basic details about covid-19

1. Ayush Saraogi (03)
Rajesh Bhagyawan(06)
Sophia Francis(14)
Pallavi Gite(17)
Charushila Kangane(24)
Manasi Parkar (37)
Suji Nair(34)
Akshay Aher(51)
Mohit Tiwari (58)
Ravish Yadav (59)
BIOMATERIAL AND MEDICAL DEVICE

2. 2

3. HOW IT ALL BEGAN?
• SARS, MERS and
bird flu ruled out
•Virus identified as
coronavirus 2019n-
CoV
•First suspected
coronavirus cases in
thailand.
•Coronavirus
genome sequence
released
Start
•WHO hold on
declaring
international health
emergency
•China implements
travel bans.
•Starts building
temporary hospital.
•Virus reaches
Russia, Spain,
Sweden, Malaysia,
Sweden.
•Japan reports
cases on cruise.
•Death toll passses
700, Hong Kong
enforces
quarantine.
•First cases
detected in Wuhan,
China.
•Wuhan market
identified as
outbreak hub
•Passengers
screened at wuhan
airport,
•WHO advices
against travel
•. First coronavirus
death reported
•First confirmed
coronavirus case in
thailand,japan,sout
h korea, US
•US, France evacuated
nationals from Wuhan
• WHO changes risk to
high,.
•Srilanka,japan, taiwan,
germany,UAE
confirm cases.
•Death toll hits 213
• WHO DECLARES
GLOBAL EMERGENCY
.
THE NO. OF
CASES OF
CORONA
VIRUS IS
STILL
INCREASIN
G DAY BY
DAY
ACROSS
THE GLOBE.
31 Dec
2019 – 6th
Jan 2020
11th Jan-
21th jan 26th Jan
6th Jan- 9th
Jan
22nd Jan
23rd Jan
24th Jan
FEBRUARY
MARCH

4. CORONAVIRUS
Corona virus is not a name of single virus rather it’s a name of family of viruses.
Seven strains of human coronaviruses are known:
 Human coronavirus 229E (HCoV-229E)
 Human coronavirus OC43 (HCoV-OC43)
 Severe acute respiratory syndrome coronavirus (SARS-CoV)
 Human coronavirus NL63 (HCoV-NL63, New Haven coronavirus)
 Human coronavirus HKU1
 Middle East respiratory syndrome-related coronavirus (MERS-CoV),
previously known as novel coronavirus 2012 and HCoV-EMC
 Latest strain corona virus named as 2019-nCoV or "novel coronavirus 2019“
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5. SOURCE AND SIGN OF CORONA VIRUS
INFECTION
 Original source of most of corona virus is some animal which affects
human and later through human to human contact it spreads into
humans.
 For example in case of SARS – Original source was bat and in case of
MERS-CoV original source was camel.
 Some scientist suspects snakes as the original source of novel
coronavirus however some scientist said its source can again be bat
because there are 96% similarities in the new corona virus as
compared to the corona virus that came from bat.
 Common signs of infection include respiratory symptoms, fever,
cough, shortness of breath and breathing difficulties. In more severe
cases, infection can cause pneumonia, severe acute respiratory
syndrome, kidney failure and even death.
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6. REPLICATION OF
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7. 2019
• Inovio Pharmaceuticals advance the
development of the former’s vaccine, INO-
4800, as a novel coronavirus vaccine.
• Regeneron’s REGN3048-3051, the
combination of neutralising monoclonal
antibodies REGN3048 and REGN3051.
• Vaxart is developing an oral recombinant
vaccine in tablet formulation using its
proprietary oral vaccine platform, VAAST.
US biotech firm
Moderna
mRNA-1273
Gilead Sciences
(GILD)
Remdesivir
• Favilavir, an anti-viral drug, as
a treatment for coronavirus.
• Clover Biopharmaceuticals is
developing a recombinant
subunit vaccine using its
patented Trimer-
Tag© technology
Biotech Company
AbbVie (ABBV)
HIV medications &
Tamiflu,
Made by
Roche (RHHBF) &
Japan's Chugai
Pharmaceutical
Co (CHGCY).
Brilacidin by
Innovation
Pharmaceuticals.
Brilacidin has
shown antibacterial,
anti-inflammatory.
Drug Maker’s- Vaccine
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8. NIOSH-Approved Particulate Filtering Face piece Respirators
• The above
BioFriendTM
BioMaskTM
facemasks are
identically comprised
of four layers of the
same material:
• Outer layer of spun-
bond polypropylene.
• Second layer of
cellulose/polyester.
• Third layer of melt-
blown polypropylene
filter material .
• Inner (fourth) layer
of spun-bound
polypropylene.
• The anti-viral/anti-influenza
materials used in the first two
active layers.
• Both the outer and second
inner layers are treated with
different compounds that
independently inactivate
viruses. Laboratory (in vitro)
tests conducted demonstrate
that.
• BioFriend TM BioMaskM
N95 surgical respirator
inactivates 99.99% of 15
different strains of Influenza
A and Influenza B viruses.
• TEST- Biocompatible by
irritation and sensitization
testing, toxicological
assessment of the products
ingredients potentially
released with inhalation or
salivary contact, and
indicates that the facemask
and respirator products are
safe for use in the intended
application.
N95 respirators
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10. Upcoming discoveries
• Wuhan is conducting a randomized clinical trial to assess
whether Kaletra (Protease inhibitor- AbbVie Brand works
against coronavirus.
• Johnson & Johnson agreed to a request over the weekend by
Chinese health authorities to try their HIV drug Prezcobix
• Hong Kong University of Science and Technology (HKUST) has
recently made an important discovery in identifying a potential
vaccine targets for the SARS-CoV-2 coronavirus
• It was found that only 20% of the SARS-CoV (2003) epitopes
identically to SARS-CoV-2(2019)
• Trials of the drug, an experimental antiviral called remdesivir
(Gilead’s product)(is only one drug right now that we think may
have real efficacy), have already been up and running in China
for a few weeks & preliminary results appear promising.

