This study examines the mediating role of perceived personal competence in the development of burnout syndrome and stress symptoms among university professors facing potentially stressful work conditions. The study validated a structural model showing that perceived personal competence has a mediating effect on depersonalization and personal fulfillment dimensions of burnout, as well as stress symptoms. Emotional exhaustion was not found to be mediated by perceived competence. Emotional exhaustion also acted as a mediating variable, facilitating the negative impact of stressors on burnout dimensions and stress symptoms.