This presentation intends to introduce about ayurvedic tablets known as gutikas or vatis. The content is suitable for undergraduate pharmacy students and high school science learners. It focusses on preparation and standardization. This topic is part of herbal drug technology of B.Pharmacy PCI curriculum.
This presentation intends to introduce about ayurvedic tablets known as gutikas or vatis. The content is suitable for undergraduate pharmacy students and high school science learners. It focusses on preparation and standardization. This topic is part of herbal drug technology of B.Pharmacy PCI curriculum.
This presentation introduces basic concepts of asavas and arishtas and largely deals with their method of preparation. The content is made so as to cater to undergraduate students in pharmacy and basic science learners. This topic is in herbal drug technology of PCI curriculum
unani or Unani medicine (Urdu: طب یونانی tibb yūnānī) is the term for Perso-Arabic traditional medicine, practiced in Mughal India and in Muslim culture in South Asia and modern day Central Asia. The term is derived from Arabic Yūnānī "Greek", as the Perso-Arabic system of medicine was in turn based on the teachings of the Greek physicians Hippocrates and Galen.The medical tradition of medieval Islam was introduced to India by the 13th century with the establishment of the Delhi Sultanate and it took its own course of development during the Mughal Empire , influenced by Indian medical teachings of Sushruta and Charaka.
In this power points viewer will be able to know the meaning of Pharmacopoeia and its coposition. History behind the different pharmacopoeia and popular pharmacopoeia existing world wide in herbal medicines. List of different pharmacopoeias also has been included.
Role of Markers in Standardization of Herbal ProductsDr-Jitendra Patel
In this Power Point Presentation the viewer will be able to know the the different markers present naturally in herbal materials. These markers may be genitally, chemically and biochemically. How markers play major role during identification, authentication, quality control, quality assurance and determination of safety and efficacy of particular medicinal plant.
Portion covered:
1. Role of markers in standardization of herbal products
2. Factor influencing identification and quality of herbal Drugs
3. Meaning of Standardization
4. Types of Markers
5. Molecular or DNA Markers
6. Chemical Markers
7. Biochemical Markers
Ayurveda (Sanskrit: आयुर्वेद Āyurveda , "life-knowledge"; English pronunciation /ˌaɪ.ərˈveɪdə/) or Ayurvedic medicine is a system of medicine with historical roots in the Indian subcontinent. Globalized and modernized practices derived from Ayurvedic traditions are a type of complementary or alternative medicine.Ayurveda is the ancient Indian system of natural and holistic medicine. When translated from Sanskrit, Ayurveda means “the science of life”
GPAT
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other pharma competative exams...
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This presentation introduces basic concepts of asavas and arishtas and largely deals with their method of preparation. The content is made so as to cater to undergraduate students in pharmacy and basic science learners. This topic is in herbal drug technology of PCI curriculum
unani or Unani medicine (Urdu: طب یونانی tibb yūnānī) is the term for Perso-Arabic traditional medicine, practiced in Mughal India and in Muslim culture in South Asia and modern day Central Asia. The term is derived from Arabic Yūnānī "Greek", as the Perso-Arabic system of medicine was in turn based on the teachings of the Greek physicians Hippocrates and Galen.The medical tradition of medieval Islam was introduced to India by the 13th century with the establishment of the Delhi Sultanate and it took its own course of development during the Mughal Empire , influenced by Indian medical teachings of Sushruta and Charaka.
In this power points viewer will be able to know the meaning of Pharmacopoeia and its coposition. History behind the different pharmacopoeia and popular pharmacopoeia existing world wide in herbal medicines. List of different pharmacopoeias also has been included.
Role of Markers in Standardization of Herbal ProductsDr-Jitendra Patel
In this Power Point Presentation the viewer will be able to know the the different markers present naturally in herbal materials. These markers may be genitally, chemically and biochemically. How markers play major role during identification, authentication, quality control, quality assurance and determination of safety and efficacy of particular medicinal plant.
