Covid-19 drugs favipiravir, tocilizumab & lopinavir/ritonavir their doses, some of their interactions & storage

1. DRUG INFORMATION CENTRE ALAA ALWAZNI
Drug Doses according to reference Important Interactions Storage
conditions
Favipiravir
(Fabivir®)
Ref…4
1600mg*2 1st day
then 600mg*2 for 5 & 10 days
respectively
(moderate & severe cases)
Ref…6
1800mg*2 1st day
then 800mg*2 for max.14 days
Pyrazinamide-increase reabsorption of uric acid in renal
tubule
Repaglinide-increase repaglinide blood level
Theophylline-increase favipiravir blood level
20°C - 25°C
not <30°C
Tocilizumab
(Actemra ®)
Ref…5
8mg/kg every 4 weeks IV infusion
maximum 800mg/dose
Ref…7
8mg/kg for pt.≥30 kg
12mg/kg for pt.<30 kg
I.V, if no clinical improvement 3
doses could be given
Warfarin-decrease warfarin blood level
Verapamil-decrease verapamil blood level
Atorvastatin, Simvastatin-decrease statin blood level
Amlodipine, Diltiazem-decrease their blood level
Theophylline-decrease theophylline blood level
Phenytoin-decrease phenytoin blood level
Diazepam, Alprazolam, Midazolam-decrease their blood
level
Omeprazole, Digoxin
Dexamethasone-decrease dexamethasone blood level
refrigerator
2°C - 8°C
protect from
light
Lopinavir &
Ritonavir
(Kaletra ®)
Ref…4
200/50mg tablet 2*2 for 5 days
(moderate & severe cases)
Ref…8
400/100mg tablet*2
OR 800/200mg*1
Amiodarone—increase amiodarone blood level
Warfarin-affect warfarin blood level
Carbamazepine, Phenobarbital, Phenytoin-decrease
kaletra blood level, decrease phenytoin blood level
Clarithromycin-increase clarithromycin blood level
Midazolam-increase midazolam blood level
Dexamethasone, Prednisolone-decrease lopinavir &
increase glucocorticoid blood level
Rifampin-increase rifampin blood level
Atorvastatin, Rosuvastatin-increase statin blood level
20°C - 25°C
not <30°C

2. DRUG INFORMATION CENTRE ALAA ALWAZNI
References
1. Avigan tablet 200mg…leaflet
2. Actemra® solution for subcutaneous injection , (Roche)…leaflet
3. Highlights of prescription information, kaletra
4. Iraqi MOH treatment protocols for covid-19 published at June 2020
5. BNF for android version 2.1.26 updates 11 Nov., 2019
6. Fabivir 200mg tab, (Awamedica)…leaflet
7. Clinical trials to evaluate the effectiveness and safety of tocilizumab for treating patients with covid 19 pneumonia,
clinicaltrials.gov website
8. Kaletra, package leaflet information, (abbvie)…leaflet