Prevalence and risk factors for the presence of serum antibodies against cani...Biogal
This study goal was to estimate the apparent prevalence and identify risk factors for antibody levels (AL) against canine distemper virus (CDV), canine parvovirus (CPV), and canine adenovirus (CAV) in three communities in the metropolitan area of Quito, Ecuador that have limited access to regular veterinary care.
This investigation implicated raw flour as a source of an outbreak of STEC infections. Although it is low-moisture food, raw flour can be a vehicle of foodborne pathogens
Prevalence and risk factors for the presence of serum antibodies against cani...Biogal
This study goal was to estimate the apparent prevalence and identify risk factors for antibody levels (AL) against canine distemper virus (CDV), canine parvovirus (CPV), and canine adenovirus (CAV) in three communities in the metropolitan area of Quito, Ecuador that have limited access to regular veterinary care.
This investigation implicated raw flour as a source of an outbreak of STEC infections. Although it is low-moisture food, raw flour can be a vehicle of foodborne pathogens
Dr. Ying Fang - Emerging swine disease diagnostics and characterization: conn...John Blue
Emerging swine disease diagnostics and characterization: connecting basic research to real-world applications - Dr. Ying Fang, Kansas State University, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Role of soluble urokinase plasminogen activator receptor (suPAR) as prognosis...IOSR Journals
Biological marker suPAR was used in many pathological conditions, including infection. suPAR
was correlated with the severity of sepsis. The purpose of this study to determine levels of suPAR infants with
risk of infection as a prognostic indicator for sepsis. Groups of infants with the risk of infection (n = 43) were
followed prospectively on days 0, 3rd and 7th and observed for the incidence of sepsis compared to the control
group (n = 10). suPAR was measured by ELISA and the course of infection measured by clinical criteria.
Results suPAR day 0, 3 and 7, displayed in the form of bloxpot and AUC as prognostic power. suPAR control
levels 9.32 ng / mL, sepsis cutoff 15, 41 ng / mL and AUC of 80.3% [95% CI 65.7%, 94.9%, p = 0.00]. Graph
shows ROC AUC sepsis suPAR day 0, the 3rd and 7th respectively 61.9%, 66.6% and 94.4%. Sepsis with
improved output 16.53 ng / mL and worsening 22.19 ng / mL and AUC of 80.8% [95% CI (0.62 to 0.99), p =
0.02]. suPAR levels was increased in neonatal sepsis patients. suPAR could be used as a prognostic factor for
neonatal sepsis.
Comparison of immunity against canine distemper, adenovirus and parvovirus af...Biogal
This study aimed at comparing the immunity of two multivalent vaccines in adult dogs in the city of Uberlândia, Minas Gerais state, Brazil.
VacciCheck was used in the study in order to determine the immunity levels of the dogs.
In July 2017, the Orleans County Health Department investigated a report of gastrointestinal illness from a corporate picnic that was catered. An environmental and epidemiological investigation identified 28 individuals who met the outbreak case definition. A detailed questionnaire based on the food that was served at the picnic was administered to the corporate employees that attended the picnic and respondent data was statistically analyzed. It was hypothesized from the statistical results that consuming roast beef (P <.05) was associated with becoming ill. An environmental investigation indicated that it was probable that the roast beef was potentially cross contaminated at the caterer’s kitchen by a strain showing similarities with a raw chicken isolate. A roast beef sample and two stool
samples from ill attendees were collected and sent for laboratory testing. Salmonella Heidelberg was identifi ed in all of the samples by the New York State Department of Health (NYSDOH) Wadsworth Laboratory. This outbreak demonstrates the importance of food service employees following proper preparation techniques in order to prevent cross-contamination.
Avian influenza virus surveillance in live bird markets, northern VietnamILRI
Poster by Dao Duy Tung, Kristen K. Coleman, Vuong N. Bui, Than The Son, Hung Nguyen-Viet, Emily R. Robie, Pham Duc Phuc and Gregory C. Gray presented at the virtual edition of the 6th World One Health Congress, 30 October–3 November 2020.
