Igennus are excited to announce the launch of our new product, Longvida® Curcumin. During this webinar, Dr Bailey reviews the research behind the therapeutic use of curcumin and why Longvida is the world’s most advanced formulation of the nutrient.
Curcumin is a polyphenol compound obtained from the rhizome of Curcuma longa, also known as turmeric. This Indian spice has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Curcumin is well documented for its antioxidant, anti-inflammatory and anti-cancer activities. Although it has been shown to be safe at high doses (12g/d), it is poorly absorbed, undergoes rapid intestinal and hepatic metabolism and is rapidly eliminated from the body. As such, standard curcumin demonstrates poor bioavailability, even at high doses, limiting its therapeutic potential.
After much research and discussion (it’s a big and complicated topic!) between the Igennus nutrition scientists, the decision as to which type of curcumin we would use for our Synergistic Nutrients range was actually a very straightforward one. Longvida Curcumin utilises a novel delivery system (SLCP), which protects curcumin from the harsh environment of the stomach and promotes its rapid absorption into the bloodstream and target tissues, even at low doses – resulting in an incredible 285x superior bioavaibility compared with standard curcumin, 65x higher peak plasma levels and 7x longer-lasting action. Longvida is the only formulation proven to deliver high levels of free form, unconjugated curcumin, into the bloodstream. Free form curcumin is the form required for therapeutic benefits, and the only form proven to cross the blood brain barrier.
This webinar covers:
- What curcumin is, what it does and how?
- Why free form curcumin is essential for therapeutic effects
- The research and current evidence for Longvida Curcumin’s unique health benefits
- How Longvida overcomes significant bioavailability issues associated with curcumin use
- To who, why and when you should recommend curcumin
…and more.
Curcumin Tumeric for Arthritis Pain and Inflammationdil210j8as
Can a curcumin supplement really help battle the pain and inflammation linked with arthritis? This short PDF discusses these dietary supplements, and whether they work or not. This report also talks about one of the most important problems that these dietary supplements possess, and offer a satisfactory solution to the problem.
Curcumin is the principal curcuminoid found in turmeric and is responsible for turmeric's yellow color. It has been used for centuries in Indian and Southeast Asian cuisine and traditional medicine due to its antioxidant and anti-inflammatory properties. However, curcumin has poor oral bioavailability due to its insolubility and rapid metabolism. New formulations using adjuvants, nanoparticles, phospholipid complexes, and lipid-based technologies have been developed to improve curcumin's absorption, bioavailability, and efficacy. Longvida is one such formulation that uses a novel solid lipid particle technology to protect curcumin from metabolism and enhance its delivery in the body.
Diabetes is a multifactorial disease leading to several complications, and therefore demands a multiple therapeutic approach. Patients of diabetes either do not make enough insulin or their cells do not respond to insulin. In case of total lack of insulin, patients are given insulin injections. Whereas in case of those where cells do not respond to insulin many different drugs are developed taking into consideration possible disturbances in carbohydrate-metabolism. For example, to manage post-prandial hyper-glycaemia at digestive level, glucosidase inhibitors such as acarbose, miglitol and voglibose are used. These inhibit degradation of carbohydrates there by reducing the glucose absorption by the cells. To enhance glucose uptake by peripheral cells biguanide such as metformin is used. Sulphonylureas, like glibenclamide, is insulinotropic and work as secretogogue for pancreatic cells. Although several therapies are in use for treatment, there are certain limitations due to high cost and side effects such as development of hypoglycemia, weight gain, gastrointestinal disturbances, liver toxicity etc. Based on recent advances and involvement of oxidative stress in complicating diabetes mellitus, efforts are on to find suitable antidiabetic and antioxidant therapy.
Medicinal plants are being looked upon once again for the treatment of diabetes. Many conventional drugs have been derived from prototypic molecules in medicinal plants. Metformin exemplifies an efficacious oral glucose-lowering agent. To date, over 400 traditional plant treatments for diabetes have been reported, although only a small number of these have received scientific and medical evaluation to assess their efficacy. The hypoglycemic effect of some herbal extracts has been confirmed in human and animal models of type 2 diabetes. The World Health Organization Expert Committee on diabetes has recommended that traditional medicinal herbs be further investigated. The present paper Reviews the Role of Insulike tablets developed by R&D cell of Lactonova Nutripharm Pvt Ltd. Hyderabad in the role of herbal nutraceutical drug INSULIKE, A nutriphenotypic approach for the treatment of diabetes.
This document summarizes information about Curcumin C3 Complex, a patented extract from turmeric containing curcuminoids. It discusses the active components, plant source, beneficial effects like antioxidant and anti-inflammatory properties. Applications mentioned include antioxidant support, immune support, and treatment of conditions like Alzheimer's, cancer, and arthritis. Several clinical trials investigating uses of Curcumin C3 Complex are briefly outlined. Contact information is provided for more details.
Turmeric: Medicinal, Cancer, Bacteria CureRose Haft
Turmeric is a perennial plant native to South Asia. Its root contains the active compound curcumin, which makes up 3-5% of the root and has powerful anti-inflammatory and antioxidant effects. Curcumin has been shown to inhibit cancer cell growth in multiple types of cancer including breast, skin, stomach, and colon cancer by neutralizing carcinogens, inhibiting enzymes involved in cancer growth, and blocking blood vessel formation in tumors. Turmeric and its curcumin compound have many other health benefits such as reducing cholesterol and protecting against chronic diseases like heart disease, arthritis, and Alzheimer's.
This document provides information on the therapeutic effects of curcumin, including its anti-inflammatory, antioxidant, analgesic, antimicrobial, and anti-cancer properties. It discusses curcumin's mechanisms of action, dosage forms, uses, contraindications, and precautions. The document is a student guide that covers topics such as the introduction to curcumin and turmeric, their pharmacokinetics, and references.
Turmeric is referred to as the "Queen of Spices". It contains many health-promoting nutrients and antioxidants that have anti-inflammatory and anti-aging properties. These properties help reduce the risk of dementia and cancer by maintaining cholesterol levels and slowing the signs of normal aging. The antioxidants in turmeric also have anti-thrombotic, cholesterol-lowering, anti-tumor and apoptosis-inducing effects.
Igennus are excited to announce the launch of our new product, Longvida® Curcumin. During this webinar, Dr Bailey reviews the research behind the therapeutic use of curcumin and why Longvida is the world’s most advanced formulation of the nutrient.
Curcumin is a polyphenol compound obtained from the rhizome of Curcuma longa, also known as turmeric. This Indian spice has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. Curcumin is well documented for its antioxidant, anti-inflammatory and anti-cancer activities. Although it has been shown to be safe at high doses (12g/d), it is poorly absorbed, undergoes rapid intestinal and hepatic metabolism and is rapidly eliminated from the body. As such, standard curcumin demonstrates poor bioavailability, even at high doses, limiting its therapeutic potential.
