Coordination modes of a new ligand derived from pyrazoline with cr(iii), mn(ii), co(ii), ni(ii), cu(ii) and zn(ii) metal ions; synthesis, identification and biological studies
This document summarizes a study that synthesized and characterized coordination complexes of Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal ions with a new ligand derived from pyrazoline. The complexes were analyzed using various techniques including elemental analysis, infrared spectroscopy, NMR spectroscopy, magnetic susceptibility measurements, and electronic spectroscopy. The data indicated the ligand behaves as a neutral bidentate toward the metal ions. The biological activities of the ligand and its complexes were screened against bacteria and fungi, with some complexes showing higher antimicrobial activity than the free ligand.
New Schiff base ligand (E)-6-(2-(4-
(dimethylamino)benzylideneamino)-2-phenylacetamido)-3,3-
dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid = (HL) Figure(1) was prepared via condensation of
Ampicillin and 4(dimethylamino)benzaldehyde in methanol
.Polydentate mixed ligand complexes were obtained from 1:1:2
molar ratio reactions with metal ions and HL, 2NA on reaction
with MCl2 .nH2O salt yields complexes corresponding to the
formulas [M(L)(NA)2Cl] ,where M =
Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and NA=nicotinamide.
The 1H-NMR, FT-IR, UV-Vis and elemental analysis
were used for the characterization of the ligand. The complexes
were structurally studied through AAS, FT-IR, UV-Vis,
chloride contents, conductance, and magnetic susceptibility
measurements. All complexes are non-electrolytes in DMSO
solution. Octahedral geometries have been suggested for each
of the complexes. The Schiff base ligands function as
tridentates and the deprotonated enolic form is preferred for
coordination. In order to evaluate the effect of the bactericidal
activity, these synthesized complexes, in comparison to the un
complexed Schiff base has been screened against bacterial
species, Staphy
Synthesis and characterization of some metal complexes of 2- Phenyl-3,4-dihyd...IOSRJAC
2-Phenyl-3,4-dihydro-quinazolin-4-yloxy)-acetic acid (L1) metal complexes with Mn2+ , Co2+, Ni2+ Cu2+ , and Zn2+ ions were studied and the structure of the complexes were elucidated using elemental analyses, infrared (IR), 1H nuclear magnetic resonance (NMR), magnetic moment and thermal analysis measurements. Besides the characterization of complexes by physicochemical technique, Biological activities of the synthesized complexes were examined against some microbial strains for evaluation of antibacterial and antifungal activities.
Spectral studies of 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino] pyrimidi...IOSR Journals
Some transition metal ions Complexes with 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino]
pyrimidin-5-yl} methyl)-2,3,4-trimethoxybenzene were prepared and characterized by elemental analyses,
Infrared , magnetic moment, electronic spectra , mass spectra, X-ray powder diffraction, molar conductance
and thermal analysis (TGA). The complexes have general formulae [ML2.2H2O] {where M = Mn (II), Co (II), Ni
(II), Cu (II), Zn (II), Pd (II) and Pt (II). The coordination behavior of the metal ions towards to the investigated
Schiff base takes place through –C=N,-NH2 and –OH groups. The obtained C, H and N elemental analysis data
showed the Metal: Ligand ratio is 1:2 [M: L] ratio. The molar conductance data reveal that all the metal
complexes are non-electrolytic in nature. From the magnetic moments the complexes are paramagnetic except
Zn metal ion complexes have octahedral geometry with coordination number eight. The thermal behavior of
these complexes shows that, the hydrated complexes have loses two water molecules and immediately followed
by decomposition of the anions and ligand molecules in the second and third stage. The Schiff bases and metal
complexes show good activity against some bacteria. The antimicrobial results indicate that, the metal
complexes have better antimicrobial activity as compared to the prepared Schiff base.
New Schiff base ligand (E)-6-(2-(4-
(dimethylamino)benzylideneamino)-2-phenylacetamido)-3,3-
dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic
acid = (HL) Figure(1) was prepared via condensation of
Ampicillin and 4(dimethylamino)benzaldehyde in methanol
.Polydentate mixed ligand complexes were obtained from 1:1:2
molar ratio reactions with metal ions and HL, 2NA on reaction
with MCl2 .nH2O salt yields complexes corresponding to the
formulas [M(L)(NA)2Cl] ,where M =
Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and NA=nicotinamide.
The 1H-NMR, FT-IR, UV-Vis and elemental analysis
were used for the characterization of the ligand. The complexes
were structurally studied through AAS, FT-IR, UV-Vis,
chloride contents, conductance, and magnetic susceptibility
measurements. All complexes are non-electrolytes in DMSO
solution. Octahedral geometries have been suggested for each
of the complexes. The Schiff base ligands function as
tridentates and the deprotonated enolic form is preferred for
coordination. In order to evaluate the effect of the bactericidal
activity, these synthesized complexes, in comparison to the un
complexed Schiff base has been screened against bacterial
species, Staphy
Synthesis and characterization of some metal complexes of 2- Phenyl-3,4-dihyd...IOSRJAC
2-Phenyl-3,4-dihydro-quinazolin-4-yloxy)-acetic acid (L1) metal complexes with Mn2+ , Co2+, Ni2+ Cu2+ , and Zn2+ ions were studied and the structure of the complexes were elucidated using elemental analyses, infrared (IR), 1H nuclear magnetic resonance (NMR), magnetic moment and thermal analysis measurements. Besides the characterization of complexes by physicochemical technique, Biological activities of the synthesized complexes were examined against some microbial strains for evaluation of antibacterial and antifungal activities.
Spectral studies of 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino] pyrimidi...IOSR Journals
Some transition metal ions Complexes with 5-({4-amino-2-[(Z)-(2-hydroxybenzylidene) amino]
pyrimidin-5-yl} methyl)-2,3,4-trimethoxybenzene were prepared and characterized by elemental analyses,
Infrared , magnetic moment, electronic spectra , mass spectra, X-ray powder diffraction, molar conductance
and thermal analysis (TGA). The complexes have general formulae [ML2.2H2O] {where M = Mn (II), Co (II), Ni
(II), Cu (II), Zn (II), Pd (II) and Pt (II). The coordination behavior of the metal ions towards to the investigated
Schiff base takes place through –C=N,-NH2 and –OH groups. The obtained C, H and N elemental analysis data
showed the Metal: Ligand ratio is 1:2 [M: L] ratio. The molar conductance data reveal that all the metal
complexes are non-electrolytic in nature. From the magnetic moments the complexes are paramagnetic except
Zn metal ion complexes have octahedral geometry with coordination number eight. The thermal behavior of
these complexes shows that, the hydrated complexes have loses two water molecules and immediately followed
by decomposition of the anions and ligand molecules in the second and third stage. The Schiff bases and metal
complexes show good activity against some bacteria. The antimicrobial results indicate that, the metal
complexes have better antimicrobial activity as compared to the prepared Schiff base.
