• Concurrent use of Streptokinase and Antiplatelet agents such as Aspirin, Dipyridamole and Clopidogrel results in elevated risk of Bleeding.
• It is Contraindicated to use Fibrinolytics and Defibrotide concomitantly.
• Drugs increasing the risk of Fibrinolytics associated Bleeding include…
o Anticoagulants (Warfarin, Heparin, Enoxaparin, Dabigatran, etc)
o Antiplatelet agents (Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate Sodium
• Herbs increasing the risk of Fibrinolytics associated Bleeding include…
o Fenugreek
o Garlic
o Ginkgo
o Evening Primrose Oil
o Clove Oil
o Anise
o Turmeric (Curcumin)
o Licorice
o Asafetida
o Capsicum (Capsaicin)
o Celery
o Kava
o Cat's claw
o Medowsweet
o Feverfew
o Tan-shen
• It is Contraindicated to use Fibrinolytics and Defibrotide concomitantly.
• Drugs increasing the risk of Fibrinolytics associated Bleeding include…
o Anticoagulants (Warfarin, Heparin, Enoxaparin, Dabigatran, etc)
o Antiplatelet agents (Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate Sodium
• Herbs increasing the risk of Fibrinolytics associated Bleeding include…
o Fenugreek
o Garlic
o Ginkgo
o Evening Primrose Oil
o Clove Oil
o Anise
o Turmeric (Curcumin)
o Licorice
o Asafetida
o Capsicum (Capsaicin)
o Celery
o Kava
o Cat's claw
o Medowsweet
o Feverfew
o Tan-shen
Drug interactions of Low Molecular weight Heparins (LMWHs)Naina Mohamed, PhD
Low Molecular weight Heparins (LMWHs) may interact majorly with drugs such as Warfarin, Heparin and Other Anticoagulants like Danaparoid, Bivalirudin, Rivaroxaban, Apixaban, Dabigatran and Antiplatelet agents such as Aspirin, Clopidogrel, Ticagrelor, etc.
Clinically Important Drug Interactions of FibrinolyticsNaina Mohamed, PhD
• It is Contraindicated to use Fibrinolytics and Defibrotide concomitantly.
• Drugs increasing the risk of Fibrinolytics associated Bleeding include…
o Anticoagulants (Warfarin, Heparin, Enoxaparin, Dabigatran, etc)
o Antiplatelet agents (Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate Sodium
• Herbs increasing the risk of Fibrinolytics associated Bleeding include…
o Fenugreek
o Garlic
o Ginkgo
o Evening Primrose Oil
o Clove Oil
o Anise
o Turmeric (Curcumin)
o Licorice
o Asafetida
o Capsicum (Capsaicin)
o Celery
o Kava
o Cat's claw
o Medowsweet
o Feverfew
o Tan-shen
In this presentation, mainly I concentrated on Hydrochlorothiazide, which is a thiazide diuretic; and talking about it's pharmacokinetics, drug indication, contraindication, adverse drug reactions and taking the drug during pregnancy and lactation, finally I hope you enjoy it as much as I DID, SALAAM.
Drug Interactions of Recombinant Tissue Plasminogen Activators (rtPA)Naina Mohamed, PhD
Drug Interactions of Recombinant Tissue Plasminogen Activators (rtPA):
• The risk of Orolingual Angioedema is increased by the concomitant use of Alteplase and ACE inhibitors (Captopril, Lisinopril, Perindopril, etc).
• Concurrent use of Alteplase and Nitroglycerin (GTN) results in Less coronary artery reperfusion, Longer time to reperfusion, and more coronary artery Reocclusion
• It is Contraindicated to use Fibrinolytics and Defibrotide concomitantly.
• Drugs increasing the risk of Fibrinolytics associated Bleeding include…
o Anticoagulants (Warfarin, Heparin, Enoxaparin, Dabigatran, etc)
o Antiplatelet agents (Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate Sodium
• Herbs increasing the risk of Fibrinolytics associated Bleeding include…
o Fenugreek
o Garlic
o Ginkgo
o Evening Primrose Oil
o Clove Oil
o Anise
o Turmeric (Curcumin)
o Licorice
o Asafetida
o Capsicum (Capsaicin)
o Celery
o Kava
o Cat's claw
o Medowsweet
o Feverfew
o Tan-shen
• It is Contraindicated to use Fibrinolytics and Defibrotide concomitantly.