After much research and discussion (it’s a big and complicated topic!) between the Igennus nutrition scientists, the decision as to which type of curcumin we would use for our Synergistic Nutrients range was actually a very straightforward one. Longvida Curcumin utilises a novel delivery system (SLCP), which protects curcumin from the harsh environment of the stomach and promotes its rapid absorption into the bloodstream and target tissues, even at low doses – resulting in an incredible 285x superior bioavaibility compared with standard curcumin, 65x higher peak plasma levels and 7x longer-lasting action. Longvida is the only formulation proven to deliver high levels of free form, unconjugated curcumin, into the bloodstream. Free form curcumin is the form required for therapeutic benefits, and the only form proven to cross the blood brain barrier.
This webinar covers:
- What curcumin is, what it does and how?
- Why free form curcumin is essential for therapeutic effects
- The research and current evidence for Longvida Curcumin’s unique health benefits
- How Longvida overcomes significant bioavailability issues associated with curcumin use
- To who, why and when you should recommend curcumin
…and more.
Curcumin Tumeric for Arthritis Pain and Inflammationdil210j8as
Can a curcumin supplement really help battle the pain and inflammation linked with arthritis? This short PDF discusses these dietary supplements, and whether they work or not. This report also talks about one of the most important problems that these dietary supplements possess, and offer a satisfactory solution to the problem.
Curcumin is the principal curcuminoid found in turmeric and is responsible for turmeric's yellow color. It has been used for centuries in Indian and Southeast Asian cuisine and traditional medicine due to its antioxidant and anti-inflammatory properties. However, curcumin has poor oral bioavailability due to its insolubility and rapid metabolism. New formulations using adjuvants, nanoparticles, phospholipid complexes, and lipid-based technologies have been developed to improve curcumin's absorption, bioavailability, and efficacy. Longvida is one such formulation that uses a novel solid lipid particle technology to protect curcumin from metabolism and enhance its delivery in the body.
Diabetes is a multifactorial disease leading to several complications, and therefore demands a multiple therapeutic approach. Patients of diabetes either do not make enough insulin or their cells do not respond to insulin. In case of total lack of insulin, patients are given insulin injections. Whereas in case of those where cells do not respond to insulin many different drugs are developed taking into consideration possible disturbances in carbohydrate-metabolism. For example, to manage post-prandial hyper-glycaemia at digestive level, glucosidase inhibitors such as acarbose, miglitol and voglibose are used. These inhibit degradation of carbohydrates there by reducing the glucose absorption by the cells. To enhance glucose uptake by peripheral cells biguanide such as metformin is used. Sulphonylureas, like glibenclamide, is insulinotropic and work as secretogogue for pancreatic cells. Although several therapies are in use for treatment, there are certain limitations due to high cost and side effects such as development of hypoglycemia, weight gain, gastrointestinal disturbances, liver toxicity etc. Based on recent advances and involvement of oxidative stress in complicating diabetes mellitus, efforts are on to find suitable antidiabetic and antioxidant therapy.
Medicinal plants are being looked upon once again for the treatment of diabetes. Many conventional drugs have been derived from prototypic molecules in medicinal plants. Metformin exemplifies an efficacious oral glucose-lowering agent. To date, over 400 traditional plant treatments for diabetes have been reported, although only a small number of these have received scientific and medical evaluation to assess their efficacy. The hypoglycemic effect of some herbal extracts has been confirmed in human and animal models of type 2 diabetes. The World Health Organization Expert Committee on diabetes has recommended that traditional medicinal herbs be further investigated. The present paper Reviews the Role of Insulike tablets developed by R&D cell of Lactonova Nutripharm Pvt Ltd. Hyderabad in the role of herbal nutraceutical drug INSULIKE, A nutriphenotypic approach for the treatment of diabetes.
This document summarizes information about Curcumin C3 Complex, a patented extract from turmeric containing curcuminoids. It discusses the active components, plant source, beneficial effects like antioxidant and anti-inflammatory properties. Applications mentioned include antioxidant support, immune support, and treatment of conditions like Alzheimer's, cancer, and arthritis. Several clinical trials investigating uses of Curcumin C3 Complex are briefly outlined. Contact information is provided for more details.
Turmeric: Medicinal, Cancer, Bacteria CureRose Haft
Turmeric is a perennial plant native to South Asia. Its root contains the active compound curcumin, which makes up 3-5% of the root and has powerful anti-inflammatory and antioxidant effects. Curcumin has been shown to inhibit cancer cell growth in multiple types of cancer including breast, skin, stomach, and colon cancer by neutralizing carcinogens, inhibiting enzymes involved in cancer growth, and blocking blood vessel formation in tumors. Turmeric and its curcumin compound have many other health benefits such as reducing cholesterol and protecting against chronic diseases like heart disease, arthritis, and Alzheimer's.
This document provides information on the therapeutic effects of curcumin, including its anti-inflammatory, antioxidant, analgesic, antimicrobial, and anti-cancer properties. It discusses curcumin's mechanisms of action, dosage forms, uses, contraindications, and precautions. The document is a student guide that covers topics such as the introduction to curcumin and turmeric, their pharmacokinetics, and references.
Turmeric is referred to as the "Queen of Spices". It contains many health-promoting nutrients and antioxidants that have anti-inflammatory and anti-aging properties. These properties help reduce the risk of dementia and cancer by maintaining cholesterol levels and slowing the signs of normal aging. The antioxidants in turmeric also have anti-thrombotic, cholesterol-lowering, anti-tumor and apoptosis-inducing effects.
This dissertation evaluated the antimicrobial activity of turmeric extracts against several microorganisms. Turmeric powder was extracted using distilled water, acetone, and methanol. The extracts were tested against various bacteria using the agar well diffusion method. Results found that the extracts showed varying levels of activity depending on the solvent used and microorganism. Methanol extracts generally showed higher activity while water extracts were also active against some microbes. The study demonstrates turmeric has compounds with antimicrobial properties against pathogens and could be developed as natural therapeutics.
Curcumin, the compound responsible for the yellow color of turmeric has much more to offer than just its color. Curcumin comes with a plethora of health benefits which makes it a hot topic in the nutraceutical industry. Unleash the world of curcumin and see the reasons why you need to spice it up!
Curcumin for Cancer Prevention & Cure 09370322999Shibu Thankachan
Call 09370322999 to knore more on our product Curcumin C3 Power™ which is the best solution for Cancer prevention
Cancer is a term used for a broad group of diseases involving unregulated cell growth. There are more than hundred types of cancerous growth of cells that can affect almost any part of the body including brain, lung, breast, skin, blood, colon or cervix.
