Curriculum Vitae
Indian Institute of Science Education and Research, Kolkata
Tuniki Balaraju
DCS, Material Science Center, Mohapur, Nadia,WB, India-741246
Ph: +91-9547371831, 8332061831 E-mail: BALASEKARRAJU@GMAIL.COM
____________________________________________________________________________________
SUMMARY:
Looking forward for an opportunity where I can involve in a challenging research task to solve
the targeted research field and also to utilize my learnt knowledge and skills on current issues,
Further I have total 6 years of research experience (4 years of Industrial) in various drug
discovery research projects including post doctoral research (PDF) experience of 2 years at
IISER Kolkata
SKILLS:
Synthetic Chemistry:
• My skills in the earlier organization and academic institution includes the synthesis of the
therapeutic medical entities, isolation and characterizing of organic molecules by the analytical
tools such as NMR, HRMS, and HPLC, Expert in handling of Organo metallic reactions. Ex:
Butyl lithium reactions, Swern Oxidation, Vinyl Magnesium Bromide (VMB) and Grubs
Metathesis reactions and Carbon Dioxide Conversion to Formic acid by Catalysis.
Scientific Skills
• Good hand in organic synthesis and purifications and developing methodologies1
.
O
S
O
O
HN
H2N
C OO
H2O
CATALYSIS O
H OH
Green EnergyOO
O
Ph
Ph
Ph
OH
Ref: Bitla S, et al, Controlled Inversion of 4'chiral Centre in Protected Carbasugar from D-Ribose. IJIRSET 5(6), 10624-10633
(2016), T Balaraju, et al, Bioorganic & medicinal chemistry letters 25 (22), 5224-5227, T Balaraju, et.al. Journal of Materials
Chemistry A
]
• Experience in Molecular Modeling & Medicinal Chemistry projects in target hit to lead projects.
Ref: Balaraju, T., A. Kumar, et al. (2013). "Aromatic interaction profile to understand the molecular basis of raltegravir
resistance." Structural Chemistry 24(5): 1499-1512
• Rich experience in usage and applications of drug designing software packages like Schrodinger
and Sybyl
• Experienced in understanding the scientific literature, understanding vital and sensitive reports of
scientific discoveries and patents.
• Experienced hand in projects like JNK (JNK Pathway in Glucose Toxicity-related to
diabetes), LPxC (Gram Negative Bacterial enzyme), GLP1 (glucagon-like peptide -1
related to diabetes disease) related to in-silico studies.
• Expertised in information retrieval, analysis and workflow and working knowledge of multiple
research information tools.
Management Skills
• Fine Communication Skills
• Experience in working in multidisciplinary group of medicinal chemist, modeler and biologist in
drug discovery project at Dr. Reddys Laboratories
• Efficient Team Coordination capabilities
EDUCATION:
• PDF (Post Doctoral Research Fellow) 2014 to Till date, IISER Kolkata, India
• Ph.D. in Medicinal Chemistry 2014, BITS-Mesra, JH, India
• M. Sc. Organic Chemistry, First Class 2006, Kakatiya University
Warangal
• B. Sc. Biology and Chemistry, First Class 2002, Osmania University,
Hyderabad.
AWARDS:
• PDF [Post Doctoral Research Fellow , IISER Kolkata, India, www.iiserkol.ac.in]
• Fellow of CSIR, India
RESEARCH EXPERIENCE: 6 years
• Industrial experience 2006 - 2010
(Senior Executive),
Department of
Molecular Modeling & Drug Designing (MMDD)
Discovery Research, Dr.Reddy’s Laboratories Ltd,
Hyderabad, INDIA
www.drreddys.com
• PDF Post Doctoral Research Experience 2014 to Till date
PATENTS:
T. Balaraju, S. Das, S. Biswas, S. Roy, “REDUCTION OF CARBON DIOXIDE COUPLED
WITH OXIDATION OF WATER USING CATALYSTS.” Application Number: 530/KOL/2015.
ORGANISATION SKILLS:
Organizing Committee Member for an international conference (IBSCC 2015, IISER Kolkata),
and also for a national conference (SMYIM 2015, Pondicherry India).
LIST OF PUBLICATIONS:
(13 International Publications, including where I am a corresponding author for one of recent journal)
Google Scholar Link
https://scholar.google.co.in/citations?hl=en&user=nuyXhcoAAAAJ&view_op=list_works&sortby=pubda
te
1 Das, S. et al. Photochemical reduction of carbon dioxide coupled with water oxidation
using various soft-oxometalate (SOM) based catalytic systems. Journal of Materials
Chemistry A (2016).
