Presentation reviews the performance of a newly developed 20 nm filter installed in a ultrahigh purity water system. Presented at the the Executive Forum at ULTRAPURE WATER Micro 2008, Phoenix, AZ, November 11-12, 2008.
Scale-up of high area filters for microfiltration of biological fluids - Poin...MilliporeSigma
Presented at INTERPHEX on March 21-23, 2017.
High area filters can present unique challenges when scaling up from discs to cartridges. A model was developed that can be used to estimate scaled-up performance. A new small scale scaling tool is also introduced that closely mimics the filtration behavior of the full scale filter and that can be used to confirm expected scaled-up performance.
With the brand Albet LabScience, we are providing you with a wide range of products for challenging filtrations in chemical and
biological laboratories, as well as for life science and analytical applications. Our extensive portfolio of filter papers is known in
laboratories throughout the world for its purity and consistency.
As a globally operating company, Hahnemühle is focusing, in addition to the standard product range for laboratories, on the
production of filter papers that are tailored to the customers’ requirements, as part of its core business
Optimization of Tangential Flow Filtration Applications and Scale Up Consider...MilliporeSigma
This presentation provides an introduction to tangential flow filtration applications for AAV and lentivirus and will review:
• Basics of tangential flow filtration (TFF)
• TFF AAV and lentivirus process overview
• Operating parameters optimization: flux-controlled microfiltration
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/remotevisit
W3/330 system is based on the electrolytic sensor method to measure water vapor transmission rate of film and package specimens. It has three independent testing cells and can be easily connected with 9 satellite systems.
Normal Flow Filtration: Design and Scale UpMilliporeSigma
This presentation explores bioprocessing filtration best practices, including design and scale up methods. You will learn:
• What is filtration?
• Filter capacity and fouling models
• Filter sizing approaches
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/remotevisit
Integrity testing is a critical operation, especially for sterilizing grade filters used in biopharmaceutical processing. When performed correctly, an integrity test is a fast, definitive, non-destructive way to assure filter retention performance. Fortunately, there are few ways a non-integral filter will pass the integrity test, eliminating the possibility a non-retentive filter is used undetected. Unfortunately, there are a lot of ways an integral filter can fail the integrity test, resulting in retests, lost time, productivity and potentially lost product.
In this webinar you will:
- Gain confidence in your integrity testing results
- Provide justification for retests
- Understand specific challenges and eliminate them to assure the integrity test can be performed correctly the first time
Scale-up of high area filters for microfiltration of biological fluids - Poin...MilliporeSigma
Presented at INTERPHEX on March 21-23, 2017.
High area filters can present unique challenges when scaling up from discs to cartridges. A model was developed that can be used to estimate scaled-up performance. A new small scale scaling tool is also introduced that closely mimics the filtration behavior of the full scale filter and that can be used to confirm expected scaled-up performance.
With the brand Albet LabScience, we are providing you with a wide range of products for challenging filtrations in chemical and
biological laboratories, as well as for life science and analytical applications. Our extensive portfolio of filter papers is known in
laboratories throughout the world for its purity and consistency.
As a globally operating company, Hahnemühle is focusing, in addition to the standard product range for laboratories, on the
production of filter papers that are tailored to the customers’ requirements, as part of its core business
Optimization of Tangential Flow Filtration Applications and Scale Up Consider...MilliporeSigma
This presentation provides an introduction to tangential flow filtration applications for AAV and lentivirus and will review:
• Basics of tangential flow filtration (TFF)
• TFF AAV and lentivirus process overview
• Operating parameters optimization: flux-controlled microfiltration
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/remotevisit
W3/330 system is based on the electrolytic sensor method to measure water vapor transmission rate of film and package specimens. It has three independent testing cells and can be easily connected with 9 satellite systems.
Normal Flow Filtration: Design and Scale UpMilliporeSigma
This presentation explores bioprocessing filtration best practices, including design and scale up methods. You will learn:
• What is filtration?
• Filter capacity and fouling models
• Filter sizing approaches
• Scale up considerations
To learn more about this topic or collaborate with our technical experts, schedule a remote visit at our M Lab™ Collaboration Centers: www.emdmillipore.com/remotevisit
Integrity testing is a critical operation, especially for sterilizing grade filters used in biopharmaceutical processing. When performed correctly, an integrity test is a fast, definitive, non-destructive way to assure filter retention performance. Fortunately, there are few ways a non-integral filter will pass the integrity test, eliminating the possibility a non-retentive filter is used undetected. Unfortunately, there are a lot of ways an integral filter can fail the integrity test, resulting in retests, lost time, productivity and potentially lost product.
In this webinar you will:
- Gain confidence in your integrity testing results
- Provide justification for retests
- Understand specific challenges and eliminate them to assure the integrity test can be performed correctly the first time
Leak Testing: Different Types Of Leak Testing Methods | Helium Leak Testing Kryovess Pvt. Ltd.