Up to 40% of all cancer deaths can be prevented by eliminating tobacco use, improving diets and physical activity, lowering alcohol consumption, eliminating workplace carcinogens and immunizing against Hepatitis B virus and human papillomavirus. Also a large proportion of cancer can be cured if detected early.
Lot of Researches have shown that Curcumin the active ingredient in turmeric has emerged as a potent multimodal cancer-preventing agent. Daily intake of required amount of Curcumin can go a long way in preventing cancer
This document summarizes the biological activities of turmeric and its main component, curcumin. It discusses curcumin's anti-inflammatory, antioxidant, and anticancer properties as demonstrated in laboratory and clinical studies. Some key points include: curcumin reduces inflammation by inhibiting NF-kB activation and suppressing COX-2 expression; it has antioxidant effects by scavenging free radicals and maintaining antioxidant enzyme activities; laboratory studies show curcumin promotes apoptosis in cancer cells and inhibits telomerase activity; clinical trials demonstrate curcumin is well-tolerated but has low oral bioavailability in humans. However, long-term, high dose administration of turmeric extract was found to have toxic and carcinogenic effects in animal
The document provides information on a brand plan for a curcumin nano particle supplement product. It discusses the growing market size for curcumin supplements, highlights clinical studies that show curcumin's benefits for reducing inflammation and managing IBD, and outlines the need for a nano-sized curcumin formulation to improve its bioavailability and targeting of inflamed tissues. The brand plan proposes a nano-sized curcumin supplement product called CurcuMed and references in vitro and in vivo studies confirming the anti-inflammatory effects of nano-sized curcumin particles.
Turmeric is commonly used as a spice in cooking and has many potential health benefits. It contains curcumin and other curcuminoids that act as powerful antioxidants and may help treat arthritis, cancer, liver and heart conditions. Curcumin can reduce inflammation, break down amyloid plaques associated with Alzheimer's, and help treat depression by modulating neurotransmitters. Turmeric is generally well tolerated but high doses may cause side effects like bleeding risk when combined with blood thinners or hypoglycemia. More research is still needed on its mechanisms and effectiveness for various diseases.
Turmeric is a super-spice that has a high antioxidant value and boosts the immune system. It is a powerful anti-inflammatory and is popular among those with arthritis and joint problems for this reason. Turmeric is antiseptic and kills yeast and parasites when used internally.
https://snec30.com
This document discusses curcumin, an active compound found in turmeric. It summarizes the health benefits of curcumin, which include fighting inflammation and chronic diseases like cancer, heart disease, and Alzheimer's. Specifically, curcumin may help treat Alzheimer's by binding to beta-amyloid proteins in the brain. The document recommends taking curcumin supplements to receive its health benefits, as curcumin intake from food alone may not provide enough. It concludes that curcumin can act as a cancer prevention supplement by reducing inflammation and destroying mutated cancer cells.
This document reviews the medicinal and pharmacological properties of turmeric (Curcuma longa). It discusses how turmeric has been used in Asian cuisines and medicines, particularly as an anti-inflammatory. The active constituents of turmeric include curcumin and volatile oils. Studies show that turmeric and curcumin have anti-inflammatory, antioxidant, and anticancer properties. They can protect the liver and may help treat diseases like diabetes, cancer, and neurological and gastrointestinal disorders.
Cancer is the uncontrolled growth of cells that can spread to other tissues. It is a major global health problem, with over 10 million new cases and 6 million deaths each year. The most common cancers worldwide are lung, breast, and colorectal cancers. Treatment options include surgery, radiation therapy, chemotherapy, immunotherapy, and biological therapy. These treatments can cause side effects like hair loss, nausea, vomiting, and reduced immune function. Turmeric contains curcumin, which has shown anti-cancer properties in pre-clinical and clinical studies. Curcumin can prevent cancer cell growth and has shown promise in preventing and treating various cancers like colon, breast, and brain cancers based on its antioxidant and anti-inflammatory properties. Further
Dr Q's CurcumaMaxx-TR is formulated to increase absorption and bioavailability of curcumin. It combines turmeric extract with BioPerine, a black pepper extract that is a clinically validated bioavailability enhancer. Studies show BioPerine increases curcumin absorption and bioavailability by 2000%. The formula also uses controlled-release technology to further increase curcumin bioavailability. Research supports curcumin's antioxidant, immune support, cell-protective, and other health-promoting activities.
The document discusses several spices and their potential health benefits. It provides information on the phytochemicals contained in various spices like turmeric, garlic, ginger, chili peppers, and their anti-inflammatory, antioxidant, and anticancer properties based on in vitro, animal, and human studies. However, more research is still needed to better understand the biological effects of individual spices and their potential roles in cancer prevention and treatment.
Curcumin, the active compound in turmeric, has been used for thousands of years in Ayurvedic medicine but was not well known to Western herbalists until recently. Curcumin has potent anti-inflammatory, antioxidant, and anti-cancer properties and can target multiple molecular pathways involved in cancer development and progression. Recent research involving over 5000 studies in the last 10 years has shown curcumin's potential for preventing and treating many medical conditions including cancer, Alzheimer's, and inflammatory diseases.
"Oral administration of nano-emulsion curcumin suppresses LPS-induced NFkB si...Nicholas Young
Sildes from a portion of my talk per invitation of the Physiology research group at aTyr Pharma June 1-3, 2014, San Diego, CA. Subsequently, this project has translated to a human clinical trial of this patented anti-inflammatory drug (nanoemulsified curcumin; patented through my collaboration with the Department of Pharmacology at Ohio State).
Curcumin for brain health | Bio Available curcuminCurQfen
CurQfen is Bio-Available curcumin used especially for brain health and disorders. Applications like Curcumin capsules, tablets, chocolates.
www.curqfen.net
Edible Bird’s Nest Attenuates Procoagulation Effects of High-Fat Diet in RatsElabscience
Edible bird’s nest (EBN) is used traditionally in many parts of Asia to improve wellbeing, but there are limited studies on its
efficacy. We explored the potential use of EBN for prevention of high fat diet- (HFD-) induced insulin resistance in rats.
Presentazione del Dott. Andrea Piccozzi all'XI congresso Ortomed
(Società Italiana di Ortopedia, Medicina e Malattie Rare dello Scheletro. Il dott. Piccozzi presenta i benefici derivanti dall'utilizzo della curcumina nelle sue forme bio-ottimizzate come la micellare nel trattamento del dolore cronico e dell'infiammazione nelle patologie osteoarticolai e non solo
Pain and Sedation in Critically Ill PatientsAllison Boyd
This document discusses pain and sedation management in critically ill patients. It provides an overview of non-pharmacologic and pharmacologic strategies for pain, including acetaminophen, ketamine, gabapentin, lidocaine, ketorolac, and various opioid analgesics. Dosing, mechanisms of action, and safety considerations are reviewed for different analgesic options. Guidelines for outpatient opioid prescribing upon discharge from the ICU are also mentioned.