Synthesis, Characterization, Antibacterial and DNA Binding Studies of Mn (II)...IOSRJAC
Mn (II) complex of the Schiff base (L), 3-(2-(2-hydroxy-3-methoxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (VHQO) was prepared and characterized by IR, UV-VIS, Mass, Elemental analysis, TGDTA, magnetic susceptibility and conductivity measurements. VHQO behaved as monobasic, tridentate ligand and formed 1:2 complex (ML2) with the metal ion (M) coordinating through ring nitrogen, azomethine nitrogen and phenolic oxygen. Thermal analysis of the complex indicated the absence of lattice and coordinated water. Based on the spectral and analytical data, octahedral geometry was assigned to the complex. Antibacterial activity of the complex against gram positive bacteria, Bacillus subtillis, Staphylococcus aureus, and gram negative bacteria, Escherichia coli, Proteus vulgaris, Pseudomonas aeroginosa , and Klebsiella pneumonia was studied. The interaction of the complex with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy and the intrinsic binding constant was calculated.
Spectroscopic, Thermal, Magnetic and conductimetric studies on some 7-hydroxy...IOSR Journals
7-hydroxy-4-methyl-8-(p-methylphenylazo)coumarin (L1) and 7-hydroxy-4-methyl-8-(p-methoxyphenylazo)coumarin (L2) have been prepared and characterized by elemental analysis, infrared (IR), proton nuclear magnetic resonance (1H NMR) and mass spectra. The important infrared (IR) spectral bands corresponding to the active groups in the two ligands and the solid complexes under investigation were studied. Also the important fragments in the ligands and complexes were done using mass spectra and the main peaks were corresponding to the molecular weights of the ligands and complexes. The solid complexes have been synthesized and characterized by elemental and thermal analyses (TG and DTA) as well as by IR, 1H NMR, magnetic measurements, electronic transition, molar conductance, mass and electron spin resonance (ESR) spectra. The proposed steriochemical structures for the investigated metal complexes suggest octahedral geometry with respect to Mn, Co, Ni, Cu and Zn divalent metal ions with the investigated ligands 1:1 and 1:2 complexes and all of the formed complexes contain coordinated and hydrated water molecules. All of the prepared solid complexes behave as non-electrolytes in chloroform.
Vibrational Characterization and Antioxidant Activity of Newly Synthesized Ga...peertechzpublication
The gallium(III) complex of orotic acid (HOA) was synthesized and its structure was determined
by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA
(NaOA) and Ga(III)-OA systems based on both the calculated and experimental spectra confi rmed the
suggested metal-ligand binding mode. Signifi cant differences in the IR and Raman spectra of the complex
were observed as compared to the spectra of the ligand and confi rmed the suggested metal-ligand
binding mode.
synthesis and characterization of hydrazone ligand and their metal complexesMUBASHIRA M
This slide mainly contain the synthesis, characterization of a few hydrazine based heterocyclic ligand such as hydralazone and phenyl hydralazone and also their metal complexes. so in this work, my aim is to synthesise the ligands; 2-thiophenecarboxylaldehydehydralazone and 2,3-butanedionephenylhydrazone. also to characterized the synthesised hydrazones by different physiochemical techniques.
Synthesis and Characterization of Template Cr(III),Fe(III), Mn(II), Cd(II) an...IOSR Journals
A new series of tetradentate N2O2 acyclic complexes of type [M(L)X2]Xn where M = Mn(II), Cd, Cr(III) and Fe(III); L is tetradentate acyclic Schiff base formed via condensation reaction, and X = Cl-, n=1 for M(III), have been prepared on the basis of condensation of 2,6-diaminopyridine and 1,4-dihydro-quinoxalin-2, 3-dione by template method. The complexes are formulated as: [M(L)Cl]Cl where M=Cr, Fe(III),[MLCl2],MII=Mn, Cd(II) and [VOL]SO4 on the basis of elemental analyses,molar conductance and other spectral data. The organic moiety formed up on template condensation behaves as tetradentate N2O2 system through the two azomethine nitrogen atoms of –C=N- and the participation of O atoms of -C=O in 2-position of pyrazine ring. However, the pyridine nitrogen atom does not take part in coordination as confirmed by FTIR,UV-Visible and H NMR spectroscopy data. The newly template metal complexes have characterized with the help of various spectral techniques H NMR,13C NMR, F.T.I.R, elemental analyses, electronic spectra, molar conductivity measurements and magnetic susceptibilities. The octahedral geometry has been proposed for Cr(III),Fe(III), Mn (II) and Cd(II) while vanadyl complex was square pyramid configuration respectively
SYNTHESIS, SPECTRAL AND ANTIMICROBIAL ACTIVITY OF MIXED LIGAND COMPLEXES OFCo(II), Ni(II), Cu(II) and Zn(II) WITH 4-AMINOANTIPYRINE AND TRIBUTYLPHOSPHINE
Synthesis and Crystal Structure of Anickel (II) and Zinc (II) Complex From 1,...IOSRJAC
:The title mononuclear nickel and zinc complexes, Ni(C11H9N4S3)2andZn(C11H9N4S3)2 .2(C3H7NO), were prepared by the reaction of Nickel(II) or Zinc(II)acetate with 1,5-bis[(2- thiophenyl)methylidene]thiocarbonohydrazide in a methanol solution. It features mono-deprotonated bisbidentate ligands, which coordinate to metal (II) ions by hydrazylN and thiocarbony lS atoms, yielding a tetracoordinated metal ions complexes. In Ni(II) complex the geometry around the metal ion is described as square planar. In the Zn(II) the metal atom shows severely tetrahedral distortion from anideal square-planar coordination geometry, as reflected by the dihedral angle between ZnN2and ZnS2 planes of 73.03(13)°. Two intramolecular hydrogen bonds are observed between the solvate dmf molecules and the coordinated ligands:N2—H2N…O1i and N6—H6N…O2 ii in this complex
Visible light assisted reduction of nitrobenzenes using Fe(bpy)3+2/rGOnanocom...Pawan Kumar
Visible-light-induced photocatalytic reduction of aromatic nitrobenzenes to the corresponding anilinesat room temperature using reduced graphene oxide (rGO) immobilized iron(II) bipyridine complex asphotocatalyst is described. The rGO-immobilized iron catalyst exhibited superior catalytic activity thanhomogeneous iron(II) bipyridine complex and much higher than metal free rGO photocatalysts. Theheterogeneous photocatalyst was found to be robust and could easily be recovered and reused for severalruns without any significant loss in photocatalytic activity.
