Dr. Meti G Y has over 12 years of experience in process R&D. He currently works as an R&D Assistant Manager at R L Fine Chem pvt ltd in Bangalore. He has a PhD in Organic Chemistry from Karnatak University. His experience includes working as a Research Scientist and R&D Chemist for other companies. He has handled projects related to developing processes for drugs to treat conditions like depression, psychosis, infections, pain, and hypertension. He is skilled in areas like patent analysis, process optimization and validation, and scale-up. He has over 15 publications in peer-reviewed journals on organic synthesis and evaluation of compounds for properties like anti-cancer and anti-inflammatory

1. Curriculum Vitae
Dr. Meti G Y
R &D Assistant manager, R L Fine Chem pvt ltd Yelahanka Bangalore
Career Objective:
To achieve a challenging position in a desired organization, where I can prove my capabilities and
strength in conjunction with organization’s goals and objectives.
Date of birth 12/10/1971
Age
44
Nationality Indian
Marital Status Married
Address for correspondence
Dr. Gangadhar Y. Meti
c/o, Ashwathamma
#21, first floor, 2nd B cross
Chikkabommasandra, GKVK post
Yelahanka new town,
Bangalore 560065 E-mail: gymeti@rediffmail.com
Dr.gym1971@gmail.com
State: Karnataka Mobile: +91-9739422694, +91-8762191241
Job Profile :
Having more than 12 years of Experience in Process R&D

2.  R L Fine Chem., Yelahanka, Bangalore working as a R&D Assistant manager (Since Dec 2013)
 Dept of Chemistry of Karnataka University Dharwad as a UGC Project fellow (June 2010- Jan
2013)
 Jubilant Organosys Ltd. Mysore, worked as a Research Scientist in Process R & D.( Nov 2003 to
May 2010)
 R L Fine Chem Yelahanka, Bangalore, worked as a R&D Chemist (Feb 2001–Oct 2003).
 Recon Ltd Bangalore, worked as a Trainee R&D Chemist. (July 1997-Dec-1997).
 Shri Kalidas Composite Pre-University College Badami, worked as a part time Lecturer. (Aug
1998 to Sept 1999)
Academic Credentials:
 Doctor of Philosophy PhD in Organic Chemistry May 2011-Mar 2015 Karnatak University,
Dharwad, India
 Junior Research Fellow (JRF) in the UGC funded Major Research Project 2010-2013
 Master of Science (M. Sc.) in Chemistry / Organic Chemistry (First Class), from June 1995-
May, 1997 Karnatak University, Dharwad, India
 Bachelor of Science (B.Sc.) in Chemistry, Physics, Mathematics (Second Class), June 1992 –
May 1995, Karnatak University, Dharwad, India.
 Post graduate Diploma in IPR (Waiting for marks card, with first class) June 2012- Sept 2015
from K S O University Mysore
Research Highlights :
I was involved in Synthetic Organic Chemistry Research during my Ph.D. course. Twenty of my research
samples have been selected for anti cancer screening (against 60 cancer cell lines) at national cancer
Institute, a daughter organization of National Institute of Health, USA. Among these samples, three have
been screened for five dose testing level.
Responsibilities:
 Responsible for planning and executing developmental activities related to improvement in
quality/efficiency/process simplification etc., of existing products as well as development of process
for new products.
 Applied six sigma concepts in the process development of Atomxetine hydrochloride,
Paliperidone palmitate, Olmesartan and Azilsartan medoxomil.

3.  Technology transfer from lab scale to kilo/pilot plant scale and commercialization through appropriate
validation, scale up and optimization studies.
 Developing non-infringing routes for the existing/new molecules.
 Online literature search, infringement analysis & suggestion and interpreting the claims in patents.
 Updating the literature for the particular project at regular interval.
 Interpretation of intermediate/finished product by IR, NMR, Mass, GC and HPLC.
 Preparing Development report, Impurity profiling, Technology transfer document and Polymorphs.
 Selection of route, Cost reduction, minimization of waste and conforming process norms.
 Documentation, safe working and good housekeeping.
 Effective co-ordination with process engineering and production department, while transferring the lab
developed technologies.
Projects Handled:
 Antidepressents like Bupropion, Citalopram hydrobromide etc.,
 Antipsychotic like Risperidone, paliperidone, Paliperidone palmitate, Ziprasidone.
 Antibiotic like Azithromycin.
 Antispasmodic like Pinaverium bromide.
 Analgesic like Tramadol etc.
 Antihistamine like Doxylamine Citrate etc.
 Norepinephrine reuptake inhibitor (NRI) or Adrenergic reuptake inhibitor (ARI) like
Atomxetine hydrocloride
 Antihypertensive like Olmesartan and Azilsartan medoxomil.
Training programs:
 Safety, Health and Environment training program periodically.
 GMP and GLP training program periodically.
 Six sigma-Designs of Experiments.
 Intellectual property rights (patents only).
 Interpersonal relationship.
Summary of Skills:
 Patent search, Patent analysis, and literature search
 Optimization, validation, scale up and Technology transfer
 Auto clave reactions and Moisture sensitive reactions