The document provides information on a brand plan for a curcumin nano particle supplement called CurcuMed. It discusses the growing market size for curcumin supplements, highlights clinical studies that show curcumin's benefits for reducing inflammation and maintaining remission in ulcerative colitis. Nano-sizing curcumin could help improve its bioavailability by increasing absorption and targeting inflamed tissues. In vitro studies show curcumin nano particles significantly reduce the inflammatory marker TNF-alpha secreted by macrophages.
The document provides information on a brand plan for a curcumin nano particle supplement product. It discusses the growing market size for curcumin supplements, highlights clinical studies that show curcumin's benefits for reducing inflammation and managing IBD, and outlines the need for a nano-sized curcumin formulation to improve its bioavailability and targeting of inflamed tissues. The brand plan proposes a nano-sized curcumin supplement product called CurcuMed and references in vitro and in vivo studies confirming the anti-inflammatory effects of nano-sized curcumin particles.
This dissertation evaluated the antimicrobial activity of turmeric extracts against several microorganisms. Turmeric powder was extracted using distilled water, acetone, and methanol. The extracts were tested against various bacteria using the agar well diffusion method. Results found that the extracts showed varying levels of activity depending on the solvent used and microorganism. Methanol extracts generally showed higher activity while water extracts were also active against some microbes. The study demonstrates turmeric has compounds with antimicrobial properties against pathogens and could be developed as natural therapeutics.
Curcumin, the compound responsible for the yellow color of turmeric has much more to offer than just its color. Curcumin comes with a plethora of health benefits which makes it a hot topic in the nutraceutical industry. Unleash the world of curcumin and see the reasons why you need to spice it up!
Curcumin for Cancer Prevention & Cure 09370322999Shibu Thankachan
Call 09370322999 to knore more on our product Curcumin C3 Power™ which is the best solution for Cancer prevention
Cancer is a term used for a broad group of diseases involving unregulated cell growth. There are more than hundred types of cancerous growth of cells that can affect almost any part of the body including brain, lung, breast, skin, blood, colon or cervix.
Up to 40% of all cancer deaths can be prevented by eliminating tobacco use, improving diets and physical activity, lowering alcohol consumption, eliminating workplace carcinogens and immunizing against Hepatitis B virus and human papillomavirus. Also a large proportion of cancer can be cured if detected early.
Lot of Researches have shown that Curcumin the active ingredient in turmeric has emerged as a potent multimodal cancer-preventing agent. Daily intake of required amount of Curcumin can go a long way in preventing cancer
This document summarizes the biological activities of turmeric and its main component, curcumin. It discusses curcumin's anti-inflammatory, antioxidant, and anticancer properties as demonstrated in laboratory and clinical studies. Some key points include: curcumin reduces inflammation by inhibiting NF-kB activation and suppressing COX-2 expression; it has antioxidant effects by scavenging free radicals and maintaining antioxidant enzyme activities; laboratory studies show curcumin promotes apoptosis in cancer cells and inhibits telomerase activity; clinical trials demonstrate curcumin is well-tolerated but has low oral bioavailability in humans. However, long-term, high dose administration of turmeric extract was found to have toxic and carcinogenic effects in animal
The document provides information on a brand plan for a curcumin nano particle supplement product. It discusses the growing market size for curcumin supplements, highlights clinical studies that show curcumin's benefits for reducing inflammation and managing IBD, and outlines the need for a nano-sized curcumin formulation to improve its bioavailability and targeting of inflamed tissues. The brand plan proposes a nano-sized curcumin supplement product called CurcuMed and references in vitro and in vivo studies confirming the anti-inflammatory effects of nano-sized curcumin particles.
Turmeric is commonly used as a spice in cooking and has many potential health benefits. It contains curcumin and other curcuminoids that act as powerful antioxidants and may help treat arthritis, cancer, liver and heart conditions. Curcumin can reduce inflammation, break down amyloid plaques associated with Alzheimer's, and help treat depression by modulating neurotransmitters. Turmeric is generally well tolerated but high doses may cause side effects like bleeding risk when combined with blood thinners or hypoglycemia. More research is still needed on its mechanisms and effectiveness for various diseases.
Turmeric is a super-spice that has a high antioxidant value and boosts the immune system. It is a powerful anti-inflammatory and is popular among those with arthritis and joint problems for this reason. Turmeric is antiseptic and kills yeast and parasites when used internally.
https://snec30.com
This document discusses curcumin, an active compound found in turmeric. It summarizes the health benefits of curcumin, which include fighting inflammation and chronic diseases like cancer, heart disease, and Alzheimer's. Specifically, curcumin may help treat Alzheimer's by binding to beta-amyloid proteins in the brain. The document recommends taking curcumin supplements to receive its health benefits, as curcumin intake from food alone may not provide enough. It concludes that curcumin can act as a cancer prevention supplement by reducing inflammation and destroying mutated cancer cells.
This document reviews the medicinal and pharmacological properties of turmeric (Curcuma longa). It discusses how turmeric has been used in Asian cuisines and medicines, particularly as an anti-inflammatory. The active constituents of turmeric include curcumin and volatile oils. Studies show that turmeric and curcumin have anti-inflammatory, antioxidant, and anticancer properties. They can protect the liver and may help treat diseases like diabetes, cancer, and neurological and gastrointestinal disorders.
Cancer is the uncontrolled growth of cells that can spread to other tissues. It is a major global health problem, with over 10 million new cases and 6 million deaths each year. The most common cancers worldwide are lung, breast, and colorectal cancers. Treatment options include surgery, radiation therapy, chemotherapy, immunotherapy, and biological therapy. These treatments can cause side effects like hair loss, nausea, vomiting, and reduced immune function. Turmeric contains curcumin, which has shown anti-cancer properties in pre-clinical and clinical studies. Curcumin can prevent cancer cell growth and has shown promise in preventing and treating various cancers like colon, breast, and brain cancers based on its antioxidant and anti-inflammatory properties. Further
Dr Q's CurcumaMaxx-TR is formulated to increase absorption and bioavailability of curcumin. It combines turmeric extract with BioPerine, a black pepper extract that is a clinically validated bioavailability enhancer. Studies show BioPerine increases curcumin absorption and bioavailability by 2000%. The formula also uses controlled-release technology to further increase curcumin bioavailability. Research supports curcumin's antioxidant, immune support, cell-protective, and other health-promoting activities.
The document discusses several spices and their potential health benefits. It provides information on the phytochemicals contained in various spices like turmeric, garlic, ginger, chili peppers, and their anti-inflammatory, antioxidant, and anticancer properties based on in vitro, animal, and human studies. However, more research is still needed to better understand the biological effects of individual spices and their potential roles in cancer prevention and treatment.
