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CONTROVERSIES
SURROUNDING
THE EFFICACY OF
FUNCTIONAL
APPLIANCES
www.indiandentalacademy.com
INTRODUCTION
A common strategy in the treatment of class II
malocclusion is frequently aimed at masking
the skeletal discrepancy or improving the
existing skeletal imbalances, arch form and
orofacial function using a variety of functional
appliances. But how effective are these
appliances in achieving the desired results &
what exactly happens at the specific sites…www.indiandentalacademy.com
DEFINITION
Loose removable appliances, designed to alter
the neuromuscular environment of the orofacial
region to improve occlusal development and
craniofacial skeletal growth
Loose fitting or passive app which harness
natural forces of the orofacial musculature that
are transmitted to the teeth & the alv bone
through the medium of the appliance.www.indiandentalacademy.com
CONCEPTS OF
FUNCTIONAL JAW
ORTHOPEDICS
www.indiandentalacademy.com
NORMAN W.KINGSLEY (1880)
Jumping the bite
Vulcanite anterior inclined bite plane
Brought the lower dentition forward
without proclining the lower incisors
Hawley bite plate, with ant inclined
plane – Retainer,For TMJ problemswww.indiandentalacademy.com
PIERRE ROBIN (1902)
Monoblock
To position the mandible forward in
pts with Pierre Robin syndrome
First appliance that influenced the
oral muscular activity
www.indiandentalacademy.com
VIGGO ANDRESEN (1908)
Followed Kinsgley’s concept & modified his
appliance –Used as a retainer after FA
Mobile loose fitting appliance with extended
lingual flanges (Myodynamic)
Construction bite
Biomechanic working retainerwww.indiandentalacademy.com
GROWTH GUIDANCE ???
To eliminate the adverse effects of abnormal
function
Lower lip trap
Hyperactive mentalis
Mouth breathingwww.indiandentalacademy.com
ANDRESEN + KARL HAUPL
Activator
Growth changes in TMJ & glenoid fossa
Permanent forward displacement of mandible
Stimulation of normal growth of the jaw
“Individual optimum”
www.indiandentalacademy.com
HERREN ACTIVATOR
Paul Herren’s concepts
Night time loose appliance didn’t work as
claimed
Acts as a splint which repositions the md
during sleep
Herren’s modifications
Over compensating the anterior position
Firmly seating the appliance against maxilla
(Myotonic)www.indiandentalacademy.com
Harvold-Woodside activator
Exceeded the postural rest position to keep the
appliance in place during night
Vertical opening – up to 15mm
Forward positioning – 3mm distal to most
protrusive position
Wider opening – Visco-elastic force
www.indiandentalacademy.com
BALTER’S CONCEPT(1960)
Bionator
Equilibrium b/w the tongue & circumoral
muscles is responsible for the shape of the
dental arches & intercuspation
The functional space of the tongue is essential
to the development of the orofacial system
Reduced bulk of the appliance
www.indiandentalacademy.com
FUNCTION REGULATOR OF
FRANKEL
Oral vestibule – operational basis
Relieves pressure from Buccinator
mechanism – widening of dental arch &
apical base
Myotonic device, becomes myodynamic
with muscular exerciseswww.indiandentalacademy.com
CONSTRUCTIO
N BITE
CONTROVERSI
ES
www.indiandentalacademy.com
Sagittal advancement
Vertical opening
Step by step/ Single step advancement
www.indiandentalacademy.com
SAGITTAL
ADVANCEMEN
T
www.indiandentalacademy.com
3- 6mm sagittal advancement
Severity of AP malrelationship &
Buccal segment interdigitation
www.indiandentalacademy.com
HERREN & SHAYE ACTIVATOR
Overcompensated anterior position
3 – 4mm beyond neutroclusion
2 – 4 mm vertical opening in incisor region
Arrowhead clasps to seat the appliance
against maxilla
Myotonic applianceswww.indiandentalacademy.com
VERTICAL
OPENING
www.indiandentalacademy.com
Andresen Activator
2mm opening- well within the
freeway space
Myotatic reflex activity & isometric
muscle contraction
Frankel & Bionator – Lip seal
www.indiandentalacademy.com
Selmer Olsen 1937,
Harvold 1946, 1974
Woodside 1973
Vertical opening – beyond rest position
- 10-15mm
Stretching of soft tissues, Viscoelastic
propertieswww.indiandentalacademy.com
Schmuth 1994
Witt 1981
Witt & Komposch 1979
4-6 mm below the intercuspal position
Long periods of continuous pressure
Isometric contraction/viscoelastic properties
www.indiandentalacademy.com
Step by step
or
Single step
advancement
www.indiandentalacademy.com
Step by step advancement
Recommended by Frankel
Minor sagittal problem (2-4mm)
Single step advancement
Major sagittal problem (6 mm)
Advancement of 3 mm each
Not more than 2.5 to 3 mmwww.indiandentalacademy.com
  Easy acceptance by the patient
  Less likelihood of dislodgement of the
appliance during both the day and night.