AssentWorks - Innovations in InnovationAssentWorks
While the stream of technology innovations in manufacturing is constantly growing, the processes driving innovation within most organizations is often outdated and restrictive. This disconnect regarding innovation governance allows new competitors to climb to the top of the industry, while less agile organizations fall into obsolescence. Michael will discuss the concepts and cultures behind Fabrication labs and Makerspaces that are having profound impacts on corporate competitiveness, intellectual property management and manufacturing process. Highlighting his own experiences operating both corporate and non-profit facilities, Michael will identify the critical topics that your organization should address to make the most of these innovation enablers.
Dr. Ying Fang - Emerging swine disease diagnostics and characterization: conn...John Blue
Emerging swine disease diagnostics and characterization: connecting basic research to real-world applications - Dr. Ying Fang, Kansas State University, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Role of soluble urokinase plasminogen activator receptor (suPAR) as prognosis...IOSR Journals
Biological marker suPAR was used in many pathological conditions, including infection. suPAR
was correlated with the severity of sepsis. The purpose of this study to determine levels of suPAR infants with
risk of infection as a prognostic indicator for sepsis. Groups of infants with the risk of infection (n = 43) were
followed prospectively on days 0, 3rd and 7th and observed for the incidence of sepsis compared to the control
group (n = 10). suPAR was measured by ELISA and the course of infection measured by clinical criteria.
Results suPAR day 0, 3 and 7, displayed in the form of bloxpot and AUC as prognostic power. suPAR control
levels 9.32 ng / mL, sepsis cutoff 15, 41 ng / mL and AUC of 80.3% [95% CI 65.7%, 94.9%, p = 0.00]. Graph
shows ROC AUC sepsis suPAR day 0, the 3rd and 7th respectively 61.9%, 66.6% and 94.4%. Sepsis with
improved output 16.53 ng / mL and worsening 22.19 ng / mL and AUC of 80.8% [95% CI (0.62 to 0.99), p =
0.02]. suPAR levels was increased in neonatal sepsis patients. suPAR could be used as a prognostic factor for
neonatal sepsis.
Comparison of immunity against canine distemper, adenovirus and parvovirus af...Biogal
This study aimed at comparing the immunity of two multivalent vaccines in adult dogs in the city of Uberlândia, Minas Gerais state, Brazil.
VacciCheck was used in the study in order to determine the immunity levels of the dogs.
In July 2017, the Orleans County Health Department investigated a report of gastrointestinal illness from a corporate picnic that was catered. An environmental and epidemiological investigation identified 28 individuals who met the outbreak case definition. A detailed questionnaire based on the food that was served at the picnic was administered to the corporate employees that attended the picnic and respondent data was statistically analyzed. It was hypothesized from the statistical results that consuming roast beef (P <.05) was associated with becoming ill. An environmental investigation indicated that it was probable that the roast beef was potentially cross contaminated at the caterer’s kitchen by a strain showing similarities with a raw chicken isolate. A roast beef sample and two stool
samples from ill attendees were collected and sent for laboratory testing. Salmonella Heidelberg was identifi ed in all of the samples by the New York State Department of Health (NYSDOH) Wadsworth Laboratory. This outbreak demonstrates the importance of food service employees following proper preparation techniques in order to prevent cross-contamination.
Avian influenza virus surveillance in live bird markets, northern VietnamILRI
Poster by Dao Duy Tung, Kristen K. Coleman, Vuong N. Bui, Than The Son, Hung Nguyen-Viet, Emily R. Robie, Pham Duc Phuc and Gregory C. Gray presented at the virtual edition of the 6th World One Health Congress, 30 October–3 November 2020.
AssentWorks - Innovations in InnovationAssentWorks
While the stream of technology innovations in manufacturing is constantly growing, the processes driving innovation within most organizations is often outdated and restrictive. This disconnect regarding innovation governance allows new competitors to climb to the top of the industry, while less agile organizations fall into obsolescence. Michael will discuss the concepts and cultures behind Fabrication labs and Makerspaces that are having profound impacts on corporate competitiveness, intellectual property management and manufacturing process. Highlighting his own experiences operating both corporate and non-profit facilities, Michael will identify the critical topics that your organization should address to make the most of these innovation enablers.