2 Balaraju, T. et al. Synthesis and anti-HCV determinant motif identification in pyranone
carboxamide scaffold. Bioorganic & medicinal chemistry letters 25, 5224-5227 (2015).
3 Bharti, S., Mishra, S., Narendra, L. V., Balaraju, T. & Balraju, K. Ceric ion-induced
synthesis of polymethyl methacrylate-grafted oatmeal: its characterizations and
applications. Desalination and Water Treatment 57, 12777-12792 (2016).
4 Bal, N. C. et al. The C‐terminal calcium‐sensitive disordered motifs regulate
isoform‐specific polymerization characteristics of calsequestrin. Biopolymers 103, 15-22
(2015).
5 Kasula, M. et al. A Conformational Mimetic Approach for the Synthesis of Carbocyclic
Nucleosides as Anti‐HCV Leads. ChemMedChem 8, 1673-1680 (2013).
6 Balaraju, T. et al. Aromatic interaction profile to understand the molecular basis of
raltegravir resistance. Structural Chemistry 24, 1499-1512 (2013).
7 Bal, N. C. et al. Skeletal Calsequestrin-Calcium Interaction: Role of Acidic C-Terminus.
Biophysical Journal 104, 173a (2013).
8 Kumar, A. et al. Identification of calcium binding sites on calsequestrin 1 and their
implications for polymerization. Molecular BioSystems 9, 1949-1957 (2013).
9 Thiyagarajan, A. et al. Structure based medicinal chemistry approach to develop 4-
methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent. Bioorganic &
medicinal chemistry letters 22, 7742-7747 (2012).
10 Sharon, A., Balaraju, T. & Bal, C. A catalytic 3D model development of HIV-integrase
and drug resistance understanding by molecular dynamics simulation. Antiviral Research
90, A43-A44 (2011).
11 Bal, N. C. et al. Probing cationic selectivity of cardiac calsequestrin and its CPVT
mutants. Biochemical Journal 435, 391-399 (2011).
12 Konreddy, A. K. et al. In-silicosimulation towards anti-HIV drug discovery: A tool in the
hour of need. GERF Bulletin of Biosciences 2, 224-228 (2011).
13 Bitla S, et al, Controlled Inversion of 4'chiral Centre in Protected Carbasugar from D-
Ribose. IJIRSET 5(6), 10624-10633 (2016) [Here, I Am Corresponding Author]
****Organizing Committee Member of INDIA-BANGLADESH Structural Chemistry Conference(IBSCC-
2015) , IISER-Kolkata, October 18-19,2015
List of conferences Organized, attended, Co-authored
IBSCC-2015
****Organizing Committee Member of Soft Matter Young Investigator Meeting 2015 SMYIM-2015
****One of Coordinator of 4th
Department of Chemistry Day of IISER Kolkata, India, January 28, 2016
http://calendar.iiserkol.ac.in/view_event/271899/
1. Bal, N. C.; Kumar, A.; Chakravarty, H.; Balaraju, T.; Bal, C.; Jena, N.; Sharon, A.; Periasamy, M.,
Skeletal Calsequestrin-Calcium Interaction: Role of Acidic C-Terminus. Biophysical Journal 2013, 104,
173a.
2. A. Sharon, Tuniki Balaraju , A. K. Konreddy, C. Bal, M. Yoyama, W. Ito, M. Baba. 27th
International
Conference on Antiviral Research. North Carolina, USA, May12-May16, 2014" α-Pyranone
Carboxamide A New scaffold Optimization as Possible Anti-HCV Agent"
3. Tuniki Balaraju , A. Sharon, C. Bal. 26th
International Conference on Antiviral Research. San
Fransisco, California, USA, May11-15, 2013 “HCV RdRp-Complex Simulation for the Understanding
of Recognition Element Mediated by Pseudonucleoside Inhibitor”
4. A. Sharon, Tuniki Balaraju, C. Bal 25th
International Conference on Antiviral Research. Sapporo,
Japan, April16-April19, 2012 "A Catalytic 3D Model Development of HIV-Integrase and Drug
Resistance Understanding by Molecular Dynamics Simulation"
5. N. C. Bal, Tuniki Balaraju, N. Jena, C. Bal, A. Sharon, M. Periasamy 243rd ACS National Meeting &
Exposition, March 25- 29 2012, San Diego, California, USA."Structural basis of functional differences
in calsequestrin 1 and 2 isoforms".
