This document discusses using atomic layer deposition to apply conformal optical coatings to complex 3D structures. Traditional optical coating methods have limitations in achieving conformality. The author details experiments applying tantalum pentoxide coatings to hemispherical domes using an ALD system. Thickness measurements show uniformity of less than 2% across the domes. Additional examples apply antireflective coatings and summarize results for 13 coating processes. The document promotes further discussion at a poster and booth during a conference.
Battery Show Europe 2022
Presented by D.Sc. Andrew Cook
ALD is an enabling technology for future batteries. ALD technology introduction has been hindered by lack of production scale equipment, but now Beneq R2R ALD technology offers a straightforward scale-up path to mass-production. Beneq has a long experience with R2R ALD on other application areas, and is now applying that know-how to offer R2R ALD solutions for battery manufacturing.
Er-doped hybrid waveguide amplifiers with multiple spatially engineered activ...Beneq
SPIE Photonics Europe 2022
Presented by D.Sc. John Rönn
Contributions by: John-Olof
Rönn, Kalle Niiranen, Mikael Saarniheimo, Sami Sneck, Beneq Oy (Finland);
Zhipei Sun, Aalto Univ. (Finland)
[12148-3]
ALD is the best alternative to traditional coating methods, like PVD, providing incomparable conformality on all length scales from waveguides and photonic devices to astronomical mirrors.
Roll-to-Roll ALD Coatings for Battery Cell Interfaces at Production ScaleBeneq
ALD/AVS 2022
Presented by D.Sc. Andrew Cook
ALD is an enabling technology for future batteries. ALD technology introduction has been hindered by lack of production scale equipment, but now Beneq R2R ALD technology offers a straightforward scale-up path to mass-production. Beneq has a long experience with R2R ALD on other application areas, and is now applying that know-how to offer R2R ALD solutions for battery manufacturing.
Different Generation Solar Cells
CIGS and CZTS Based Technology
Ink Based Technology
CIGS Device Structure
Making more efficient solar cells
Developing thin film technologies using alternative less costly materials and methods
Incorporate innovative cheaper deposition methods such as electrodeposition and printing technology
ALD for energy application - Lithium ion battery and fuel cellsLaurent Lecordier
This presentation offers a review of latest works done on Ultratech Cambridge Nanotech ALD tools related to atomic layer deposition of Li2O and other lithium-based thin films for lithium-ion battery applications. It illustrates the benefits of ALD for deposition in 3D nanostructure.
Battery Show Europe 2022
Presented by D.Sc. Andrew Cook
ALD is an enabling technology for future batteries. ALD technology introduction has been hindered by lack of production scale equipment, but now Beneq R2R ALD technology offers a straightforward scale-up path to mass-production. Beneq has a long experience with R2R ALD on other application areas, and is now applying that know-how to offer R2R ALD solutions for battery manufacturing.
Er-doped hybrid waveguide amplifiers with multiple spatially engineered activ...Beneq
SPIE Photonics Europe 2022
Presented by D.Sc. John Rönn
Contributions by: John-Olof
Rönn, Kalle Niiranen, Mikael Saarniheimo, Sami Sneck, Beneq Oy (Finland);
Zhipei Sun, Aalto Univ. (Finland)
[12148-3]
ALD is the best alternative to traditional coating methods, like PVD, providing incomparable conformality on all length scales from waveguides and photonic devices to astronomical mirrors.
Roll-to-Roll ALD Coatings for Battery Cell Interfaces at Production ScaleBeneq
ALD/AVS 2022
Presented by D.Sc. Andrew Cook
ALD is an enabling technology for future batteries. ALD technology introduction has been hindered by lack of production scale equipment, but now Beneq R2R ALD technology offers a straightforward scale-up path to mass-production. Beneq has a long experience with R2R ALD on other application areas, and is now applying that know-how to offer R2R ALD solutions for battery manufacturing.
