How Cytokines involved in Depression.

1. PRESENTED BY
ANKUSH BISWAS
M.PHARM(PHARMACOLOGY), 1ST YEAR, 1STSEM

2.  Depression
 Cause of depression & Major area of depression
 Cytokines
 Types of cytokines
 Mechanism of DEPRESSION
 Antidepressant drugs
 References

3. DEPRESSION
 DEFINITION :
Depression is a chronic mental disorder of multi-
factorial origin, including genetic and environmental
factors.

4.  CAUSE OF DEPRESSION:
a) Genetic characteristics,
b) Changes in hormone levels,
c) certain medical illnesses,
d) stress, grief, or substance abuse,
e) Death or loss
 MAJOR AREA OF DEPRESSION:
i. Amygdala
ii. Hippocampus
iii. Prefrontal cortex
iv. Anterior cingulate cortex
v. Nucleus accumbens

5. CYTOKINES
 Definition:
Cytokines are a broad and loose category of small
proteins (~5–20 kDa) that are important in cell
signaling.

9. Antidepressant drugs:
 NMDA antagonist – Ketamine, memantine, AZD6765, traxoprodil, MK-0657,
GLYX-13, NRX-1047, D-cycloserine, sarcosine
 Selective serotonin reuptake inhibitors (SSRIs) - Citalopram (Celexa),
Escitalopram (Lexapro),Fluoxetine (Prozac), Paroxetine (Paxil, Pexeva),
Sertraline (Zoloft), Vilazodone (Viibryd)
 Monoamine oxidase inhibitors –
Phenelzine (Nardil), Tranylcypromine (Parnate), Selegiline (Eldepryl)
 Tricyclic antidepressants –
I. NA + 5-HT reuptake inhibitors – Imipramine, Amitriptyline, Doxipin,
Trimipramine
II. Predominantly NA reuptake inhibitors – Desipramine, Amoxapine,
Reboxetine

10. REFERENCES:
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681811/
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244798/
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741070/
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799810/
 Goodman & Gilman's The Pharmacological Basis of
Therapeutics, 12th Edition (PAGE -398-414)
 Necrosis Methods Protocols 2013