Portion covered:
1. Role of markers in standardization of herbal products
2. Factor influencing identification and quality of herbal Drugs
3. Meaning of Standardization
4. Types of Markers
5. Molecular or DNA Markers
6. Chemical Markers
7. Biochemical Markers
Ayurveda (Sanskrit: आयुर्वेद Āyurveda , "life-knowledge"; English pronunciation /ˌaɪ.ərˈveɪdə/) or Ayurvedic medicine is a system of medicine with historical roots in the Indian subcontinent. Globalized and modernized practices derived from Ayurvedic traditions are a type of complementary or alternative medicine.Ayurveda is the ancient Indian system of natural and holistic medicine. When translated from Sanskrit, Ayurveda means “the science of life”
GPAT
Niper &
other pharma competative exams...
For more posts, follow us on .... be
@pharmahelpers
@pharmahelpers
@pharmahelpers
Also follow us on...
Facebook @ Pharma Helpers
Whatsapp @ 8421773854 OR https://chat.whatsapp.com/FFVRcxiiqC91PvnEvmK2F1
Instagram @ https://www.instagram.com/p/COM-VYqJ3Xo/?igshid=1ac01ibq2sa2k
introduction to Ayurveda is simplified foe beginners . this presentation gives brief information on history of ayurveda, method treatment , disease and prevention. this article finds more insight to healthy way of living through ayurveda. tridosha, datu and parkriti has been briefed well and simplified.
Basic principles involved in the traditional systems of medicine PDF.pdfDivya Kanojiya
Basic principles involved in the traditional systems of medicine like: Ayurveda, Siddha, Unani and Homeopathy.
Method of preparation of Ayurvedic formulations like: Arista, Asava, Gutika, Taila, Churna, Lehya and Bhasma.
Basic principles involved in the traditional systems of medicine PDF.pdfDivya Kanojiya
Basic principles involved in the traditional systems of medicine like: Ayurveda, Siddha, Unani and Homeopathy.
Method of preparation of Ayurvedic formulations like: Arista, Asava, Gutika, Taila, Churna, Lehya and Bhasma.
Alternative system of medicine (ayurvedic, unani, homeopathy, sidhha, sujog, ...Ravish Yadav
the topic include information on other system of medicine which ois practice in india. which include traditional system information as well as pancha mahabhutas
Metabolic Pathways in Higher Plants and their DeterminationDr. Siddhi Upadhyay
a) Brief study of basic metabolic pathways and formation of different secondary metabolites through these pathways- Shikimic acid pathway, Acetate pathways and Amino acid pathway.
b) Study of utilization of radioactive isotopes in the investigation of Biogenetic studies.
Bioinformatics: Introduction, Objective of Bioinformatics, Bioinformatics Databases, Concept of Bioinformatics, Impact of Bioinformatics in Vaccine Discovery
Application of computers in Pharmacy – Drug information storage and retrieval, Pharmacokinetics, Mathematical model in Drug design, Hospital and Clinical Pharmacy, Electronic Prescribing and discharge (EP) systems, barcode medicine identification and automated dispensing of drugs, mobile technology and adherence monitoring
Diagnostic System, Lab-diagnostic System, Patient Monitoring System, Pharma Information System
Isolation, Identification and Analysis of PhytoconstituentsDr. Siddhi Upadhyay
Isolation, Identification and Analysis of Phytoconstituents
a) Terpenoids: Menthol, Citral, Artemisin
b) Glycosides: Glycyrhetinic acid & Rutin
c) Alkaloids: Atropine,Quinine,Reserpine,Caffeine
d) Resins: Podophyllotoxin, Curcumin
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
2. CONTENT
■ The holistic concept of Ayurvedic system of medicine.
■ A study on different types ofAyurvedic formulations like Churna,
Kwath, Gutika,Taila,Ghrita,Avaleha,Asavas,Arista, Bhasma and
Pisti.
■ Evaluation of Ayurvedic formulations
5. What is Ayurveda?
•Is a system of traditional medicine native to the Indian
Subcontinent
•Practiced in other parts of the world like USA, Europe,
Australia, New Zealand, Singapore, Malaysia etc as a
form of complementary and alternative medicine
•Involves use of herbs, therapies and Yoga as exercise
•Or applied on their own as a form of Complementary or
Alternative (CAM) treatment
6. Ayurveda – the Wisdom of Life
• Offers a proven guide for a life of
happiness, vitality, love and purpose.
