Digital Library Home Access: User Validation, E- Resources Proxying and Federation. Francisco Fernandez et al. 2nd Conference National Digital Libraries of Health (Sevilla, 2008)
Polling system solution using blockchain & LiferayDhanraj Dadhich
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Polling system solution using block-chain and Liferay. This presentation explain about Registration, Permission Access, States of Data, Integration of the protocol, single human authentication, Transaction Security, Polling System, Delegation / Casting vote, etc.
I am expecting responses / note on the presentation for further improvement. Please feel free to write us back on info@dfrozensoft.com / sales@dfrozensoft.com / dhanraj@dfrozensoft.com
Digital Consent: Taking UMA from Concept to RealityForgeRock
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This document discusses digital consent and the User-Managed Access (UMA) standard. It argues that current "post-compliance" consent tools like OAuth are limited and that customers need "Consent 2.0" solutions that provide context, control, choice and respect regarding personal data sharing. The UMA standard uses federated authorization on top of OAuth to enable party-to-party sharing driven by policy rather than requiring direct user involvement. The document demonstrates how UMA works in action and notes that ForgeRock will deliver two key OpenUMA components by the end of 2015 to help realize Consent 2.0.
Documentum is an enterprise content management system that provides a unified environment for capturing, storing, accessing, organizing, controlling, retrieving and archiving unstructured information. It stores content and associated metadata in a central repository. Content can be any file type and is managed through its lifecycle with services that support workflows, records management, delivery, and integration with external systems. Security services include authentication, authorization, auditing and information rights management.
Enterprise Content Management, Documentum Overview. This presentation shows what is ECM, why we need ECM, EMC History, EMC Content Management Portfolio, Documentum and Captiva Products overview
GraphTalks Rome - Identity and Access ManagementNeo4j
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This document summarizes a presentation about using graph databases for identity and access management (IAM). It discusses how IAM systems traditionally assume rigid hierarchies that do not reflect modern complex organizations. Graph databases provide a flexible model for IAM by representing relationships between users, roles, devices, and other entities as nodes connected by relationships. This allows querying complex access scenarios and augmenting existing IAM systems. The presentation provides examples of building full IAM systems or augmenting existing ones using a graph database to better model complex real-world relationships.
ITIL v3 defines access management as the process of granting authorized users the right to use a service, while preventing access to non-authorized users. Access management enables users to use services documented in the service catalog. It manages identity, access rights, services, and uses directory services to manage access and rights. The goal is to provide users the right level of access to services according to defined policies and security management.
Polling system solution using blockchain & LiferayDhanraj Dadhich
Â
Polling system solution using block-chain and Liferay. This presentation explain about Registration, Permission Access, States of Data, Integration of the protocol, single human authentication, Transaction Security, Polling System, Delegation / Casting vote, etc.
I am expecting responses / note on the presentation for further improvement. Please feel free to write us back on info@dfrozensoft.com / sales@dfrozensoft.com / dhanraj@dfrozensoft.com
Digital Consent: Taking UMA from Concept to RealityForgeRock
Â
This document discusses digital consent and the User-Managed Access (UMA) standard. It argues that current "post-compliance" consent tools like OAuth are limited and that customers need "Consent 2.0" solutions that provide context, control, choice and respect regarding personal data sharing. The UMA standard uses federated authorization on top of OAuth to enable party-to-party sharing driven by policy rather than requiring direct user involvement. The document demonstrates how UMA works in action and notes that ForgeRock will deliver two key OpenUMA components by the end of 2015 to help realize Consent 2.0.
Documentum is an enterprise content management system that provides a unified environment for capturing, storing, accessing, organizing, controlling, retrieving and archiving unstructured information. It stores content and associated metadata in a central repository. Content can be any file type and is managed through its lifecycle with services that support workflows, records management, delivery, and integration with external systems. Security services include authentication, authorization, auditing and information rights management.