Ascaris lumbricoides and other Gastrointestinal Helminthic Parasites among Qe...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Risk Factors Early in the 2010 Cholera Epidemic, Haiti.docxhealdkathaleen
Risk Factors Early
in the 2010 Cholera
Epidemic, Haiti
Katherine A. O’Connor, Emily Cartwright,
Anagha Loharikar, Janell Routh, Joanna Gaines,
Marie-Délivrance Bernadette Fouché,
Reginald Jean-Louis, Tracy Ayers,
Dawn Johnson, Jordan W. Tappero,
Thierry H. Roels, W. Roodly Archer,
Georges A. Dahourou, Eric Mintz, Robert Quick,
and Barbara E. Mahon
During the early weeks of the cholera outbreak that
began in Haiti in October 2010, we conducted a case–
control study to identify risk factors. Drinking treated water
was strongly protective against illness. Our results highlight
the effectiveness of safe water in cholera control.
On October 19, 2010, the Haitian Ministry of Public Health and Population (MSPP) was notifi ed of
increased cases of acute watery diarrhea resulting in death
among adults in Artibonite Department. Within 2 days,
MSPP’s Laboratoire National de la Santé Publique had
identifi ed toxigenic Vibrio cholerae O1, serotype Ogawa,
biotype El Tor in stool specimens (1). The fi rst reports of
illness consistent with cholera occurred on October 16,
and, by November 19, cholera had reached all 10 Haitian
administrative departments (2).
Because the fi rst cases were in persons who worked
near the Artibonite River, contaminated river water was
suspected as the initial source. In a proactive effort to
protect the population, MSPP rapidly implemented a
cholera prevention campaign that began on October 22,
2010, to discourage the population from drinking river
water, distribute water treatment products, and promote
water treatment, handwashing, sanitation, and safe food
preparation. To inform further prevention activities, we
conducted a case–control study during the second and
third weeks of the outbreak to identify risk factors for
symptomatic cholera.
The Study
This study was conducted in Artibonite Department
close to where the fi rst cases were identifi ed. On the
basis of detailed hypothesis-generating interviews with
patients and known risk factors associated with cholera
in other investigations in the Americas, we created a
questionnaire to assess multiple exposures, including
river and other water-related exposures, sanitation and
hygiene practices, foods, and other factors. We enrolled
and interviewed participants from October 31 through
November 13, 2010, with a 4-day break during November
5–8 because of Hurricane Tomas. To rapidly generate
relevant information to guide outbreak response, we set
a goal of enrolling 50 case-patients and 100 controls, a
sample size that, although limited, was in line with that of
previous successful emergency investigations.
Eligible case-patients were persons >5 years of age
who were hospitalized between October 22 and November
9 for acute watery diarrhea at the Médecins Sans
Frontières cholera treatment unit in Petite Rivière, a town
in a densely populated rural region near the Artibonite
River. Only case-patients with the fi rst case of ...
Fluoroquinolone resistant rectal colonization predicts risk of infectious com...TC İÜ İTF Üroloji AD
Fluoroquinolone resistant rectal colonization predicts risk of infectious complications after transrectal prostate biopsy. Evidence based on journal club by Samed Verep
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay.
Determination of baseline Widal titre among apparently healthy population in ...IOSR Journals
Present study was conducted to determine the baseline widal titer of healthy population of Dehradun city. A total of 300 serum samples were collected from healthy individual with no history of fever and who had not received any vaccination for enteric fever. Tube agglutination test was done with commercially available antigens which contained the Salmonella enterica serovar typhi O and H antigens, the Salmonella enterica serovar paratyphi AH antigen and paratyphi BH antigen. In the present study an agglutination titer for TO – 1:20 is 28%, for 1:40 is 24%, followed by 1:80 and 1: 160 which is 10%, 4% respectively. The highest sample with an anti-H titre found with 1:20 (22%) followed by 1:40(17%). Based upon the results of the study it has been recommended that a single Widal can be significant in an endemic region when higher titre (1:160) is obtained.