• Drugs increasing the risk of Fibrinolytics associated Bleeding include…
o Anticoagulants (Warfarin, Heparin, Enoxaparin, Dabigatran, etc)
o Antiplatelet agents (Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate Sodium
• Herbs increasing the risk of Fibrinolytics associated Bleeding include…
o Fenugreek
o Garlic
o Ginkgo
o Evening Primrose Oil
o Clove Oil
o Anise
o Turmeric (Curcumin)
o Licorice
o Asafetida
o Capsicum (Capsaicin)
o Celery
o Kava
o Cat's claw
o Medowsweet
o Feverfew
o Tan-shen
Drug interactions of Low Molecular weight Heparins (LMWHs)Naina Mohamed, PhD
Low Molecular weight Heparins (LMWHs) may interact majorly with drugs such as Warfarin, Heparin and Other Anticoagulants like Danaparoid, Bivalirudin, Rivaroxaban, Apixaban, Dabigatran and Antiplatelet agents such as Aspirin, Clopidogrel, Ticagrelor, etc.
Clinically Important Drug Interactions of FibrinolyticsNaina Mohamed, PhD
• It is Contraindicated to use Fibrinolytics and Defibrotide concomitantly.
• Drugs increasing the risk of Fibrinolytics associated Bleeding include…
o Anticoagulants (Warfarin, Heparin, Enoxaparin, Dabigatran, etc)
o Antiplatelet agents (Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate Sodium
• Herbs increasing the risk of Fibrinolytics associated Bleeding include…
o Fenugreek
o Garlic
o Ginkgo
o Evening Primrose Oil
o Clove Oil
o Anise
o Turmeric (Curcumin)
o Licorice
o Asafetida
o Capsicum (Capsaicin)
o Celery
o Kava
o Cat's claw
o Medowsweet
o Feverfew
o Tan-shen
In this presentation, mainly I concentrated on Hydrochlorothiazide, which is a thiazide diuretic; and talking about it's pharmacokinetics, drug indication, contraindication, adverse drug reactions and taking the drug during pregnancy and lactation, finally I hope you enjoy it as much as I DID, SALAAM.
Drug Interactions of Recombinant Tissue Plasminogen Activators (rtPA)Naina Mohamed, PhD
Drug Interactions of Recombinant Tissue Plasminogen Activators (rtPA):
• The risk of Orolingual Angioedema is increased by the concomitant use of Alteplase and ACE inhibitors (Captopril, Lisinopril, Perindopril, etc).
• Concurrent use of Alteplase and Nitroglycerin (GTN) results in Less coronary artery reperfusion, Longer time to reperfusion, and more coronary artery Reocclusion
• It is Contraindicated to use Fibrinolytics and Defibrotide concomitantly.
• Drugs increasing the risk of Fibrinolytics associated Bleeding include…
o Anticoagulants (Warfarin, Heparin, Enoxaparin, Dabigatran, etc)
o Antiplatelet agents (Aspirin, Clopidogrel, etc)
o Pentosan Polysulfate Sodium
• Herbs increasing the risk of Fibrinolytics associated Bleeding include…
o Fenugreek
o Garlic
o Ginkgo
o Evening Primrose Oil
o Clove Oil
o Anise
o Turmeric (Curcumin)
o Licorice
o Asafetida
o Capsicum (Capsaicin)
o Celery
o Kava
o Cat's claw
o Medowsweet
o Feverfew
o Tan-shen
Danaparoid can interact majorly with drugs such as Warfarin, Hirudins (Bivalirudin, Lepirudin) and Other Anticoagulants like Heparin, Enoxaparin, Dalteparin, Tinzaparin, Fondaparinux, Phenindione, Argatroban, Rivaroxaban, Apixaban and Dabigatran.
a clinically oriented discussion of blood coagulation and related diseases and treatment. also discussing DIC, plasma fractions and anti-platelet drugs.
Concomitant use of Heparin and Telavancin or Oritavancin is contraindicated. Heparin may also interact majorly with other Anticoagulants such as Enoxaparin, Dalteparin, Bivalirudin, Danaparoid, Rivaroxaban, Apixaban and Dabigatran.
