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CURRICULUM VITAE
Career Objective: Research and development position in bioorganic/synthetic organic/medicinal
chemistry program focused at drug discovery and development
Personal profile:
Name : Ramprasad Ghosh
Present position and address : Dr. D S Kothari Post-Doctoral Fellow (Since April, 2015)
Department of Chemistry, University of
Calcutta, 92 APC Road, Kolkata 700009
E-mail :ramprasad.ghosh28@gmail.com
Phone No : +91-8820119422
Date of birth : January 22, 1982
Nationality : Indian
Sex & Marital Status : Male & Married
Core Competencies and Skills:
(i) Highly experienced in organic synthesis, synthetic methodology, carbohydrate chemistry. Organic
synthesis relating to carbocyclic, bicyclic and spirocyclic nucleosides, mono- and di- and tri-saccharides for
glycoconjugates and application to drug-delivery and vaccine developments.
(ii) Experienced in milligram to multigram synthesis of small organic molecules
(iii) Highly skilled in the phosphorus and fluorine based carbohydrate molecules (mono, diphosphonate
and fluorophosphonate) for the enzyme inhibition study.
(iv) Expert in purification of organic reaction mixtures via extraction, distillation, recrystallization,
chromatography
(iii) Proficient in performing small scale air and moisture sensitive reactions.
(v) Excellent skills in analytical and prep HPLC, NMR (1D and 2D) and mass spectrometry (GC-MS, MALDI,
ESI).
(vi) Vast knowledge of analysis of complex molecular structure by modern analytical methods.
Academic profile:
Assistant Professor & HOD of Chemistry (October, 2014-April, 2015): 6 Months
Indus International University, VPO. Bathu, Himachal Pradesh, 174301, India
2nd Post Doctoral Research (April, 2013 – March, 2014): 1 year
College of Pharmacy, Dalhousie University, 5968 College street, Halifax, Nova Scotia, Canada
Project: Synthesis of carbohydrate based phosphonate and fluorophosphonates derivatives: Application as
enzyme inhibitors and use them as potential anti-bacterial agents.
1st Post Doctoral Research (August, 2010 – April, 2013): 2 years and 8 months
Department of Chemistry, University of Calgary, 2500 University Drive, Calgary, Alberta, Canada.

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Project: Synthesis of oligosaccharides having therapeutic value and Chemical modifications of
Cyclodextrins: Use of glycoconjugates for drug delivery, anti-adhesive therapy and development of
carbohydrate based vaccines.
Ph.D. (April, 2005 – June, 2010): 5 years 3 months
Department of Chemistry, Indian Institute of Chemical Biology (IICB), Jadavpur University, India
Thesis Title: Studies on the synthesis of modified nucleosides derived from carbohydrate–based chiral
precursors
M. Sc. (2002-2004):
Subject – Chemistry (Specialization in Organic Chemistry)
Department of Chemistry, University of Delhi, Delhi-110 007, India
B. Sc. (1999-2002):
Subject – Chemistry (Major), Physics, Mathematics
Department of Chemistry, R.K.M. Residential College, Narendrapur, University of Calcutta, India
Industrial Experience:
2004 (July-December): Technical Trainee, Department of Analytical Method Validation, Dr. Reddy’s
Laboratories Limited, Hyderabad, India.
2005 (January-March): Research chemist, Organic Synthesis Department, TCG-Life Sciences, Kolkata,
India.
Research Experience:
During my doctoral research I have worked on the synthesis of novel carbocyclic and locked bicyclic
nucleosides from D-glucose-derived substrates having therapeutic value as anti-viral, anti-cancer agents.
Some spirocyclic and 3-alkyl nucleosides synthesis were also contributed by me. Synthesized compounds
were characterized by various analytical methods like NMR (1D and 2D), Mass spectroscopy, X-ray
crystallography etc.
During 1st post doctoral research I have worked on (a) Cyclodextrin (CD) based methodology development to
obtain multi-functionalized CDs. (b) Using the structurally modified CDs for synthesizing structurally well
defined glyco-conjugates having different oligosaccharide epitopes (c) Applications of the glycoconjugates
for drug-delivery into the cancerous cells using HeLa cell lines, anti-adhesive therapy and, as diagnostic tools.
In my 2nd post doctoral research I have worked on (a) Synthesis of glucose-1,6-bisphosphonate for studying
the mechanism of action of β-phosphogluco mutase enzyme (b) Synthesis of fluorophosphonate-based
carbohydrate derivatives as transition state analogues of enzymes involved in catalyzing phosphoryl transfer.
Currently evaluation of glucose-1,6-bisphosphonate's binding affinity with the β-PGM by various methods
like WATERLOGSY and STD-NMR is being carried out and by enzyme kinetics experiments we can get idea
about Ki, KM value etc. 1'-fluoro-glucose-1,6-bisphosphonate derivatives will be evaluating against β-PGM to
study the interaction between them by using 19F and 31P NMR spectroscopy. Once we have some idea about
the binding interaction using WTAERLOGSY experiments to obtain affinity constant (Kd) value. Also, enzyme

