This meta-analysis reviewed randomized controlled trials examining whether bisphosphonate drugs affect indirect bone healing. The analysis included 8 studies and 2508 patients. It found no statistically significant differences in short-term or long-term bone healing between bisphosphonate-treated groups and controls. A subgroup analysis found higher lumbar fusion rates at 6 months for bisphosphonate groups. While some animal studies suggest bisphosphonates may increase callus formation, the dosage for treating osteoporosis in humans appears insufficient to affect healing. The timing of bisphosphonate infusion also did not impact fracture healing. However, limitations include variability between studies and potential for bias.