6. R. Kuhu, T. Balaraju, A. Kesharwani, S. Ganguly, A. Sharon.World Congress of Virus and Infections-
(WCVI-2010). Busan, South Korea, July 31- Aug 03, 2010. "Targeting drug discovery catalyzed by 3D
HIV-Integrease model”
7. A. Sharon, T. Balaraju, C. Bal. 15th
International Conference by Indian Society of Chemist & Biologist.
Saurashtra University, Rajkot, Feb 4-7, 2011 "A molecular dynamics study of HIV-integrease towards
anti-HIV drug discovery
PERSONAL DETAILS:
• DOB: 01-March-1982
• Fathers Name : Shri Tuniki Dhanaia
• Mothers Name: Shrimati Tuniki Sarojana
• Marital Status: Married
PERMANENT ADDRESS:
H.No: 1-30; Village: Ramajipet; Post: Peddakandukur; Mondal: Yadagirigutta; Dist:
Nalgonda; State: Telangana; India; Pin-508286 Ph: 9247443532
REFERENCES:
Dr. Ashoke Sharon
Associate Professor
( PhD Supervisor)
Department of Chemistry,
BIT-Mesra,
Ranchi,
Jharkhand,
INDIA-835215
+919546383186
E-mail asharon@bitmesra.ac.in
Dr. Naresh Chandra Bal
(Research Scientist)
Waxner Medical Center
College of Medicine
Department of Physiology & Cell
Biology
102 Hamilton Hall
1645 Neil Avenue
Columbus, OH 43210-1218
Phone: 614-292 2310
Dr. Soumyajit Roy
Associate professor
(PostDoc(PDF) Supervisor)
DCS, Material Science Center
IISER-Kolkata, Mohanpur, Nadia, India
PIN – 741246
e-mail : s.roy@iiserkol.ac.in
Phone: +91-9007222901
Samiron Phukan Ph.D
(Associate Director)
LupinLimited (Research Park)
Village: Nande
Taluka : Mulshi
Pune-412115
INDIA
+919765800479; FAX: 91-20-6674-9560
e-mail: samironphukan@lupin.com
Fax: 614-292-4888
E-mail nareshbal.osu@gmail.com

Tuniki Balaraju_Curriculum Vitae-AUGUST-2016

  • 1.
    Curriculum Vitae Indian Instituteof Science Education and Research, Kolkata Tuniki Balaraju DCS, Material Science Center, Mohapur, Nadia,WB, India-741246 Ph: +91-9547371831, 8332061831 E-mail: BALASEKARRAJU@GMAIL.COM ____________________________________________________________________________________ SUMMARY: Looking forward for an opportunity where I can involve in a challenging research task to solve the targeted research field and also to utilize my learnt knowledge and skills on current issues, Further I have total 6 years of research experience (4 years of Industrial) in various drug discovery research projects including post doctoral research (PDF) experience of 2 years at IISER Kolkata SKILLS: Synthetic Chemistry: • My skills in the earlier organization and academic institution includes the synthesis of the therapeutic medical entities, isolation and characterizing of organic molecules by the analytical tools such as NMR, HRMS, and HPLC, Expert in handling of Organo metallic reactions. Ex: Butyl lithium reactions, Swern Oxidation, Vinyl Magnesium Bromide (VMB) and Grubs Metathesis reactions and Carbon Dioxide Conversion to Formic acid by Catalysis. Scientific Skills • Good hand in organic synthesis and purifications and developing methodologies1 . O S O O HN H2N C OO H2O CATALYSIS O H OH Green EnergyOO O Ph Ph Ph OH Ref: Bitla S, et al, Controlled Inversion of 4'chiral Centre in Protected Carbasugar from D-Ribose. IJIRSET 5(6), 10624-10633 (2016), T Balaraju, et al, Bioorganic & medicinal chemistry letters 25 (22), 5224-5227, T Balaraju, et.al. Journal of Materials Chemistry A ] • Experience in Molecular Modeling & Medicinal Chemistry projects in target hit to lead projects.
  • 2.