A detailed study of Transition Metal Complexes of a Schiff base with its Phys...Abhishek Ghara
The many activities of metal ions in biology have stimulated the development of metal based therapeutics. It has been found that biologically active compounds become more effective and bacteriostatic upon chelation with metal ions also the biological activity of many drugs has been shown to be enhanced on complexing with metal ions, hence promoting their use in Pharmacology. The present work deals with the synthesis of metal complexes derived from a novel Schiff base drug synthesized from urea and salicylaldehyde and its physico-chemical analysis to find out ligand- metal ratio of this complex in solution. For the structure elucidation of these complexes “Monovariation method (Mole ratio method/ Yoe-Jones Method)” has been used to ascertain the ligand-metal ratio in the complex. The stability constant of the formed complex was calculated by molar conductance measurement using Modified Job’s method (Method of Continuous Variations). The analysis has been carried out using conductometry. To confirm metal-ligand ratio, conductometric titrations were carried out at room temperature using analytical grade metal salts. Titrations were carried out with “systronics conductivity-meter” using dip type conductivity cell having cell constant 1 at room temperature.
Synthesis and Thermal Study of Co (II), Ni (II), Cu (II) Mixed Ligand Complex...IOSR Journals
The mixed ligand complexes of Co (II), Ni (II) and Cu (II) with histidine (His.) and 8-hydroxyquinoline (Qui.) have been synthesized and characterized.The resulting complexes were characterized by vibrational and electronic spectral data, thermogravimetric studies , metal analysis and molar conductance measurements. The histidine acts as tridentate ligand, coordinating through the two nitrogen atoms of imidazole ring and the amino group and carboxylate oxygen whereas 8-hydroxyquinoline shows a bidentate nature and the coordination occurs through nitrogen of imine group and oxygen of phenol group. The experimental data suggest that a mononuclear octahedral structure with general formula [M (His.)(Qui.) H2O ] where M= Co (II), Ni (II) and [Cu (His.)(Qui.)H2O] .H2O, thermo gravimetric studies reveal the presence of coordinated water molecules in all complexes. The molar conductance measurements reveal non-electrolytic nature of complexes.
the photo chemistry of ligand field is very important to have an idea for the intrinsic properties of different coordination compound, and the electronic properties such as, LMCT,LLCT, MLCH etc..........
Synthesis, Characterization, Antibacterial and DNA Binding Studies of Mn (II)...IOSRJAC
Mn (II) complex of the Schiff base (L), 3-(2-(2-hydroxy-3-methoxybenzylidene) hydrazinyl) quinoxalin-2(1H)-one (VHQO) was prepared and characterized by IR, UV-VIS, Mass, Elemental analysis, TGDTA, magnetic susceptibility and conductivity measurements. VHQO behaved as monobasic, tridentate ligand and formed 1:2 complex (ML2) with the metal ion (M) coordinating through ring nitrogen, azomethine nitrogen and phenolic oxygen. Thermal analysis of the complex indicated the absence of lattice and coordinated water. Based on the spectral and analytical data, octahedral geometry was assigned to the complex. Antibacterial activity of the complex against gram positive bacteria, Bacillus subtillis, Staphylococcus aureus, and gram negative bacteria, Escherichia coli, Proteus vulgaris, Pseudomonas aeroginosa , and Klebsiella pneumonia was studied. The interaction of the complex with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy and the intrinsic binding constant was calculated.
Spectroscopic, Thermal, Magnetic and conductimetric studies on some 7-hydroxy...IOSR Journals
7-hydroxy-4-methyl-8-(p-methylphenylazo)coumarin (L1) and 7-hydroxy-4-methyl-8-(p-methoxyphenylazo)coumarin (L2) have been prepared and characterized by elemental analysis, infrared (IR), proton nuclear magnetic resonance (1H NMR) and mass spectra. The important infrared (IR) spectral bands corresponding to the active groups in the two ligands and the solid complexes under investigation were studied. Also the important fragments in the ligands and complexes were done using mass spectra and the main peaks were corresponding to the molecular weights of the ligands and complexes. The solid complexes have been synthesized and characterized by elemental and thermal analyses (TG and DTA) as well as by IR, 1H NMR, magnetic measurements, electronic transition, molar conductance, mass and electron spin resonance (ESR) spectra. The proposed steriochemical structures for the investigated metal complexes suggest octahedral geometry with respect to Mn, Co, Ni, Cu and Zn divalent metal ions with the investigated ligands 1:1 and 1:2 complexes and all of the formed complexes contain coordinated and hydrated water molecules. All of the prepared solid complexes behave as non-electrolytes in chloroform.
Vibrational Characterization and Antioxidant Activity of Newly Synthesized Ga...peertechzpublication
The gallium(III) complex of orotic acid (HOA) was synthesized and its structure was determined
by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA
(NaOA) and Ga(III)-OA systems based on both the calculated and experimental spectra confi rmed the
suggested metal-ligand binding mode. Signifi cant differences in the IR and Raman spectra of the complex
were observed as compared to the spectra of the ligand and confi rmed the suggested metal-ligand
binding mode.
synthesis and characterization of hydrazone ligand and their metal complexesMUBASHIRA M
This slide mainly contain the synthesis, characterization of a few hydrazine based heterocyclic ligand such as hydralazone and phenyl hydralazone and also their metal complexes. so in this work, my aim is to synthesise the ligands; 2-thiophenecarboxylaldehydehydralazone and 2,3-butanedionephenylhydrazone. also to characterized the synthesised hydrazones by different physiochemical techniques.
Synthesis and Characterization of Template Cr(III),Fe(III), Mn(II), Cd(II) an...IOSR Journals
A new series of tetradentate N2O2 acyclic complexes of type [M(L)X2]Xn where M = Mn(II), Cd, Cr(III) and Fe(III); L is tetradentate acyclic Schiff base formed via condensation reaction, and X = Cl-, n=1 for M(III), have been prepared on the basis of condensation of 2,6-diaminopyridine and 1,4-dihydro-quinoxalin-2, 3-dione by template method. The complexes are formulated as: [M(L)Cl]Cl where M=Cr, Fe(III),[MLCl2],MII=Mn, Cd(II) and [VOL]SO4 on the basis of elemental analyses,molar conductance and other spectral data. The organic moiety formed up on template condensation behaves as tetradentate N2O2 system through the two azomethine nitrogen atoms of –C=N- and the participation of O atoms of -C=O in 2-position of pyrazine ring. However, the pyridine nitrogen atom does not take part in coordination as confirmed by FTIR,UV-Visible and H NMR spectroscopy data. The newly template metal complexes have characterized with the help of various spectral techniques H NMR,13C NMR, F.T.I.R, elemental analyses, electronic spectra, molar conductivity measurements and magnetic susceptibilities. The octahedral geometry has been proposed for Cr(III),Fe(III), Mn (II) and Cd(II) while vanadyl complex was square pyramid configuration respectively
SYNTHESIS, SPECTRAL AND ANTIMICROBIAL ACTIVITY OF MIXED LIGAND COMPLEXES OFCo(II), Ni(II), Cu(II) and Zn(II) WITH 4-AMINOANTIPYRINE AND TRIBUTYLPHOSPHINE
Synthesis and Crystal Structure of Anickel (II) and Zinc (II) Complex From 1,...IOSRJAC
:The title mononuclear nickel and zinc complexes, Ni(C11H9N4S3)2andZn(C11H9N4S3)2 .2(C3H7NO), were prepared by the reaction of Nickel(II) or Zinc(II)acetate with 1,5-bis[(2- thiophenyl)methylidene]thiocarbonohydrazide in a methanol solution. It features mono-deprotonated bisbidentate ligands, which coordinate to metal (II) ions by hydrazylN and thiocarbony lS atoms, yielding a tetracoordinated metal ions complexes. In Ni(II) complex the geometry around the metal ion is described as square planar. In the Zn(II) the metal atom shows severely tetrahedral distortion from anideal square-planar coordination geometry, as reflected by the dihedral angle between ZnN2and ZnS2 planes of 73.03(13)°. Two intramolecular hydrogen bonds are observed between the solvate dmf molecules and the coordinated ligands:N2—H2N…O1i and N6—H6N…O2 ii in this complex
Visible light assisted reduction of nitrobenzenes using Fe(bpy)3+2/rGOnanocom...Pawan Kumar
Visible-light-induced photocatalytic reduction of aromatic nitrobenzenes to the corresponding anilinesat room temperature using reduced graphene oxide (rGO) immobilized iron(II) bipyridine complex asphotocatalyst is described. The rGO-immobilized iron catalyst exhibited superior catalytic activity thanhomogeneous iron(II) bipyridine complex and much higher than metal free rGO photocatalysts. Theheterogeneous photocatalyst was found to be robust and could easily be recovered and reused for severalruns without any significant loss in photocatalytic activity.
