Vitrolife medium and Embryo Glue contain hyaluronan, which is found naturally in the uterus and involved in embryo implantation. Embryo Glue has a higher concentration of hyaluronan and is used to transfer embryos back to the uterus on the day of transfer. While some studies found higher pregnancy rates with Embryo Glue, others did not find a significant benefit. There is no evidence it harms embryos. Using these products increases the cost of treatment cycles.

1. All embryos must be grown in culture medium. Vitrolife medium differs from our
standard culture media in that it contains a compound called Hyaluronan, a complex
macromolecule found in the tubal and uterine fluid of many species. Data suggests that
it is involved in fertilisation, embryo development and implantation and that its activity
peaks around embryo implantation on Day 5.
Eggs are placed into Vitrolife medium with Hyaluronan immediately after the egg
collection and resultant embryos are cultured in this media until your embryo
transfer. Embryo Glue is the final stage of the Vitrolife media range, into which your
embryos are placed before transfer. Some Embryo Glue is transferred with the
embryo(s) back into your uterus. Embryo Glue can be used in the transfer of embryos
at any developmental stage.
Embryo Glue is an extension of the Vitrolife culture media but with increased amount of
Hyaluronan. It has been proposed that Embryo Glue may be beneficial at transfer by
allowing improved mixing of the embryo with uterine secretions and that is could act as
a binding agent between uterine lining and the embryo. There are some reports of
higher pregnancy rates especially after the transfer of frozen embryos however, other
unpublished presentations have not supported these observations. There is no data to
suggest that using Embryo Glue is detrimental to embryos.
Vitrolife Media and Embryo Glue are available to PIVET patients. This will significantly
increase the cost of the treatment cycle and due to this cost, if your cycle is cancelled
and you are using Embryo Glue / Vitrolife media, there is a fee that needs to be paid as
your dishes are set up in the media the day before your egg collection. If you are
interested, please speak to your Clinician.
Embryo Glue is an implantation promoting transfer medium which contains a substance
known as hyaluronic acid. Hyaluronic acid is found in the human uterus, and by adding
it to the culture media it more closely mimics the natural environment. A high
concentration of hyaluronic acid is transferred with the embryo back into the uterus on
the day of transfer. It can be used in the transfer of an embryo at any stage.
If you would like more information please visit Vitrolife.
Who would benefit from Embryo Glue?
Embryo Glue may benefit couples who have had multiple cycles without implantation
although it is available to any patient.
What is the cost of Embryo Glue?

2. Embryo Glue is a more expensive medium than our standard medium therefore it will
cost you more to use. The cost for a fresh IVF cycle is $500 and for a FET cycle $350.
Are there any risks to using Embryo Glue?
There appears to be no risks to using Embryo Glue to yourself or resultant babies. Data
analysis at PIVET show’s that is does no damage to your embryos, and will give you
the same chance of pregnancy as our standard medium however it may have an added
benefit for patients with implantation failure.
OUR LOCATIONS
PIVET Leederville
PIVET Medical Centre, 166-168 Cambridge Street, Leederville WA 6007 Australia
(08) 9422 5400
(08) 9382 4576
Bunbury Centre
Brecken Health Care, 12-16 Vasse Street, SOUTH BUNBURY WA 6230 Australia
(08) 9791 4174
(08) 9791 4174
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© Pivet Medical Center, 2019