• Human beings are not viewed as
mere thinking physical machines, but
• Rather as fields of intelligence in
dynamic exchange with the energy
and information of the environment.
7. Ayurveda – a holistic system
• A Comprehensive System with
equal emphasis on the body, mind
and spirit
• Strives to restore the innate
harmony of the individual
• It is not only about treating sickness
but – preventing disease and
enhancing health, longevity, vitality
and happiness.
8. Vedas
• It is the bedrock upon which Ayurveda rests
• Considered to be composed around 1500-
2000 BC
• Four Vedas
Rig-veda :contains hymns to be recited
Sam-veda : collection of hymns to be sung
Yajur-veda : entire sacrificial rite
Athar-veda : contains information on
health and sickness
9. EarliestTexts
• 760 BC
• 660 BC
: Charaka Samhita – herbal or plant
based pharmacopoeia
: Sushruta Samhita – Surgical
approaches
• 7thCentury : Ashtanga Sangraha of Vagbhata
– summary of previous two
•
•
AD 100
1331
: Nagarjuna – iatrochemistry
: Madhava Nidana by Madhava
– Ayurvedic Diagnosis
• 14thCentury :Sarangadhara Samhita
– Pulse diagnosis
11. Ayurveda in 20th Century
• Ayurveda flourished till 12thcentury, till the Muslim
invasion
Not much progress from 12th to 17thcentury•
• British invasion : 1833 virtually all Ayurveda
schools closed, opening of British medical schools
•
•
•
•
1920 : a national revival and resurgence of
interest in traditional Indian culture and practices
1946 : Formal Govt. recognition and reacceptance
of Ayurveda and resurgence of research.
Currently, however it holds a secondary place in
medicine in India
India Govt. officially recognizes as legitimate:
Allopathy, Homoeopathy, Naturopathy, Unani
Tibb, Ayurveda, and its cousins Siddha and Yoga.
12. Ayurvedic Approach of Health
and Disease
Promotion
of
Health
Prevention
of
Disease
Ayurveda
Science of Longevity
with quality of life
Holistic
management
of disease
13. Dosha - 3 (Vata, Pitta, Kapha)
Agni
Dhatu
Mala
- 13 (Metabolic fire)
- 7 (Body tissues)
- 3 (Waste products)
Indriya - 5 (Sensory motor organs)
Manas - 1 (Mind)
Atma - Soul
Components
of
Health
Definition of Health
Physical &
Physiological
Psychological
Spiritual
One whose doshas, agni, functions of doshas and malas are in
state of equilibrium, who has cheerful atman, mind, intellect
and sense organs is designated as healthy.
14. The Four Components of Life
Health according to Ayurveda is perfect
balance between
• Body : Sharir
• Senses : Indriya
• Mind : Sattva
• Spirit (Soul) : Atma
15. INDRIYA (Senses & Functions):
• Gyan-Indriya (Senses) : Sight, Hearing,
Smell, Touch & Taste
• Karm-Indriya (Voluntary functions) :
MANAS (Mind) : Supreme Indriya that
controls all Indriyas
• Has three abstract qualities – ‘Sattva’,
‘Rajas’ and ‘Tamas’.
16. ATMA (Soul/Self/Spirit) :
• Param Atma : Supreme, immortal pure
has only Sattva, free of happiness or
sorrow.
• Jiv Atma : resides in living body
attached to Rajas and Tamas, witness
every function & emotion throughout the
life.
17. AYURVEDA
TRIDOSHA THEORY- 3 DOSHAS
PANCHAMAHABHUTA THEORY- 5 elements
VATA PITTA
PRITHVI
Earth
JALA
Water
AGNI
Fire
VAYU
Air
AKASH
Space
EQUILIBRIUM
of 3 DOSHAS
DISEQUILIBRIUM
of 3 DOSHAS
HEALTH DISEASE
SOULKAPHA +
18. Effecting Human Physiology
Space :
• In the human body, many spaces are
aspects of the Space element.