Enterprise Content Management, Documentum Overview. This presentation shows what is ECM, why we need ECM, EMC History, EMC Content Management Portfolio, Documentum and Captiva Products overview
GraphTalks Rome - Identity and Access ManagementNeo4j
Â
This document summarizes a presentation about using graph databases for identity and access management (IAM). It discusses how IAM systems traditionally assume rigid hierarchies that do not reflect modern complex organizations. Graph databases provide a flexible model for IAM by representing relationships between users, roles, devices, and other entities as nodes connected by relationships. This allows querying complex access scenarios and augmenting existing IAM systems. The presentation provides examples of building full IAM systems or augmenting existing ones using a graph database to better model complex real-world relationships.
ITIL v3 defines access management as the process of granting authorized users the right to use a service, while preventing access to non-authorized users. Access management enables users to use services documented in the service catalog. It manages identity, access rights, services, and uses directory services to manage access and rights. The goal is to provide users the right level of access to services according to defined policies and security management.
Technical Challenges in Resource DiscoveryPaul Walk
Â
The document discusses several technical challenges in resource discovery. It addresses the tension between open and closed systems and how both approaches are needed. A particular challenge discussed is synchronization across distributed repositories in an open world. The document also discusses emerging standards like ResourceSync that aim to address this challenge. It notes the importance of APIs but cautions that they need to be designed with developers in mind and provide full access to data to be truly useful. Overall quality of data is also discussed as a challenge that can limit what people are able to do.
Presentation by Todd Carpenter given at the American Library Association Conference on June 25, 2017 about the Resource Access in the 21st Century (RA21) project. The RA21 project is focused on improving the access control systems for digital content subscribed to by libraries.
1. The document summarizes a presentation on the RA21 (Resource Access in the 21st Century) Task Force, which aims to address challenges with the current IP-based system for accessing scholarly resources and propose new solutions.
2. It outlines problems with the current system such as inconsistent user experiences for off-campus access and discusses the task force's work to date including developing draft principles and plans to test solutions through pilot programs in 2017.
3. Stakeholders are encouraged to get involved by taking a survey or expressing interest in participating in pilots to help develop best practices for improved access systems beyond IP authentication.
The document discusses remote access technology for libraries. It defines remote access as allowing library users to access subscribed resources from anywhere without disruption. It describes various tools for remote access, including RemoteXS, EZProxy, VPN, Shibboleth, and OpenAthens. The Vikram Sarabhai Library uses RemoteXS to provide remote access to over 1755 users, authenticating users and giving access to online databases. Issues discussed include publisher site changes breaking the service and inability to access offline databases remotely.
Webinar: Preserving user privacy and protecting online contentOpenAthens
Â
Adam Snook, OpenAthens product manager, discusses preserving user privacy and protecting online content. Adam also explains RA21 and what federated single sign-on is.
Debates on Open Source Software: "The house believes that the future of Web in UK Higher and Further Education communities lies in the adoption of open source software".
See http://www.ukoln.ac.uk/web-focus/events/workshops/webmaster-2002/debate/
The document discusses the SHARE Notification Service, which aims to maximize research impact by keeping interested parties informed of research activities and outputs. It provides an overview of SHARE's mission and funding, describes the notification service which alerts subscribers about new research releases, and discusses early lessons learned. It also outlines plans for a Phase II that would provide a more comprehensive linked dataset to improve discovery and assessment of research impacts.
COAR: All About the SHared Access Research Ecosystem (SHARE)CASRAI
Â
The webinar discussed the SHared Access Research Ecosystem (SHARE) initiative, which aims to maximize research impact by keeping interested parties informed of researchers' activities. It described the SHARE Notification Service, which notifies stakeholders like funders and institutions about research outputs. The service collects metadata on articles, datasets, and other research releases from various sources and sends notifications. While progress was made in the first phase, challenges remain around metadata standards, rights, and scale. A second phase is planned to provide additional functionality and address some user needs.
RA21 is working on pilots to improve off-campus access to library resources. The Privacy Preserving Persistent WAYF pilot aims to enhance the Shibboleth identity provider discovery process. It will incorporate additional authentication hints, improve the sign-in flow, and enable cross-provider persistence of user choices. The WAYF Cloud pilot seeks to provide seamless access similar to IP authentication by leveraging existing authentication systems and forming standards for exchanging user data between publishers through a central WAYF Cloud software. Both pilots aim to improve the user experience for off-campus access.
