Dr. Swamy Venuturupalli talks about Rheumatoid Arthritis, Early Diagnosis and Treatment at the James R. Klinenberg symposium on Rheumatic diseases in Pasadena, CA.
Dr. Swamy Venuturupalli talks about Rheumatoid Arthritis, Early Diagnosis and Treatment at the James R. Klinenberg symposium on Rheumatic diseases in Pasadena, CA.
Rheumatoid arthritis Part 1 Basics & guideline application on real life cases...Ahmed Yehia
Rheumatoid arthritis Part 1 Basics & guideline application on real life cases Ahmed Yehia Ismaeel, Beni-Suef University
مبادرة ياللا نذاكر روماتولوجي
رابط شرح المحاضرة على يوتيوب
https://youtu.be/VP_-0_GqhOI?si=uZNYIyUBkMRXjpuH
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
5. Case Scenario
Case Scenario Here
A 58-year-old lady with a 3-year history of
rheumatoid arthritis is referred by her GP
with a flare up of her arthritis. She has a
high ESR and CRP and is rheumatoid
factor positive. In the last year she has
been taking various NSAIDs and 3
months ago was found to have iron
deficient anemia. An upper GI endoscopy
showed a gastric ulcer. NSAIDs were
stopped.
How would you treat this lady’s
rheumatoid arthritis?
6. Rheumatoid arthritis (RA)
RA is a chronic, progressive inflammatory
disease; characterized by symmetric
small joint inflammation, swelling, and
deformity and systemic manifestations.
8. Clinical manifestations
Articular manifestations:
• Affects mainly small joints of the hands and toes
• Joint involvement is usually symmetric
• Symptoms painful joints and prolonged morning joint stiffness.
• Signs warm, tender, swollen, red joints, with limited mobility.
Extra-articular manifestations:
• The clinical manifestations of RA can extend to include systemic organs e.g. pleural
effusion, conjunctivitis, anemia, vasculitis, etc.
9. Diagnosis
• Serological:
Abnormal blood antibodies
"rheumatoid factor“ in 80%
of RA patients.
Elevated CRP & ESR
Positive anti-CCP antibodies.
• Joint X-ray:
can show joint swelling and bony
erosions typical of RA.
10. Drug treatment of RA
Aims of drug treatment are:
1. To reduce pain, stiffness and
improve joint function
(symptomatic drug
treatment).
2. To prevent chronic deformity
by arresting the
inflammation that results in
joint destruction (DMARDs).
11. Symptomatic treatment
• NSAIDs: analgesic/anti-inflammatory drugs may
be used to relief pain.
– They are relatively ineffective when used alone in
RA They do not prevent joint damage.
• Corticosteroids: anti-
inflammatory/immunosuppresive.
NSAIDs and/or corticosteroids are used as a
‘bridge therapy’ provide symptomatic relief till
the therapeutic effect of DMARDs is observed.
12. • List the DMARDs
• Describe the mech. Of action of drug therapy for
rheumatoid arthritis that potentially slows
disease progression (DMARDs) and avoids side
effects of NSAIDs.
Learning Outcome 1
13. DMARDs
non-biologic & biologic
• They prevent disease progression and slow down joint
destruction by modifying the immune reactions.
• They should be started as early as possible (within 3
months of symptom onset) more favorable outcome.
• 1 or more DMARDs are used depending on disease severity.
• There is a lag between starting therapy and observing an
effect (3 weeks to 3 months).
• It is usual to continue DMARDs with conventional NSAIDs
drugs.
14. Methotrexate
• MOA:
It is a folic acid antagonist cytotoxic and immuno-
suppressant properties inhibits cytokine production &
nucleic acid biosynthesis inhibits activation &
proliferation of PMLs, T cells, and macrophages.
• It is used in more than 60% of RA cases.
• It is given once weekly orally.
• The toxic effects of methotrexate can be reversed by
the subsequent administration of folinic acid
(leucovorin)
• Common adverse effects:
– GIT: nausea and mucosal ulceration.