• The spaces in the mouth, nose,
tract,gastrointestinal tract, respiratory
abdomen, thorax, capillaries, etc.
19. Air :
• All movements involve Air as an
element.
• The nature of the elements themselves
determine the nature of physiology.
• With the human body Air is present in
the pulsations of the heart, lungs etc.
20. • Fire : The source of Fire and light in the
solar system is the sun.
• In the human body, the source of Fire is
metabolism.
• Fire works in the digestive system as well
as in the gray matter of the brain, where
Fire manifests as intelligence. Fire also
activates the retina to perceive light.
• Therefore body temperature, digestion,
thinking etc are all the functions of the
Fire.
21. Water:
• It manifests in the body as the
secretions of digestive juices, in the
mucous membranes and in plasma and
cytoplasm.
• Water is vital for the functioning of all the
systems of the body.
• For example, dehydration resulting from
diarrhea and vomiting is due to water
element.
22. Earth :
• The fifth element, is also present in the
microcosm of the human being.
• Life is possible on this planet because
the Earth holds all living and non-living
substances to its solid surface.
23. Tridosha
Ayurveda is based on 3 energies.
Their balanced state is health and
imbalance disease.
• VATA – the kinetic energy, movement,
division, growth, etc.
• PITTA – the thermal energy, heat
generation, intellect,sight, etc.
• KAPHA – the potential energy
24. • Tridoshas are Vata, Pitta & Kapha
• Tridosha concept is applicable in living organisms
• Tridoshas are biological entities responsible for
structure, function and behaviour dimensions of
all living organisms
• Therefore human body mind constitution
(Prakriti), diseases, Medicines and Food all has
been categorized in Vata type, Pitta type and
Kapha type.
• But nothing is absolute pure; every thing is
permutation and combination of Tridoshas
26. Most fundamental Principle
“Prakriti Purusha Samya”
Prakriti (Nature): Governed by
•
•
•
Air
Sun and
Water
Purusha (Living body):
Regulated by 3 vital entities: “Doshas” –
•
•
•
Vata,
Pitta and
Kapha
29. Concept of Prakriti
(Body Mind Constitution and Temperament)
• Concept of Prakriti (human constitution) is related to
physiological attributes to health and disease.
• Prakriti is determined by relative predominance of
dosha in intra-uterine life of a fetus.
•
•
Prakriti is unchangeable throughout the life span, but
One can take remedial measures in diet and
behavior suitable to his/her prakriti to maintain health
and prevention of disease.
30. Significance of Prakriti in Clinical
Medicine
• For Promotive & Preventive Health
–
–
■ Know your prakriti and diseases susceptibility
■ Prakriti will tell the risk factors, course of disease,
complications and prognosis
■ – Follow your diet, behaviour, profession and life
style suitable to your prakriti to lead a healthy life.
• Curative Health
–
–
–
Select the drugs and dose as per prakriti
Drug body interaction and reaction pattern depend upon
the prakriti of individual & drug
Associated complications of a disease, prognosis and
their treatment can be improved as per prakriti of
disease & individual
31. Concept of Sapta Dhatus
( 7 Body Tissues)
Body is made up of Seven Tissues and their
function is to maintain the body matrix
1. Rasa
(Plasma)
3. Mansa
(Muscles)
4. Medas
(Fats)
5. Asthi
(Bones)
6. Majja
(Bone marrow)
7. Shukra
(Reproductive
tissues)
2. Rakta
(Blood)
Ojas
(Responsible for Immunity)
32. Causes of diseases…
• Man made activities -
Prajnaparadha
• Environmental factors
• Genetic factors
Psychological factors….
33. Diagnosis in Ayurveda
The two main pillars on which the diagnosis
•
•
History of Illness:
Examination of the Patient:
• a) General Examination or Ashta Vidha Pariksha:
Examination of the pulse (Naadi Pariksha), Tongue,
Urine and stool examination, Speech, Examination
by palpation and percussion, Gait (bodily
movement), General appearance of the patient, and
Examination of the constitution (Prakriti).