Hirudins such as Bivalirudin, Desirudin, Lepirudin can interact majorly with drugs such as Warfarin, Heparin, Enoxaparin, Dalteparin, Tinzaparin, Fondaparinux, Phenindione, Argatroban, Rivaroxaban, Apixaban and Dabigatran.
Brief overview of Haematostasis & its players. Haemostasis is divided into 4 different stages. The first 2 stages are called Primary Haemostasis & Secondary Haemostasis, and the third stage is the natural anticoagulants at its work to stop the propagation of thrombosis and final stage is Fibrinolysis.
• Vorapoxar may interact with CYP3A4 enzyme inhibitors such as Ketoconazole, Itraconazole, Posaconazole, Clarithromycin, Nefazodone, Ritonavir, etc.
• Vorapoxar may also interact with CYP3A4 enzyme inducers like Rifampin.
• Cilostazol is a selective inhibitor of phosphodiesterase 3 (PDE3) and it is an antiplatelet drug and a vasodilator.
• Cilostazol can interact with Omeprazole, Fluoxetine, Fluvoxamine, Aspirin, Ticlopidine, Ticagrelor, Nefazodone, Azole antifungals, Idelalisib, Amiodarone, Cobicistat, Piperaquine and Ginkgo.
Glycoprotein IIB/IIIA inhibitors interact with Other Antiplatelets (Aspirin, Ticlopidine, Dipyridamole, etc.) and Ginkgo and increase the risk of bleeding.
Drug Interactions of Dipyridamole (Antiplatelt - Adenosine reuptake inhibitor)Naina Mohamed, PhD
Dipyridamole is used as an Antiplatelet drug by inhibiting the reuptake of adenosine. Dipyridamole can interact with many drugs including ADP blockers (Clopidogrel, Prasugrel, Ticlopidine, Ticagrelor, etc), Glycoprotein IIB/IIIA inhibitors (Abciximab, Tirofiban, etc.), Fibrinolytics (Reteplase, Tenecteplase, Streptokinase, etc.), Adenosine, Treprostinil, Sulfinpyrazone, Regadenoson, Distigmine and Ginkgo.
Drug Interactions of ADP receptor Blockers (Antiplatelets)Naina Mohamed, PhD
· ADP receptor Blockers (Antiplatelets) include Thienopyridines (Clopidogrel, Prasugrel, Ticlopidine) and Non-Thienopyridines (Ticagrelor, Cangrelor, Elinogrel ).
· The risk of adverse effects could be reduced by healthcare professionals through the screening, education, and follow up on suspected drug interactions.
Aspirin is an antiplatelet drug and it produces antiplatelet activity in lower doses (75-100 mg daily), while Higher dose of Aspirin (Up to 3600 mg daily in divided doses) is required for it’s analgesic effects.
§ Islamic fasting is similar to Alternate Day Fasting (ADF), since the feast and fast periods of Islamic fasting lasts 12 hours in average.
§ Though Islamic fasting is associated with some adverse effects, there was no detrimental effects on health attributed directly to them, in health individuals. And the adverse effects of fasting could be minimized very easily by following the preventive measures.
§ The chronic patients with Diabetes, Coronary Artery Disease (CAD), Cancer, Ulcer, Urolithiasis, Chronic Kidney Disease (CKD), etc. should consult the healthcare professionals before observing Fasting.
§ Moreover, Islam exempts the Sick, Travelers and Pregnant, Breast Feeding and Menstruating women from fasting.
§ Islamic Fasting can be good for health if it's done correctly.
• Concomitant use of Dabigatran and Itraconazole or Ketoconazole is contraindicated.
• Drugs such as Heparin, Enoxaparin, Dalteparin, Tinzaparin, Bivalirudin, Lepirudin, Fondaparinux, Phenindione, Danaparoid, Rivaroxaban, Apixaban, Verapamil, Quinidine, Amiodarone, Ketoconazole, Itraconazole, Ritonavir, Saquinavir, Nelfinavir, Tacrolimus and Cyclosporine increase the risk of Dabigatran induced bleeding.
