™
1g Gold Applicator
Other Ingredients: none
Applicator use: Place 0.25mL on spoon.
Place in mouth and swallow. Adjust dose as
needed.
PlusCBD Oil™
3 & 10g Green Applicator
Other Ingredients: none
Other Ingredients: none
Applicator use: Place 0.25mL on spoon.
Place in mouth and swallow. Adjust dose as
needed.
PlusCBD Oil™
3 & 10g Gold Applicators
Other Ingredients: none
Other Ingredients: none
PlusCBD Oil™
30ct Capsules
Other Ingredients: Food Starch - modified, Vegetable
Cellulose, Silicon Dioxide, Vegetarian Capsule (Vegetable
Cellulose, Water)
Use: 1 capsule daily.
PlusCBD Oil™
1gm Grams
Other Ingredients:
None
SUGGESTED USE: Take 1 serving daily. Scoop 250 mg (1/4
container). Place in mouth and swallow.
TOTAL PLANT COMPLEX– FOR THE PURIST
PlusCBD Oil™
1gm Grams
Other Ingredients:
None
SUGGESTED USE: Take 1 serving daily. Scoop 250 mg (1/4
container). Place in mouth and swallow.
GOLD FORMULA– FOR MAXIMUM EFFECT
PROUD
MEMBERS OF:
American Herbal Products Association
Hemp Industries Association
Kentucky Hemp Industries Association
Kentucky Hemp Industry Council
European Industrial Hemp Association
National Hemp Association
Takeaways
What to Look For In a CBD
Company/Product?
–Full Traceability
–No medical claims or dosing
recommendations
–Efforts to grow research
–GRAS self-determination/safety
assessments
–Commitment to Education
–Involvement with Trade Organizations
Thank you for attending
our teleseminar!
QUESTIONS?

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Plus CBD Oil - Hemp-Derived CBD: 10 Things You Need To Know

  • 1. 10 Things You Need To Know About Hemp-Derived CBD Presented by: AimĂŠe Shunney, ND
  • 2. 10 Things You Need To Know About Hemp-Derived CBD 1.Semantics 2.History 3.Balance is Everything 4.Utility 5.Grow Practices 6.Source 7.Whole Plant Synergy 8.Research 9.Safety 10.Legal Questions
  • 3. 1. Know Your Definitions Cannabis Sativa, Agricultural Hemp, Medical Cannabis, CBD & THC
  • 4. Words Matter •Cannabis Sativa L. – Source of medical cannabis and agricultural hemp – Contains 60-100 constituents – THC: psychoactive – CBD: not-psychotoxic •Medical Cannabis (MC) - cannabis for medical purposes – Marijuana (MJ) - cannabis for recreational purposes •Agricultural Hemp (AH) – until recently referred to the commercial use of the cannabis stalk and seed – less than 0.3% THC by dry weight
  • 5. 2. History of Cannabis Use & Safety
  • 6. History of Cannabis • First reported as medicine > 5000 years • Introduced into Western medicine in 1840s by Dr. W.B. O’Shaughnessy • Cannabis extract from cannabis plants was the medicine of choice in the early 1930s • Promoted as analgesic, sedative, anti- inflammatory, antispasmotic, and anticonvulsant properties • Available in 1906 Mfg by Eli Lilly, Wyeth Park-Davis, Sharp & Dohme
  • 7. 3. The Endocannabinoid System (ECS) Balance is Everything
  • 8. Master Control System (ECS) •Endocannabinoids are “messengers”, isolated from brain and peripheral tissues that communicate via cannabinoid receptors –Anandamide and 2AG –Main Receptors: CB1 and CB2 •Involved in the direct regulation of appetite, metabolic health, pain/inflammation, thermoregulation, intra- ocular pressure, sensation, muscle control, motivation/reward, mood, and memory •Involved in learning and synaptic plasticity
  • 9. Balance is Everything •ECS tone requires CB1 and CB2 balance as well as ‘optimal’ CB1 activation •Optimal CB1 activity decreases anxiety, reduces pain, decreases inflammation, controls sensory perception, memory and cognitive function •Anandamide binds to CB1 as does THC which can over stimulate CB1 –Stress will increase Anandamide –Anandamide derived from Omega6 •Overstimulation of CB1 has many negative effects
  • 10. WHY SHOULD WE CARE ABOUT ECS TONE? Source: http://eurheartjsupp.oxfordjournals.org/content/10/suppl_B/B34/F1.expansion
  • 11. Master Control System (ECS) “…Science has linked the ECS with complex processes from anxiety to immunity…This research bonanza is revealing more and more about the ECS master control system and it’s shining star, cannabidiol.”