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kinetics experiments are currently going on to get the Ki, KM value. If successful, these compounds could be
use as potential inhibitor design against the β-PGM and subsequent development of anti-bacterial agents.
Presently in my 3rd post doctoral research I am working on finding the anti-bacterial agents with novel mode
of action like targeting glmS-Riboswitch activation. Towards this end I am synthesizing Carba-glucosamine-6-
phosphate derivatives from D-glucosamine. In previous studies it was shown that carba-GlcN6P induces glmS-
riboswitch self-cleavage very efficiently Based on this result, the aim of the current project is to discover,
characterize, and investigate new carba-GlcN6P derivatives and analyze them with respect to riboswitch
activation and their potential mode of action. Also, the potential of the compounds to inhibit bacterial growth
and, hence, to act as new antibiotics will be explored. The results of this project will help to answer the
important question whether interference with riboswitch function can be an effective strategy for inhibiting
bacterial growth.
Awards and Fellowships:
1. Awarded the Dr. D.S.Kothari post-doctoral fellowship by UGC, New Delhi, January 2015.
2. Qualified National Eligibility Test (NET) and awarded junior research fellow (JRF, CSIR-NET) in Chemical
Sciences in 2004, India
3. Qualified GATE (Graduate Aptitude Test for Engineers) examination in Chemistry in 2004, India. (90.41
percentile, All India Rank-310)
4. Jean and Asit Ganguly Scholarship for pursuing M.Sc (2002-2004), Department of Chemistry, University of
Delhi, India
Professional Membership:
Member of the Canadian Society for Chemistry since 2012.
Research papers published:
1. Cyanoethylation of cyclodextrin derivatives. Ramprasad Ghosh, Moulimala Bhowmick, Ping Zhang, Chang
Chun Ling*, Canadian Journal of Chemistry, 2016, 94, 436-443
2. DIBAL-H-mediated O-desilylation with highly sterically hindered cyclodextrin substrates. Ramprasad
Ghosh, Cormac Hennigan, Chang-Chun Ling*. Tetrahedron, 2013, 69, 5227-5233
3. Diisobutylaluminum Hydride Mediated Regioselective O-Desilylation: Access to Multi-Substituted
Cyclodextrins. Ramprasad Ghosh, Ping Zhang, Aixia Wang, Chang-Chun Ling*. Angew. Chem. Int. Edn., 2012,
51, 1548-1552. Published as Hot paper & frontispiece.
4. Locked Nucleosides Based on Oxabicyclo[3.2.1]octane and Oxabicyclo[2.2.1]heptane Skeletons.
Ramprasad Ghosh, Joy Krishna Maity, Basudeb Achari and Sukhendu B Mandal* J. Org. Chem., 2010, 75,
2419-2422.
5. A synthetic route to fully substituted chiral cyclopentylamine derivatives: precursors of carbanucleosides.
Ramprasad Ghosh, Joy Krishna Maity, Michael G.B. Drew, Basudeb Achari, Sukhendu B Mandal,* Synthesis,
2010, 8, 1303-1310

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6. Introduction of Vinyl and Hydroxymethyl Functionalities at C-4 of Glucose-Derived Substrates: Synthesis of
Spirocyclic, Bicyclic, and Tricyclic Nucleosides. Joy Krishna Maity, Ramprasad Ghosh, Michael G. B. Drew,
Sukhendu B. Mandal* J. Org. Chem., 2008, 73, 4305–4308.
7. Nucleoside synthesis from 3-alkylated sugars: role of 3β-oxy substituents in directing nucleoside
formation. Sk. Sahabuddin, Ramprasad Ghosh, Basudeb Achari and Sukhendu B. Mandal* Org. Biomol.
Chem., 2006, 4, 551–557.
Patent:
8. Preparation of amphiphilic cyclodextrin-based glycodendrimers used in medicines, cosmetics, and foods.
Chang-Chun Ling*, Lina Cui, Ramprasad Ghosh, Ping Zhang, Aixia Wang. PCT Int. Appl, 2015, WO
2015048897 A1 20150409
Names and Addresses of the Referees:
1. Prof. Sukhendu Bikas Mandal (Ph.D Supervisor), Indian Institute of Chemical Biology, Department of
Chemistry, 4, Raja S.C. Mullick Road, Kolkata-700032, India.
E-mail: sbmandal@iicb.res.in, Ph. No. +91-9748918247
2. Prof. Chang Chun Ling (1st post-doctoral supervisor), University of Calgary, Department of Chemistry, 2500
university drive, Calgary T2N1N4, Alberta, Canada
E-mail: ccling@ucalgary.ca, Ph. No. +1-403-2202768
3. Prof. David Jakeman (2nd post-doctoral supervisor), Dalhousie University, Department of Chemistry, 5968
college street, Halifax B3H4R2, Nova Scotia, Canada
E-mail: david.jakeman@dal.ca, Ph. No. +1-902-494-7159
4. Prof. Dilip Kumar Maity (3rd post-doctoral supervisor), University of Calcutta, Department of Chemistry, 92
APC Roafd, Kolkata 700009, India
E-mail: maitidk@yahoo.com, Ph. No. +91-33-2350-9937 (Extn. 439)