• Coadministration of Dabigatran with P-Glycoprotein Inducers like Carbamazepine, Rifampin or St. John's wort elevate the risk of Thrombosis.
Argatroban can interact majorly with drugs such as Heparin, Enoxaparin, Dalteparin, Tinzaparin, Bivalirudin, Lepirudin, Fondaparinux, Phenindione, Danaparoid, Rivaroxaban, Apixaban, and Dabigatran.
Warfarin interacts majorly with drugs such as Tamoxifen, Simvastatin, Penicillins, cephalosporins, Macrolide antibiotics, Fluoroquinolones, Sulphonamides, Azole antifungals, Amiodarone, Enoxaparin, Danaparoid, Antiplatelets, Fish oil, Vitamin K rich foods, Green tea, Pomegranate etc.
Complementary and alternative therapies for Coronary Heart Disease (CHD)Naina Mohamed, PhD
Dietary supplements used to treat Coronary Heart Disease (CHD) include Omega 3 fatty acids, Vitamin C, Vitamin E, Fiber and Coenzyme Q10. And the Mind-Body approaches to treat CHD include Chelation therapy, Meditation, Acupuncture, Reflexology and Tai chi.
Complementary and alternative therapies for hypertensionNaina Mohamed, PhD
To treat hypertension many CAM approaches are useful including Mind and Body Practices such as Dynamic Aerobic (Endurance) Exercise, Dynamic Resistance Exercise, Device-Guided Slow Breathing, Transcendental Meditation (TM), Biofeedback Techniques and Acupuncture, Herbal Supplements such as Garlic, Black cumin, Cinnamon, Flaxseed, Sour Tea, Ginger, Cardamom, Green Tea, Sweet basil, Celery, Ginseng, Saffron, Goldthread, Oats, Chinese hawthorn, Carrot, Tomato, Pomegranate, Radish and Sesame and Dietary Supplements like Coenzyme Q10, Omega 3 FAs, Melatonin and Vitamin D.
Complementary and alternative therapies for hyperlipidemiaNaina Mohamed, PhD
CAM for Hyperlipidemia includes Dietary Supplements (Omega-3 Fatty Acids, Plant sterols and stanols, Soy protein, Flax seed, Red yeast rice), Herbal Supplements (Ginger, Garlic, Ginseng) and Mind – Body Practices (Transcendental Meditation and Yoga).
¢ The imbalance between caloric intake and expenditure might result in to Overweight or Obesity.
¢ An US study reported that the Complementary and Alternative Medicine (CAM) use is high and continues to increase.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
1. D R U G
I N T E R A C T I O N S
O F
F I B R I N O LY T I C S
( P A R T 2 )
( D R U G I N T E R A C T I O N S O F
S T R E P T O K I N A S E )
D r P. N a i n a M o h a m e d P h D
P h a r m a c o l o g i s t
2. INTRODUCTION
• Streptokinase is a Fibrinolytic agent and it is isolated and purified from streptococci
bacteria.
• Our body develops an immunity to Streptokinase, since it is a bacterial product.
Hence, it is not recommended to use Streptokinase again after four days from the
administration. Further thrombotic events could be treated with Tissue plasminogen
activators (tPA).
• Streptokinase is used in Acute Myocardial Infarction, Arterial and Venous Thrombosis
and Pulmonary Embolism.
• Due to the lack of fibrin specificity of Streptokinase, it produces more fibrinogenolysis
which makes it a less desirable thrombolytic drug than tPA compounds.
• Overdose of Streptokinase or tPA can be treated with Aminocaproic acid.
• Interaction between one or more coadministered medications leading to change in
their effectiveness or toxicity, is termed as “Adverse drug interaction”.
• Fibrinolytic agents can interact with prescription drugs, Over-the-counter (OTC)
3. MECHANISM OF ACTION OF FIBRINOLYTICS
• Ideally, thrombolytic drugs should be given within the first 2 hours of Ischemic Stroke
and Acute Myocardial Infarction.