Different Generation Solar Cells
CIGS and CZTS Based Technology
Ink Based Technology
CIGS Device Structure
Making more efficient solar cells
Developing thin film technologies using alternative less costly materials and methods
Incorporate innovative cheaper deposition methods such as electrodeposition and printing technology
ALD for energy application - Lithium ion battery and fuel cellsLaurent Lecordier
This presentation offers a review of latest works done on Ultratech Cambridge Nanotech ALD tools related to atomic layer deposition of Li2O and other lithium-based thin films for lithium-ion battery applications. It illustrates the benefits of ALD for deposition in 3D nanostructure.
Progress in all inorganic perovskite solar cellMd Ataul Mamun
Since their first introduction in the research arena, the hybrid organic-inorganic perovskite photovoltaic cells have been showing frequent record breaking power conversion efficiencies (PCEs). Despite the rapid increase in PCE by engaging new perovskite materials as active layers as well as new fabrication techniques, their stability remains too poor to go for a mass production. Mainly the organic materials in the hybrid PSCs are responsible for this instability. Consequently, very recently, different approaches are taken to replace these organic components by inorganic ones to fabricate all-inorganic PSCs. Though these first-generation all-inorganic PSCs are yet to produce competitive PCEs like their counterparts, they have already demonstrated superb stability to be a propitious bidder for solar cell energy yielding. The state-of-the-art quantum dots based cells shown efficiency as high as 10.77% and intact stability for months.
CIGS solar cells are one of the leading thin film solar cells to be made commercially viable. There are a lot of ways in manufacturing it and we have specialized a two stage process which gives advantages over material growth during commercial manufacture. An advancement of the two stage process is done to increase the throughput and maximize profits. A lab scale emulation of the commercial process is done to study device performance as a result of the advanced process. Factors such as reproducibility and elemental optimization were a concern and the reason behind these concerns were researched. This thesis serves as an experimental test bed to study device performance before up-scaling the growth recipe for pilot production.
Atomic Layer Deposition solutions for SiC Power ElectronicsBeneq
Power Electronics International
Brussels, Belgium
19.04.2023
Atomic Layer Deposition solutions for SiC Power Electronics
Integrated ALD passivation/gate dielectric stack for SiC MOSFET
Presented by Mikko Söderlund from Beneq Oy
This presentation summarizes history and recent development of perovskite solar cells. If you have any questions or comments, you can reach me at agassifeng@gmail.com
Power GaN 2018: Epitaxy, Devices, Applications and Technology Trends report b...Yole Developpement
GaN market growth is fed by Lidar, wireless charging and fast charging solutions.
More information on : https://www.i-micronews.com/category-listing/product/power-gan-2018-epitaxy-devices-applications-and-technology-trends.html
Slides of invited "ALD 101" tutorial by Puurunen at ALD 2021 Riikka Puurunen
(INVITED) Fundamentals of atomic layer deposition: an introduction (“ALD 101”)
Riikka L. Puurunen, Aalto University School of Chemical Engineering, Department of Chemical and Metallurgical Engineering, AVS 21st International Conference on Atomic Layer Deposition (ALD 2021), Virtual Meeting 27.6.-30.6.2021. Tutorial Session 27.6.2021
ABSTRACT: Atomic layer deposition (ALD) has become of global importance as a processing technology for example in semiconductor device fabrication, and its application areas are continuously expanding. The significance of ALD was highlighted e.g. by the recent (2018) Millennium Technology Prize. Tens of companies are offering ALD tools, and thousands of people are involved in ALD R&D globally. A continuous need exists to educate new people on the fundamentals of ALD.
While ALD for manufacturing may be regarded mature, as a scientific field, ALD—in the author’s view—is developing. For example, understanding of the early history of ALD is evolving, related to the two independent inventions of ALD under the names Atomic Layer Epitaxy in the 1970s and Molecular Layering in the 1960s [1-4]. Also, significantly varying views exist in the field related to the description and meaningfulness of even some core ALD concepts [5].
The purpose of this invited “ALD 101” tutorial is to familiarize a newcomer with fundamentals of ALD. The presentation largely follows the organization of a recent encyclopedia chapter on ALD [6]. Surface chemistry concepts will be introduced, such as ideal ALD from repeated, separate self-terminating (saturating and irreversible) reactions; growth per cycle in ALD; various monolayer concepts relevant to ALD; typical classes of surface reaction mechanisms and saturation-determining factors; growth modes; and ways to describe growth kinetics. Concepts, where differing views exist in the field and which thus need special attention, are pointed out. Typical deviations from the presented ideality are discussed.