A detailed study of Transition Metal Complexes of a Schiff base with its Phys...Abhishek Ghara
The many activities of metal ions in biology have stimulated the development of metal based therapeutics. It has been found that biologically active compounds become more effective and bacteriostatic upon chelation with metal ions also the biological activity of many drugs has been shown to be enhanced on complexing with metal ions, hence promoting their use in Pharmacology. The present work deals with the synthesis of metal complexes derived from a novel Schiff base drug synthesized from urea and salicylaldehyde and its physico-chemical analysis to find out ligand- metal ratio of this complex in solution. For the structure elucidation of these complexes “Monovariation method (Mole ratio method/ Yoe-Jones Method)” has been used to ascertain the ligand-metal ratio in the complex. The stability constant of the formed complex was calculated by molar conductance measurement using Modified Job’s method (Method of Continuous Variations). The analysis has been carried out using conductometry. To confirm metal-ligand ratio, conductometric titrations were carried out at room temperature using analytical grade metal salts. Titrations were carried out with “systronics conductivity-meter” using dip type conductivity cell having cell constant 1 at room temperature.
Synthesis and Thermal Study of Co (II), Ni (II), Cu (II) Mixed Ligand Complex...IOSR Journals
The mixed ligand complexes of Co (II), Ni (II) and Cu (II) with histidine (His.) and 8-hydroxyquinoline (Qui.) have been synthesized and characterized.The resulting complexes were characterized by vibrational and electronic spectral data, thermogravimetric studies , metal analysis and molar conductance measurements. The histidine acts as tridentate ligand, coordinating through the two nitrogen atoms of imidazole ring and the amino group and carboxylate oxygen whereas 8-hydroxyquinoline shows a bidentate nature and the coordination occurs through nitrogen of imine group and oxygen of phenol group. The experimental data suggest that a mononuclear octahedral structure with general formula [M (His.)(Qui.) H2O ] where M= Co (II), Ni (II) and [Cu (His.)(Qui.)H2O] .H2O, thermo gravimetric studies reveal the presence of coordinated water molecules in all complexes. The molar conductance measurements reveal non-electrolytic nature of complexes.
the photo chemistry of ligand field is very important to have an idea for the intrinsic properties of different coordination compound, and the electronic properties such as, LMCT,LLCT, MLCH etc..........
Elementary steps in catalysis using transition metal compoundsChris Sonntag
Description of the basic steps in catalysis
Discussion of oxidation addition, reductive elimination and migration reactions with examples
Catalytic cycles
Similar to Coordination modes of a new ligand derived from pyrazoline with cr(iii), mn(ii), co(ii), ni(ii), cu(ii) and zn(ii) metal ions; synthesis, identification and biological studies
Anthranillic acid and tributylphosphine4652 6725-1-pbTaghreed Al-Noor
Mixed ligand complexes of bivalent metal ions, viz; Co(II), Ni(II), Cu(II) and Zn(II) of the
composition [M(A)2((PBu3)2]in(1:2:2)(M:A:(PBu3). molar ratio, (where A- Anthranilate ion
,(PBu3)= tributylphosphine. M= Co(II),Ni(II),Cu(II) and Zn(II).
The prepared complexes were characterized using flame atomic absorption, by FT-IR,
UV/visible spectra methods as well as magnetic susceptibility and conductivity measurements. The
metal complexes were tested in vitro against three types of pathogenic bacteria microorganisms:
(Staphylococcus, Klebsiella SPP .and Bacillas)to assess their antimicrobial properties. Results. The
study shows that all complexes have octahedral geometry; in addition, it has high activity against
tested bacteria. Based on the reported results, it may be concluded that.The results showed that the
deprotonated ligand(nthranilc acid ) to anthranilate ion (A-) by using (KOH) coordinated to metal
ions as bidentate ligand through the oxygen atom of the carboxylate group (−COO−), and the
nitrogen atom of the amine group (-NH2), where the Tributylphosphine coordinated as a
Studies On The Cobalt(II) And Copper(II) Complexes Of 2,5-Substituted 1,3,4-T...IOSR Journals
New metal complexes of Co(II),and Cu(II) have been synthesized by reacting metal solutions with the ligand 2,5-substituted 1,3,4-triazoles in alcoholic medium. Molecular formulae of the complexes were determined and are further characterized by IR spectroscopy, magnetic susceptibility and molar conductance studies. The ligand acts as a bidentate ligand co-ordinating through the nitrogen atoms present in the ring.
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METALLO - BIOACTIVE COMPOUNDS AS POTENTIAL NOVEL ANTICANCER THERAPYijac123
Mono and bi-organometallic complexes of Cu(II), Ni(II), Mn(II), Zn(II) and Ag(I) complexes with
oxaloamide ligand has much potential as therapeutic and diagnostic agents. The ligand allows the
thermodynamic and kinetic reactivity of the metal ion to be controlled and also provide a scaffold for
functionalization. Specific examples involving the design of metal complexes as anticancer agents are
discussed. These complexes have been synthesized and characterized by (1H-NMR, mass, IR, UV-VIS,
ESR) spectra, magnetic moments and conductance measurements, elemental and thermal analyses. Molar
conductances in DMF solution indicates that, the complexes are non-electrolytes. The ESR spectra of solid
Cu(II) complexes (2-5) show an axial type indicating a d(X2-y2) ground state with a significant covalent
bond character. However, Mn(II) complex(9), shows an isotropic type indicating an octahedral geometry.