  More favorable mandibular response
  Decreased muscle strain or fatigue
  Less proclination of lower incisors
Advantages of staged advancement
www.indiandentalacademy.com
Neumann
•Tries to avoid stepwise advancement
recommended by Frankel.
•Advances the mandible the width of the
entire tooth,
•Exception - severe malocclusion in the vertical
vector as well as in the horizontal vector.
www.indiandentalacademy.com
PERIODIC FORWARD REPOSITIONING
Robert Shaye,JCO-1983
Construction bite- Full protrusive position
Reactivation after 3 months
Reduced muscular strain
Increased mandibular length
www.indiandentalacademy.com
Timing
of
treatment
www.indiandentalacademy.com
Arne Bjork, AJO-1951
Early treatment – Greater effect on the apical
base of the dentition
Deciduous dentition – Most effective
Mixed dentition – less effective
Permanent dentition – very limited effectwww.indiandentalacademy.com
Frankel
Late mixed or transitional dentition
period
Greatest adaptational change in soft &
hard tissues
www.indiandentalacademy.com
Pancherz & Hagg, AJO-1985
Favorable time -Peak of pubertal growth spurt
Increased condylar growth
Decreased dental effects
Early Rx - Unstable occlusion
- Extended retentionwww.indiandentalacademy.com
Demish - 1973
Compared the body height with
timing & duration of activator Rx
No interdependence b/w Rx effect &
pubertal growth spurt.
www.indiandentalacademy.com
Effects of
functional
appliances
www.indiandentalacademy.com
EFFECTS ON MAXILLARY
GROWTH
Hotz,AJO- 1970; Meach AJO-1966
Harvold & Vargervik, AJO 1971
Evald & Vargervik, AJO 1966
Freunthaller, AO 1967
McNamara, AJO-1973,1980,1982
Restriction of maxillary
growth
Head gear effectwww.indiandentalacademy.com
Jacobsson, AJO-1967,
Activator can cause a backward tilt
of the maxilla, as well as a restriction in
the normal downward and forward
growth of the maxilla
Frankel – No effect on maxillary growth
www.indiandentalacademy.com
Almeida et al, EJO-2004
No significant difference in maxillary
skeletal measurement
Mandibular size significantly increased
Major effects are dentoalveolar with a
smaller skeletal effect
(Bionator)
www.indiandentalacademy.com
EFFECTS ON MANDIBULAR
GROWTH
2 SCHOOLS OF THOUGHT
Increased
mandibular growth
Normal growth
www.indiandentalacademy.com
Arne Bjork et al AJO-1951
The mandibular growth that occur in the
course of the Rx lies within the range
of normal growth. The Rx results
achieved are mainly confined to
reshaping of the alveolar archeswww.indiandentalacademy.com
Creekmore & Radney, AJO-1983
Compared Frankel, Edgewise therapy &
untreated samples
• No significant difference in forward mand.