For continuous education, a collaborative OpenLearning website on ALD is under construction [7]. Many of the images used in this tutorial—and in Refs. 6 and 7—are available in Wikimedia Commons [8] for easy and free reuse. To contribute to collective learning of the early history of ALD, the open-science effort Virtual Project on the History of ALD [4] still welcomes new volunteer participants.
[1] E. Ahvenniemi et al., J. Vac. Sci. Technol. A 35 (2017) 010801 (2017).[2] R.L. Puurunen, ECS Transactions 86 (6) (2018) 3-17; OA: DOI:10.1149/osf.io/exyv3[3] G.N. Parsons et al., J. Vac. Sci. Technol. A 38 (2020) 037001.[4] http://vph-ald.com[5] J.R. van Ommen, R.L. Puurunen, ALD 2020, https://youtu.be/jqm_wf49WwM[6] J.R. van Ommen, A. Goulas, R.L. Puurunen, Kirk-Othmer Encyclopedia on Chemical Technology, submitted. [7] http://openlearning.aalto.fi, ALD [8] https://commons.wikimedia.org/wiki/Category:Atomic_layer_deposition
Power Module Packaging 2018: Material Market and Technology Trends report by ...Yole Developpement
Power packaging is continuously adapting to power application market trends.
More information on that report at : https://www.i-micronews.com/category-listing/product/power-module-packaging-2018-material-market-and-technology-trends.html
The Battery Show Japan Showcase Presentation.pdfBeneq
Battery Japan 2023
September 13-15, 2023
Atomic Layer Deposition and some of the aspects around using R2R ALD Coatings for Battery Cell Interfaces.
Presented by Dr. Andrew Cook from Beneq Oy
Progress in all inorganic perovskite solar cellMd Ataul Mamun
Since their first introduction in the research arena, the hybrid organic-inorganic perovskite photovoltaic cells have been showing frequent record breaking power conversion efficiencies (PCEs). Despite the rapid increase in PCE by engaging new perovskite materials as active layers as well as new fabrication techniques, their stability remains too poor to go for a mass production. Mainly the organic materials in the hybrid PSCs are responsible for this instability. Consequently, very recently, different approaches are taken to replace these organic components by inorganic ones to fabricate all-inorganic PSCs. Though these first-generation all-inorganic PSCs are yet to produce competitive PCEs like their counterparts, they have already demonstrated superb stability to be a propitious bidder for solar cell energy yielding. The state-of-the-art quantum dots based cells shown efficiency as high as 10.77% and intact stability for months.
CIGS solar cells are one of the leading thin film solar cells to be made commercially viable. There are a lot of ways in manufacturing it and we have specialized a two stage process which gives advantages over material growth during commercial manufacture. An advancement of the two stage process is done to increase the throughput and maximize profits. A lab scale emulation of the commercial process is done to study device performance as a result of the advanced process. Factors such as reproducibility and elemental optimization were a concern and the reason behind these concerns were researched. This thesis serves as an experimental test bed to study device performance before up-scaling the growth recipe for pilot production.
Atomic Layer Deposition solutions for SiC Power ElectronicsBeneq
Power Electronics International
Brussels, Belgium
19.04.2023
Atomic Layer Deposition solutions for SiC Power Electronics
Integrated ALD passivation/gate dielectric stack for SiC MOSFET
Presented by Mikko Söderlund from Beneq Oy
This presentation summarizes history and recent development of perovskite solar cells. If you have any questions or comments, you can reach me at agassifeng@gmail.com
Power GaN 2018: Epitaxy, Devices, Applications and Technology Trends report b...Yole Developpement
GaN market growth is fed by Lidar, wireless charging and fast charging solutions.
