There are some diseases that humans can only catch once because after the initial infection, the body's immune system remembers how to fight the disease if exposed again. Examples include chickenpox. Other diseases like the common cold or strep throat can infect people many times because there are multiple variants of the disease, so the immune system may not recognize repeat infections. Still other diseases can be prevented altogether by vaccines, which expose the body to a harmless version of the disease, allowing it to develop protective antibodies before actual exposure.