– Myelosuppression, esp; leucopenia (periodic CBC).
– Hepatotoxicity is common (monitoring liver functions is
essential).
– Acute pneumonia-like syndrome.
15. Hydroxychloroquine
(anti-malarial drug)
MOA : unknown, but might be:
• Inhibition of phagocytic functions.
• Stabilization of lysosomal membranes
Side effects:
• GIT: diarrhea
• Corneal deposits & Retinopathy: the most disturbing toxic effect, rare,
is a result of gradual accumulation of the drug in the retina
irreversible retinal damage with permanent blindness
• Skin discoloration & rash
• Hemolysis in G6PD deficiency.
16. Leflunomide
MOA:
• It inhibits the mitochondrial enzyme,
dihydroorotate dehydrogenase (DHODH)
inhibits pyrimidine base synthesis
suppresses T cell and B cell proliferation &
activation.
Adverse effects:
• GIT: nausea & diarrhea
• Hepatotoxicity
• Hypokalemia
• Alopecia & rash
17. Sulphasalazine
• MOA:
A prodrug cleaved by gut bacteria
5-aminosalicylic acid & sulfapyridine.
Sulfapyridine is thought to be the
principal anti-rheumatic agent.
• Adverse reactions:
– GIT: nausea, vomiting, diahrrea
– Myelosuppression: Occasional
leucopenia and thrombocytopenia.
– Hemolysis in G6PD deficiency.
19. Biologic DMARDs
• Inflammatory cytokines play a central role in RA.
• Biological DMARDs are antibodies and antibody
fusion proteins that inhibit the action of cytokines by
blocking the cytokine from binding to its specific
receptor administered S.C or i.v.
• Antibodies for the treatment of RA can be divided into
three groups: chimeric antibodies, humanized
antibodies, and human antibodies.
20. Biologic DMARDs
• Cytokine inhibitors used in the treatment of
RA are:
– Inhibitor of IL-1 (anakinra),
– Inhibitors of TNF (infliximab, etanercept,
and adalimumab)
– Inhibitor of IL-6 (tocilizumab).
• These drugs each have a stronger effect
than methotrexate
• Methotrexate + any biological agent
more effective than methotrexate alone.
21. Biologic DMARDs
A competitive IL-1
receptor antagonist
Inhibitor of IL-1
Anakinra
Complex with
cytokine/cytokine
receptor and
prevent its
interaction with
corresponding
receptor on
target cells.
Chimeric antibody
Human antibody
Fusion protein
Inhibitors of
TNFα
Infliximab
Adalimumab
Etanercept
Humanized
antibody of IL-6
receptor
Inhibitor of IL-6
Tocilizumab
Prevent T cell
costimulation
Fusion protein
CD80/86
inhibitor
Abatacept
B cell depletion
Chimeric antibody
CD20
Rituximab
23. Biologic DMARDs
Main side effects
injection/infusion-related reactions
infections (TB, fungal, sepsis, and reactivation of hepatitis B)
never use 2 biologic DEMARDs together.
Increased risk of lymphoma and other cancers.
Contraindications to the use of TNF-α inhibitors.
– Acute and chronic infections
– Recent malignancies
– Live virus vaccination
– Demyelinating disorders
– Class III or IV heart failure
24. • Correlate the knowledge to a clinical situation.
Learning
Outcome
2
25. A clinical correlate
Disease activity
DMARD monotherapy
Combination DMARD (methotrexate +
……)
or
Biologic DMARD +/- methotrexate
Low High
26. Case Report
• A 58-year-old lady with a 3-year history of
rheumatoid arthritis is referred by her GP
with a flare up of her arthritis. She has a
high ESR and CRP and is rheumatoid
factor positive. In the last year she has
been taking various NSAIDs and 3
months ago was found to have iron
deficient anemia. An upper GI endoscopy
showed a gastric ulcer. NSAIDs were
stopped. How would you treat this
lady’s rheumatoid arthritis?
27. Case Report
• Goals of therapy:
1. Prevent disease progression Start
DMARD monotherapy or combination
therapy depending on disease activity.