1ScIeNtIFIc REPORTS | (2018) 8:1250 | DOI:10.1038/s41598-018-19638-x
www.nature.com/scientificreports
Histology, immunohistochemistry,
and in situ hybridization reveal
overlooked Ebola virus target
tissues in the Ebola virus disease
guinea pig model
Timothy K. Cooper1, Louis Huzella 1, Joshua C. Johnson 1, Oscar Rojas1, Sri Yellayi1,3,
Mei G. Sun2, Sina Bavari2, Amanda Bonilla1, Randy Hart1, Peter B. Jahrling 1, Jens H. Kuhn 1
& Xiankun Zeng 2
Survivors of Ebola virus infection may become subclinically infected, but whether animal models
recapitulate this complication is unclear. Using histology in combination with immunohistochemistry
and in situ hybridization in a retrospective review of a guinea pig confirmation-of-virulence study, we
demonstrate for the first time Ebola virus infection in hepatic oval cells, the endocardium and stroma of
the atrioventricular valves and chordae tendinae, satellite cells of peripheral ganglia, neurofibroblasts
and Schwann cells of peripheral nerves and ganglia, smooth muscle cells of the uterine myometrium
and vaginal wall, acini of the parotid salivary glands, thyroid follicular cells, adrenal medullary cells,
pancreatic islet cells, endometrial glandular and surface epithelium, and the epithelium of the vagina,
penis and, prepuce. These findings indicate that standard animal models for Ebola virus disease are not
as well-described as previously thought and may serve as a stepping stone for future identification of
potential sites of virus persistence.
Ebola virus disease (EVD) is a severe and frequently lethal affliction of humans caused by infection with any
of three members of the mononegavirus family Filoviridae: Bundibugyo virus (BDBV), Ebola virus (EBOV),
and Sudan virus (SUDV). A fourth virus, Taï Forest virus (TAFV), has thus far caused only a single reported
human infection, which was nonlethal1. EVD is an exotic disease with case numbers rarely surpassing the lower
hundreds1; however, from 2013–2016, EBOV caused an EVD outbreak in Western Africa encompassing 28,616
infections and 11,310 deaths in Guinea, Liberia, and Sierra Leone2. Long term sequelae in individual survivors of
acute EVD and the similar Marburg virus disease (MVD) and filovirus persistence followed by disease relapse or
sexual transmission had been reported before this outbreak3–8. However, observations during and following the
Western African EVD outbreak suggest that sequelae and filovirus persistence may be common events9. Reported
sequelae include arthralgia, cardiac valvulopathy, parotid gland inflammation, peripheral paresthesia or dyses-
thesia, and gastrointestinal motility disorders10–14. Semen may contain detectable EBOV RNA for more than 500
days following recovery, and EBOV RNA has been detected in breast milk of a subclinically infected mother15,16.
Replicating EBOV has been isolated from the cerebrospinal fluid of an EVD survivor suffering a disease relapse
and from the aqueous hu.
Microbial source tracking markers for detection of fecal contaminationFatima Batool
MST ( Microbial Source Tracking Markers) are being used nowadays for the detection of fecal contamination in water bodies. Conventionally, Fecal Inhibitor Bacteria (FIB) were used for detection of fecal contamination but there are many limitations of this method.
Running Head Salmonella in the Caribbean .docxtoltonkendal
Running Head: Salmonella in the Caribbean 1
Salmonella in the Caribbean 4
Angela Brown
Salmonella in the Caribbean
Southern New Hampshire University
The two articles that I have choose to write about is outbreak of multidrug- resistant salmonella infections link to pork – Washington 2015 and outbreak of salmonella Heidelberg infections linked to a single poultry producer- 13 states 2012-2013. After reading about the outbreak of multidrug- resistant salmonella infections link to pork I learned that on the basis of cases investigated before August 2015, a supplemental questionnaire that went into more detail in addressing meat and livestock exposures was developed. Among 80 patients (42% of all confirmed cases) who were interviewed, 59 (74%) reported eating pork during the 7 days preceding illness. This was significantly higher than the most recently published (2007) Foodborne Diseases Active Surveillance Network (FoodNet) population survey of healthy persons, in which 43% reported eating pork in the week before they were interviewed. After reading the outbreak of salmonella Heidelberg infections linked to a single poultry producer I have learned that initial state-based interviews found that chicken was commonly consumed by the persons with infections. A structured questionnaire was developed to collect detailed information on chicken and other exposures noted during initial interviews, and exposures commonly linked to Salmonella Heidelberg, such as eggs. Of 70 patients who responded, 55 (79%) reported consuming chicken in the week before illness onset, a percentage significantly higher than the 64.9% reported in the 2006–2007 foodborne diseases active surveillance network (FoodNet) Population Survey of healthy persons. These resources will be helpful. Plasmids are mobile genetic elements that can be gained or lost relatively easily, which might explain the variable resistance profiles. Resistance to third-generation cephalosporins (e.g., ceftriaxone) is clinically important because extended-spectrum cephalosporins are commonly used for treatment of severe salmonellosis in children. WADOH and PHSKC investigation into the source of pork traced the pork consumed by 35 (59%) of the 59 interviewed patients who reported eating pork back to a U.S. Department of Agriculture’s Food Safety and Inspection Service–inspected pork slaughter establishment in Graham, Washington. This was the largest Salmonella outbreak in Washington in recent history, and highlights that pork is an important source for human Salmonella infections. Best practices in all parts of the pork production industry, from farm to processing plant, can help reduce the risk for future outbreaks. In addition, prevention strategies that incl ...