  • 13.
  • 14. GW PHARMACEUTICALS: BEST CANNABIS PLAY AND A RENEWED BUY AFTER Q4 RESULTS READ THIS NEW BOOK: “The Medicinal Powers Of Cannabis” By John Hicks, MD Available At GreenHealthCube.com
  • 15. 5. Environmental and Health Impact of Grow Practices Agricultural Hemp vs Medical Cannabis
  • 16. Comparing Hemp to Medical Cannabis Indoor Grown Medical Cannabis • Enormous Carbon Foot Print • Environmentally Harmful • Wasteful Water Demands • Huge Strain on Power Grid • Consequences of Fungicides, Pesticides and Fertilizers • Unsustainable Outdoor Grown Agricultural Hemp • Sequesters CO2 • Environmentally Helpful • Requires 80% less water • Sun Powered Outdoor Grow – No artificial light Sources required • Zero Fungicides, Pesticides and Fertilizers • Textbook Sustainability
  • 18. 2014
  • 19. 6. Does Source of CBD Matter?
  • 20. NO! Source Does Not Matter • CBD is CBD • CBD from AH or high-CBD strain MC act the same in our bodies • CBD from AH affords a non- psychoactive option
  • 21. And…Agricultural Hemp is Amazing! • Non-psychotoxic –Supports health and balance without a ‘high’ • Whole Plant Incredibly Useful –Food, fiber, building materials, fuels – 25K uses! • Nutrient-rich – EFAs, amino acids, vitamin E, phosphorus, potassium, sodium, magnesium, sulfur, calcium, iron, zinc • Eco-friendly – Sequesters CO2 – No herbicides – Repletes soil
  • 23. Whole Plant Synergy •Entourage Effect – refers to the idea that different constituents of cannabis work synergistically –Overstates the importance of THC –Ignores the benefits from all the other parts of the plant not used when only ingesting flowers •Hemptourage Effect – refers to the idea that you get superior synergistic benefit from ingesting the over 500 components found in the whole plant –Minimal THC
  • 24. TOTAL PLANT COMPLEX – GREEN FORMULA
  • 26. 8. State of the Research
  • 27. Why Don’t We Have More Research? • Cannabis is listed as a Schedule 1 drug, making it difficult to conduct research over certain limits • CBD is not directly scheduled, there is no reference of CBD in the Federal Acts • AH not a controlled substance • Only allowed to be grown under research oversight and illegal to commercially grow and extract in US • Good source material for phytocannabinoids is difficult to obtain. • Issues with growing, selling, and transporting across state lines. • Can be imported
  • 29. CBD’s Remarkable Safety Profile •Studies showing CBD as non-toxic –Does not induce changes on food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure and body temperature) – Does not affect gastrointestinal transit nor alter psychomotor or psychological functions. – Chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. •Conclusion: Based on recent advances in cannabinoid administration in humans, CBD shows safety in humans and animals
  • 30. 10. State of Legal Issues
  • 31. Remember: • Hemp is not defined as “marijuana” under the Controlled Substances Act (CSA) • Expressly and intentionally excludes: mature stalks, fiber from stalks, oil or cake made from seeds, any other compound, manufacture, salt, derivative, mixture, or preparation of such mature stalks (except resin extracted therefrom), fiber, oil, or cake, or the sterilized seed of such plant which is incapable of germination. • Naturally occurring cannabinoids in agricultural hemp foods, including oils, were never scheduled under the CSA. • Agricultural hemp fiber, stalk, seed, and oils can be lawfully imported into the United States and these portions of the hemp plant may enter into US commerce
  • 32. In order to make the highest quality CBD products, we believe it is imperative to be a part of every step of the supply chain process. FULL TRACEABILITY FROM SEED TO SHELF™
  • 33. THE DIFFERENCE BETWEEN OUR OILS The raw oil is a total plant CO2 extract from agricultural hemp, imported from Europe. Cannabidiolic Acid, or CBDA, comprises a significant proportion of the extracted cannabinoids in the raw oil. CBDA is an acidic cannabinoid, the naturally-occurring raw form of CBD that is produced directly in the plant, and contains many beneficial properties distinct from CBD. RAW DECARBOXYLATION DISTILLED TOTAL PLANT COMPLEX GOLD FORMULA Our Gold Formula is the ultimate step in refining our oil, where excess plant material is distilled from our decarboxylated oil in a solvent-free process, rendering the oil gold in color. The final oil comprises only of CBD, minor cannabinoids, and plant-derived fatty acids. Our Gold Formula oil is the highest-concentrated form of CBD oil that we offer. The raw oil undergoes a process called decarboxylation (a gentle heating process), in which most of the remaining CBDA is converted into CBD to maximize the concentration of CBD. For example, if the raw oil consisted of 100 milligrams of CBDA and 100 milligrams of CBD, the decarb oil will contain a sum of 200 milligrams of CBD after decarboxylation, along with many of the cannabinoids, terpenes, plant sterols, vitamin E and other natural plant material that comprises our Total Plant Complex.
