A new mass spectrometry data acquisition system allows for simultaneous total ion chromatography and single-ion monitoring from a single sample injection. This provides total ion chromatograms as well as chromatograms for up to 32 individual ions. Using this system along with low-bleed columns improves detection limits by a factor of ten compared to EPA method 8270, while maintaining uncompromised component responses in total ion chromatograms. The degree of confidence in compound identification is also improved due to acquiring scan and SIM data simultaneously.