• b) Systemic Examination: This consists of
examination of the different systems, Skin and Hair,
and Eyes .
34. The factors responsible for prevention of
illness and promotion of health
Day regimen (Dinacharya)
Night regimen (Ratricharya )
Seasonal regimen (Rutucharya)
Seasonal Purification (Rutu
anusara Shodhana)
36. Basic treatment modalities
Pacification Treatment Purification Treatment
Pacifies doshas locally Removes doshas from body
Comparatively of temporary Effect lasts for long
action.
Done in minimal or moderate
dosha and of minimal or
moderate strength
Done in profound dosha and of
profound strength
Does not interfere much with
tissues (dhatus)
Normalizes tissue (dhatu)
functions
38. DrugTherapy in Ayurveda
• DRUG (AUSHADHA)
"One which ensures alleviation the disease but
does not give rise to any other disorders”
• PLANT origin
• MINERAL origin
• ANIMAL origin
• Single or Compound formulations of
above
• Employed as per ‘Yukti’ (planning).
39. Rasayana
• Rejuvenation Therapy
• Delays Aging
• Provide Immunity
• Improve Memory and
sensory perception
Traditional way to be EVER
GREEN
40. Personal Health is a BALANCE
of -
• Good Food
• Good Regimen
• Good emotions
• Good Environment
41. Food inAyurveda
Quantity and Quality well defined….
Food Combinations are important
Natural food are highlighted…
43. Seasonal Regimens
• Different Regimens in different seasons
• Improves immunity
• Fight against infectious diseases
• Prevents seasonal diseases
44. Social Health
• Healthy Societies….
• Pollution free air, water, land etc…..
• Good Health education
45. Caring the Nature
• Protection of Ecosystem
• Cultivation of medicinal plants
• Prevents massive exploitation of
natural resources
• Preventing pollution….
46. Benefits of Ayurveda
Physical Benefits
The basic constitution represents
the individual’s psychological and
physical nature, distinctly.
Non-invasive diagnostic Ayurvedic treatments are
beneficial for chronic diseases such as diabetes,
heart ailments and cancer.
Difficult diseases like asthma and tumor growths
(gulmas) are managed effectively.
47. A discerning diet according to one’s dosha type, and well
regulated life (dinacharya) helps strengthen one’s
natural immune system.
•Detoxification methods like Panchakarma and other herbal remedies
make the body more responsive to medicines and treatment.
•It hastens the healing process.
•Yogasanas achieve the twin purpose of strengthening body-parts such
as bone, muscle and vital organs like heart, liver, stomach, intestine as
well as
•Keeping out blood circulation and psychological conditions strong and
resilient.
48. Psychological Benefits:
It is said that the condition of body and mind are
integral to the overall health of an individual.
Ayurvedic massages, inhalation of herbal (Aromatherapy)
preparations, panchakarma (nasya) besides much-tested
yogasanas and meditation leave a calming effect on the
nerves.
49. Spiritual Benefits:
The treatment methods, diet and lifestyle regimen in
Ayurveda are meticulously planned to heal the body
as well enrich the mind
So that each can improve from their own levels to
the higher goal of realizing the full self-potential.
It was with Ayurveda that the unique longevity and
rejuvenating method of rasayana was born for
mankind to progress in the path of spirituality.
50. • Ayurveda is not only treatment, it is a way of life
• Has no side effects
• Gives happy, healthy disease free long life
• Makes you Tension Free
• Relaxes mind
• Provides knowledge about life
• Tells about good and bad dietary effects to life
• Tells the way for life goals, with keeping good
health status
Summary of Benefits of Ayurveda
121. Macroscopic study
• Visual inspection provides the simplest and quickest
means by which to establish identity, purity and quality.
• Macroscopic identity of medicinal plant materials is
based on shape, size, colour, surface characteristics,
texture, fracture characteristics and appearance of the
cut surface.
122. Microscopic study
• Detail of cell structure and arrangement of the
cells useful for differentiating similar species.
• Select a representative sample of the material & If it is
dried parts of a plant than it may require softening before
preparation for microscopy, preferably by being placed in
a moist atmosphere, or by soaking in water.
