This study examines the impact of government taxation policy on the sales revenue of small and medium enterprises (SMEs) in Uasin Gishu County, Kenya, highlighting taxation as a critical factor affecting their growth and profitability. The research reveals statistically significant relationships between taxation policies and sales revenue, indicating that unfavorable tax conditions can hinder SME performance and encourage operations in informal markets. The study suggests that modifications to taxation rates and compliance costs for SMEs could enhance their sales revenues, overall profitability, and consequently, government tax revenues.