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
Similar to Complete abstract book astmh atlanta 2012-usa (20)
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Hot Selling Organic intermediates
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
Complete abstract book astmh atlanta 2012-usa
1. Advancing global health since 1903
THEAMERICANJOURNALOF
TROPICALMEDICINEANDHYGIENE
VOLUME 87 NOVEMBER 2012 NUMBER 5 SUPPLEMENT
Supplement to
The American Journal of Tropical Medicine and Hygiene
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www.astmh.org
and 35.9-71.1 % in Asia. Between 1993 and 2010, globally, continued
feeding for children with diarrhea appears to be unchanged (β=0.15,
p=0.82). Likewise, no significant improvements in continued feeding
were observed in Latin America (β= -0.10, p=0.78) or Sub-Saharan Africa
(β= -0.15, p=0.27). Prevalence of continued feeding in Asia appears to
be increasing significantly at 0.25% increase rate per year (p=0.05).
Sub-Saharan Africa has the highest diarrhea-associated mortality of any
region in the world but has seen no improvements in continued feeding
for children with diarrhea since 1993.These findings indicate the need for
quantitative and qualitative research to understand barriers to continued
feeding on the part of caregivers, and renewed efforts to promote
continued feeding as a core component of diarrhea case management in
settings where the burden of diarrhea is high.
1053
TRENDS IN ANTIBIOTIC RESISTANCE AND DIARRHEAL
DISEASE EPIDEMIOLOGY IN A MILITARY POPULATION IN THE
PERUVIAN AMAZON, 2003-2011
Kristen Heitzinger1
, Ryan C. Maves2
, Eric R. Hall2
, Claudio
Rocha2
, Rene C. Guzman3
, Franca R. Jones2
, Drake H. Tilley2
1
University of Washington, Seattle, WA, United States, 2
U.S. Naval Medical
Research Unit - 6, Lima, Peru, 3
Vargas Guerra Army Base, Iquitos, Peru
In Peru, where antibiotic use is unregulated, the effective treatment of
diarrheal disease is often complicated by the development of antibiotic
resistant organisms. We aimed to investigate the trends in diarrheal
disease etiology and antibiotic resistance in a military population in the
Peruvian Amazon in order to guide diarrhea treatment. From 2003 to
2011, diarrheal disease surveillance was conducted among personnel at
the Vargas-Guerra Army Base in Iquitos, Peru. All individuals experiencing
diarrhea were requested to present to the army health post where a stool
sample was taken for culture. Diarrheagenic bacteria were isolated from
34.5% of the 638 cases. From the 215 samples in which a single bacterial
pathogen was isolated, Shigella flexneri, Enterotoxigenic E. coli (ETEC) and
Enteroinvasive E. coli (EIEC), were the most common pathogens and were
identified in 47.0%, 30.2%, and 5.6% of samples, respectively. There
were no trends in the prevalence of Shigella flexneri or EIEC over the study
period, however, the prevalence of ETEC decreased significantly (Odds
Ratio= 0.86, 95% CI=0.75, 0.97; p=0.02). Of 101 isolates of Shigella
flexneri cultured, 95.0% demonstrated resistance to tetracycline, 89.1%
to chloramphenicol, 84.2% to ampicillin, and 80.2% to cotrimoxazole.
Resistance of Shigella flexneri to ciprofloxacin and azithromycin remained
low (0% and 8.9%, respectively). There were no significant trends in
resistance to any other antibiotics over time. These data demonstrate
a high prevalence of Shigella flexneri and diarrheagenic E. coli among
diarrhea cases in a military population in the Peruvian Amazon. Although
antibiotic resistance to penicillins and sulfa antibiotics remains high in this
population, more appropriate or less frequent use of certain antibiotics
may have led to decreasing resistance.