growth b/w class I, II & untreated samples
• Forward gr of maxilla was reduced in cl II FR
• Both Frankel samples moved the l/incisors
forward www.indiandentalacademy.com
No significant diff. in yearly growth
increments for mand. length, maxillary length,
maxillomandibular differential & lower facial
height
Retraction of u/incisors - 37%
Labial movement of l/incisors - 26%
Retraction of maxilla - 16%
Normal forward growth of mandible- 21%www.indiandentalacademy.com
Woodside, Harvold et al AJO-1983
Consistent change in bone shape & internal
structure are obtained when the alteration in
neuromuscular activity is continuous
Only Herbst appliance can produce continuous
force
Removable appliances produce only intermittent
force
There is no clinically useful amount of condylar
remodeling associated with func.app therapywww.indiandentalacademy.com
Harvold & Vargervik, AJO-1971
Selective & controlled influence on the buccal
segments
Normal forward development of the maxilla
was delayed
Growth in mand length was unaffected
(Activator)
www.indiandentalacademy.com
Kevin O’Brien et al, AJO-2003
Studied the effectiveness of early orthodontic
treatment with the twin block appliance
Substantial reduction of overjet was due
to dentoalveolar change, with a small
element of favorable skeletal change.
www.indiandentalacademy.com
www.indiandentalacademy.com
www.indiandentalacademy.com
Pancherz, AJO-1984
Equal dental & skeletal changes
Mandibular growth appeared not to be
affected by activator Rx
Threshold for adaptive remodeling process in
the condyle
(Activator)
www.indiandentalacademy.com
Paola Cozza et al,EJO-2004
Orthopedic retraction of maxilla
No significant increase in mandibular length
Anterior displacement of mandible
Anterior relocation of glenoid fossa (NSCo
angle)
(Activator)
www.indiandentalacademy.com
Studies by McNamara
Form function relationship – Functional
protrusion in Rhesus monkey
McNamara - AJO,1973
Elgoyhen et al – AJO,1972
McNamara-1972
McNamara-1976
McNamara- EJO,1980
McNamara - AJO,1981
McNamara - AJO,1982www.indiandentalacademy.com
Cast gold or ticonium onlays
To alter the mandibular postural position
Ant- 4 to 5 mm
Vertical- 2 to 3 mmwww.indiandentalacademy.com
ELECTROMYOGRAPHIC FINDINGS
Decrease in the activity of posterior
Temporalis
Increase in the activity of Masseter
Increase in the activity of Lateral pterygoid
muscle
Distinct change in muscle activity
www.indiandentalacademy.com
CEPHALOMETRIC FINDINGS
Implants were placed in maxilla, mandible,
frontal bone & cranial base regions
Mandibular changes – Growth of the condyle
increased in the following directions
Posterior condylar growth
Posterosuperior condylar growth
Superior condylar growthwww.indiandentalacademy.com
HISTOLOGIC FINDINGS
Significant adaptations could be seen along the
posterior & posterosuperior regions of the TMJ
(after 2weeks)
Increased deposition of new bone along the
posterior border of the ramus & anterior border
of the postglenoid spine
Greatest response – After 6 weeks
4 fold increase in the posterior thickness of
condylar cartilage www.indiandentalacademy.com
Adaptive response to functional
protrusion
www.indiandentalacademy.com
Studies by Petrovic & Stutzmann
Petrovic,Stutzmann-1972,1974,1975
Lateral pterygoid muscle apparently plays
a regulating role in the control of condylar
cartilage’s growth rate
Stutzmann-1972
Retrodiscal pad apparently has a mediator
role in the efforts of the LPM to control condylar
growth www.indiandentalacademy.com
Interaction b/w STH, Somatomedin,
Testosterone & LPM activity on the
condylar cartilage growth rate
www.indiandentalacademy.com
Primary cartilage Secondary cartilage
Diff.chondroblasts
Matrix secretion
Not influenced by local
factors
Subjected to general
extrinsic factors
Prechondroblasts
No matrix
Influenced by local
factors
Local extrinsic factors
www.indiandentalacademy.com
Nature of cells of secondary cartilage
Petrovic,Stutzmann-1976,1982
www.indiandentalacademy.com
Role of LPM & Retrodiscal pad
in condylar cartilage growth
