Multi-algorithm Ensemble Learning at Scale: Software, Hardware and Algorithmic Approaches: Multi-algorithm ensemble machine learning methods are often used when the true prediction function is not easily approximated by a single algorithm. The Super Learner algorithm, also known as stacking, combines multiple, typically diverse, base learning algorithms into a single, powerful prediction function through a secondary learning process called metalearning. Although ensemble methods offer superior performance over their singleton counterparts, there is an implicit computational cost to ensembles, as it requires training and cross-validating multiple base learning algorithms. We will demonstrate a variety of software- and hardware-based approaches that lead to more scalable ensemble learning software, including a highly scalable implementation of stacking called “H2O Ensemble”, built on top of the open source, distributed machine learning platform, H2O. H2O Ensemble scales across multi-node clusters and allows the user to create ensembles of deep neural networks, Gradient Boosting Machines, Random Forest, and others. As for algorithm-based approaches, we will present two algorithmic modifications to the original stacking algorithm that further reduce computation time — Subsemble algorithm and the Online Super Learner algorithm. This talk will also include benchmarks of the implementations of these new stacking variants.