    Ref: Balaraju, T.,A. Kumar, et al. (2013). "Aromatic interaction profile to understand the molecular basis of raltegravir resistance." Structural Chemistry 24(5): 1499-1512 • Rich experience in usage and applications of drug designing software packages like Schrodinger and Sybyl • Experienced in understanding the scientific literature, understanding vital and sensitive reports of scientific discoveries and patents. • Experienced hand in projects like JNK (JNK Pathway in Glucose Toxicity-related to diabetes), LPxC (Gram Negative Bacterial enzyme), GLP1 (glucagon-like peptide -1 related to diabetes disease) related to in-silico studies. • Expertised in information retrieval, analysis and workflow and working knowledge of multiple research information tools. Management Skills • Fine Communication Skills • Experience in working in multidisciplinary group of medicinal chemist, modeler and biologist in drug discovery project at Dr. Reddys Laboratories • Efficient Team Coordination capabilities EDUCATION: • PDF (Post Doctoral Research Fellow) 2014 to Till date, IISER Kolkata, India • Ph.D. in Medicinal Chemistry 2014, BITS-Mesra, JH, India • M. Sc. Organic Chemistry, First Class 2006, Kakatiya University Warangal • B. Sc. Biology and Chemistry, First Class 2002, Osmania University, Hyderabad. AWARDS: • PDF [Post Doctoral Research Fellow , IISER Kolkata, India, www.iiserkol.ac.in] • Fellow of CSIR, India
  • 3.
    RESEARCH EXPERIENCE: 6years • Industrial experience 2006 - 2010 (Senior Executive), Department of Molecular Modeling & Drug Designing (MMDD) Discovery Research, Dr.Reddy’s Laboratories Ltd, Hyderabad, INDIA www.drreddys.com • PDF Post Doctoral Research Experience 2014 to Till date PATENTS: T. Balaraju, S. Das, S. Biswas, S. Roy, “REDUCTION OF CARBON DIOXIDE COUPLED WITH OXIDATION OF WATER USING CATALYSTS.” Application Number: 530/KOL/2015. ORGANISATION SKILLS: Organizing Committee Member for an international conference (IBSCC 2015, IISER Kolkata), and also for a national conference (SMYIM 2015, Pondicherry India). LIST OF PUBLICATIONS: (13 International Publications, including where I am a corresponding author for one of recent journal) Google Scholar Link https://scholar.google.co.in/citations?hl=en&user=nuyXhcoAAAAJ&view_op=list_works&sortby=pubda te 1 Das, S. et al. Photochemical reduction of carbon dioxide coupled with water oxidation using various soft-oxometalate (SOM) based catalytic systems. Journal of Materials Chemistry A (2016). 2 Balaraju, T. et al. Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold. Bioorganic & medicinal chemistry letters 25, 5224-5227 (2015). 3 Bharti, S., Mishra, S., Narendra, L. V., Balaraju, T. & Balraju, K. Ceric ion-induced synthesis of polymethyl methacrylate-grafted oatmeal: its characterizations and applications. Desalination and Water Treatment 57, 12777-12792 (2016). 4 Bal, N. C. et al. The C‐terminal calcium‐sensitive disordered motifs regulate isoform‐specific polymerization characteristics of calsequestrin. Biopolymers 103, 15-22 (2015).
  • 4.