1054
CLUSTER OF GUILLAIN-BARRÉ SYNDROME DUE TO A
WATERBORNE OUTBREAK OF CAMPYLOBACTER JEJUNI
INFECTION -- SAN LUIS RIO COLORADO, SONORA, MEXICO
AND YUMA, ARIZONA, UNITED STATES, 2011
José Alomia1
, Brendan Jackson2
1
Sonora SubDirectorate of Epidemiological Intelligence, for the Binational
GBS Investigation Team, Hermosillo, Mexico, 2
Centers for Disease Control
and Prevention, for the Binational GBS Investigation Team, Atlanta, GA,
United States
From May 31-June 16, 2011, a cluster of 15 suspected cases of Guillain-
Barré Syndrome (GBS) which sometimes follows Campylobacter jejuni
infection, was reported in San Luis Rio Colorado (SLRC), Sonora, Mexico
and Yuma County (YC), Arizona. Epidemiological teams from Mexico
and the United States conducted a binational outbreak investigation
to confirm this cluster and determine the etiology. We performed
additional case-finding and classified GBS cases through interviews and
medical record review. To investigate exposures, we reviewed disease
surveillance data, performed C. jejuni stool culture, conducted a case-
control study examining food and water exposures of cases with GBS or
C. jejuni infection, and performed an environmental assessment of water
systems. From May 4-July 21, 2011, 16 SLRC residents and 8 YC residents
developed GBS, far exceeding the expected number of cases. Twenty-
one GBS patients (81%) reported antecedent diarrhea. Approximately
two weeks before this cluster, weekly YC C. jejuni reports doubled
compared with the 3 previous years. Though C. jejuni diagnostics were
limited, 2 GBS patients had stool cultures yielding C. jejuni and 4 others
had positive serologic or stool antigen tests. In the case-control study,
all 7 GBS case-patients from YC traveled to SLRC during the exposure
period versus 37% of 19 matched controls (mOR: 10.2; CI: 1.4-inf.). Few
case-patients or controls (<20%) drank tap water, but >95% reported
exposure through other routes. Case-patients consumed more washable,
uncooked produce items than controls (Median: 7 vs. 5; P = 0.04). The
SLRC municipal water system had a history of inadequate chlorination and
pipe disruptions. Inadequately disinfected tap water contaminated with C.
jejuni was the likely source of this first mainland North American outbreak
of GBS. Improved water treatment practices were implemented and the
institution of new epidemiological surveillance strategies in SLRC since
this investigation will improve early detection of diarrheal outbreaks and
facilitate public health actions.
1055
IDENTIFICATION AND CONFIRMATION THROUGH MULTIPLEX
PCR OF THE SPECIES OF ARCOBACTER IN ISOLATES FROM
HUMAN AND ANIMAL FECAL SAMPLES IN LIMA, PERU
Rito Zerpa1
, Maritza Puray-Chavez1
, Carlos R. Sevilla1
, Paolo A.
Wong1
, Percy Lezama2
, Lilian Patiño3
, Jorge O. Alarcon1
1
Instituto de Medicina Tropical, Universidad Nacional Mayor de San
Marcos, Lima, Peru, 2
Frigorifico La Colonial SAC, Callao, Peru, 3
Instituto
Nacional de Salud del Niño, Lima, Peru
A multiplex PCR was used to confirm the identity of isolates that are
phenotypically suggestive of Arcobacter from human and animal stool
samples in Lima, Peru. We evaluated 57 bacterial isolates from human
fecal samples (3), pigs (52), lion (1) and rabbit (1), with the following
phenotypic characteristics suggestive of Arcobacter: gram-negative rods,
curve-shaped C or S, mobile, aerobic and microaerophilic, circular colonies
1 to 2mm in diameter at 18-24 hours of incubation in microaerophilic
conditions on blood agar, non-hemolytic and lactose negative colonies on
MacConkey agar, oxidase and catalase positive. The study of genotype
was performed by multiplex PCR, as reported previously, using primers
targeting the 16S and 23S rRNA genes for the detection of three species:
A. butzleri, A. cryaerophilus, A. skirrowi, with a molecular weight of
401-bp, 257-bp, 641-bp, respectively. It was confirmed molecularly that
Arcobacter was in 87.7% (50/57) of the isolates studied, 90% (45/50) of
which corresponded to A. butzler, 8.0% (4/50) to A. cryaerophilus and
2% (2/50) to A. skirrowi. A proportion of 12.3% were negative with the
primers used. Of the three human samples, two isolates corresponded to
A. butzleri and one to A. cryaerophilus. The rabbit and lion isolates were
A. butzleri. Of the pig isolates, 91.1% (41/45) A. butzler, 6.7% (3/45)
were A. cryaerophilus, and 2.2% (1/45) A. skirrowi. The presence of A.