4.  Crystallization techniques
 Impurity preparation.
 Column chromatography
Achievements:
 Successfully validated and implemented the “non infringing process route” to commercial plant for
Bupropion, Risperidone, Ziprasidone, Azithromycin.
 Gained commanding knowledge on Intellectual Property Rights (patents only)
Publications:
 Synthesis of biphenyl derivatives as ACE and α-amylase inhibitors, Gangadhar Yamanappa
Meti, Ravindra Ramappa Kamble, Dharesh Bhimaraya Biradar, Sheetal Babu Margankop, Med.
Chem. Res. (Springer), 2013, 22:5868-77.
 An efficient synthesis, X-ray and spectral characterization of biphenyl derivatives, G. Y. Meti, R.
R Kamble, D. B. Biradar, T. Taj, T. Gireesh, I. M Khazi, S. T. Vaidyanathan, R. Mohandoss, B.
Sridhar, and V. Parthasarathy, J. Chem. Sci (Springer) 123, 2011, 393–401.
 Synthesis of 4H-pyrido [1,2-a]pyrimidin-4-one derivatives as Anti-inflammatory agents,
Gangadhar Meti, Pramod Kattimani, Ravindra Kamble, H. C. Devarajegowda, Mahadev Kumbar,
D. Jagadeesh Prasad, World. J. Pharm. Sci. 2015, 3, 277-287.
 2-[4-(Morpholin-4-ylmethyl)phenyl]benzonitrile, Gangadhar Y. Meti, R. R Kamble, A. J. Ravi, H.
K. Arunkashi and H. C. Devarajegowda, Acta Cryst. 2013, E69, o129.
 5-{4-[(5-Benzyl-2H-tetrazol-2-yl)-methyl]biphenyl-2-yl}-1H-tetrazole monohydrate, Gangadhar Y.
Meti, S. Jayaseelan, R. R. Kamble, Atukuri Dorababu and H. C. Devarajegowda, Acta Cryst.
2013. E69, o743–o744.
 Bis-Tetrazole Derivatives of Biphenyls: Molecular Docking, Synthesis and ACE Inhibition Studies,
Gangadhar Y. Meti, Atulkumar A. Kamble, Kuramkote S. Devaraju, Bodhaguru M. Harish and
Ravindra R. Kamble, Bioorg. Med. Chem Letters (Elsevier) (Communicated).
 Synthesis and anticancer activity of 6-chloro-5-(2-chloroethyl)-1,3-dihydro- 2H-indol-2-one
derivatives.E J Medi Che (Communicated). Gangadhar Y. Meti, Ravindra R. Kamble, Pramod
P. Kattimani, Atulkumar A. Kamble, T. M. Girish, H. C. Devarajegowda.
 Facile Synthesis of novel quinoline derivatives as anticancer agents, S. B. Margankop, R. R.
Kamble, J. Hoskeri, D. J. Prasad, G. Y. Meti, Med. Chem. Res. (Springer), DOI No.
10.1007/s00044-013-0855-2.

5.  Synthesis of novel imidazo [2,1-b][1,3,4] thiadiazoles appended to sydnone as anticancer agents,
Tegginamath Gireesh, Ravindra R. Kamble, Tasneem Taj, Pramod P. Kattimani, Gangadhar Y.
Meti, Med. Chem. Res. (Springer), 2013, 22:4367-75.
 Expedient synthesis of benzimidazoles from amides, Pramod P. Kattimani, Ravindra R. Kamble,
Gangadhar Y. Meti, RSC.Adv, 2015,5, 29447-29455.
 Ring Opening of Tetrazole via Unusual Vilsmeir-Haack Reaction Forming Novel Triazenes.
Atukuri Dorababu, Ravindra R. Kamble, H. C. Devarajegowda and Gangadhar Y. Meti. Letters in
Organic Chemistry, 2015, 12, 122-128.
 Synthesis of Novel 1,2,4-Triazole Derivatives as Antimicrobial Agents via the Japp-Klingemann
Reaction: Investigation of Antimicrobial Activities. Journal of Chemistry, (2013),
http://dx.doi.org/10.1155/2013/909706,Tasneem Taj, Ravindra R. Kamble, Atukuri Dorababu, and
Gangadhar Y. Meti.
 Electronic Effect of Substituents Present on Carbonyl Compounds: Analysis of Product Formation
in One-Pot Synthesis of 1, 3, 4-thiadiazole Ring. ACSj.18204, Sheetal B. Marganakop, Ravindra
R. Kamble, Gangadhar Y. Meti and Mahadev N. Kumbar
References: Need basis