www.indiandentalacademy.com
Inhibition of chondroblast differentiation
Interruption blood supply from LPM &
retrodiscal pad
Periodic forward repositioning
Best procedure for eliciting supplementary
lengthening of the mandible
www.indiandentalacademy.com
Christine Mills et al,AJO-1998
Slight inhibition of forward maxillary growth
Mandibular length increased by 6.5 mm in Rx
group ( 2.3 mm in control group)
Uprighting of u/incisors
Distalization of u/molars
Vertical movement of l/molars
(Twin block)
www.indiandentalacademy.com
Rabie et al, AJO-2001
Cellular changes in glenoid fossa &
amount of bone formation
Increased bone formation in the glenoid
fossa
Highest level of new bone formation-post
region of fossa
Orientation of mesenchymal cells in the
post. region in the direction of pull
www.indiandentalacademy.com
Rabie et al, AJO-2003
Expression of Sox 9, type II collagen
Sox 9 Transcription factor
Differentiation of mesenchymal cells to
chondrocytes
Type II collagen
Synthesized by chondrocytes
Forms the framework of cartilage matrixwww.indiandentalacademy.com
Growth Treatment
Sox 9 Day 9 Day 5
Type II
collagen
Day 11 Day 7
Functional appliance therapy accelerates condylar
growth by speeding up the entry & progression of cells
into the process of chondrogenesis
www.indiandentalacademy.com
Rabie et al, AJO-2003
Replicating mesenchymal cells in condyle &
glenoid fossa
During growth
Condyle – Posterior region
gl.fossa - Anterior region
During forward positioning
Condyle & fossa – Posterior regionwww.indiandentalacademy.com
Functional appliances are useful where
dysfunction has played a role in the etiology
of the malocclusion. Generally in functional
class II problems with posterior displacement
and functional deep overbite problems with
large interocclusal spaces, functional
appliances have good prognoses for successful
therapy.
Conclusion
www.indiandentalacademy.com
The possibility of growing the mandible with
the functional appliances still remains an
issue of controversy. Probably more
research clinically and at the molecular
level is necessary to conclude.
www.indiandentalacademy.com
www.indiandentalacademy.com
Colin Nelson,AJO-1993
Compared Frankel & Harvold activator
Two measurements
Ar-Pg – Increased in both groups
Co-Pg – No significant difference
Ar point
changes with condylar positionwww.indiandentalacademy.com

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Controversies surrounding the efficacy of functional appliance

  • 2. INTRODUCTION A common strategy in the treatment of class II malocclusion is frequently aimed at masking the skeletal discrepancy or improving the existing skeletal imbalances, arch form and orofacial function using a variety of functional appliances. But how effective are these appliances in achieving the desired results & what exactly happens at the specific sites…www.indiandentalacademy.com
  • 3. DEFINITION Loose removable appliances, designed to alter the neuromuscular environment of the orofacial region to improve occlusal development and craniofacial skeletal growth Loose fitting or passive app which harness natural forces of the orofacial musculature that are transmitted to the teeth & the alv bone through the medium of the appliance.www.indiandentalacademy.com
  • 5. NORMAN W.KINGSLEY (1880) Jumping the bite Vulcanite anterior inclined bite plane Brought the lower dentition forward without proclining the lower incisors Hawley bite plate, with ant inclined plane – Retainer,For TMJ problemswww.indiandentalacademy.com
  • 6. PIERRE ROBIN (1902) Monoblock To position the mandible forward in pts with Pierre Robin syndrome First appliance that influenced the oral muscular activity www.indiandentalacademy.com
  • 7. VIGGO ANDRESEN (1908) Followed Kinsgley’s concept & modified his appliance –Used as a retainer after FA Mobile loose fitting appliance with extended lingual flanges (Myodynamic) Construction bite Biomechanic working retainerwww.indiandentalacademy.com