Leak testing method is a very known and important method using for leak detection in the industries. Leak test and leak detection using air decay, helium or water submerse methods. The choice of the detection method depends on which method is most appropriate for the system at hand. Leak testing methods each have their own sensitivity, expressed as the lowest leak rate the method can detect. Highly sensitive methods are required to test highly leak prone systems such as vacuum systems.
OX2/230 is professionally designed for the determination of oxygen transmission rate of film and package specimens. This instrument is applicable to various materials with high, medium and low oxygen permeability.
VAC-V2 can be used to measure gas permeability rate, solubility coefficient, diffusion coefficient and permeability coefficient at various temperature of plastic films, laminated films, high barrier material, sheets, foils, etc.
syringe filters are most common type of filtration devices in small scale applications.we use syringe filters mostly for preparing samples of HPLC, GC, Atomic Absorption and ...
depends on what solutions we use, different types of membranes apply in syringe filters.
please see this file to find out more about syringe filters.
W3/060 is based on cup method to measure water vapor transmission rate of plastic films, foils and finished packages. It has Six independent testing cells and can be easily connected with 9 satellite systems.
Using Solid Phase Microextraction for Cannabis TestingGERSTEL
In the quickly changing landscape of cannabis testing, laboratories are faced with the challenge of providing accurate results for a variety of different tests on challenging matrices. The wide variety of matrices encountered, including both plants, foods, and oily extracts, have complex chemical compositions which include pigments, fats, proteins and sugars. The sample preparation methods used must provide analyses free of these interferences for accurate and robust testing. In this seminar, we will present simple and effective sample preparation and analysis methods using solid phase microextraction (SPME) for determination of residual solvents and terpenes. SPME is a solvent-less extraction technique that is quantitative, sensitive, cost effective, and easy to automate. We will describe how to use SPME to cleanly, accurately and quantitatively determine residual solvents from hemp extract and terpenes from cannabis plant material. For both applications, descriptions of the method procedure along with data showing accuracy and reproducibility will be presented.
Selection, sizing, and operation of bioprocess filtration trains for optimal ...Merck Life Sciences
To increase filter lifetime and improve the economics of filtering bioprocess streams, a prefilter is often installed upstream of a final sterilizing-grade filter. However, determining the economic optimum prefilter and final filter configuration can be challenging. Numerous prefilter options are available, the prefilter to final filter area ratio must be determined, and operating conditions must be selected that will both satisfy the filtration requirements and provide for an economical process that minimizes the filtration system footprint.
One approach towards achieving an optimal filtration system design is to test the bioprocess fluid with several filter configuration combinations and at a range of operating conditions. However, this can be a daunting task and even impractical given the high cost and limited availability of valuable bioprocess fluids. A better approach is to run a limited filtration trial and use a mathematical model that can accurately predict the behavior of the prefilter and final filter under different conditions.
In this webinar we describe a filtration model and test methodology to rapidly and efficiently design an optimal dual-stage filtration process. The model and methodology were applied to Milligard® PES filters, a new class of autoclavable and gamma sterilizable PES membrane prefilters that are designed to protect microfiltration and nanofiltration final filters in bioprocess streams. We show how a model fit to the data from one set of filtration conditions can be used to predict filtration performance at other prefilter to final filter area ratios and operating conditions, and to determine the economic optimum filtration configuration.
In this webinar, you will learn:
- How filters for microfiltration of biological fluids work.
- The effect of operating conditions on filtration performance.
- How to design an optimal series filtration (prefilter and final filter) process.
W3/0120 is based on cup method to measure water vapor transmission rate of plastic films, foils and finished packages. It has 12 independent testing cells and conforms to ASTM, ISO international standards.
VAC-VBS is based on the differential pressure method, and can be used for determination of gas transmission rate of films, sheeting, high barrier materials and aluminum foils.
Leak Testing: Different Types Of Leak Testing Methods | Helium Leak Testing Kryovess Pvt. Ltd.
Leak testing method is a very known and important method using for leak detection in the industries. Leak test and leak detection using air decay, helium or water submerse methods. The choice of the detection method depends on which method is most appropriate for the system at hand. Leak testing methods each have their own sensitivity, expressed as the lowest leak rate the method can detect. Highly sensitive methods are required to test highly leak prone systems such as vacuum systems.
OX2/230 is professionally designed for the determination of oxygen transmission rate of film and package specimens. This instrument is applicable to various materials with high, medium and low oxygen permeability.
VAC-V2 can be used to measure gas permeability rate, solubility coefficient, diffusion coefficient and permeability coefficient at various temperature of plastic films, laminated films, high barrier material, sheets, foils, etc.
syringe filters are most common type of filtration devices in small scale applications.we use syringe filters mostly for preparing samples of HPLC, GC, Atomic Absorption and ...
depends on what solutions we use, different types of membranes apply in syringe filters.
please see this file to find out more about syringe filters.
W3/060 is based on cup method to measure water vapor transmission rate of plastic films, foils and finished packages. It has Six independent testing cells and can be easily connected with 9 satellite systems.