Cytotoxic evolution IC50 of the ligand and its complexes have been carried out. Cu(II) Complexes show
enhanced activity in comparison to the parent ligand or standard drug. Copper is enriched in various
human cancer tissues and is a co-factor essential for tumor angiogenesis processes. However, the use of
copper binding ligand to target tumor, copper could provide a novel strategy for cancer selective
treatment.
Design, Synthesis and Structural Inspection of Some Novel Di- And Tri-Azometh...CrimsonPublishersACSR
In this study, NBA imine compound was synthesized via an easy one-pot condensation of 3-nitro-benzaldyhide with 2-amino benzoic acid in 1:1 ratio and DAPH imine compound derived from 2,6-diacetyl pyridine and phenyl hydrazine hydrochloride. Consequences of the newly synthesized compounds
hooked up with the aid of FT-IR, elemental analyses, 13C-NMR ,1H-NMR and digital spectral research.
Experiments had been consistent with their chemical structures. Theoretical DFT calculations had been
implemented to confirm the molecular geometry of the investigated chemo-sensors. The sensor property
of all organized imines had been tested upon addition of the metal ions, consisting of Cr(III) ,Fe(II) ,Co(II) ,
Ni(II) ,Cu(II) ,Zn(II) ,Mn(II), VO(II) and Pd(II) .The interactions among receptors and ions are effortlessly
monitored with the aid of UV-visible spectroscopy. DAPH receptor confirmed color modification from
blood red to excessive deep green color to Co(II) ,a yellow color to Cu(II) and different colors to different
ions. Where the NBA receptor showed color modification from light yellow to excessive deep orange color
to Fe(II), pale orange to Pd(II) and different colors for other ions.
Synthesis and characterization of some Chromium(III) complexes of dibasic tri...IJERA Editor
Coordination complexes of Cr(III)with four tridentate Schiff base ligands viz. N-(2-hydroxy-1-naphthaldehyde)- -(4-nitrobenzoyl)hydrazone(HNNH = H2L 1 ), N-(2-hydroxy-4-methoxybenzaldehyde)- -(2-furoyl) hydrazone (HMFH = H2L 2 ), N-(2-hydroxyacetophenone)- -(2-theonyl) hydrazone (HATH = H2L 3 ) and N-(2- hydroxy-5-methylacetophenone)- -(3-toloyl) hydrazone (HMAT = H2L 4 ) have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, thermogravimetric analysis and spectral (IR, electronic, NMR) measurements. IR spectra indicates that the ligand behave as dibasic tridentate ligand in a chelate coordinating to Cr(III) ion through ketonic oxygen, azomethine nitrogen and by both enolic and phenolic protons (except in H2L 1 by naphtholic oxygen atom) via double deprotonation of ligands. The magnetic and spectral data indicate chelate in octahedral environment and analytical data suggest 1:1 stoichiometries for the complexes
Synthesis and Spectral Characterization of UO2(VI), Th(IV) and ZrO(IV) Complexes with benzimidazolyl-2-hydrazones of diacetyl monoxime and benzil monoxime
Ranjan Kumar Mohapatra1, Pradeep Kumar Das2
Synthesis and characterization of the mixed ligand complexesTaghreed Al-Noor
This paper presents the synthesis and study of some new mixed-ligands complexes
containing anthranilic acid and amino acid L-alanine (Ala) with some metals. The resulting
products were found to be solid crystalline complexes which have been characterized by using
(FT-IR,UV-Vis) spectra , melting point, molar conductivity , chloride ion content were also
determin by (mohr method) and determination the percentage of the metal in the complexes by
(AAS).The proposed structure of the complexes was suggested using program , Chem Office
3D(2004) .The general formula have been given for the prepared complexes :
[M(A)(Ala)]. nH2O n= 0,2
AH = Anthranilic acid = C7H7NO2 AlaH = alanine = C3H7NO2
Anthranilate ion = C7H6NO2- Ala- = Alanin ate ion = C3H6NO2-
M(II): Mn(II) ,Fe(II),Co(II) , Ni(II) , Cu(II) , Zn(II) and Cd
Spectral Studies of Some Transition Metal Ion complexes with 4-[(E)-(Ferrocen...IOSR Journals
Several new complexes of some transition metal ions with organometallic compounds were derived from ferrocencecarboxylaldehyde and 4-amino-2-hydroxy pyridine. These organometallic complexes were investigated by using some analytical techniques like infrared, mass spectra, electronic spectra, electron spin resonance, thermal analysis, magnetic moment, conductivity and antimicrobial activity. From the obtained elemental analysis data, organometallic compounds complexes shows 1:2 [M: L] ratio and general formula of the complex is [ML2.2H2O]. These complexes revealed a non-electrolytic nature. The magnetic moment values of the complexes exhibited the paramagnetic as well as diamagnetic in nature. The coordination behavior of the metal ions towards to the investigated organometallic compounds takes place through >C=N- and –OH groups. The electronic spectral data shows that all the complexes are covalent in nature, octahedral structure with co-ordination number six. Organometallic compound complexes were loses two water molecules subjected to simultaneous thermo gravimetric analysis, to study their decomposition mechanism and thermal stability. Mass spectra of the organometallic compound and their complexes are matched with theoretical values of the masses. The prepared organometallic compounds and their metal complexes were screened for their antibacterial activity against some bacterial species, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus Pyogones. The Antimicrobial activity data show the metal complexes to be more active than the parent organometallic compounds.
Synthesis, Physicochemical Characterization and Structure Determination of So...IOSR Journals
Some novel nickel(II) complexes with the ligand (z)-4-((2-hydroxy-3-
methoxyphenyl)diazenyl)-1,5-dimethyl-2-phenyl-1H-pyrazol-3-(2H)-one,GAAP,guiacolazoantipyrine, L
having molecular formulae [Ni(L)2X2] and [Ni(L)2(NCS)Cl] where X = Cl-, Br-, NO3
- were synthesized and
characterized. The elemental analysis, Spectral (IR, UV-Visible, EPR, FAB – mass) studies and thermo
gravimetric analysis reveals that the Ni(II) is six coordinated in its complexes. A rhombic symmetry can be
tentatively proposed for the complexes. The magnetic susceptibility measurements show that the complexes are
paramagnetic in nature. The powder XRD study shows its anisotropic nature
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Coordination modes of a new ligand derived from pyrazoline with cr(iii), mn(ii), co(ii), ni(ii), cu(ii) and zn(ii) metal ions; synthesis, identification and biological studies
1. Chemistry and Materials Research
ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online)
Vol.3 No.12, 2013
www.iiste.org
Coordination Modes of a New Ligand Derived from Pyrazoline
with Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) Metal Ions;
Synthesis, Identification and Biological Studies
Mahmoud Najim Al-Jibori; SinanMidhatAl-Bayatiand AnaamMajeedRasheed
Department of Chemistry, College of Science, Al-Mustansiriyah University
Corresponding author e-mail: mahmoudnajim71@yahoo.com,ss_senan@yahoo.com, and
anaam_m71@yahoo.com
Abstract
The solid complexes of Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with 2-[5-(2-hydroxy phenyl) 1,3,4oxadiazol-2yl]-5-methyl-2, 4 dihydro-3H-pyrazol-3-one] have been synthesized and characterized by elemental
analysis, molar conductance, magnetic susceptibility, UV-Visible spectroscopy. The FT-IR data suggest that the
ligand behaves as a neutral bidentate with NO donor atoms sequence towards central metal ion. The
microanalytical data reveals the stereochemistry of the complexes has been found to be 1:1(metal:ligand) except
that of Ni(II) complex which is formed in1:2 ratio. The physicochemical data suggest the octahedral geometry
for all complexes except for Ni(II) and Zn(II) complex which were square planner and tetrahedral respectively.