Fibrinolytics
Bind to fibrin on the
surface of the clot
Activation of fibrin-
bound Plasminogen
Plasmin is cleaved
from fibrin-bound
Plasminogen
Plasmin breaks
cross-links between
fibrin molecules
Dissolution of clot
5. STREPTOKINASE
& ANTIPLATELET AGENTS
• Close monitoring for bleeding is recommended, if concomitant use of Fibrinolytics and
Antiplatelet agents such as Aspirin, Clopidogrel, etc. is required.
http://www.neurology.org/content/79/13_Supplement_1/S68.long
Streptokinase +
Antiplatelet agents
(Aspirin, Dipyridamole,
Clopidogrel, etc)
Additive effects Increased risk of bleeding
6. FIBRINOLYTICS & DEFIBROTIDE
• Use of Fibrinolytic agents should be discontinued before initiating Defibrotide.
http://reference.medscape.com/drug/activase-tpa-alteplase-342287#3
Fibrinolytics +
Defibrotide
Defibrotide increases
tissue plasminogen
activator (tPA)
function, and
decreases the activity
of tissue plasminogen
activator inhibitor
Increased risk of
bleeding
Contraindicated
7. FIBRINOLYTICS & ANTICOAGULANTS
• Observe patients for external bleeding and be alert for signs and symptoms of internal bleeding,
if concomitant use of an anticoagulant and a fibrinolytic agent is required.
https://www.ncbi.nlm.nih.gov/pubmed/11085346
Fibrinolytics +
Anticoagulants (Warfarin,
Heparin, Enoxaparin,
Dabigatran, etc)
Additive
anticoagulation
Increased risk of
bleeding
8. FIBRINOLYTICS & PENTOSAN
POLYSULFATE SODIUM
• Monitor the patient closely for bleeding complications, if Fibrinolytics and Pentosan
polysulfate sodium are used concomitantly.
https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=8930#sect
ion-9
9. THROMBOLYTICS & FENUGREEK
• Caution is advised if fenugreek and thrombolytic agents are used concomitantly.
• Monitor the patients for signs and symptoms of excessive bleeding.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949941/
Thrombolytics +
Fenugreek
Coumarins of
Fenugreek may affect
blood coagulation
Increased risk of
bleeding
10. THROMBOLYTICS & GARLIC
• Monitor for signs and symptoms of excessive bleeding, if excessive garlic is consumed
with concomitant use of thrombolytic agents.
• Garlic supplements should be discontinued at least 10 days prior to elective surgery.
http://ijpho.ssu.ac.ir/article-1-32-en.pdf
Thrombolytics +
Garlic
Garlic may reduce
thromboxane B2
Inhibition of platelet
aggregation
Increased risk of
bleeding
11. THROMBOLYTICS & GINKGO
• If both agents are taken together, monitor bleeding time and signs and symptoms of
excessive bleeding.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1490168/
Thrombolytics + Ginkgo
Ginkgolide B of Ginkgo may
inhibit Platelet Activating
Factor (PAF) induced Platelet
aggregation
Increased risk of bleeding
12. THROMBOLYTICS & EVENING PRIMROSE
OIL
• Caution is advised if evening primrose oil and thrombolytic agents are used
concomitantly.
• Monitor the patients for signs and symptoms of excessive bleeding.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2541068/pdf/bmj00459-0008.pdf
Thrombolytics + Evening
Primrose Oil
Gamma-linolenic acid of
Evening primrose oil inhibits
Thromboxane B2 synthesis and
increases Prostacyclin synthesis
Additive anticoagulant effect Increased risk of bleeding
13. THROMBOLYTICS & CLOVE OIL
• Avoid concomitant use of clove oil with thrombolytic agents. If both are taken together
monitor the patient closely for signs and symptoms of bleeding.
http://jpma.org.pk/full_article_text.php?article_id=4757
Thrombolytics + Clove
oil
Clove oil inhibits Platelet
aggregation
Increased risk of
bleeding
14. THROMBOLYTICS & ANISE
• Concomitant use warrants monitoring of the patients for signs and symptoms of
increased bleeding.
http://www.ajhp.org/content/57/13/1221.long
Increased risk of
bleeding
Coumarin of Anise
may increase the
anticoagulant effect
Thrombolytics +
Anise
15. THROMBOLYTICS & TURMERIC
(CURCUMIN)
• Caution is advised if curcumin and thrombolytic agents are used concomitantly.