Removing dependencies between services: Messaging and Apache KafkaDaniel Muñoz Garrido
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The document discusses using a message broker like Apache Kafka to share information between services. It notes the drawbacks of direct calls between services, including lack of knowledge of external services and complex data consistency. Using a message broker allows services to focus on their own logic and publishes information without needing to know consumer throughput. It then provides an overview of Kafka, including that it is a distributed streaming platform that uses topics and partitions to store records with offsets and timestamps. Producers write to and consumers read from Kafka in parallel consumer groups. Real world examples are given of using Kafka for transactions across updating web services and ensuring consistent states.
Banking managment
Bug Tracking
Chat-Server-system
College Information System
CourierInformationSystem
CYBER_SHOPPING
Data Centric Knowledge Management System
Distributed Cycle Minimization Protocol
E-COMMERCE Mechanism
Finance Managment
Global intractive solutins
Health Center System
IntranetChatting
MobileService management
NetConferening
online order processing system with AJAX enabled
OnLineExam process
web based Manufacturing
WEBREPORTING PROCESS
Andhra Pradesh State Finance Corporation (APSFC)
Classifieds
Customer Relationship Management for AIRLINE Industry
DataMart Management Software
E Procurement System
e-Classifieds
Ecommerce shopping cart
Elearn
Employee Resource Info sys
ENTERPRISE REOURCE PLANNING MANAGEMENT
e-Shopping
E-TRANSACTION_Totalproj
EWheelz
EzeeMail system
foresty management system
Fuji Distribution
global communication
GLOBAL COMMUNICATION MEDIA
Google map-wc
GovtSchemes-wc
human resource management system
Info ware Services
Insurance
Intranet Mailing System
Intrusion Detection System over Abnormal Internet Sequence
Lending Tree
Master and Science Research Center
Matrimony.com
MediTracker
MingleSpot
net-banking
On-line java compiler with security editor
ONLINE_EXAMS_POJECT
OnlineBanking
OnlineLibrary
PayRoll
Pharmacy system
product service management system
Project online music application
project status info system
project status information system
Resource out Sourcing
ResourcePlanner
SecuredNetAuction
ShoutBox
smartcard
SpeedAge
Status Information System
StockAnalyzer
stores management system
TelecomConnectionSystem-wc
Univesity Admission System
Web-Based Library
OpenAthens Conference 2018 - Adam Snook - Quick wins for an easier user journ...OpenAthens
Â
The document discusses improving the user experience for accessing online resources through federated authentication. It notes that login can be a barrier and libraries try to improve discovery. The OpenAthens redirector provides a single sign-on link structure to check location and authenticate users. Personalization across platforms is now possible through federated access without compromising privacy. The RA21 initiative aims to facilitate seamless access across devices and locations through alternatives to IP authentication using existing federated technologies. Improving the organization discovery experience, providing personalization linked to login, and account linking features can enhance the user experience.
The document discusses building chatbots using IBM Watson. It provides an overview of IBM Bluemix and IBM Watson, including how Watson was developed and commercialized. It also discusses Watson's capabilities in natural language processing, machine learning, and cognitive computing. The document reviews Watson's ecosystem and common use cases for various companies. It examines SDKs for building conversational interfaces and the limitations of current natural language understanding technologies. Finally, it describes the key components of Watson Conversation for developing chatbots, including intents, entities, and dialog flow.
APNIC Service Team Lead Anna Mulingbayan gives an introduction to APNIC at the PCTA Convention 2023, held in Boracay, Philippines from 10 to 14 April 2023.
APNIC Service Team Lead Anna Mulingbayan gives an introduction to APNIC at the PCTA Convention 2023, held in Boracay, Philippines from 10 to 14 April 2023.
