This document summarizes several neural tube closure disorders including Chiari malformations, encephaloceles, anencephaly, spinal dysraphism, and tethered cord syndrome. It describes the anatomy, clinical presentation, and treatment for each condition. Neural tube closure occurs during early gestation and disorders result from failed closure of the brain and spinal cord. The most common types are Chiari malformations, spinal dysraphism including meningoceles and myelomeningoceles, and encephaloceles. Presentation depends on the specific region and tissues involved. Treatment involves surgical repair when possible to address neurological deficits and complications.