  • 8. GROWTH GUIDANCE ??? To eliminate the adverse effects of abnormal function Lower lip trap Hyperactive mentalis Mouth breathingwww.indiandentalacademy.com
  • 9. ANDRESEN + KARL HAUPL Activator Growth changes in TMJ & glenoid fossa Permanent forward displacement of mandible Stimulation of normal growth of the jaw “Individual optimum” www.indiandentalacademy.com
  • 10. HERREN ACTIVATOR Paul Herren’s concepts Night time loose appliance didn’t work as claimed Acts as a splint which repositions the md during sleep Herren’s modifications Over compensating the anterior position Firmly seating the appliance against maxilla (Myotonic)www.indiandentalacademy.com
  • 11. Harvold-Woodside activator Exceeded the postural rest position to keep the appliance in place during night Vertical opening – up to 15mm Forward positioning – 3mm distal to most protrusive position Wider opening – Visco-elastic force www.indiandentalacademy.com
  • 12. BALTER’S CONCEPT(1960) Bionator Equilibrium b/w the tongue & circumoral muscles is responsible for the shape of the dental arches & intercuspation The functional space of the tongue is essential to the development of the orofacial system Reduced bulk of the appliance www.indiandentalacademy.com
  • 13. FUNCTION REGULATOR OF FRANKEL Oral vestibule – operational basis Relieves pressure from Buccinator mechanism – widening of dental arch & apical base Myotonic device, becomes myodynamic with muscular exerciseswww.indiandentalacademy.com
  • 15. Sagittal advancement Vertical opening Step by step/ Single step advancement www.indiandentalacademy.com
  • 17. 3- 6mm sagittal advancement Severity of AP malrelationship & Buccal segment interdigitation www.indiandentalacademy.com
  • 18. HERREN & SHAYE ACTIVATOR Overcompensated anterior position 3 – 4mm beyond neutroclusion 2 – 4 mm vertical opening in incisor region Arrowhead clasps to seat the appliance against maxilla Myotonic applianceswww.indiandentalacademy.com
  • 20. Andresen Activator 2mm opening- well within the freeway space Myotatic reflex activity & isometric muscle contraction Frankel & Bionator – Lip seal www.indiandentalacademy.com
  • 21. Selmer Olsen 1937, Harvold 1946, 1974 Woodside 1973 Vertical opening – beyond rest position - 10-15mm Stretching of soft tissues, Viscoelastic propertieswww.indiandentalacademy.com
  • 22. Schmuth 1994 Witt 1981 Witt & Komposch 1979 4-6 mm below the intercuspal position Long periods of continuous pressure Isometric contraction/viscoelastic properties www.indiandentalacademy.com
  • 23. Step by step or Single step advancement www.indiandentalacademy.com
  • 24. Step by step advancement Recommended by Frankel Minor sagittal problem (2-4mm) Single step advancement Major sagittal problem (6 mm) Advancement of 3 mm each Not more than 2.5 to 3 mmwww.indiandentalacademy.com
  • 25.   Easy acceptance by the patient   Less likelihood of dislodgement of the appliance during both the day and night.   More favorable mandibular response   Decreased muscle strain or fatigue   Less proclination of lower incisors Advantages of staged advancement www.indiandentalacademy.com
  • 26. Neumann •Tries to avoid stepwise advancement recommended by Frankel. •Advances the mandible the width of the entire tooth, •Exception - severe malocclusion in the vertical vector as well as in the horizontal vector. www.indiandentalacademy.com
  • 27. PERIODIC FORWARD REPOSITIONING Robert Shaye,JCO-1983 Construction bite- Full protrusive position Reactivation after 3 months Reduced muscular strain Increased mandibular length www.indiandentalacademy.com
  • 29. Arne Bjork, AJO-1951 Early treatment – Greater effect on the apical base of the dentition Deciduous dentition – Most effective Mixed dentition – less effective Permanent dentition – very limited effectwww.indiandentalacademy.com
  • 30. Frankel Late mixed or transitional dentition period Greatest adaptational change in soft & hard tissues www.indiandentalacademy.com