Curcumin, the active compound in turmeric, has been used for thousands of years in Ayurvedic medicine but was not well known to Western herbalists until recently. Curcumin has potent anti-inflammatory, antioxidant, and anti-cancer properties and can target multiple molecular pathways involved in cancer development and progression. Recent research involving over 5000 studies in the last 10 years has shown curcumin's potential for preventing and treating many medical conditions including cancer, Alzheimer's, and inflammatory diseases.
"Oral administration of nano-emulsion curcumin suppresses LPS-induced NFkB si...Nicholas Young
Sildes from a portion of my talk per invitation of the Physiology research group at aTyr Pharma June 1-3, 2014, San Diego, CA. Subsequently, this project has translated to a human clinical trial of this patented anti-inflammatory drug (nanoemulsified curcumin; patented through my collaboration with the Department of Pharmacology at Ohio State).
Curcumin for brain health | Bio Available curcuminCurQfen
CurQfen is Bio-Available curcumin used especially for brain health and disorders. Applications like Curcumin capsules, tablets, chocolates.
www.curqfen.net
Edible Bird’s Nest Attenuates Procoagulation Effects of High-Fat Diet in RatsElabscience
Edible bird’s nest (EBN) is used traditionally in many parts of Asia to improve wellbeing, but there are limited studies on its
efficacy. We explored the potential use of EBN for prevention of high fat diet- (HFD-) induced insulin resistance in rats.
Presentazione del Dott. Andrea Piccozzi all'XI congresso Ortomed
(Società Italiana di Ortopedia, Medicina e Malattie Rare dello Scheletro. Il dott. Piccozzi presenta i benefici derivanti dall'utilizzo della curcumina nelle sue forme bio-ottimizzate come la micellare nel trattamento del dolore cronico e dell'infiammazione nelle patologie osteoarticolai e non solo
Pain and Sedation in Critically Ill PatientsAllison Boyd
This document discusses pain and sedation management in critically ill patients. It provides an overview of non-pharmacologic and pharmacologic strategies for pain, including acetaminophen, ketamine, gabapentin, lidocaine, ketorolac, and various opioid analgesics. Dosing, mechanisms of action, and safety considerations are reviewed for different analgesic options. Guidelines for outpatient opioid prescribing upon discharge from the ICU are also mentioned.
The document provides information on a brand plan for a curcumin nano particle supplement called CurcuMed. It discusses the growing market size for curcumin supplements, highlights clinical studies that show curcumin's benefits for reducing inflammation and maintaining remission in ulcerative colitis. Nano-sizing curcumin could help improve its bioavailability by increasing absorption and targeting inflamed tissues. In vitro studies show curcumin nano particles significantly reduce the inflammatory marker TNF-alpha secreted by macrophages.
The document provides information on a brand plan for a curcumin nano particle supplement product. It discusses the growing market size for curcumin supplements, highlights clinical studies that show curcumin's benefits for reducing inflammation and managing IBD, and outlines the need for a nano-sized curcumin formulation to improve its bioavailability and targeting of inflamed tissues. The brand plan proposes a nano-sized curcumin supplement product called CurcuMed and references in vitro and in vivo studies confirming the anti-inflammatory effects of nano-sized curcumin particles.
The document provides information on a brand plan for a curcumin nano particle supplement called CurcuMed. It discusses the growing market size for curcumin supplements, highlights clinical studies that show curcumin's benefits for reducing inflammation and maintaining remission in ulcerative colitis. Nano-sizing curcumin could help address its poor absorption and increase its delivery to inflamed tissues in IBD. In vitro studies show curcumin nano particles significantly reduce the inflammatory marker TNF-alpha secreted by macrophages.
Apremilast is a small molecule drug that works by inhibiting phosphodiesterase 4. It is approved for treating plaque psoriasis and psoriatic arthritis. A pooled analysis found that apremilast significantly improved palmoplantar psoriasis compared to placebo. Clinical trials showed apremilast was generally well tolerated and effective for psoriasis, with about 30% of patients achieving 75% clearance of psoriasis. Some studies have found apremilast may also help treat vitiligo and lichen planus when used off-label. Its oral administration and safety profile make it a useful option during the COVID-19 pandemic.
The document discusses the use of biologicals such as infliximab and adalimumab in treating Crohn's disease. It provides details on their indications, administration protocols, effectiveness, safety considerations like risks of tuberculosis and autoimmune reactions, and constraints to their use like cost and lack of insurance coverage. Special precautions are needed with biologicals regarding vaccinations, screening for latent infections, and monitoring for adverse effects. Overall, biologicals are effective for inducing and maintaining remission in severe Crohn's disease and fistulizing disease when conventional treatments have failed or are not tolerated.
Dr Andrea Jorgensen - The future of innovation in atrial fibrillation and str...Innovation Agency
Presentation by Dr Andrea Jorgensen, Senior Lecturer - Biostatistics, University of Liverpool: Personalised Medicine in the treatment of AF at The future of innovation in AF and stroke prevention in the NWC, 27 June 2018, Haydock Park Racecourse
Premier on medicinal fungus as effective adjuvant & complementary agents for ...Chee-Cheow Lee
This document discusses cancer, its characteristics, current cancer treatment approaches, and the potential for using medicinal mushrooms and their compounds as complementary and adjuvant cancer therapies. It provides information on several medicinal mushrooms - Coriolus versicolor, Phellinus linteus, Antrodia camphorata, and their extracted compounds. Studies show combinations of chemotherapy and these mushrooms/compounds can be more effective than chemotherapy alone in treating cancers like lung cancer and liver cancer. The compound Antroquinonol isolated from A. camphorata has been shown to inhibit the growth of various cancer cell types and has a high safety profile.
Premier on Medicinal Fungus as effective Adjuvant & Complementary Agents for ...Chee-Cheow Lee
This document discusses cancer and potential complementary and adjuvant treatments. It summarizes the characteristics and current treatment approaches for cancer. It then discusses various medicinal mushrooms and compounds that show promise as complementary agents, including polysaccharides from Coriolus versicolor and Phellinus linteus, and the compound Antroquinonol isolated from Antrodia camphorata. Antroquinonol in particular has shown safety and efficacy against various cancer types in both in vitro and in vivo studies. The document concludes by discussing how these natural compounds can be applied at different stages of cancer prevention and treatment.
This document discusses the management of inflammatory bowel disease. It defines IBD and describes the two major types, ulcerative colitis and Crohn's disease. It covers the etiology, clinical features, drug therapy including mesalamine, corticosteroids, immunosuppressants, biologics, antibiotics, and supportive therapies. It also discusses complications, side effects of treatments, and the role of genetic factors like mutations in the NOD2 gene.
At Quantum Naturals our mission is to deliver highest quality nutraceutical products at the best value to our customers. We are committed in our focus to provide premium-quality, natural nutritional supplements that are as close to nature as possible. As we continue growing across the region, we make it a point to remain loyal and true to our core values that have built us the foundation of where we stand today.