    5 Kasula, M.et al. A Conformational Mimetic Approach for the Synthesis of Carbocyclic Nucleosides as Anti‐HCV Leads. ChemMedChem 8, 1673-1680 (2013). 6 Balaraju, T. et al. Aromatic interaction profile to understand the molecular basis of raltegravir resistance. Structural Chemistry 24, 1499-1512 (2013). 7 Bal, N. C. et al. Skeletal Calsequestrin-Calcium Interaction: Role of Acidic C-Terminus. Biophysical Journal 104, 173a (2013). 8 Kumar, A. et al. Identification of calcium binding sites on calsequestrin 1 and their implications for polymerization. Molecular BioSystems 9, 1949-1957 (2013). 9 Thiyagarajan, A. et al. Structure based medicinal chemistry approach to develop 4- methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent. Bioorganic & medicinal chemistry letters 22, 7742-7747 (2012). 10 Sharon, A., Balaraju, T. & Bal, C. A catalytic 3D model development of HIV-integrase and drug resistance understanding by molecular dynamics simulation. Antiviral Research 90, A43-A44 (2011). 11 Bal, N. C. et al. Probing cationic selectivity of cardiac calsequestrin and its CPVT mutants. Biochemical Journal 435, 391-399 (2011). 12 Konreddy, A. K. et al. In-silicosimulation towards anti-HIV drug discovery: A tool in the hour of need. GERF Bulletin of Biosciences 2, 224-228 (2011). 13 Bitla S, et al, Controlled Inversion of 4'chiral Centre in Protected Carbasugar from D- Ribose. IJIRSET 5(6), 10624-10633 (2016) [Here, I Am Corresponding Author] ****Organizing Committee Member of INDIA-BANGLADESH Structural Chemistry Conference(IBSCC- 2015) , IISER-Kolkata, October 18-19,2015 List of conferences Organized, attended, Co-authored IBSCC-2015 ****Organizing Committee Member of Soft Matter Young Investigator Meeting 2015 SMYIM-2015 ****One of Coordinator of 4th Department of Chemistry Day of IISER Kolkata, India, January 28, 2016 http://calendar.iiserkol.ac.in/view_event/271899/ 1. Bal, N. C.; Kumar, A.; Chakravarty, H.; Balaraju, T.; Bal, C.; Jena, N.; Sharon, A.; Periasamy, M., Skeletal Calsequestrin-Calcium Interaction: Role of Acidic C-Terminus. Biophysical Journal 2013, 104, 173a. 2. A. Sharon, Tuniki Balaraju , A. K. Konreddy, C. Bal, M. Yoyama, W. Ito, M. Baba. 27th International Conference on Antiviral Research. North Carolina, USA, May12-May16, 2014" α-Pyranone Carboxamide A New scaffold Optimization as Possible Anti-HCV Agent" 3. Tuniki Balaraju , A. Sharon, C. Bal. 26th International Conference on Antiviral Research. San Fransisco, California, USA, May11-15, 2013 “HCV RdRp-Complex Simulation for the Understanding of Recognition Element Mediated by Pseudonucleoside Inhibitor” 4. A. Sharon, Tuniki Balaraju, C. Bal 25th International Conference on Antiviral Research. Sapporo, Japan, April16-April19, 2012 "A Catalytic 3D Model Development of HIV-Integrase and Drug Resistance Understanding by Molecular Dynamics Simulation"
  • 5.
    5. N. C.Bal, Tuniki Balaraju, N. Jena, C. Bal, A. Sharon, M. Periasamy 243rd ACS National Meeting & Exposition, March 25- 29 2012, San Diego, California, USA."Structural basis of functional differences in calsequestrin 1 and 2 isoforms". 6. R. Kuhu, T. Balaraju, A. Kesharwani, S. Ganguly, A. Sharon.World Congress of Virus and Infections- (WCVI-2010). Busan, South Korea, July 31- Aug 03, 2010. "Targeting drug discovery catalyzed by 3D HIV-Integrease model” 7. A. Sharon, T. Balaraju, C. Bal. 15th International Conference by Indian Society of Chemist & Biologist. Saurashtra University, Rajkot, Feb 4-7, 2011 "A molecular dynamics study of HIV-integrease towards anti-HIV drug discovery PERSONAL DETAILS: • DOB: 01-March-1982 • Fathers Name : Shri Tuniki Dhanaia • Mothers Name: Shrimati Tuniki Sarojana • Marital Status: Married PERMANENT ADDRESS: H.No: 1-30; Village: Ramajipet; Post: Peddakandukur; Mondal: Yadagirigutta; Dist: Nalgonda; State: Telangana; India; Pin-508286 Ph: 9247443532 REFERENCES: Dr. Ashoke Sharon Associate Professor ( PhD Supervisor) Department of Chemistry, BIT-Mesra, Ranchi, Jharkhand, INDIA-835215 +919546383186 E-mail asharon@bitmesra.ac.in Dr. Naresh Chandra Bal (Research Scientist) Waxner Medical Center College of Medicine Department of Physiology & Cell Biology 102 Hamilton Hall 1645 Neil Avenue Columbus, OH 43210-1218 Phone: 614-292 2310 Dr. Soumyajit Roy Associate professor (PostDoc(PDF) Supervisor) DCS, Material Science Center IISER-Kolkata, Mohanpur, Nadia, India PIN – 741246 e-mail : s.roy@iiserkol.ac.in Phone: +91-9007222901 Samiron Phukan Ph.D (Associate Director) LupinLimited (Research Park) Village: Nande Taluka : Mulshi Pune-412115 INDIA +919765800479; FAX: 91-20-6674-9560 e-mail: samironphukan@lupin.com
  • 6.