• Any water-soluble contents can be removed from the cells
by soaking in water. Starch grains can be gelatinized by
heating in water.
124. • Measurement of specimen
• Stomatal number
• Stomatal index
• Palisade ratio
• Vein-islet number
• Vein termination number
• Lycopodium spore method
125. Foreign organic matter
• Parts of the medicinal plant material or
materials other than those named with the
limits specified for the plant material
concerned;
• Any organism, part or product of an
organism, other than that named in the
specification and description of the plant
material concerned;
• Mineral admixtures that is adhering to the
medicinal plant materials, such as soil, stones,
sand, and dust.
Foreign matter: NMT 2%w/w
126. Ash value
• It involves non-volatile inorganic components.
• High ash value is the indicative of contamination, substitution,
adulteration or carelessness in preparing the crude drugs.
127. Total ash
• Total ash is designed to measure the total amount of material
produced after complete incineration of the drug material at as
low temperature as possible (about 450°C) to remove all the
carbons.
• Total ash usually consists of carbonates, phosphates, silicates
and silica.
• IP and USP: 675±25°C
• BP : 600±25°C
• WHO: 500-600°C
128. Acid insoluble ash
• Ash insoluble in HCl is the residue obtained after
extracting the total ash with HCl. It gives idea about the
earthy matter
•
•
•
•
IP method: 25mL 2M HCL solution
USP method: 25mL 3N HCL solution
BP method: 15mLwater and 10mLHCL
WHO method: 25 ml of hydrochloric acid (~70g/l)
129. Water soluble ash
• Total ash content which is soluble in water. It’s good
indicator of presence of previous extraction of water soluble
salts in the drug or incorrect preparation or amount of inorg.
matter
• Carbonated ash: Ash is treated with ammonium carbonate.
• Nitrated ash: Ash is treated with dilute nitric acid.
130. Extractive value
• Amount of the active constituents present in crude drug
material when extracted with specific solvent.
• There are following
Methods for determin-
-nation of Extractive
value.
a) Cold method
b) Hot method
c)Soxhlet method
132. Insoluble matter:
• Presence of woody matter or vegetable debris or pieces of
bark materials.
• Eg. In catechu
Water insoluble matter: NMT 33%
Alcohol insoluble matter: NMT 30%
133. Total solid content
• The residue obtained when prescribed amount of preparation
is dried to constant weight under the specified condition
(Residue on evaporation)
• Powdered extract: NLT 95%
• Semisolid extract: NLT 70%
134. Water Content
• Loss on drying (Gravimetric determination)
• Volumetric Azeotropic distillation (toluene distillation)
method
• Titrimetric Karl fisher method
• Gas chromatographic method
135. Volatile oil content
• Volatile oils are the liquid components of the plant cells,
immiscible with water, volatile at ordinary temperature and
can be steam distilled at ordinary pressure
• Many herbal drugs contain volatile oil which is used as
flavourig agent.
• E.g. Clove: NLT 15%v/w
136. Bitterness value
• Medicinal plant materials that have a strong bitter taste
("bitters") are employed therapeutically, mostly as appetizing
agents. Their bitterness stimulates secretions in the
gastrointestinal tract, especially of gastric juice.
• The bitter properties of plant material are determined by
comparing the threshold bitter concentration of an extract of
the materials with that of a dilute solution of quinine
hydrochloride.
• The bitterness value is expressed in units equivalent to the
bitterness of a solution containing 1g of quinine hydrochloride
R in 2000 ml.
137. • Bitterness value calculated in units per g using the
following formula:
Where,
a= the concentration of the stock test solution (ST) (mg/ml),
b = the volume of test solution ST(in ml) in the tube with the
threshold bitter concentration,
c = the volume of quinine hydrochloride R (in mg) in the tube
with the threshold bitter concentration.
138. Haemolytic activity
• Many medicinal plant materials, of the families
Caryophyllaceae, Araliaceae, Sapindaceae, Primulaceae,
and Dioscoreaceae contain saponins.
• The most characteristic property of saponins is their
ability to cause haemolysis; when added to a suspension
of blood, saponins produce changes in erythrocyte
membranes, causing haemoglobin to diffuse into the
surrounding medium.