The ligand (L) and its metal complexes were screened for their antibacterial activity against E-coli and Bascillus
microorganisms andfungicidal activity againstAspergillusnigar and Candida albicans with respect to standard
antibiotic drugs tetracycline and Amphoteriain
Keywords: Pyrazol and Oxadiazol complexes.
1. Introduction
The coordination chemistry of transition metal complexes of heterocyclic compounds, involving oxadiazole,
thiadiazoel and pyrazole ligand have attracted much attention in recent years due to the fact that those ligands
around central metal ions in natural systems are unsymmetrical [1]ring closure reactions involvingoxadiazole
and pyrozoles derivatives have carried out through hydrazides condensation with carbon disulfide in acidic
medium[2-3]which are generally believed to show good models of biological systems [4]. The bidendate ligands
of pyrazolines derivatives have been extensively examinal due to their wide applications in various fields like
biological, analytical and therapeutical [5-6].Thus in this paper, we report the antifungal and antibacterial
activites of new metal complexes of Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with the ligand and its
metal complexes are characterized by physicochemical and spectra techniques.
2. Experimental
2.1. Materials and Physical Measurements:
All starting materials and solvents were purchased from Aldrich and Fluka companies and used without further
purification. Melting points of the prepared compounds were determined on electro-thermal capillary apparatus
and are uncorrected, elemental analysis (C.H.N) were carried out using a Perkin-Elmer model 2400 instrument,
FT-IRspectra were recorded on Shimadzu model FT-IR-8400S. 1H-NMR spectra were obtained with
Brukerspectrotometer model ultrashield at 300MHz in d6-DMSO solution with the TMS as internal standard.
2.2. Preparation of [2-(5-mercapto-1,3,4-oxadiazole-2yl phenol] (A2) compound:
The starting material [2-(5-mercapto-1,3,4-oxadiazole-2yl phenol] was prepared according to the method
published in literature [7], scheme 1.
1
2. Chemistry and Materials Research
ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online)
Vol.3 No.12, 2013
www.iiste.org
O
N
N
C
NHNH2
+
CS2
KOH
Reflux
SH
O
tr.
HCl
OH
OH
[A2]
[A2]
(B)
Scheme 1
0.388gm of [A2] compound in (10ml) of ethanol absolute was added to (2mmol, 0.136g) of hydrated hydrazine
(99% N2H4.H2O), and then the mixture was refluxed for about 6hrs. on hot plate, the crude yellow precipitate of
2-[5hydrazino-1,3,4-oxadiazole]phenol [B] was collected after pouring the mixture poured in ice-water
bath,filtered,washed with petroleum ether, dried in air and recrystallized from mixture of chloroform:
ethanol(5:10ml.) to give yellow purified crystal, scheme 2.
N
N
O
N
N
SH
99%
OH
NHNH2
O
+ N2H4.H2O
OH
[A2]
[B]
2.3. Preparation of Ligand 2-[5-(2-hydroxy phenyl) 1,3,4-oxadiazol-2-yl]-5-methyl-2,4-dihydro-3Hpyrazol-3one [L]:
(0.01m, 1.92g) of [B] compound in 10ml of ethanol absolute was gradually added to (0.01m, 1.30g) of ethyl
acetoe acetate in (5ml) of ethanol absolute and then the mixture was refluxed after stirring at room temperature
for 15 minutes,then it was concentrated by evaporation on water bath until crude yellow precipitate was formed,
filtered, washed several times with chloroformand acetone then dried in a desiccator overnight to afford 70%
yield, scheme 3.
O
O
N O
N
N
N
NHNH2
+ H3C
CH3
O
C CH2 C O C2H5
O
N
N
6-7 Hrs.
OH
OH
[L]
[B]
3. Results and Discussion
The physical properties of the prepared complexes were shwn in Table1.All the complexes were stable in air and
not hygroscopic, soluble in most common organic solvents like ethanol,acetonitrile,DMF and DMSO.The results
obtained from C.H.N elemental analyses were in agreement with the suggested formula of prepared complexes.
The measurements of molar conductance for metal complexes solutions in DMF solvent displayed values of
70,149 and 166 -1.cm2mol-1 for Cr(III),Ni(II) and Cu(II) complexes respectively supporting the electrolytic
behavior in 1:1 and 2:1 ratios[8],in contrast the Mn(II),Co(II) and Zn(II) complexes were neutral and recorded
molar conductance fall in the range 15-30 -1.cm2mol-1[10]
3.1.1H-NMR Spectra:
The spectral data for the free ligand in DMSO-d6 solution was reported along with the possible assignments in
experimental. All the protons areat their expected region. The Ar-H, NH and CH=N proton signals, are shown in
the regions of 6.36-7.9, 8.27 and 4.15 ppm, respectively,figure(1).
The weak signal at 11ppm could be assigned to the deshielded proton of phenolic -OH[11].The number of
protons calculated from integration curves and the recorded chemical shifts in figure 1. Reveal the proposed
structure of the formed new ligand [12].
3.2. G.C. Mass Spectra:
2
3. Chemistry and Materials Research
ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online)
Vol.3 No.12, 2013
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The gas chromatography-mass spectrum analysis is shown at figure(2), which provides vital information for
elucidating the structure of the ligand its purity through the separation column enclosing data of retention
relative to solvent (ethanol) used in preparation of standard solution.
The spectrum shows the molecular ion peak at m/e=258 and the isotopic peak in low abundance at m/e=259
(M+) due to C13 and N15 isotopes. The base peak at m/e=120 is due to the fragment intensity of these peak
reflects the stability and relative intersecting of the ion [13].
3.3. Infrared Spectra:
The disappearance of medium absorption at 3180cm-1 of [B] compound in the IR spectrum of free ligand
confirms the ring closure in the presence of new bands of C=O,-OH,C=N-,N-N and –OH groups that were
recognized in the structure of new ligand.