We firmly believe that integration of modern scientific techniques into ancient Ayurvedic herbal armamentarium can result in substantial number of treatments or adjuvant therapies for lifestyle health conditions. Our prime focus is on weight management, diabetes or pre diabetes, anabolic androgenic adaptogens, arthritis and herbal based body fitness products. All the three categories of our product range are supported with scientific rationale and data.
We work as specialist on extensive variety of products and formulas. We ensure that purity and quality is foremost in the mind of every Quantum Natural employee. We are also dedicated to continuous investment to improve our technical advantage by scientific research and technical cooperation to better serve our customers. We are equipped with state-of-art, high-tech processing and manufacturing unit where optimum quality standards are achieved. We use only the most reliable sources of quality raw materials. Our unit has huge production capacity for manufacturing world class nutraceuticals and is managed by well positioned experts and professionals. As the Founder and Managing Director of Quantum Naturals, I along with my team, stand committed to provide much sought after "Quality of Life" through the mantra of "Eating for Treating" and "Health thru Nature". We are looking forward to see you on facebook at www.facebook.com/qnaturals or thru ccindia@quantum-naturals.com
Are There Proven Herbal Approaches To Cancerjdavidpitcher
Herbal products like tomatoes, garlic, green tea, and soybeans have been shown to help prevent certain cancers when consumed regularly. Herbs like ginger and mistletoe may help treat nausea from chemotherapy and potentially extend survival time for some cancer patients. However, more research is still needed to determine definitive doses and effects for specific cancer types. While herbal medicines pose little risk, they are not a replacement for conventional cancer treatments.
Savella Vs. Cymbalta Consideration For FormularyMmorshed217
The document compares Savella and Cymbalta for the treatment of fibromyalgia. Both drugs were shown to be effective in randomized controlled trials. Savella demonstrated significant improvements in pain and response rates compared to placebo in two large multicenter trials. Cymbalta also demonstrated efficacy in treating fibromyalgia. Overall, both drugs provide benefit for fibromyalgia patients but Savella may have a slightly lower cost and less severe side effects. The pharmacy and therapeutics committee will need to decide whether additional benefits of one drug outweighs the other for their formulary needs.
Medilief is a Delhi-based company focused on oncology, critical care, and nephrology therapies. It began in 2011 with the goal of providing high-quality pharmaceutical products and services. Today it is one of the fastest growing oncology companies in India, with a mission to develop innovative solutions to cure critical illnesses and improve quality of life globally through a dedicated team of professionals.
Oral ketamine can be used as an adjuvant analgesic in palliative care patients to help manage refractory pain. Low dose oral ketamine has been shown to reduce opioid consumption and improve pain relief when used together with opioids like morphine. While studies have not found oral ketamine to provide statistically significant pain relief on its own, it appears to have an opioid-sparing effect. Based on the evidence, an initial oral dose of 0.25-0.5 mg/kg of ketamine is recommended when used adjunctively with opioids in palliative care patients. Close monitoring is needed due to potential side effects like hallucinations.
This study examined the effects of ubiquinol-10 supplementation in 20 women with fibromyalgia syndrome (FMS) over 12 weeks. Patients receiving ubiquinol supplementation experienced reductions in tender points, fibromyalgia impact questionnaire scores, and symptoms like muscle twitching and sleep disturbances compared to an unsupplemented FMS group. The supplemented group also demonstrated reductions in oxidative stress markers and increases in antioxidant enzyme levels. The results suggest ubiquinol-10 may help ameliorate symptoms and oxidative stress associated with FMS.
journal club ppt.pptx presentation of journalsumit132451
This document summarizes a clinical trial studying the efficacy of atogepant, a CGRP receptor antagonist, for the preventive treatment of migraine. The trial involved over 1000 participants randomized to receive either atogepant 30 mg, atogepant 60 mg, or placebo once daily for 12 weeks. The primary objectives were to evaluate the safety and tolerability of atogepant, and test for superiority over placebo in reducing monthly migraine days. Secondary outcomes included reductions in acute medication use days and improvements in migraine-related quality of life and impairment. The trial design, inclusion/exclusion criteria, endpoints, and funding source are described in detail.
Pregabalin is effective for treating several types of neuropathic pain according to a neurologist's presentation. It works by reducing the release of neurotransmitters involved in pain signaling. Small studies show pregabalin can help chemotherapy-induced neuropathy and refractory trigeminal neuralgia when other treatments don't work or aren't tolerated. The presentation includes two case studies where pregabalin provided significant pain relief - one for severe chemotherapy-induced neuropathy and another for trigeminal neuralgia in a multiple sclerosis patient.
Brain Health & Malnutrition - Neuronutrizione e NeuroprotezioneMaurizio Salamone
“BRAIN HEALTH AND MALNUTRITION (BHM)”:
Campagna di screening e sensibilizzazione sulla protezione del patrimonio cerebrale
L’intervento, progettato e realizzato grazie alla collaborazione tra Metagenics Academy, Brain & Malnutrition Onlus e 126 professionisti della nutrizione italiani mira a sensibilizzare adulti non affetti da patologie neurodegenerative su “neuronutrizione e neuroprotezione per il mantenimento del patrimonio cerebrale”, inteso come integrità strutturale e funzionale.
This document discusses the relationship between the intestines and sports. It notes that athletes are generally healthy young people but can still experience frequent gastrointestinal disorders like IBD and IBS. It discusses the pillars of functional medicine and nutrition as they relate to the gastrointestinal tract, including the gut barrier, microbiota, mitochondria, detoxification, immunity, inflammation and more. It emphasizes the importance of micronutrients, probiotics, prebiotics, antioxidants and anti-inflammatory agents in supporting gastrointestinal and overall health, especially for athletes. Clinical studies are referenced showing benefits of specific formulations and strains.
Human Gut Mycobiota is still a mistery for us. Most of the reasearch on this topichas been conducted in the last 5 years. We are starting to comprehend the interactions with our gastrointestinal system and the virus and bacterial communities. 13% of gut microbiota in weight, about 150 species; most of them can shift from commensalism to virulent parassitosis according to our immune competence. Gut fungal overgrowth is actually underestimated in dignaosis and treatment. Many FGIDS and SIBO are frequently mixed bacteral and fungal dysbiosis
Presentazione per il congresso Brain & Malnutrition 2018
Viene analizzato il ruolo della Vitamina D nel mantenimento del funzionamento del SNC ed eventuali risvolti clinici preventivi e di trattamento nelle patologie neurologiche alla luce delle più recenti evidenze scientifiche.
