Derek D. Smith is a clinical research professional seeking a new position in Boulder, Colorado. He has a Bachelor's degree in clinical research from Campbell University and over 2 years of professional experience in clinical trials coordination and data management at Duke University Hospital. His resume details his responsibilities in ensuring regulatory compliance, subject recruitment, data collection and entry, sample processing, and coordinating with study sponsors and investigators.
I have recently relocated to the Denver, Colorado area and I am actively seeking a position, in research, that can challenge and utilize the professional knowledge I have acquired over the past four years. I am a self motivated, ambitious young professional who has worked very hard to become an effective asset and team member to each organization which I have been a part of. Since my graduation with a BS Clinical Research, I have worked in a variety of positions including corporate CRO research (INC Research), direct clinical care (Nursing Assistant at UNC and Duke Hospitals), and most recently, Clinical Research on the site level with the Duke University Cardiothoracic Surgery Research Team. My previous team lead and research practice manager, included as references on my resume, will likely cite my ability and willingness to learn quickly, interact with subjects/patients in a personable manner, and develop productive working relationships with my team members. I pride myself on my work ethic and enjoy working around others that inspire that same dedication.
I have recently relocated to the Denver, Colorado area and I am actively seeking a position, in research, that can challenge and utilize the professional knowledge I have acquired over the past four years. I am a self motivated, ambitious young professional who has worked very hard to become an effective asset and team member to each organization which I have been a part of. Since my graduation with a BS Clinical Research, I have worked in a variety of positions including corporate CRO research (INC Research), direct clinical care (Nursing Assistant at UNC and Duke Hospitals), and most recently, Clinical Research on the site level with the Duke University Cardiothoracic Surgery Research Team. My previous team lead and research practice manager, included as references on my resume, will likely cite my ability and willingness to learn quickly, interact with subjects/patients in a personable manner, and develop productive working relationships with my team members. I pride myself on my work ethic and enjoy working around others that inspire that same dedication.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdf
Derek smith resume v.7
1. Derek D. Smith
3234 W 23rd
Ave.
Denver Co, 80211
derek.d.smith3@gmail.com
(919)624-7256
I am an ambitious, self-motivated, research professional in Boulder, Colorado looking for the right
position to utilize and challenge the expertise I have gained through dedication to education and the
clinical research profession.
FORMAL EDUCATION
Bachelor of Science in Clinical Research August 2014
Campbell University, Buies Creek, NC
High School Diploma June 2008
Green Hope High School, Morrisville, NC
PROFESSIONAL EXPERIENCE
Clinical Trials Assistant II November 2015 – August 2016
Cardio-Thoracic Surgery Office of Clinical Research
Duke University Hospital
Durham, NC
Team Contributions
Develop project timelines, track milestones
Maintain records of weekly progressions and projections
Take meeting minutes twice weekly for NIH review
Upload and update meeting agenda weekly
Create and update master CT surgery screening log daily
Determine eligibility using procedures - imaging (CT and Echo) – Hx
Plan social events for team building / celebrations
Train new team members on all CTA processes
Subject/Study Responsibilities
Extract, label and archive source documents from MaestroCare.
Enter data and upload source documents into EDC databases: eClinical – REDCap – InChoir.
Redact all 18 HIPAA patient identifiers from source documents
Administer and record audio of neurocognitive testing - stroke scales – questionnaires - delirium
assessments.
Collect, label, and spin tissue and blood samples in research lab.
2. 2
Routinely package and ship biological materials to sponsors and laboratory vendors.
Consent eligible subjects for low-risk studies
Enter data and maintain the International Registry of Aortic Dissections
Navigate Duke eIRB to submit and receive approvals: amendments – continuing reviews –
safety events.
Track all changes made to informed consents and protocols in the eIRB
Ensure the study materials and drug kits: timely shipped – received – maintained properly.
Monitoring
Organize and maintain regulatory and subject binders to remain audit ready.
Assist in hosting site audits: FDA – NIH – industry sponsors.
Request CRA access to subject medical charts.
Close out CRA’s remote monitoring queries in EDC
Collaborate with CRAs to document: location – completion – and accuracy of study related
documents.