The IR spectrum of the ligand exhibits characteristic absorption at 1697cm-1for C=O, as well as the strong
absorption at 1166-1070cm-1 assigned to(N-N)mode of pyrazoline ring[14].As well as the broad band in the
region 3400-3500 cm-1 may be attributed to hydrogen bonded –OH groups [14]. The spectra of all complexes
show a broad absorptions in the regions(3600-3200)cm-1, attributable to O-H of the coordinated water molecules
beside the rocking of O-H of coordinated water molecules[13-15].The imine–C=N- stretching frequency of the
free ligand at1608cm-1 was undergone to downshift in all spectra of metal complexes in the regions(15001597)cm-1,this confirmed the participation of nitrogen atom of –C=N- of pyrazoline moiety in bonding with
central metal ions[14-15].As well as,the negative shift in absorption of –C=O groupgivesa considerable
investigation of coordination the metal ions through oxygen atom of carbony group in 2-position of pyrazoline
ring that was formed in keto form isomer rather enol form in solid metal complexes[16].Furthermore,the farinfra-red spectra of all complexes exhibited weak to medium bands in the regions (440-506)cm-1 and (406447)cm-1 to M-O and M-N bonds respectively [14].All the metal complexes except Ni(II)complex showed very
weak absorptions in the region(280-366)cm-1which may be attributed to M-Cl bonds,this support the
coordination of chloride ions to metal ions[16-17].
3.5. Electronic Spectra and Magnetic Susceptibility Measurements:
The free ligand solution in ethanol spectrosol (10-3M) concentration showed high intensity absorption in UV
regions definitely at (32679, 37174 and 46082) cm-1 which may be assigned to ligand field and intra-ligand
charge transfer transitions respectively, due to presence of chromospheres C=N, C=O of pyrazole and oxadiazole
moieties [18].
The electronic spectral data of the free ligand and their metal complexes with Cr(III), Mn(II), Co(II), Ni(II),
Cu(II) and Zn(II) ions complexes were recorded in ethanol as shown in Table 3.The chromium(III) complex
solution in absolute ethanol showed three weak bands in regions(14124, 16129 and 18181) cm-1, which are
assigned to 4A2g(F) 4T2g(F), 4A2g(F) 4T1g and 4A2g 4T1g(P) transitions, respectively that are constituent with
an octahedral geometry around Cr(III) ion[17-18].The off white complex of manganese(II) complex in ethanol
exhibited multiple weak bands at 18761 and 22222cm-1 that are assignable to 6A1g 4T2g and 6A1g 4A1g,Eg (G)
respectively, which associates with spin-forbidden transitions of high spin octahedral Mn(II) complex[19].
The cobalt(II) complex solution in ethanol displayed well resolved bands at 17550 and 20350 cm-1,that could be
assigned to 4T1g(F) 4T2g(F) and 4T1g(F) 4T1g(P) transitions respectively confirming the geometry of high
spin octahedral around Co(II) ion[20]The high intensity band at 29500cm-1 was assigned to the metal to ligand
charge transfer[21],this supports the high delocalization between C=O,C=-N- groups with cobalt(II)ion and this
could be refered to high covalency factor of Co-N and Co-O bonds in the formed complex[21]. The magnetic
moment of 4.05B.M for the solid Co(II) complex.The nickel(II) complex displayed two bands in the visible
region 25641 and 31347 cm-1, which are assigned to1A1g 1A2g and 1A1g 1B1g respectively and one band
referred to overlapping of d-d transition with L M C.T indicating the square planner environment around Ni(II)
complex [20].
The electronic spectrum of copper(II) complex in ethanol showed low energy weak band at 16950 cm-1 and a
high intensityone at 29630 cm-1. The first band in visible region typically is expected for 10Dq that are
corresponded to the Eg2 2T2g transition[22-23] .
3
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ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online)
Vol.3 No.12, 2013
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Moreover, the diamagnetic property (µ=0 B.M) of copper(II) complex may be considered as indicative of spinspin coupling for binuclear Cu(II)-Cu(II) through the molecular association[23].
The magnetic moment values for Cr(III), Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) complexes were shown in
Table 4.
The complexes of Cr(III), Mn(II) and Co(II) complexes have magnetic moments fall in the range (3.45, 5.5 and
4.05)B.M respectively,this indicate that these complexes are typically high spin complexes and are constituents
with expected values of d3,d5 and d7 octahedral complexes[24].
3.6. Biological Activity:
The ligand in DMSO and its metal complexes were screened for their antibacterial and fungal activities at the
same concentration and conditions similar to that of the tested complexes It is found obviously, Table 4 that
metal complexes especially Zn(II) are potentially active against A. flavus and C. albican. Also, it is found that
all complexes except for (L), Mn(II) and Cr(II) didn't show antibacterial activity in comparison with tetracycline
(32.5+0.2), while all other complexes show high activity towards G+ and G- antifungal strains in range of
(12.20+0.5) for greater range compared with Amphetamine B (standard). The improved activity of metal
complexes can be explained on the basis of chelation theory [25-26]. This theory explains that a decrease in the
polarizability of the metal could enhance the lipophilicity of the complexes, which leads to abreakdown of the
permeability of the cells, resulting in interference with normal cell processes [25-26].
This indicates that the chelation tends to make the ligand to act as more powerful and potent antimicrobial
agents, thus, inhibiting the growth of bacteria and fungi more than the parent ligand (L).
The data in table 4 indicate that Zn(II) complex displayed the highest antimicrobial activity against G+ and Gbacteria and fungi under study, this was investigated on increasing of Lipophilic layer of these complexes and
the chelation processes dominantly effects the biological behavior of the complexes that are potent against
microbial and fungal strains.
4. Biological Activity:
The In-vitro biological activity of the investigated free ligand and its metal complexes were tested against the
bacteria Escherichia coli and Staphylococcus aureus by disc diffusion method using nutrient agar as medium
and streptomycin as control. The antifungal activities of the compounds were also tested by the well diffusion
method against the fungi Aspergillusniger and Candida albicans, on potato dextrose agar as the medum and
miconazole as control. Each of the compounds was dissolved in DMSO and solutions of different concentrations
(25, 50 and 100) ppm were prepared separately. In a typical procedure, a well was made on agar medium
inoculated with microorganism. The well was filled with the test solution using a micropipette and the plate was
incubated 24 hrs. for bacteria at 37oC and 72 hrs. for fungi at 30oC. during this period, the test solution diffused
and the growth of the inoculated microorganism was affected the inhibition zone was developed, at which the
concentration was noted. All determinations were performed in triplicate.
The bacteria sub. Cultures, Staphylococcus aureus and Escherichia coli were used for antibacterial test,
whereas Aspergillusflavus and Candida albicans were used for antifungal test at the biology depentnat
laboratories at Al-Mustansiriyah University, College of Science, using the modified Kirby-Baver disc diffusion
method [8]. Briefly, 100 ml of the tested bacteria/ fungi were grown in 10 ml of freath media until they reached
105 cells ml-1 for bacteria and 102 cells ml-1 for fungi. 100 ml of microbial suspension was spread on the agar
plate corresponding to the broth in which they were maintained.