Simposio Salute Gastrointestinale- Spazio Nutrizione 2018Maurizio Salamone
Vi invitiamo al Simposio sulla Salute Gastrointestinale nell'ambito del congresso AMIA (Associazione Medicina Anti Aging) a Spazio Nutrizione 2018. Relatori del Simposio la dott. Federica Cavallini, la Dott.ssa Maria Isabella Zuccalà e il Dott. Maurizio Salamone
Micronutrizione e modulazione dell'infiammazione nello sportivoMaurizio Salamone
E' possibile modulare i processi infiammatori nello sportivo per ottimizzare salute e performance. Sostanze naturali come Curcumina, Omega 3, Vitamina D e magnesio hanno dimostrato efficacia e profilo di sicurezza ineguagliati
This document discusses vitamin D and pain. It provides information on vitamin D metabolism and transformation to its active form. It discusses vitamin D's mechanism of actions, roles in epigenetics, immunomodulation, and relationship to conditions like pain, cardiovascular risk factors, depression, asthma control, testosterone levels, and mortality in the elderly. The document also addresses vitamin D deficiency, testing and interpretation of vitamin D levels, recommended intake, risk factors for deficiency, and treatment of deficiencies. Safety of vitamin D supplementation is discussed. The summary concludes by noting some natural substances like curcumin that have synergistic anti-inflammatory activity with vitamin D.
Vitamina D in chiave Anti-aging- Amia- Spazio Nutrizione 2016Maurizio Salamone
Presentazione al congresso AMIA nell'ambito della kermesse "Spazio Nutrizione 2016" L'argomento Vit. D è stato affrontato in un ottica di salvaguardia della salute e modulazione del processo di invecchiamento. E' stato affrontato anche il rapporto tra la vitamina ormone e il sistema immunitario. Si è parlato di integrazione e trattamento delle carenze secondo le attuali linee guida italiane e internazionali.
AFMS Alimenti per fini medici speciali - Quadro regolatorio e situazione attu...Maurizio Salamone
La presentazione è stata utilizzata per una lezione presso l'Università di Milano- Cattedra di Scienze del Farmaco. Oggetto il quadro normativo degli AFMS (Alimenti per Fini Medici Speciali) drammaticamente modificato negli ultimi 12 mesi. Vengono analizzate la normativa, la classificazione e alcune classi di prodotti presenti sul mercato.
Vitamina B9 SNP del 5MTHFR, metilazione e iperomocisteinemiaMaurizio Salamone
I folati non sono tutti uguali. Polimorfismi genetici limitatnti possono portare a bassi valori di folati attivi circolanti con implicazioni negative sui processi di metilazione e sul metabolismo dell'omocisteina. La conseguenza più comune di una carenza di folati è l'iperomocisteinemia, ma si possono avere anche deficit nella produzione delle basi del DNA. aumento dei processi di aging e disturbi in altri importanti processi metabolici. Il 5 metil tetraidrofolato è una soluzione semplice e poco costosa per rimediare efficacemente.
Tutto quello che bisognerebbe conoscere sulla vitamina B12 ma che nessuno osa mai chiedere. Assorbimento, ruolo biologico, diagnostica. stati carenziali, interazioni con altri nutrienti,
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Kat...rightmanforbloodline
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
TEST BANK For Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, Verified Chapters 1 - 66, Complete Newest Version.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
2. Forinternaluseonly–Q12015
Curcumin in chronic pain
Summary:
1. Chronic pain and inflammation
2. Curcumin from Turmeric
3. Active principles of turmeric
4. Curcumin and chronic pain
5. Mechanism of action (antinflammatory)
6. Mechanism of action (anti oxidant)
7. Epigenetic activity of curcumin
8. Absortion of curcumine
9. Curcumin and liver
10. Bio-avaliability and solutions
11. Curcumin tolerability
12. Take home messages
4. Forinternaluseonly–Q12015
Chronic and degenerative illness
express high grade of inflammation
Cardiovascular diseases
INFLAMMATION
Cancer
Auto-immune
diseases
Neuro degenerative
diseases
Type II diabetes
High grade or Low grade
6. Forinternaluseonly–Q12015
Acute pathological pain:
• Sharp, fast, pricking
• Occurs very rapidly
• Carried by large diameter myelinated Aδ fibers
• Usually alleviated with the help of professional
Chronic pathological pain:
• Burning, aching
• Gradually increases
• Carried by small diameter non-myelinated ‘C’ fibers
• Persistent pain that lasts many months to years
• Little apparent cause & not self limiting
• Pain often increases over time & is aggravated by many
factors
9. Forinternaluseonly–Q12015
Precautions in patients >70 years
GI side effects
Risks of gastic ulcers
Attention in patients treated with
anti-coagulatns
Risk of kidney impairment
Side effects and risks of NSAID’s
“Gli utilizzatori di FANS hanno
ulcere sintomatiche complicate 3-4
volte più frequentemente rispetto
ai non utilizzatori” 2
“Disturbi gastrici e intestinali
compaiono nel 10 - 30%
degli utilizzatori di FANS” 1
1-2Nederlandse Huisartsen Genootschap – pijnbestrijding: farmacotherapeutische richtlijn
3Cannon 2006, Chan 2006, Helin-Salmivaara 2006, Kearney 2006, McGettigan 2006
11. Forinternaluseonly–Q12015
• Rhizomatous, herbaceous,
perennial, plant
• Family Zingiberaceae
• Lives well with mild temperatures
(20°-30° C. and high rains
• Reach 1 m in hight
• Nice hermafrodite flowers in 20cm
inflorescence (August)
• Active sustances are concentrated
in rhizomes
Turmeric, the plant (Curcuma longa)
12. Forinternaluseonly–Q12015
Curcumin: THE active principle of turmeric
(1,7-bis (4-hydroxy-3-méthoxy-phényl) hepta-1,6-diène-3,5-dione)
Turmeric powder
contains 3-7% of Curcuminoids
essential oils and fibers
15. Forinternaluseonly–Q12015
23
24
25
26
27
28
29
0
5
10
15
20
0
5
10
15
20
“Randomized, single blind study on efficacy and tolerability of
curcumin in patients with reumatoid poliarthritis “
Chandran et al. A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phytother. Res. 2012;26:1719–
1725.
° n = 45 : curcumin n =15 ; diclofenac n = 15 ; curcumin and diclofenac n = 15
° 8 weeks , 1000 mg curcumin (BCM-95) e 100 mg diclofenac
Curcumin vs. NSAID’ (diclofenac )
Tassodisedimentazioneeritrocitaria(ESR)
- 11% - 8%
Significative reduction of
Disease Activity Score (DAS)
Significative reduction of
Joints pain
- 83%
- 69%
- 97% - 89%
Significative reduction of
Joints swelling
%Incidenza
%Incidenza
Curcumin
extract Diclofenac
1000 mg 100 mg
p < 0.05 p < 0.05 p < 0.05
Curcumin
extract Diclofenac
1000 mg 100 mg
Curcumin
extract Diclofenac
1000 mg 100 mg
16. Forinternaluseonly–Q12015
280
290
300
310
320
330
340
350
360
Ibuprofen Curcumina
° n = 367 : curcumin extract n = 182 ; ibuprofen n = 185
° After 4 weeks 1500 mg curcumin (2 capsuls 3x/die) e 1200 mg
ibuprofen (2 capsuls 3x/die).