Ensure the study materials and drug kits: timely shipped – received – maintained properly.
Collaborate with Investigational Drug Services: review and track drug accountability.
Certified Nursing Assistant I (Nurse Aide) April 2015 – September 2015
UNC Memorial Hospital 7-3
Chapel Hill, NC
Assist nurses, Occupational Therapists, PhysicalTherapists, and Speech Therapists on the
Rehabilitation floor of UNC Memorial Hospital.
Obtain and record vital signs, obtain and record blood glucose levels.
Obtain samples of patient input and output for laboratory analysis.
Assist with feeding, ambulation, transfers, toileting, TED stockings, dressing, changing linens among
other duties.
Discharge and admission of patients.
Certified Nursing Assistant I March 2015 – August 2015
Duke Regional Hospital 4-1
Durham, NC
Assist nurses on the General Medicine floor of Duke Regional.
Obtain and record vital signs, obtain and record blood glucose levels.
Obtain samples of patient input and output for laboratory analysis.
Assist with feeding, ambulation, transfers, toileting, TED stockings, dressing, changing linens among
other duties.
Discharge and admission of patients.
3. 3
Quality Assurance Intern at INC Research May 2014 – August 2014
Raleigh, NC
Recorded audit findings in INC Resolution.
Took “meeting minutes” during audits for later reference.
Compiled team lists, training files, and gap reports.
Worked full-time with a five member team to conduct internal audits, mock FDA audits, and
site audits.
Compiled regulatory binders for auditors to use as a reference.
Used RAVE database to enter study site information.
APPLICABLE COURSEWORK
Advanced Human Physiology
Biostatistics Medical Terminology
Clinical Biochemistry
Data Management
General Chemistry I/II
General Physics I
Human Anatomy and Physiology
Interpersonal Skills
Microbiology and Immunology
New Product Development
Organic Chemistry I/II
Pharmacology
Physical & Clinical Assessment
Regulatory Affairs I/II
Scientific and Technical Writing
Scientific Literature Seminar I/II
ACADEMIC HONORS & AWARDS
Campbell University Scott-Ellis Scholarship 2011 - 2014
Dean’s List Appalachian State University 2008 – 2009
CERTIFICATIONS
Duke Surgery Clinical Research Unit Informed Consent Certified January 2016
Collaborative Institutional Training Initiative (CITI) Biomedical Research November 2015
o IRB
o Informed Consent
o Vulnerable Populations: Prisoners, Children, and Pregnant Women
o FDA regulated research
o Conflict of Interest
Collaborative Institutional Training Initiative (CITI) Good Clinical Practice November 2015
o New Drug Development
o ICH GCP E6 and FDA
o Medical Devices
o Detecting and Evaluating Adverse Events
4. 4
o Reporting Serious Adverse Events
o Monitoring by Industry Sponsors
o Audits and Inspections of Clinical Trial
Collaborative Institutional Training Initiative (CITI) Research Involving November 2015
Children
HIPAA Privacy and Security for Clinicians Certification May 2015
Healthcare Provider CPR/BLS Certified August 2014
Certified Nurse Aide I North Carolina October 2014
o 100 hrs. Course Instruction
o 60 hrs. Clinical (WakeMed)
o NNAAP Skills and Written
Healthcare Provider CPR/BLS Certified August 2014
COMMUNITY ACTIVITIES
Farmer Foodshare August 2015 - Present
Clinical Research Club Campbell University August 2012, 2013, 2014
Relay for Life May, 2012
Health and Hunger Coalition Volunteer September, 2010
Adventurers Volunteer Week (Camp Trinity) July 2007, July 2010
Appalachian Service Project (ASP) May 2006, May 2007, May 2008
REFERENCES
Stacey Welsh RN
Clinical Research Coordinator III
Cardio-thoracic Surgery
Duke University Medical Center
stacey.welsh@duke.edu
(919)-452-2271
Beth Hollister RN
Research Practice Manager
Surgery Chairman
Duke University Medical Center
(919)-681-2172
Holly Gunning RN
Clinical Nurse II 7 Bedtower - Rehabilitation
UNC Memorial Hospital
Holly.Gunning@unchealth.edu
(919)730-8454