butzler, A. cryaerophilus and A. skirrowi were confirmed in 87.7% of the
total isolates of human, pig, rabbit and lion fecal samples. The remaining
12.3% of the isolates are likely composed of other species of Arcobacter.
3. A-471
The number(s) following author name refers to the abstract number.
www.astmh.org
Abstract Author Index
Kuschner, Robert A. 418
Kushner, Adam L. 286
Kuzmin, Ivan 566
Kwak, Byung Hyung 676
Kwambai, Titus 271
Kwambana, Brenda 1419
Kwarteng, Alexander 522
Kwarteng, Anthony 1176
Kweza, Patience 1252
Kwiatkowski, Dominic 503, 999
Kwityn, Clifford 1034
Kwofie, Kofi D. 256
Kwon, Chang-hee 580
Kyabayinze, Daniel 463, 1307,
1309, 1020
Kyari, Fatima 1274
Kyebambe, Peterson S. 656
Kyelem, Carole G. 377
Kyelem, D. 483
Kyle, Dennis E. 431, 866, 867,
989
Kyobutungi, Catherine 1360
L
LaBaer, Josh 41
Labbé, Pierrick 1205
LaBeaud, A. Desiree 50, 423, 721
Laclette, Juan P. 98, 1076, 99
Lacoste, Maryjane 880
LaCrue, Alexis N. 431
Lafferty, Kevin 757
LaForce, Marc 1408
Lafosse, Elsie 47
Lafuente-Monasterio, Maria
Jose 1325
Lage, Regina C. G. 529
Laguna-Torres, Victor A. 1135,
942, 1400
Lai, Chih-Yun 1394
Lakwo, Tom L. 520
Lal, Sham 340, 341
Lalji, Shabbir 546, 918
Lalloo, David 362, 1441
Lam, Felix 1345
Lam, Polo C. H.. 24
Lambert, Lynn 1423
Lamberton, Poppy H. L. 479
Lamine, Diakité Moussa 1337
Lammie, Patrick 482, 645
Lampah, Daniel A. 155, 1424
Lan, Nguyen T. P. 637
Lanata, Claudio F. 516, 941,
1248, 1258
Laney, Sandra J. 1489
Lang, Jean 110, 630
Lanou, Herman 292
Lantagne, Daniele S. 1252
Lanteri, Charlotte A. 837, 1063
Lantz, Chris 438
Laquer, Kari 176
Larbi, Irene A. 1109
Larissa Aurore Tobola,
Bouyoukou Hounkpatin 703
LaRocque, Regina C. 42, 43, 45,
1410, 41, 1041
Larrauri, Luis 446
Larsen, David 1180
Larsen, David A. 12, 468, 694,
1435
Larson, Erik 629
Larson, Nick 1213
Larson, Peter S. 915, 917
Larsson, Catherine 1011
Lasanajak, Yi 761
Laserson, Kayla 513, 514, 515,
952, 961, 453, 1403
Latourette, Matthew 1427
Lau, Colleen 118
Lau, Louis 1395
Lau, Rachel 862
Lauby-Secretan, Beatrice 141
Laucella, Susana A. 1153
Laufer, Miriam K. 871, 1438,
857, 857
Laurens, Matthew B. 5, 7, 1335
Laver, Susan M. L.. 1252
Law, Charity W. 1167
Lawal, Ismail 958
Lawrie, Alison 3
Lazo, John S. 537
Le, Binh 1209
Le, Christy 1002
Le, Huu Tho 246
Le, Minh Nhat 246
Le Bras, Jacques 862, 863, 863,
864, 868
Le Nagard, Hervé 868
Ledermann, Jeremy P. 1377, 566
Lee, Angela 1357
Lee, Andrew H. 439
Lee, Bi-Yao 1119
Lee, Bruce Y. 127, 296
Lee, Ming-Chieh 877
Lee, Marcus C. S. 439
Lee, Patricia J. 683
Lee, Sue 548, 1269
Lee, Susan Shin-Jung 1119
Leed, Susan E. 683