  • 31. Pancherz & Hagg, AJO-1985 Favorable time -Peak of pubertal growth spurt Increased condylar growth Decreased dental effects Early Rx - Unstable occlusion - Extended retentionwww.indiandentalacademy.com
  • 32. Demish - 1973 Compared the body height with timing & duration of activator Rx No interdependence b/w Rx effect & pubertal growth spurt. www.indiandentalacademy.com
  • 34. EFFECTS ON MAXILLARY GROWTH Hotz,AJO- 1970; Meach AJO-1966 Harvold & Vargervik, AJO 1971 Evald & Vargervik, AJO 1966 Freunthaller, AO 1967 McNamara, AJO-1973,1980,1982 Restriction of maxillary growth Head gear effectwww.indiandentalacademy.com
  • 35. Jacobsson, AJO-1967, Activator can cause a backward tilt of the maxilla, as well as a restriction in the normal downward and forward growth of the maxilla Frankel – No effect on maxillary growth www.indiandentalacademy.com
  • 36. Almeida et al, EJO-2004 No significant difference in maxillary skeletal measurement Mandibular size significantly increased Major effects are dentoalveolar with a smaller skeletal effect (Bionator) www.indiandentalacademy.com
  • 37. EFFECTS ON MANDIBULAR GROWTH 2 SCHOOLS OF THOUGHT Increased mandibular growth Normal growth www.indiandentalacademy.com
  • 38. Arne Bjork et al AJO-1951 The mandibular growth that occur in the course of the Rx lies within the range of normal growth. The Rx results achieved are mainly confined to reshaping of the alveolar archeswww.indiandentalacademy.com
  • 39. Creekmore & Radney, AJO-1983 Compared Frankel, Edgewise therapy & untreated samples • No significant difference in forward mand. growth b/w class I, II & untreated samples • Forward gr of maxilla was reduced in cl II FR • Both Frankel samples moved the l/incisors forward www.indiandentalacademy.com
  • 40. No significant diff. in yearly growth increments for mand. length, maxillary length, maxillomandibular differential & lower facial height Retraction of u/incisors - 37% Labial movement of l/incisors - 26% Retraction of maxilla - 16% Normal forward growth of mandible- 21%www.indiandentalacademy.com
  • 41. Woodside, Harvold et al AJO-1983 Consistent change in bone shape & internal structure are obtained when the alteration in neuromuscular activity is continuous Only Herbst appliance can produce continuous force Removable appliances produce only intermittent force There is no clinically useful amount of condylar remodeling associated with func.app therapywww.indiandentalacademy.com
  • 42. Harvold & Vargervik, AJO-1971 Selective & controlled influence on the buccal segments Normal forward development of the maxilla was delayed Growth in mand length was unaffected (Activator) www.indiandentalacademy.com
  • 43. Kevin O’Brien et al, AJO-2003 Studied the effectiveness of early orthodontic treatment with the twin block appliance Substantial reduction of overjet was due to dentoalveolar change, with a small element of favorable skeletal change. www.indiandentalacademy.com
  • 46. Pancherz, AJO-1984 Equal dental & skeletal changes Mandibular growth appeared not to be affected by activator Rx Threshold for adaptive remodeling process in the condyle (Activator) www.indiandentalacademy.com
  • 47. Paola Cozza et al,EJO-2004 Orthopedic retraction of maxilla No significant increase in mandibular length Anterior displacement of mandible Anterior relocation of glenoid fossa (NSCo angle) (Activator) www.indiandentalacademy.com
  • 48. Studies by McNamara Form function relationship – Functional protrusion in Rhesus monkey McNamara - AJO,1973 Elgoyhen et al – AJO,1972 McNamara-1972 McNamara-1976 McNamara- EJO,1980 McNamara - AJO,1981 McNamara - AJO,1982www.indiandentalacademy.com
  • 49. Cast gold or ticonium onlays To alter the mandibular postural position Ant- 4 to 5 mm Vertical- 2 to 3 mmwww.indiandentalacademy.com
  • 50. ELECTROMYOGRAPHIC FINDINGS Decrease in the activity of posterior Temporalis Increase in the activity of Masseter Increase in the activity of Lateral pterygoid muscle Distinct change in muscle activity www.indiandentalacademy.com