  • 37. 2-10 sprays = 1mg-5mg CBD PlusCBD Oil™ 1oz 100mg Spray Unflavored Peppermint Vanill a Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Natural Vanilla Flavor, Stevia Leaf Extract, Potassium Sorbate Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Peppermint Oil (Mentha Piperita), Stevia Leaf Extract, Potassium Sorbate Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Stevia Leaf Extract, Potassium Sorbate
  • 38. PlusCBD Oil™ 2oz 200mg Spray 2-10 sprays = 1mg-5mg CBD Unflavored Peppermint Vanilla Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Natural Vanilla Flavor, Stevia Leaf Extract, Potassium Sorbate Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Peppermint Oil (Mentha Piperita), Stevia Leaf Extract, Potassium Sorbate Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Stevia Leaf Extract, Potassium Sorbate
  • 39. 2-10 sprays = 3mg-15mg CBD PlusCBD Oil™ 2oz 500mg Spray Unflavored Peppermint Vanill a Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Natural Vanilla Flavor, Stevia Leaf Extract, Potassium Sorbate Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Peppermint Oil (Mentha Piperita), Stevia Leaf Extract, Potassium Sorbate Other Ingredients: Glycerin (Kosher), Purified Water, Polysorbate 80 (Kosher), Sunflower Lecithin, Stevia Leaf Extract, Potassium Sorbate
  • 40. Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed. PlusCBD Oil™ 1g Green Applicator Other Ingredients: none
  • 41. Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed. PlusCBD Oil™ 1g Gold Applicator Other Ingredients: none
  • 42. Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed. PlusCBD Oil™ 3 & 10g Green Applicator Other Ingredients: none Other Ingredients: none
  • 43. Applicator use: Place 0.25mL on spoon. Place in mouth and swallow. Adjust dose as needed. PlusCBD Oil™ 3 & 10g Gold Applicators Other Ingredients: none Other Ingredients: none
  • 44. PlusCBD Oil™ 30ct Capsules Other Ingredients: Food Starch - modified, Vegetable Cellulose, Silicon Dioxide, Vegetarian Capsule (Vegetable Cellulose, Water) Use: 1 capsule daily.
  • 45. PlusCBD Oil™ 1gm Grams Other Ingredients: None SUGGESTED USE: Take 1 serving daily. Scoop 250 mg (1/4 container). Place in mouth and swallow. TOTAL PLANT COMPLEX– FOR THE PURIST
  • 46. PlusCBD Oil™ 1gm Grams Other Ingredients: None SUGGESTED USE: Take 1 serving daily. Scoop 250 mg (1/4 container). Place in mouth and swallow. GOLD FORMULA– FOR MAXIMUM EFFECT
  • 47.
  • 48. PROUD MEMBERS OF: American Herbal Products Association Hemp Industries Association Kentucky Hemp Industries Association Kentucky Hemp Industry Council European Industrial Hemp Association National Hemp Association
  • 49. Takeaways What to Look For In a CBD Company/Product? –Full Traceability –No medical claims or dosing recommendations –Efforts to grow research –GRAS self-determination/safety assessments –Commitment to Education –Involvement with Trade Organizations
  • 50. Thank you for attending our teleseminar! QUESTIONS?