The inhibition zone was measured by the disc method[9], the diameters of the inhibition zone were measured in
millimeters. Standard disc of tetracycline (antibacterial agent) and Amphotericine is (antifungal agent) several as
tre controls for antimicrobial activity. However, the filter discs impregnated with 10 ml of (DMSO solvent +
D.W) were used as a negative (-ve) control. The used agar (Meuller-Hinton) was rigorously tested for
composition and pH.
% R.I = 100 (A-B) / (C-B)
Where A= area if inhibition sample plate.
B= area of inhibition in the DMSO (control).
C= area of inhibition in the standard plate.
4
5. Chemistry and Materials Research
ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online)
Vol.3 No.12, 2013
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The ligand was compared to the standard with respect to negative (-ve),positive(+ve) grams of bacteria and
fungi (two types of strands that were mentioned in Table2.
Conclusions
In the present work, a series of Cr(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with new ligand (L),
have been prepared and characterized on the basis of elemental analysis,molar conductivity in DMF,magnetic
susceptibility and FTIR and UV-Visible spectroscopy.All the complexes were octahedral geometries and are
formed in 1:1 ratio except for Ni(II) complex which were in2:1(L:M),respectively. All complexes have been
screened biologically against +ve and –ve Grams bacteria and fungi, it is found that most newly complexes
showed remarkable activity against the tested microorganisms in comparison with standard Tetracycline and
Amphertoriaine drugs.
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Universities Press, New Delhi.
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7. Chemistry and Materials Research
ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online)
Vol.3 No.12, 2013
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Table (2): Antibacterial Activity of Ligand and its Metal Complexes
Inhibition Escherichia coli
Staphy. aurea
Fungi
Compound
+
-
G
G
Asp.
Can.
15.9+0.3
20.5+0.1
18.3+0.1
16.0+0.1
[Cr(L)Cl2(H2O)2]Cl .EtOH
18.32+0.1
21.0+0.1
14.3+0.1
15.11+0.1
[Co(L)Cl2(H2O)2]
33.51+0.2
23.51+0.1
10.91+0.2
13.11+0.1
[Cu2(L)2Cl2(H2O)4]Cl2
35.22+0.11
21.11+0.2
17.51+0.3
10.9+0.1
[Mn(L)Cl2(H2O)2]
25.41+0.31
18.95+0.1
17.05+0.3
12.0+0.1
[Ni(L)2]Cl2
31.45+0.11
17.51+0.2
14.71+0.2
15.0+0.1
[Zn(L)Cl2]
35.91+0.25
22.17+0.1
20.11+0.1
18.99+0.1
L
Control DMSO= O
Antibacterial
Antifungal
Antibacterial reagent
+
-
+
-
G
+
G
30.11+0.25
-
-
-
Amphoteriaine
G
32.51+0.2
Tetracycline
G
-
19.89+0.2
20.5+0.1
-
G , G = Gram positive and negative of bacteria and Fungi.
Table (3): The Characteristic Stretching Vibration Frequencies (cm-1) Located at FT-IR of (L) and its
Metal Complexes
Compounds
C=O
C=N
N-N
M-N
M-O
M-Cl
1697 (s)
1608(s)
1070 (m)
3220
1653 (s)
350 (vw)
[Cr(L)Cl2(H2O)2]lCl.C2H5OH
1597(s)
1082 (m)
499 (w)
416 (m)
a
3440
833
1060 (s)
366 (vw)
[Mn(L)Cl2(H2O)2]
1500(s)
1072
492 (w)
420 (m)
3560
850a
1649 (s)
320 (vw)
[Co(L)Cl2(H2O)2]
1514(s)
1078 (m)
476(m)
435(w)
a
3600
844
1610 (s)
[Ni(C12H10N4O3)2]Cl2.2H2O
1598(s)
1080 (m)
494(m)
457(w)
3266
1608 (s)
280 (w)
[Cu2(C12H10N4O3)2Cl2(H2O)4]Cl2
1543 (s)
1074
506(m)
447(w)
a
3489
835
1650
[Zn(C12H10N4O3)Cl2]F
1535
1083
440(m)
445(w)
330
3590(br.)
Where : s=strong, m=medium, w=weak and vw= very weak and a=rocking of O-H for coordinated water
molecules.
L
7
8. Chemistry and Materials Research
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Vol.3 No.12, 2013
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Table(4): Electronic Spectra, molar conductance in (DMF) and magnetic moments (B.M) for (L) and its
metal complexes
Molar
Absorption
Cond.
eff.
1
Compound
UV-Vis.(cm- )
Geometry
-1
cm
B.M
1
2
-1
.cm mol
*
46082
L
37174
*
32679
C.T
[Cr(L)Cl2(H2O)2]Cl.EtOH
[Mn(L)Cl2(H2O)2]
[Co(L)Cl2(H2O)]
4
18761
22222
4
4
4
A2g
14124
16129
18181
T2g
A2g
4
A2g
A1g
T2g
4
T1g
4
T1g
4
5.5
Oh
15
4.05
Oh
166
0
S.P
149
0
Oh
30
0
Th
T2g
A2g
M L C.T
1
1
1
A1g
25641 31347
A1g
2
[Cu2(L)2Cl2(H2O)4]Cl2
20
4
1
[Ni(L)2]Cl2.2H2O
Oh
A1g, Eg(G)
4
17550
20350
29500
3.45
4
4
A1g
70
T1g (P)
6
6
T1g
4
B1g
B2g
Eg
Tg
B1g
16950
29630
2
2
2
A2g
L M C.T
[Zn(L)Cl2]
30550
L M C.T
L=C12H10N4O3 formula of the free ligand,Oh.=octahedral ,Th.=tetrahedral and s.p=square planner geometries.
8
10. Chemistry and Materials Research
ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online)
Vol.3 No.12, 2013
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Figure 2: GC-Mass Spectrum of Ligand (L)
HO
N O
N
O
O
CH3
N
CH3
N
N
N
N
N
OH
OH
(b)
(a)
Figure (3):Tautomerism structures of ligand
HO
Cl
Cl
H2O
M
OH2
O
N
O
CH3
N
N
N
H3C
N
N
N
x.y
O
N
O
Cl2.2H2O
Ni
O
OH
CH3
N
N
Where M= Cr(III), Mn(II) or Co(II)
x= Cl, y= C2H5OH for Cr(III)
N
N
O
OH
HO
Cl
Cl
Zn
O
N
O
N
N
N
H3C
N
O
H 2O
O
OH2
Cu
Cl
Cu
OH2
O
CH3
N
N
OH
Cl2
Cl
H 2O
CH3
N
N
N
N
O
OH
Figure(4)-stereochemical structures of metal complexes
10
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