More information on : https://www.i-micronews.com/category-listing/product/power-gan-2018-epitaxy-devices-applications-and-technology-trends.html
Slides of invited "ALD 101" tutorial by Puurunen at ALD 2021 Riikka Puurunen
(INVITED) Fundamentals of atomic layer deposition: an introduction (“ALD 101”)
Riikka L. Puurunen, Aalto University School of Chemical Engineering, Department of Chemical and Metallurgical Engineering, AVS 21st International Conference on Atomic Layer Deposition (ALD 2021), Virtual Meeting 27.6.-30.6.2021. Tutorial Session 27.6.2021
ABSTRACT: Atomic layer deposition (ALD) has become of global importance as a processing technology for example in semiconductor device fabrication, and its application areas are continuously expanding. The significance of ALD was highlighted e.g. by the recent (2018) Millennium Technology Prize. Tens of companies are offering ALD tools, and thousands of people are involved in ALD R&D globally. A continuous need exists to educate new people on the fundamentals of ALD.
While ALD for manufacturing may be regarded mature, as a scientific field, ALD—in the author’s view—is developing. For example, understanding of the early history of ALD is evolving, related to the two independent inventions of ALD under the names Atomic Layer Epitaxy in the 1970s and Molecular Layering in the 1960s [1-4]. Also, significantly varying views exist in the field related to the description and meaningfulness of even some core ALD concepts [5].
The purpose of this invited “ALD 101” tutorial is to familiarize a newcomer with fundamentals of ALD. The presentation largely follows the organization of a recent encyclopedia chapter on ALD [6]. Surface chemistry concepts will be introduced, such as ideal ALD from repeated, separate self-terminating (saturating and irreversible) reactions; growth per cycle in ALD; various monolayer concepts relevant to ALD; typical classes of surface reaction mechanisms and saturation-determining factors; growth modes; and ways to describe growth kinetics. Concepts, where differing views exist in the field and which thus need special attention, are pointed out. Typical deviations from the presented ideality are discussed.
For continuous education, a collaborative OpenLearning website on ALD is under construction [7]. Many of the images used in this tutorial—and in Refs. 6 and 7—are available in Wikimedia Commons [8] for easy and free reuse. To contribute to collective learning of the early history of ALD, the open-science effort Virtual Project on the History of ALD [4] still welcomes new volunteer participants.
[1] E. Ahvenniemi et al., J. Vac. Sci. Technol. A 35 (2017) 010801 (2017).[2] R.L. Puurunen, ECS Transactions 86 (6) (2018) 3-17; OA: DOI:10.1149/osf.io/exyv3[3] G.N. Parsons et al., J. Vac. Sci. Technol. A 38 (2020) 037001.[4] http://vph-ald.com[5] J.R. van Ommen, R.L. Puurunen, ALD 2020, https://youtu.be/jqm_wf49WwM[6] J.R. van Ommen, A. Goulas, R.L. Puurunen, Kirk-Othmer Encyclopedia on Chemical Technology, submitted. [7] http://openlearning.aalto.fi, ALD [8] https://commons.wikimedia.org/wiki/Category:Atomic_layer_deposition
Power Module Packaging 2018: Material Market and Technology Trends report by ...Yole Developpement
Power packaging is continuously adapting to power application market trends.
More information on that report at : https://www.i-micronews.com/category-listing/product/power-module-packaging-2018-material-market-and-technology-trends.html
The Battery Show Japan Showcase Presentation.pdfBeneq
Battery Japan 2023
September 13-15, 2023
Atomic Layer Deposition and some of the aspects around using R2R ALD Coatings for Battery Cell Interfaces.
Presented by Dr. Andrew Cook from Beneq Oy
Use of UV curable adhesives for precision placement of micro-opticsguest83eea
This presentation discusses work done at the Microelectronics Group of Lucent/Agere Systems. It focuses on the problems we overcame to qualify a dimensionally stable adhesive for high volume manufacturing.
CIGS Solar Cells: How and Why is their Cost Falling?Jeffrey Funk
My master's students use concepts from my (Jeff Funk) forthcoming book (Technology Change and the Rise of New Industries) to analyze the economic feasibility of CIGS (Cadmium Indium Gallium Selenide) Solar Cells. Improvements in efficiencies and reductions in cost per area (through new processes and increasing the substrate size) are causing steady reductions in the cost of electricity from them. See my other slides for details on concepts, methodology, and other new industries..