  • 51. CEPHALOMETRIC FINDINGS Implants were placed in maxilla, mandible, frontal bone & cranial base regions Mandibular changes – Growth of the condyle increased in the following directions Posterior condylar growth Posterosuperior condylar growth Superior condylar growthwww.indiandentalacademy.com
  • 52. HISTOLOGIC FINDINGS Significant adaptations could be seen along the posterior & posterosuperior regions of the TMJ (after 2weeks) Increased deposition of new bone along the posterior border of the ramus & anterior border of the postglenoid spine Greatest response – After 6 weeks 4 fold increase in the posterior thickness of condylar cartilage www.indiandentalacademy.com
  • 53. Adaptive response to functional protrusion www.indiandentalacademy.com
  • 54. Studies by Petrovic & Stutzmann Petrovic,Stutzmann-1972,1974,1975 Lateral pterygoid muscle apparently plays a regulating role in the control of condylar cartilage’s growth rate Stutzmann-1972 Retrodiscal pad apparently has a mediator role in the efforts of the LPM to control condylar growth www.indiandentalacademy.com
  • 55. Interaction b/w STH, Somatomedin, Testosterone & LPM activity on the condylar cartilage growth rate www.indiandentalacademy.com
  • 56. Primary cartilage Secondary cartilage Diff.chondroblasts Matrix secretion Not influenced by local factors Subjected to general extrinsic factors Prechondroblasts No matrix Influenced by local factors Local extrinsic factors www.indiandentalacademy.com
  • 57. Nature of cells of secondary cartilage Petrovic,Stutzmann-1976,1982 www.indiandentalacademy.com
  • 58. Role of LPM & Retrodiscal pad in condylar cartilage growth www.indiandentalacademy.com
  • 59. Inhibition of chondroblast differentiation Interruption blood supply from LPM & retrodiscal pad Periodic forward repositioning Best procedure for eliciting supplementary lengthening of the mandible www.indiandentalacademy.com
  • 60. Christine Mills et al,AJO-1998 Slight inhibition of forward maxillary growth Mandibular length increased by 6.5 mm in Rx group ( 2.3 mm in control group) Uprighting of u/incisors Distalization of u/molars Vertical movement of l/molars (Twin block) www.indiandentalacademy.com
  • 61. Rabie et al, AJO-2001 Cellular changes in glenoid fossa & amount of bone formation Increased bone formation in the glenoid fossa Highest level of new bone formation-post region of fossa Orientation of mesenchymal cells in the post. region in the direction of pull www.indiandentalacademy.com
  • 62. Rabie et al, AJO-2003 Expression of Sox 9, type II collagen Sox 9 Transcription factor Differentiation of mesenchymal cells to chondrocytes Type II collagen Synthesized by chondrocytes Forms the framework of cartilage matrixwww.indiandentalacademy.com
  • 63. Growth Treatment Sox 9 Day 9 Day 5 Type II collagen Day 11 Day 7 Functional appliance therapy accelerates condylar growth by speeding up the entry & progression of cells into the process of chondrogenesis www.indiandentalacademy.com
  • 64. Rabie et al, AJO-2003 Replicating mesenchymal cells in condyle & glenoid fossa During growth Condyle – Posterior region gl.fossa - Anterior region During forward positioning Condyle & fossa – Posterior regionwww.indiandentalacademy.com
  • 65. Functional appliances are useful where dysfunction has played a role in the etiology of the malocclusion. Generally in functional class II problems with posterior displacement and functional deep overbite problems with large interocclusal spaces, functional appliances have good prognoses for successful therapy. Conclusion www.indiandentalacademy.com
  • 66. The possibility of growing the mandible with the functional appliances still remains an issue of controversy. Probably more research clinically and at the molecular level is necessary to conclude. www.indiandentalacademy.com
  • 68. Colin Nelson,AJO-1993 Compared Frankel & Harvold activator Two measurements Ar-Pg – Increased in both groups Co-Pg – No significant difference Ar point changes with condylar positionwww.indiandentalacademy.com