° Simple turmeric extract
Mobility
Distance covered in 6 minutes
(Time 0 and after 4 weeks)
p = 0,010
Meterswalkedin6minutes
Chronic Pain
(Time 0 and after 4
weeks)
0
1
2
3
4
5
6
Ibuprofen Curcumina
p = 0,018
%Incidence
1200 mg 1500 mg 1200 mg 1500 mg
)
- 41%
+ 14% + 11%
Curcumin vs. NSAID’ (ibuprofen)
“Efficacy and safety of curcumin vs. Ibuprofen in patients
with knee arthrosis : a multicentric study“
Kuptniratsaikul V et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee
osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8.
- 39%
17. Forinternaluseonly–Q12015
Combination of Curcumin an ginger is effective as well as NSAID’S (indometacine)
Objective: measure effective of a blend of curcumin and ginger on pain
in patients with rheumatoid arthritis
3 groups NSAID’S (Indometacine) vs. 200 mg (CG) vs. 400 mg (CG)
Results:
Arthritic score
14d
Arthritic score
28d
Nsaid’s
(Indometacine)
39.6% 50%
200 mg 41.7% 58.3%
400 mg 52.1% 78.6%
0
4
8
12
16
7 giorni 14 giorni 28 giorni
Controllo (dopo trattamento) Indometacina
200 mg curcumina +zenzero 400 mg curcumina+zenzero
- 78,6%- 52%Arthriticscore
18. Forinternaluseonly–Q12015
° n = 15 : curcumin 400 mg nimesulide 100mg achetominophen 1g
Cicle with 3 subtances with a wash out of 48 hour
Curcumin vs. Nimesulide and Acetoaminophene in acute pain
Comparative evaluation of the pain-relieving properties of
a lecithinized formulation of curcumin (Meriva®),
nimesulide, and acetaminophen
Di Pierro F1, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni S
19. Forinternaluseonly–Q12015
Curcumin studies in neuropatic pain in animal model
Zhao X, Xu Y, Zhao Q, Chen CR, Liu AM, et al. (2012)
Curcumin exerts antinociceptive effects in a mouse model of
neuropathic pain: descending monoamine system and opioid receptors
are differentially involved. Neuropharmacology 62: 843–854. 14.
Ji FT, Liang JJ, Liu L, Cao MH, Li F (2013)
Curcumin exerts antinociceptive effects by inhibiting the activation of
astrocytes in spinal dorsal horn and the intracellular extracellular signal-
regulated kinase signaling pathway in rat model of chronic constriction
injury.
Chin Med J (Engl) 126: 1125–1131
20. Forinternaluseonly–Q12015
Curcumin in cancer patients
Objective: Efficacy of curcumin in cancer patient ongoing chemio or radiotherapy
measured with Karnofsky Scale as developed by Karnofsky, Abelmann, Craver, and
Burchenal - 60 days with curcumin or placebo
Results:
Curcumin 100 mg
A Controlled Study of a Lecithinized
Delivery System of Curcumin to
alleviate the Adverse Effects of
Cancer Treatment
23. Pubmed 18/11/2015
2367 publications
Curcumin anti-oxidant power is 10 time higher than Vit. E
- Direct activity on ROS
- Induction of NRF2
- Induce mitocondrial biogenesis
Curcumin is a powerful anti-oxidant
30. Curcuma polvere
Curcumina principio attivo (1)
Fitosoma (1)
Oli (1)
Ciclodestrina(1)
Forma micellare o Solubilizzata (2)
X 9,5 – 51,1
X 57,7
X 335
X 1350
X 7,3
Source:
• (1) Jäger et al, Nutrition Journal 2014, 13:11, comparative absorption of curcumin formulations.
• (2) Schiborr et al, Mol. Nutr. Food Res. 2014, 58, 516-527.
X 1
Biodisponibilità vs. Curcuma
Bioavailability of IMPROVED Curcumins
31. Forinternaluseonly–Q12015
• Curcuma longa is GRASS in the USA
Turmeric tolerability
• Curcumin is not carcinogenic
• No concerns of genotoxicity.
• ADI* of 3 mg/kg bw/day based on the NOAEL of 250-320
mg/kg bw/day
• Intake of curcumin from the normal diet amounts to less than
7% of the ADI of 3 mg/kg bw/day
• Possible weak interference with anti-coagulant that normally
do not require dosage adjustments.
*ADI = Accettable daily Intake
34. Forinternaluseonly–Q12015
D.A.I. Medicina Interna, Medicina Specialistica
U.O. Medicina Interna Universitaria “Cesare Frugoni”
Centro di Assistenza e Ricerca Sovraziendale per le Malattie Rare
Università Degli Studi “ALDO MORO” di Bari
Direttore: Prof. Carlo Sabbà
REGIONE PUGLIA
AZIENDA OSPEDALIERA
OSPEDALE POLICLINICO CONSORZIALE
Piazza Giulio Cesare, 11 – 70124 BARI
Testing 3 “levels” of curcumin activity
ANALYSYS OF GENIC EXPRESSION OF MONONUCLEATE BLOOD CELLS OF PATIENTS
WITH METABOLIC SYNDROME AND OSTEOARTHROSIS: POTENZIAL APPLICATIONS IN
DIAGNOSIS, MONITORING AND TREATMENT AFTER 3 MONTHS OF
SUPPLEMENTATION WITH CURCUDYN. (MSC/PBMC/CURCUMIN/15)
First Level
GENE EXPRESSION
• Quantitative analysis of (mRNA) PCR
Quantitative Real Time (RT-qPCR); RT-qPCR Primer
• SNP’s Genotyping on DNA
Second Level
INFLAMMATION’s MARKERS
• C Reactive Protein
• TNF alfa
• IL 6, IL 10
Third Level
SYMPTOMS AND LIFE QUALITY
• Chronic pain (Forms)
• Mobility
• Quality of Life (Form ILMA)
35. Take home messages
Curcumin is effective on chronic pain and inflammation
as NSAID’s
«Enhanced » curcumins have better bioavailability
Curcumin is safe, can be used with all patients
36. Contatti: msal37@gmail.com +39 3663461468
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Maurizio Salamone, biologist
Science Manager Metagenics Italia srl.
DISCLAIMER: M.SALAMONE IS AN EMPLOYEE OF
METAGENICS, A GLOBAL COMPANY THAT MARKETS
NUTRACEUTICALS