Rotary PEALD: in-situ monitoring of optical coatingsBeneq
SALD Day, Eindhoven, Netherlands
09.06.2022
Rotary PEALD: in-situ monitoring of optical coatings. Presented jointly by Beneq Oy and Laser Zentrum Hannover e.V.
Enhancing light sources color homogeneity in high-power phosphor-based white ...TELKOMNIKA JOURNAL
Color uniformity is one of the essentials for the on-going development of WLED. To achieve a high color uniformity index, increasing the scattering events within the phosphor layers was reported to be the most efficient method and in this article, ZnO is the chosen material to apply in this method. After analyzing the scattering properties through the scattering cross-section , scattering coefficient and scattering phase function , the which outcomes comfirm that ZnO can enhance the scattered light in the phosphor layers. Moreover, the findings from the study of ZnO concentration from 2% to 26% suggest that color uniformity also depends on the fluctuation of ZnO concentration, therefore, to control color uniformity the focus should be implied on both size and concentration of ZnO. The experimental results from this research show that the luminous flux of WLED is at the peak if the concentration of ZnO is at 6%, and when the concentration of ZnO is at 18% and has 100 nm particles size, the ΔCCT reaches the lowest level. The final choice should be based on the desired characteristic of WLEDs, however, if the WLED need to excel in both luminous flux and ΔCCT then 6% ZnO concentration with particles size from 100 nm-300 nm is the optimal choice.
Similar to Conformal optical coatings on complex 3D-macrostructures using atomic layer deposition (20)
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Lateral Ventricles.pdf very easy good diagrams comprehensive
Conformal optical coatings on complex 3D-macrostructures using atomic layer deposition
1. Conformal optical coatings on
complex 3D-macrostructures
using atomic layer deposition
D.Sc. John Rönn
Advanced ALD, Beneq Oy
Paper: TC.4
john.ronn@beneq.com
2. 8/18/2022
Motivation
Optics and optical sciences are widely used in everyday life
Production of optical coatings is well-established with traditional fabrication technologies
Low cost
Low temperature
High throughput
Excellent uniformity
3. 8/18/2022
Motivation
Optics and optical sciences are widely used in everyday life
Production of optical coatings is well-established with traditional fabrication technologies
Low cost
Low temperature
High throughput
Excellent uniformity
Conformality
4. 8/18/2022
Motivation
Optics and optical sciences are widely used in everyday life
Production of optical coatings is well-established with traditional fabrication technologies
Low cost
Low temperature
High throughput
Excellent uniformity
Conformality
5. 8/18/2022
Conformal Optical Coatings with Beneq ALD
Film growth studies on 3D-macrostructures
Setup: P400A, 2x Monitor Hemispherical Domes, 1x Dummy Dome
150 mm
6. 8/18/2022
Conformal Optical Coatings with Beneq ALD
Film growth studies on 3D-macrostructures
Setup: P400A, 2x Monitor Hemispherical Domes, 1x Dummy Dome
7. 8/18/2022
Conformal Optical Coatings with Beneq ALD
Film growth studies on 3D-macrostructures
Setup: P400A, 2x Monitor Hemispherical Domes, 1x Dummy Dome
18. Beneq® is a leading supplier of production and research equipment for atomic layer deposition
(ALD), a provider of thin film coating services, and the world’s premier manufacturer of thin
film electroluminescent (TFEL and TASEL) displays.
www.beneq.com | www.lumineq.com
Tel. +358 9 7599 530
info@beneq.com | lumineq@beneq.com
firstname.lastname@beneq.com
Editor's Notes
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service
Leading supplier of Atomic Layer Deposition (ALD) equipment for Industrial and R&D
Headquarters & ALD Fab in Espoo, Finland
Operating world’s largest ALD dedicated plant, with more than 40 ALD production systems
Extended service and demo capabilities, from proof-of-concept to pilot production
30+ years of industrial ALD experience at your service