This document discusses emerging and re-emerging challenges in water quality. It outlines key water quality parameters and indicators, including physiochemical factors and bio-indicators like E. coli. Emerging challenges include polluted runoff transporting pathogens, combined sewer overflows during storms, and rapid urbanization overwhelming sanitation systems. Re-emerging pathogens are also discussed, driven by new environments, technologies, and intensive livestock practices. Recommendations focus on improved sanitation, integrated water management, wastewater treatment, and monitoring to address these challenges.