ADV Slides: Trends in Streaming Analytics and Message-oriented MiddlewareDATAVERSITY
Â
Streaming and real-time data has high business value, but that value can rapidly decay if not processed quickly. If the value of the data is not realized in a certain window of time, its value is lost and the decision or action that was needed as a result never occurs. Streaming data – whether from sensors, devices, applications, or events – needs special attention because a sudden price change, a critical threshold met, a sensor reading changing rapidly, or a blip in a log file can all be of immense value, but only if the alert is in time.
The document describes several projects involving e-learning and knowledge transfer systems for medical organizations. It discusses a project for the International Headache Society that included a new e-learning section on their members-only website with video and reading libraries and interactive case-based learning. It also describes a 'PROSPECT' knowledge transfer project funded by Pfizer that provided pain management case studies and a system for field representatives to track client meetings. Finally, it summarizes an early e-learning pilot project for the NHS that allowed nursing staff to take online courses and receive certificates upon completion.
Este documento describe un sistema inteligente y autĂłnomo de control y monitoreo para la Biblioteca Virtual del Sistema Sanitario PĂşblico de AndalucĂa utilizando hardware de cĂłdigo abierto como Arduino y sus shields. El sistema usa sensores como de temperatura, humedad, agua, huellas digitales y calidad del aire, asĂ como cámaras y detectores de movimiento conectados a Arduino. Los datos son enviados a la plataforma Xively para su visualizaciĂłn y almacenamiento en la nube. Se proponen mejoras como una interfaz
Technical Challenges in Resource DiscoveryPaul Walk
Â
The document discusses several technical challenges in resource discovery. It addresses the tension between open and closed systems and how both approaches are needed. A particular challenge discussed is synchronization across distributed repositories in an open world. The document also discusses emerging standards like ResourceSync that aim to address this challenge. It notes the importance of APIs but cautions that they need to be designed with developers in mind and provide full access to data to be truly useful. Overall quality of data is also discussed as a challenge that can limit what people are able to do.
Presentation by Todd Carpenter given at the American Library Association Conference on June 25, 2017 about the Resource Access in the 21st Century (RA21) project. The RA21 project is focused on improving the access control systems for digital content subscribed to by libraries.
1. The document summarizes a presentation on the RA21 (Resource Access in the 21st Century) Task Force, which aims to address challenges with the current IP-based system for accessing scholarly resources and propose new solutions.
2. It outlines problems with the current system such as inconsistent user experiences for off-campus access and discusses the task force's work to date including developing draft principles and plans to test solutions through pilot programs in 2017.
3. Stakeholders are encouraged to get involved by taking a survey or expressing interest in participating in pilots to help develop best practices for improved access systems beyond IP authentication.
The document discusses remote access technology for libraries. It defines remote access as allowing library users to access subscribed resources from anywhere without disruption. It describes various tools for remote access, including RemoteXS, EZProxy, VPN, Shibboleth, and OpenAthens. The Vikram Sarabhai Library uses RemoteXS to provide remote access to over 1755 users, authenticating users and giving access to online databases. Issues discussed include publisher site changes breaking the service and inability to access offline databases remotely.
Webinar: Preserving user privacy and protecting online contentOpenAthens
Â
Adam Snook, OpenAthens product manager, discusses preserving user privacy and protecting online content. Adam also explains RA21 and what federated single sign-on is.
Debates on Open Source Software: "The house believes that the future of Web in UK Higher and Further Education communities lies in the adoption of open source software".
See http://www.ukoln.ac.uk/web-focus/events/workshops/webmaster-2002/debate/
The document discusses the SHARE Notification Service, which aims to maximize research impact by keeping interested parties informed of research activities and outputs. It provides an overview of SHARE's mission and funding, describes the notification service which alerts subscribers about new research releases, and discusses early lessons learned. It also outlines plans for a Phase II that would provide a more comprehensive linked dataset to improve discovery and assessment of research impacts.
COAR: All About the SHared Access Research Ecosystem (SHARE)CASRAI
Â
The webinar discussed the SHared Access Research Ecosystem (SHARE) initiative, which aims to maximize research impact by keeping interested parties informed of researchers' activities. It described the SHARE Notification Service, which notifies stakeholders like funders and institutions about research outputs. The service collects metadata on articles, datasets, and other research releases from various sources and sends notifications. While progress was made in the first phase, challenges remain around metadata standards, rights, and scale. A second phase is planned to provide additional functionality and address some user needs.