• The haemolytic activity of plant materials, or a
preparation containing saponins, is determined by
comparison with that of a reference material, saponin R,
which has a haemolytic activity of 1000 units per g.
140. • Calculate the haemolytic activity of the medicinal plant
material using the following formula:
1000 ×a/b
Where,
1000 = the defined haemolytic activity of saponin R in relation to ox
blood,
a = quantity of saponin R that produces total haemolysis (g)
b = quantity of plant material that produces total haemolysis (g)
141. Determination of tannins
• Tannins (or tanning substances) are substances capable of
turning animal hides into leather by binding proteins to
form water-insoluble substances that are resistant to
proteolytic enzymes.
• This process, when applied to living tissue, is known as an
"astringent" action and is the reason for the therapeutic
application of tannins.
• Chemically, tannins are complex substances; usually occur
as mixtures of polyphenols that are difficult to separate and
142. • Calculate the quantity of tannins as a percentage using the
following formula:
where w = the weight of the plant material in grams
T1= Weight of material extracted in water
T2= Weight of material not bound to hide powder
T0= Weight of hide powder material soluble in water
143. Determination of swelling
index
• The swelling index is the volume in ml taken up by the
swelling of 1 g of plant material under specified
conditions.
• Its determination is based on the addition of water or a
swelling agent as specified in the test procedure for each
individual plant material (either whole, cut or pulverized).
144. Determination of foaming
index
• Many medicinal plant materials contain saponins that can
cause a persistent foam when an aqueous decoction is shaken.
• The foaming ability of an aqueous decoction of plant materials
and their extracts is measured in terms of a foaming index.
Calculate the foaming index using the following formula:
foaming index =
where a = the volume in ml of the decoction used for
preparing the dilution in the tube where foaming to a
height of 1 cm is observed.
145. Determination of pesticide
residues
• Not more than 1%
• An ARL (in mg of pesticide per kg of plant material) can be
calculated on the basis of the maximum acceptable daily intake
of the pesticide for humans (ADI), as, recommended WHO,
and the mean daily intake (MDI) of the medicinal plant
material.
ADI = maximum acceptable daily intake of pesticide (mg/kg of body weight);
E = extraction factor, which determines the transition rate of the pesticide from
the plant material into the dosage form;
MDI = mean daily intake of medicinal plant product.
146. Some example of Pesticides :
• Chlorinated hydrocarbons and related pesticides: BHC, DDT
• Chlorinated phenoxyalkanoic acid herbicides: 2,4-D; 2,4,5-T
• Organophosphorus pesticides: malathion, methyl parathion, parathion
• Carbamate insecticides: carbaryl (carbaril)
• Dithiocarbamate fungicides: ferbam, maneb, nabam, thiram, zineb
• Inorganic pesticides: calcium arsenate, lead arsenate
• Miscellaneous: ethylene dibromide, ethylene oxide, methyl bromide
• Pesticides of plant origin: tobacco leaf and nicotine; pyrethrum flower,
pyrethrum extract and pyrethroids; derris root and rotenoids.
147. Determination of arsenic and
heavy metals
• Contamination of medicinal plant materials with arsenic
and heavy metals can be attributed to many causes
including environmental pollution and traces of pesticides.
• Limit test for arsenic
• Limit test for cadmium and lead
• The contents of lead and cadmium may be determined by
inverse voltametry or by atomic emission
spectrophotometry.
• The following maximum amounts in dried plant materials,
which are based on the ADI values, are proposed:
▫ lead, 10 mg/kg;
▫ cadmium, 0.3 mg/kg.
150. Aflatoxins Content
• Aflatoxins are naturally occuring mycotoxins produced
mainly by Aspergillus flavus and Aspergillus parasiticus.
• The presence of aflatoxins can be determined by
chromatographic methods using standard aflatoxins B1,
B2, G1, G2 mixtures.