Using Solid Phase Microextraction for Cannabis TestingGERSTEL
In the quickly changing landscape of cannabis testing, laboratories are faced with the challenge of providing accurate results for a variety of different tests on challenging matrices. The wide variety of matrices encountered, including both plants, foods, and oily extracts, have complex chemical compositions which include pigments, fats, proteins and sugars. The sample preparation methods used must provide analyses free of these interferences for accurate and robust testing. In this seminar, we will present simple and effective sample preparation and analysis methods using solid phase microextraction (SPME) for determination of residual solvents and terpenes. SPME is a solvent-less extraction technique that is quantitative, sensitive, cost effective, and easy to automate. We will describe how to use SPME to cleanly, accurately and quantitatively determine residual solvents from hemp extract and terpenes from cannabis plant material. For both applications, descriptions of the method procedure along with data showing accuracy and reproducibility will be presented.
Selection, sizing, and operation of bioprocess filtration trains for optimal ...Merck Life Sciences
To increase filter lifetime and improve the economics of filtering bioprocess streams, a prefilter is often installed upstream of a final sterilizing-grade filter. However, determining the economic optimum prefilter and final filter configuration can be challenging. Numerous prefilter options are available, the prefilter to final filter area ratio must be determined, and operating conditions must be selected that will both satisfy the filtration requirements and provide for an economical process that minimizes the filtration system footprint.
One approach towards achieving an optimal filtration system design is to test the bioprocess fluid with several filter configuration combinations and at a range of operating conditions. However, this can be a daunting task and even impractical given the high cost and limited availability of valuable bioprocess fluids. A better approach is to run a limited filtration trial and use a mathematical model that can accurately predict the behavior of the prefilter and final filter under different conditions.
In this webinar we describe a filtration model and test methodology to rapidly and efficiently design an optimal dual-stage filtration process. The model and methodology were applied to Milligard® PES filters, a new class of autoclavable and gamma sterilizable PES membrane prefilters that are designed to protect microfiltration and nanofiltration final filters in bioprocess streams. We show how a model fit to the data from one set of filtration conditions can be used to predict filtration performance at other prefilter to final filter area ratios and operating conditions, and to determine the economic optimum filtration configuration.
In this webinar, you will learn:
- How filters for microfiltration of biological fluids work.
- The effect of operating conditions on filtration performance.
- How to design an optimal series filtration (prefilter and final filter) process.
W3/0120 is based on cup method to measure water vapor transmission rate of plastic films, foils and finished packages. It has 12 independent testing cells and conforms to ASTM, ISO international standards.
VAC-VBS is based on the differential pressure method, and can be used for determination of gas transmission rate of films, sheeting, high barrier materials and aluminum foils.
Understanding the Impact of Chromatographic System Dispersion on Separation P...Waters Corporation
The last 10 years have seen substantial improvements in both chromatographic columns and instrumentation that have enabled faster and more efficient separations. The once common 4.6 x 150 mm column packed with 5 µm particles has been gradually replaced by smaller columns packed with smaller solid-core particles. To maximize the performance of these highly efficient solid-core particles one must understand the impact that instrument dispersion has on the chromatographic separation.
The presentation describes the automated process of the system and present a number of applications from sample matrices such as food, polymers, and pharmaceuticals to show the utility of the system.
The Thornton 5000TOCi Intelligent Sensor Management (ISM®) sensor provides continuous, fast, and reliable monitoring of TOC levels of reverse osmosis membranes, effectiveness of TOC destruct UV lamps, resin bed performance, organics shedding, and quality of final rinse water. With continuous on-line measurements, the 5000TOCi sensor ensures TOC excursions will not be missed.
This product guide covers the basics of Millipak® Final Fill Filters. Learn how to maximize product recovery and enhance protection of your high value product.
High Flow Filter for UPW Applications – A Field Case Study
1. High Flow Filter for UPW Applications – A Field Case Study Gary Van Schooneveld, CT Associates Inc. Peter Nadolny, W.L. Gore and Associates, Inc November 12, 2008
6. Screening Tests – Filter Retention The test is a modified version of SEMATECH Provisional Test Method for Determining Particle Contribution and Retention by UPW Distribution System Components (1992). Technology Transfer Number 92010949B.
9. High Purity Water System 18.1 M - cm Resistivity 40 – 100 ppb Total Organic Carbon (TOC) < 1 count/mL 100 nm Particle Concentration Typical Performance Parameter
14. Case Study Instrumentation Sentra 0 – 10 psi P sensor Filter housing vent ports Pressure Drop Thornton Model 200CR End of loop Resistivity Fluid Measurement Technologies Model 7700 NRM End of loop Nonvolatile residue G.E. Sievers Model 500RL End of loop TOC PMS M50 Into test filter Particle concentration PMS UDI 50 (x2) End of loop Out of filter Particle concentration Instrument Location Property
21. Filter Rinse Measurements Flushing times required to achieve NVR and TOC cleanliness levels Flushing times required to achieve inorganic cleanliness levels Flushing times required to achieve particulate cleanliness levels
![[object Object],[object Object],[object Object],[object Object],Introduction](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)