RA21 is working on pilots to improve off-campus access to library resources. The Privacy Preserving Persistent WAYF pilot aims to enhance the Shibboleth identity provider discovery process. It will incorporate additional authentication hints, improve the sign-in flow, and enable cross-provider persistence of user choices. The WAYF Cloud pilot seeks to provide seamless access similar to IP authentication by leveraging existing authentication systems and forming standards for exchanging user data between publishers through a central WAYF Cloud software. Both pilots aim to improve the user experience for off-campus access.
Removing dependencies between services: Messaging and Apache KafkaDaniel Muñoz Garrido
Â
The document discusses using a message broker like Apache Kafka to share information between services. It notes the drawbacks of direct calls between services, including lack of knowledge of external services and complex data consistency. Using a message broker allows services to focus on their own logic and publishes information without needing to know consumer throughput. It then provides an overview of Kafka, including that it is a distributed streaming platform that uses topics and partitions to store records with offsets and timestamps. Producers write to and consumers read from Kafka in parallel consumer groups. Real world examples are given of using Kafka for transactions across updating web services and ensuring consistent states.
Banking managment
Bug Tracking
Chat-Server-system
College Information System
CourierInformationSystem
CYBER_SHOPPING
Data Centric Knowledge Management System
Distributed Cycle Minimization Protocol
E-COMMERCE Mechanism
Finance Managment
Global intractive solutins
Health Center System
IntranetChatting
MobileService management
NetConferening
online order processing system with AJAX enabled
OnLineExam process
web based Manufacturing
WEBREPORTING PROCESS
Andhra Pradesh State Finance Corporation (APSFC)
Classifieds
Customer Relationship Management for AIRLINE Industry
DataMart Management Software
E Procurement System
e-Classifieds
Ecommerce shopping cart
Elearn
Employee Resource Info sys
ENTERPRISE REOURCE PLANNING MANAGEMENT
e-Shopping
E-TRANSACTION_Totalproj
EWheelz
EzeeMail system
foresty management system
Fuji Distribution
global communication
GLOBAL COMMUNICATION MEDIA
Google map-wc
GovtSchemes-wc
human resource management system
Info ware Services
Insurance
Intranet Mailing System
Intrusion Detection System over Abnormal Internet Sequence
Lending Tree
Master and Science Research Center
Matrimony.com
MediTracker
MingleSpot
net-banking
On-line java compiler with security editor
ONLINE_EXAMS_POJECT
OnlineBanking
OnlineLibrary
PayRoll
Pharmacy system
product service management system
Project online music application
project status info system
project status information system
Resource out Sourcing
ResourcePlanner
SecuredNetAuction
ShoutBox
smartcard
SpeedAge
Status Information System
StockAnalyzer
stores management system
TelecomConnectionSystem-wc
Univesity Admission System
Web-Based Library
OpenAthens Conference 2018 - Adam Snook - Quick wins for an easier user journ...OpenAthens
Â
The document discusses improving the user experience for accessing online resources through federated authentication. It notes that login can be a barrier and libraries try to improve discovery. The OpenAthens redirector provides a single sign-on link structure to check location and authenticate users. Personalization across platforms is now possible through federated access without compromising privacy. The RA21 initiative aims to facilitate seamless access across devices and locations through alternatives to IP authentication using existing federated technologies. Improving the organization discovery experience, providing personalization linked to login, and account linking features can enhance the user experience.
The document discusses building chatbots using IBM Watson. It provides an overview of IBM Bluemix and IBM Watson, including how Watson was developed and commercialized. It also discusses Watson's capabilities in natural language processing, machine learning, and cognitive computing. The document reviews Watson's ecosystem and common use cases for various companies. It examines SDKs for building conversational interfaces and the limitations of current natural language understanding technologies. Finally, it describes the key components of Watson Conversation for developing chatbots, including intents, entities, and dialog flow.