11.  Limit human to human transmission including, reducing secondary
infections among close contacts and health care workers,
preventing transmission amplification events, and preventing
further international spread from China
 Identify, isolate and care for patients early, including providing
optimized care for infected patients
 Communicate critical risk and event information to all
communities and counter misinformation
 Minimize social and economic impact through multisectoral
partnership
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WHO’s STRATEGIC OBJECTIVES
towards CORONOVIRUS

12. • Spraying alcohol or chlorine all over your body kill the coronavirus (ans–
no)
• Pets at home spread the new coronavirus (ans-no)
• Vaccines against pneumonia protect you against the coronavirus (ans-no)
• Antibiotic effective in preventing and treating the coronavirus (ans-no)
• Putting on sesame oil block the new coronavirus from entering the body
(ans-No)
• Thermal scanners in detecting people infected with the coronavirus (ans-
NO)
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MYTH BUSTERS

13. Coronavirus in india
two cases reported yesterday,
one in the nation's capital and the other in Telangana,
the total count of Indian patients has now gone up to
five — a trivial tally when one considers our proximity
and close business ties with China, the hotbed of the
epidemic.
The Drug Controller General of India has granted
approval to the Indian Council of Medical Research to
use a combination of lopinavir and ritonavir in the event
of the coronavirus disease in India turns into a public
health emergency, reported the Economic Times. 13

14. LABS TESTING FOR CORONAVIRUS
IN INDIA
 The National Institute of Virology, Pune, and ten
other laboratories under the Indian Council of
Medical Research’s (ICMR) Viral Research and
Diagnostics Laboratories network are equipped to
test samples.
 The ICMR has tested 510 samples as of 06 February,
of which three tested positive, according to the latest
coronavirus update in India.
 India is adding more coronavirus testing laboratories
across the country.
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15. IMPACT ON INDIA’S TRADE WITH CHINA
 With China under lockdown, India is expected to witness a major
impact on imports and exports in various industries including
pharmaceuticals, electronics, mobiles, and auto parts.
 China is the biggest exporter to India, followed by the US and UAE.
In 2018, China exported goods worth $90.4bn to India and
accounted for 14.63% of the exports.
 In 2017, telecom instruments, electronics components, computer
hardware and peripherals, industrial machinery for dairy, and
organic chemicals were the top five items imported by India
accounting for 46% of the imports from China.
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16. HOW THE COVID-19 OUTBREAK
IMPACTS THE INDIAN
PHARMACEUTICAL INDUSTRY
 Bulk drugs and drug intermediates accounted for
$1.5bn or 3% of India’s imports from China.
 According to the Trade Promotion Council of India,
approximately 85% of active pharmaceutical ingredients
(APIs) imported by Indian companies are from China.
 India’s overdependence on China for APIs exposes it to
raw material supply disruption and price volatility.
Another major hindrance to the Indian pharmaceutical
industry is its low capacity utilisation, according to a
report from the Ministry of Commerce and Industry
(MCI). India has a capacity utilisation between 30% and
40% as against 75% of China.
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17. OPPORTUNITIES FOR INDIAN
PHARMACEUTICAL
MANUFACTURERS
Although the Wuhan coronavirus outbreak could have
a significant impact on the Indian pharmaceutical
industry unless it is brought under control over the next
few months, it also provides an opportunity to India’s
pharmaceutical manufacturers to grab share from their
Chinese competitors.
Indian pharmaceutical companies currently have two
months’ stock of APIs and intermediates, quoted the
Economic Times. In the absence of a major disruption
due to the outbreak, the existing stocks may address
the issue of shortage, it added.
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18. NURSES DANCE FOR DISCHARGED
PEOPLE FROM ISOLATION.MP4
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