• IP method: NMT 2 µg/kg of aflatoxins B1& Total aflatoxins 4 µg/kg
• USP method: NMT 5ppb of aflatoxins B1& Total aflatoxins 20ppb
151. Radioactive contamination
• The range of radionuclides that may be released into the
environment as the result of a nuclear accident might include
long-lived and short-lived fission products, actinides, and
activation products.
• Microbial growth in herbals is usually avoided by irradiation.
This process may sterilize the plant material but the
radioactivity hazard should be taken into account.
• The nature and the intensity of radionuclides released may
differ markedly and depend on the source (reactor,
reprocessing plant, fuel fabrication plant, isotope production
unit, etc.).
• The radioactivity of the plant samples should be checked
accordingly to the guidelines of International Atomic
152. CHROMATOGRAPHY OF HERBAL DRUG
• Seperation, identification, impurity detection
and assay of herbal drug in the formulation or
in the extract are carried out by following
methods :-
a)TLC
b)HPTLC
c)HPLC/Densitometric chromatography
d)GLC
153. Evaluation of Ayurvedic
formulation: ASAVAS, ARISTA
1. Organoleptic Parameters
a) Colour of sample
b) Odour of sample
c) Taste of sample
d) Determination of pH of sample
154. 2. Physical Parameters
a) Determination of foreign organic matter
b) Determination of ash value
Total ash value
Acid insoluble ash
Water soluble ash
Sulphated ash
c) Determination of extractive value
Alcohol soluble extractive value
Water soluble extractive value
d) Determination of moisture content
e) Determination of physical constant
Melting point
Boiling point
Refractive index
Optical rotation
f) Determination of specific gravity
g) Determination of solid content
h) Determination of alcohol content
155. 3. Chemical tests
a) Alkaloids – Dragandroffs test
b) Glycosides – Molish test
c) Flavonoids – Shinoda test
d) Phenolic – Lead acetate test
e) Tannins – Ferric chloride test
f) Steroids – Salkowski reaction
g) Amino acids – Ninhydrine test
h) Carbohydrates – Fehling’s test, Benedict test
4. Toxicological parameters
a)Pesticides residue
b) Heavy metal
c) Microbial contamination
156. Evaluation of Ayurvedic
formulation:TAILA, GHRITA
Colour
Smell
Appearance
Touch Oily
Clarity
Specific gravity
Acid value mg/gm
Saponfication value
Iodine value gm/100gm
157. Evaluation of Ayurvedic
formulation: BHASMA, PISTI
1. organoleptic characters
Sound : The Bhasma should have
imperceptible sound
on grinding the Bhasma between teeth.
Colour : depends
Touch - Soft ~ Imperceptible coarseness in the
Bhasma
Taste - should be tasteless
Odour -should be odourless
159. Evaluation of Ayurvedic
formulation: CHURNA,
KWATH1 Study of organoleptic characters
i. Colour
ii. Odour
iii. Taste
2 Determination of physico-chemical parameters
Moister content, Total ash
Acid insoluble ash, Water soluble ash
Water soluble extractive, Alcohol soluble extractive
Crude fiber contents
160. 3 Quantitative estimation of selected phyto- constituents
Total alkaloids
4 Evaluation of Churna
Powder fineness
Bulk density
Tap density
Angle of repose
Compressibility
Hausner ratio
5 Determination of Ph
6 Establishing the safety pertaining to Heavy metals &
Microbial load
162. 4. Physical evaluation:
• Ash value
• Acid insoluble ash
• Water insoluble ash
• Alcohol soluble extractive
• pH
• Volatile oil
• Melting temperature
• Loss on drying
163. 5. Pharmaceutical parameters
• Hardness
• Uniformity in weight
• Uniformity in diameter
• Friability test
• Dissolution time
• Disintegration time
164. Evaluation of Ayurvedic
formulation: AVALEHA
1. Organoleptic Evaluation
2. Physico-chemical Evaluation
• Reducing sugar
• Total sugar
3. Analytical Evaluation
• Chromatography
4. Biological Evaluation
• Test for heavy metals
• Microbial contamination
• Shelf life
165. 5. Physical evaluation
• Loss on drying at 105°c
• Total ash
• Acid insoluble ash
• pH
• Specific gravity
• Total solid contents
• Fat contents