This document discusses differentiation models and their rationale. It describes differentiated instruction as meeting the unique needs of diverse students. Teachers should understand each student's learner profile of learning style, intelligence preference, gender, and culture. Neuroscience research shows there are three primary brain networks involved in learning - recognition, strategic, and affective networks. Different models of differentiated instruction exist, such as Tomlinson's model and Universal Design for Learning, both of which are supported by research. Formative assessment is important for differentiation to identify student needs and adjust instruction. Differentiated classrooms differ from traditional classrooms in their use of flexible grouping, tiered assignments, and merging of standards with student readiness.