• Monitor for signs and symptoms of excessive bleeding.
http://www.sciencedirect.com/science/article/pii/0049384885902762?via%3Dihub
Thrombolytics +
Turmeric (Curcumin)
Curcumin inhibits
platelet aggregation
Increased risk of
bleeding
16. THROMBOLYTICS & LICORICE
• Monitor the patients for signs and symptoms of excessive bleeding.
http://www.sciencedirect.com/science/article/pii/S0049384803005425
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345862/
Thrombolytics +
Licorice
Licorice may inhibit
Thrombin and
Platelet aggregation
Increased risk of
bleeding
17. THROMBOLYTICS & ASAFETIDA
• Monitor the patient closely for signs and symptoms of bleeding.
http://www.ajhp.org/content/57/13/1221.long
Thrombolytics +
Asafetida
Additive
anticoagulant effects
increased risk of
bleeding
18. THROMBOLYTICS & CAPSICUM
(CAPSAICIN)
• Signs and symptoms of excessive bleeding should be monitored closely if capsaicin
and thrombolytic agents are taken concomitantly.
http://www.ajhp.org/content/57/13/1221.long
Increased risk of bleeding
Capsaicin may inhibit
platelet aggregation and
enhance fibrinolytic activity
Thrombolytics + Capsicum
(Capsaicin)
19. THROMBOLYTICS & CELERY
• Monitor the patient closely for signs and symptoms of bleeding.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064255
Thrombolytics +
Celery
Celery may inhibit
Platelet aggregation
Increased risk of
bleeding
20. THROMBOLYTICS & KAVA
• Monitor the patient closely for signs and symptoms of bleeding.
https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-2006-957597.pdf
Thrombolytics +
Kava
Kava may inhibit
Cyclooxygenase
(COX)
Inhibition of Platelet
aggregation
Increased risk of
bleeding
21. THROMBOLYTICS & CAT'S CLAW
• Monitor the patient closely for signs and symptoms of bleeding.
http://www.ajhp.org/content/66/11/992.long
Thrombolytics + Cat's claw
Rhynochophylline of Cat's
claw may inhibit Platelet
aggregation
Increased risk of bleeding
22. THROMBOLYTICS & MEADOWSWEET
• Monitor the patient closely for signs and symptoms of bleeding.
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2710.2002.00444.x/full
Increased risk of
bleeding
Salicylate content of
Meadowsweet Possess
Antiplatelet activity
Thrombolytics +
Meadowsweet
23. THROMBOLYTICS & FEVERFEW
• Caution is advised if feverfew is taken with thrombolytic agents. Monitor the patient
closely for signs and symptoms of bleeding.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210009/
Thrombolytics + Feverfew
Parthenolide of Feverfew
reduce Thromboxane A2
production
Inhibition of platelet
aggregation
Increased risk of bleeding
24. THROMBOLYTICS & TAN-SHEN
• Avoid concomitant administration of thrombolytic agents with Tan-shen.
http://www.sciencedirect.com/science/article/pii/S0003497598006249
Thrombolytics + Tan-
shen
Tan-shen may inhibit
cAMP
phosphodiesterase
Additive antiplatelet
effects
Increased risk of
bleeding
25. CONCLUSION
• Drug interactions can result in significant morbidity and mortality and
thus minimizing the risk for drug interactions should be a goal in drug
therapy.
• The risk of adverse effects could be reduced by healthcare professionals
through the screening, education, and follow up on suspected drug
interactions.
• If possible, the patients are recommended to fill all their prescriptions at
one pharmacy.
• Pharmacists can play a crucial role in identifying possible drug interactions
by asking patients on Fibrinolytics about their herbal and other alternative
medicine product use.
26. REFERENCES
o Stockley’s Drug Interactions, 9e
Karen Baxter
o Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e
Laurence L. Brunton, Bruce A. Chabner, Björn C. Knollmann
o Basic & Clinical Pharmacology, 12e
Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor
o A Manual of Adverse Drug Interactions
J.P. Griffin, P.F. D'Arcy
o Clinical Manual of Drug Interaction Principles for Medical Practice
Gary H. Wynn, Jessica R. Oesterheld, Kelly L. Cozza, Scott C. Armstrong
o Handbook of Drug Interactions: A Clinical and Forensic Guide
Ashraf Mozayani, Lionel Raymon