APNIC Service Team Lead Anna Mulingbayan gives an introduction to APNIC at the PCTA Convention 2023, held in Boracay, Philippines from 10 to 14 April 2023.
APNIC Service Team Lead Anna Mulingbayan gives an introduction to APNIC at the PCTA Convention 2023, held in Boracay, Philippines from 10 to 14 April 2023.
ADV Slides: Trends in Streaming Analytics and Message-oriented MiddlewareDATAVERSITY
Â
Streaming and real-time data has high business value, but that value can rapidly decay if not processed quickly. If the value of the data is not realized in a certain window of time, its value is lost and the decision or action that was needed as a result never occurs. Streaming data – whether from sensors, devices, applications, or events – needs special attention because a sudden price change, a critical threshold met, a sensor reading changing rapidly, or a blip in a log file can all be of immense value, but only if the alert is in time.
The document describes several projects involving e-learning and knowledge transfer systems for medical organizations. It discusses a project for the International Headache Society that included a new e-learning section on their members-only website with video and reading libraries and interactive case-based learning. It also describes a 'PROSPECT' knowledge transfer project funded by Pfizer that provided pain management case studies and a system for field representatives to track client meetings. Finally, it summarizes an early e-learning pilot project for the NHS that allowed nursing staff to take online courses and receive certificates upon completion.
Similar to Digital Library Home Access: User Validation, E- Resources Proxying and Federation (20)
Este documento describe un sistema inteligente y autĂłnomo de control y monitoreo para la Biblioteca Virtual del Sistema Sanitario PĂşblico de AndalucĂa utilizando hardware de cĂłdigo abierto como Arduino y sus shields. El sistema usa sensores como de temperatura, humedad, agua, huellas digitales y calidad del aire, asĂ como cámaras y detectores de movimiento conectados a Arduino. Los datos son enviados a la plataforma Xively para su visualizaciĂłn y almacenamiento en la nube. Se proponen mejoras como una interfaz
Trabajo sobre la experiencia de la Biblioteca Virtual del SSPPA en las redes sociales, estrategia de comunicaciĂłn, canales, estadĂsticas y proyectos
Juan A. Hernández-Morales, Verónica Juan-Quilis
PĂłster sobre la web de la ciudadanĂa de la Biblioteca Virtual del SSPA. Recursos de calidad sobre salud para la ciudadanĂa. Juan A. Hernández Morales et al.
Muñoz, Laura; Juan, Verónica. Comunicación presentada al confreso One HEALTH: Information in an Interdependent World. (MLA'13). Boston 3-5 de mayo de 2013.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Â
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
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chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
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Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
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Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
The skin is the largest organ and its health plays a vital role among the other sense organs. The skin concerns like acne breakout, psoriasis, or anything similar along the lines, finding a qualified and experienced dermatologist becomes paramount.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Â
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
 A statistics is a measure which is used to estimate the population parameter
 Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
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Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
Osvaldo Bernardo Muchanga-GASTROINTESTINAL INFECTIONS AND GASTRITIS-2024.pdfOsvaldo Bernardo Muchanga
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GASTROINTESTINAL INFECTIONS AND GASTRITIS
Osvaldo Bernardo Muchanga
Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
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Digital Library Home Access: User Validation, E- Resources Proxying and Federation
1. Digital Library Home Access: User Validation, E-
Resources
Proxying and Federation
Sevilla february 20-21, 2008
Andalusian Public Health System Virtual Library
Francisco Fernández Ordoñez, francisco.fernandez.ord@juntadeandalucia.es
Francisco JesĂşs Jordano, franciscoj.jordano@juntadeandalucia.es
3. 2. Initial stage
• Andalusian Public Health System staff: 92.070 professionals
• The Health professionals we serve works for 15 different institutions, including hospitals, primary care centers, research centers, training
institutions, etc.
• Every Institution operates their own human resources department and IT systems.
