The study examined the prevalence and characteristics of headaches among 372 medical students in Zagazig University in Egypt. The one-year prevalence of headache was 8.9%, with tension-type headache being more prevalent in males (7.7%) and migraine being more prevalent in females (6.9%). While the site, characteristics and frequency of headaches were similar between males and females, a positive family history of headaches had a statistically significant impact on prevalence among students. Further research is needed to better understand headaches in the college-aged population.