2. Symptomatic therapy start steroid
therapy till pain & stiffness subsides and
withdraw gradually.
28. Goals of
therapy:
1. To reduce pain & stiffness of joints
(symptomatic drug treatment)
NSAIDs or steroids).
2. To prevent chronic joint destruction
(DMARDs).
29. Disease activity
DMARD monotherapy Combination DMARD (methotrexate + ……)
or
Biologic DMARD +/- methotrexate
There is a lag between starting
DMARDs therapy and observing an
effect (3 weeks to 3 months).
NSAIDs and/or corticosteroids are
used as a ‘bridge therapy’ provide
symptomatic relief till the therapeutic
effect of DMARDs
DMARDs should be started as early as
possible (within 3 months of symptom
onset) more favorable outcome.
1 or more DMARDs are used
depending on disease severity.
31. Questions
Rheumatoid arthritis is a relatively common autoimmune disease, with
multiple treatment options. Which of the following is an example of a
drug class that has been shown to halt or reverse the progression of
this disease in most patients?
• aspirin
• azathioprine
• everolimus
• methotrexate
• prednisone
32. JQ is a 40 year old golfer who has developed a progressively more painful stiffness in her arms
and legs over the past year that interferes with her ability to compete in golf tournaments.
During her most recent medical checkup, her lab results reveal an elevated erythrocyte
sedimentation rate (ESR), elevated CRP level and a high RF level. X-ray imaging revealed
the presence of bilateral erosion of several joints in her arms and legs. After being referred
to a rheumatologist, she is prescribed methotrexate. Which of the following best describes
the mechanism of action of this drug?
• increases adenosine levels
• inhibits dihydrofolate reductase
• inhibits IL-6 signal transduction
• small molecule kinase inhibitor
• TNF-alpha receptor antagonist
33. Which component of sulfasalazine is
responsible for the therapeutic effect in
rheumatoid arthritis ?
• Sulfapyridine
• 5–aminosalicylic acid
• Both (a) and (b)
• Intact sulfasalazine molecule
34. In a follow-up visit, JQ is still exhibiting significant signs of
RA, and has not achieved her therapeutic goal. After some
discussion about treatment options, adalimumab (s.c. every
2 weeks) is added to her treatment regimen. Major side
effects with this class of medication include:
• infections & malignancy
• mucosal ulcers
• osteoporosis
• renal impairment
35. • While TNF-alpha inhibitors are the most commonly used
biologic DMARDs, an IL-6 receptor antagonist has also been
found to be effective in treating arthritis. An example of this
drug class is:
• abatacept
• ankinra
• leflunomide
• rituximab
• tocilizumab
The exact etiology is unclear
It results from a complex interaction between genes and environment breakdown of immune tolerance and synovial inflammation.
Antigen presenting cells (APC), Activated T cells, B cells and macrophages production of soluble mediators (cytokines e.g. TNF-α, IL-1, IL-6, etc.) that cause joint inflammation, cartilage destruction, bone erosion, and deformity.
Methotrexate inhibits dihydrofolate reductase enzyme. Reduced folate (tetrahydrofolate, FH4) is involved in the de novo synthetic pathways for purine and pyrimidine precursors of DNA and RNA required for cell proliferation.
Experimental monoclonal antibodies are usually produced by immunizing a mouse with an antigen, and therefore, the antibody is 100% mouse antibody. When such an antibody is used as a therapeutic agent in humans, it causes a strong anaphylactic reaction.
In an effort to reduce as far as possible the content of heterologous proteins, various chimeric antibodies, humanized antibodies, and human antibodies have been developed for the treatment of RA.
Biological agents other than cytokine inhibitors used in the treatment of RA include:
Abatacept, which inhibits the action of T-cell co-stimulatory molecules CD80 and CD86
Rituximab, which targets CD20 destruction of B cell inhibit production of autoantibodies
DMARD monotherapy hydroxychloroquine or methotrexate.
Combination DMARD therapy methotrexate + leflunomide or hydroxychloroquine or sulfasalazine