• Andalusian Public Health System Institutions:
1. Servicio Andaluz de Salud (SAS). 83.000 professionals, 29 hospitals and 1452 primary care centers.
2. ConsejerĂa y Delegaciones Provinciales de Salud.
3. Empresa PĂşblica de Emergencias Sanitarias.
4. Empresa PĂşblica Hospital Costa del Sol.
5. Empresa PĂşblica Hospital de Poniente.
6. Empresa PĂşblica Hospital Alto Guadalquivir.
7. Empresa PĂşblica Sanitaria Bajo Guadalquivir.
8. Escuela Andaluza de Salud PĂşblica.
9. FundaciĂłn Progreso y Salud.
10. FundaciĂłn Andaluza para la IntegraciĂłn Social del Enfermo Mental.
11. FundaciĂłn Iavante.
12. Agencia de EvaluaciĂłn de TecnologĂas Sanitarias de AndalucĂa.
13. Agencia de Calidad Sanitaria de AndalucĂa.
14. Cabimer.
15. Bancelan.
4. 3. User Validation system - requirements
• Ready available for every Andalusian Public Health System staff.
• Do not duplicate existing LDAP directories, human resources databases, etc.
• No software installation required, the solution must allow access just using a web browser (Firefox, Explorer,
Opera, etc).
• Single Sign-On: The ability of a single user to access multiple applications, information providers, using a single form
of authentication, such as a username/password.
• Secure: no unauthorized access, no user and password sharing.
• Auditing and reporting facilites: solution stores all web access and identity logs in one location
5. 4. User Validation system - key idea
Federated Identity Management
• BV-SSPA user validation system intends to keep authentication as an issue local to the organization
the user belongs to.
• BV-SSPA trusts and accept identity and authentication information established by Andalusian Public
Health System Institutions.
• Delegated Identity Administration, the solution have the ability to delegate administration of identity
information across corporate boundaries.
7. 6. User Validation system – PAPI software
• PAPI (Access Point to Information Providers) is a system for providing access control to restricted
information resources across the Internet.
• PAPI is distributed as free software. There are implementations of the PAPI components in Java, Perl and
PHP.
• PAPI is developed, maintained and supported for RedIRIS Spanish National Research Network
(http://www.rediris.es/index.en.html)
• PAPI is available at: http://papi.rediris.es/
identity access e-resources
management management proxying
8. 3. e-Resources Proxying
Users want access e-Resources regardless of their location
• E-Resources publishers usually offer several alternatives to control access to their producs.
• In enviroments with a huge amount of users, like SSPA, the mos extended validation method is IP control.
• This IP control forces our users to connect to e-resources through a limited number of computers, avoiding the ubiquitous access to
information.
PUBLISHER X
INTRANET
HOME
PROVIDER Y
9. 3. e-Resources Proxying
What are the alternatives?
• To resolve this problem there are diferent alternatives: VPNs, propietary products, information replication, etc.
• Finally we adopted the rewriting proxy solution provided by the PAPI system.
• Some of the features of this solutions are:
• Integartion with PAPI Single Sign On system.
• No aditional software is needed. The final user can access resources from home, a cybercafe, movil device, etc.
• This solution is based on the HTTP standard protocol, so access is granted to any browser.
• PAPI is a Open Source solution, we can adapt it to our needs, get updates from the comunity and participate on it.
10. 3. e-Resources Proxying
What is a rewriting proxy (I)?
• A rewriting proxy is a mediator between the user and final resources.
• Access to e-resources won´t be made directly to the publisher´s website.
• This mediator will manage the e-resource application and will show to the final user the result.
• In addition this mediator changes the HTML source, and the links from the original source are transformed to point to this mediator.
• The mediator is accesible regardless user´s localization, and it´s protected by PAPI.
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11. 3. e-Resources proxying
What is a rewriting proxy (II)?
• Users inside intranet still can access resources directly.
• Now there is a point of access to information for SSPA users outside intranet.
PUBLISHER X
INTRANET
PROVIDER Y
HOME
BV-SSPA
12. 3. e-Resources Proxying
Providers, publishers, resources
• Our goal: give user access to resources engage with publishers.
• There is another actor: providers.
• We have to write mediators for providers too, and make this providers transform HTML for final publisher into their own mediators.
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