Drug targeting nanotechnology uses nanoparticles ranging from 1-100nm to selectively deliver drugs to target organs, tissues, or cells. Nanoparticles protect drugs from degradation and increase bioavailability, allowing sustained release over time. There are two main types of nanoparticles for drug delivery - organic nanoparticles like polymers, liposomes, and lipid nanoparticles, and inorganic nanoparticles like metal nanoparticles of gold, silver, and iron. Nanoparticles like liposomes and nanocrystals are able to encapsulate both hydrophobic and hydrophilic drugs and increase drug solubility, efficacy, and reduce side effects. Examples of FDA approved drugs that use nanotechnology for targeted delivery include Rapamune and Emend.

1. Drug targeting nanotechnology
Presented by :
Ahmed wael kishk

2. Drug targeting nanotechnology
The study , design , synthesis ,
mainipulation and application of
functional matrials at nanometer scale .
One nano meter being equal to 1x1o-9 .
That is at atomic and molecular levels .
It has many application specially in
medicine .

3. High specific medical intervention at
molecular scale for diagnosis ,
prevention , and treatment of
diseases .
In drug delivery , it is the ability of
drug to selectivity accumulate in the
require organ or tissue and at the
same time penetrate target cells to
deliver the bioactive agent .

4. Targeting strategies :
Working backwards is sometimes an
effective way to solve a problem .
In drug delivery research , this
means starting with delivery
methods .
The target may be whole organs or
tissue types or disease-specific
structure or structure inside cells .

5. More than 150 years ago , michael
faraday prepared gold particles in
nanometer scale .
These colloidal gold particles were
conjugated with anti-bodies to target
specific staining known ans immune-
gold staining .
1960s , loposomes and polumers cells
were first prepared , how ever it was
never referred as nano-particles until
2000

6. •Advantages
• Nano structures have the ability to
protect drugs encapsulated within
them from hydrolytic and enzymatic
degradation in the gestrontestinal tract
• Targeting the delivery of a wide range
of drug to various area of the body for
sustained release and thus are able to
deliver drugs and also able to deliver
protiens and genes through the peroral
administration .

7. • nanotechnology drugs increase oral
bioavailability of drugs due to
specialized up take mechanism and are
able to remain in the blood circulation
for longer time .

8. There are mainly 2 types of
nanoparticles as, Organic nano-
particles Polymers in DDS (polymeric
miscalls, polymeric NPs, polymeric drug
conjugates ) .
nano crystals and lipid based NPs like
liposomes, solid lipids and Inorganic
nanoparticles Metal NPs (gold, silver,
iron, platinum, quantum dots) .

9. Liposomes:
Lipids are amphiphilic molecules : both
hydrophobic and hydrophilic parts are
included in same molecule.
When it is contact with water, lipid
bilayer is formed Liposomes are able to
carry both hydrophobic and hydrophilic
drugs incorporated in to their vesicle
tails and heads .

10. It increases solubility of drugs;
improve pharmacokinetic properties
reduction of side effects, increase of
an in-vitro and in-vivo anticancer
activity and therapeutic index of
chemotherapeutic agents.

11. Nano-Crystals:
The drug which needs to be injected in
to the cell is produced in nano size and
it can function as its own carrier.
The drug particles readily water
soluble as a result of it nanosize.
The nanocrystals can reduce
accumulation of carrier particles and
directly drug can incorporate with
target site.

12. Nanocrystals become stable in
aqueous dispersion without any
stabilizers.
These can efficiently take up by tumor.

13. Polymeric nanoparticles :These are
synthetic polymers and size ranging
from10-100nm .
Polymer Drug conjugates:
Protein and peptide
Dendrimers : are synthetic polymers
with well defined size and structural
branched chain.

14. Metal nano-particles (MNP) :
Gold, silver, iron, platinum, ceramic,
quantum dots and super magnetic
uses as NPs because of it shape
depending optical, magnetic, electrical
properties and size.

15. • Applications :
Rapamune (Pfizer) an
immunosuppressant , Emend (Merck) an
antiemetic , Megace ES (Par) treats
apetite loss , TriCor (Abbot) cholesterol
and triglyceride lowering , Invega
Sustenna (Janssen) an antipsychotic drug.
The first 4 are oral dosage forms and the
last an IM depot. These drugs were
manufactured under license using Elan’s
NanoCrystal technology (now a part of
Alkermes).

16. Reference :
https://www.ajol.info/index.php/tjpr/article/view/44546
http://cdn.intechopen.com/pdfs/40262/InTech-
Nanotechnology_in_drug_delivery.pdf
https://www.researchgate.net/profile/Janith_Wanigasek
ara/publication/294675586_Applications_of_Nanotechn
ology_in_Drug_Delivery_and_Design_-
_An_Insight/links/587eef3508ae9a860ff54287/Applicatio
ns-of-Nanotechnology-in-Drug-Delivery-and-Design-An-
Insight.pdf?origin=publication_detail