Leeds, Janet M. 103
Leepitakrat, Surachai 578
Legac, Jenny 677
Legros, Mathieu 872
Lehane, Michael 71, 76
Leiby, David A. 905, 905
Leitner, Gabriel 797
Leitner, Wolfgang W. 611, 611
Lekpor, Cecilia E. 333
Lele, Albertine K. 337
Lemey, Philippe 17, 119
Lemma, Seblewengel 903
Lemnge, Martha M. 861
Lemos, Larissa S. 250
Lengeler, Christian 1328
Lenhart, Audrey 281, 724, 786
Lennon, Niall J. 429
Lennox, Gayle 1254
Leon, Juan S. 1255
Leontsini, Elli 774, 775, 963, 965
Leow, Kak S. 560
Lepore, Timothy 60
Lepore S.R., Timothy J. 59
Lerdprom, Rujira 877
Leroy, Didier 681, 986
Lesage, Pierre-Loup 1345
Lescano, Andrés G. 227, 259,
445, 640, 929, 1196, 1223
Lescuyer, Arlette 1451
Leshem, Eyal 829
Leslie, Toby 454, 461
Lesser, Adriane 1353
Lessler, Justin 1082
Letizia, Andrew 951
Leung, Daniel T. 42, 43, 45, 518,
1041, 1410
Leung, Zachary 1470
Leutner, Silke 980
Levens, Joshua 592
Levin, Joshua Z. 429
Levine, Jessica 54
Levine, Myron M. 236, 513, 515,
961, 1288, 514, 1059, 1060
Levine, Rebecca 563
Levy, Danielle 1275
Levy, Karen 1042
Levy, Michael Z. 275, 825
Lewallen, Susan 1268, 1271
Lewis, Kayla 1240
Lewis, Michael D. 981
Lezama, Percy 1055
Lhermitte-Vallarino, Nathaly 40
Li, Hongmin 1071
Li, Jianyong 24
Li, Jian 665
Li, Lixin 103
Li, Li 1104
Li, Qigui 840, 841
Li, Shanping 389
Li, Tao 189, 449
Li, Tiger 1099
Li, Xiangming 1461
Li, Yu 455
Li, Yuexin 834, 834
Liang, Ai Wei 110
Liang, Li 719
Liang, Song 960
Liang, Yousheng 532
Liao, Hua-Xin 632
Libraty, Daniel H. 15
Lichtner, Franz 1459
Lieberman, Marya 1240
Lieshout, L. V. 1434
Lietman, Tom M. 29
Lievens, Marc 188
Liles, W. C. 1449
Lillebø, Kristine 1278, 1279,
1280
Lilue, Jingtao 1499
Lim, Burton K. 53
Lim, Chang-kweng 1392
Lim, Jacqueline K. 1016, 1017
Lim, Kee-Chong 1035
Lim, Pharath 985
Lim, Yvonne A. L. 248
Lima, Aldo A. M. 517, 1049
Lima, Helena C. A. V. 19
Lima, Marcelo d. Lima. 265, 266
Noélia L. Lima. 517
Limbach, Keith 495
Limkittikul, Kriengsak 1016,
1017, 1101
Lin, Feng-Chang 363
Lin, Jingwen 978
Lin, Jessica T. 357, 689, 689, 889
Lin, Ren-Yong 449
Lin, Zhaoting 983
Linares-Perez, Nivaldo 944, 1249
Lindblade, Kim 485, 626, 938,
1124, 1125, 1243, 391
Lindh, Jenny 191, 214, 217
Lindo, John F. 1130
Lindquist, Susan 1297
Lindroth, Erica 67
Lindsay, Robbin 1090, 1287
Lindsay, Steve 191, 214, 217,
1220, 1388, 464, 1419
Lindsay, Thomas 1419
Lindsley, Craig W. 730
Lingam, Raghu 804
Linser, Paul 1362
Linthicum, Kenneth K. 211
Liomba, Mike 857, 857
Liong, Kek-Yee 983
Lipkin, W. Ian 1103
Lissandrin, Raffaella 448, 1067
Little, Kristen M. 485, 1124,
1125, 1478
Littrell, Megan 1021, 1299, 1300
Liu, Canhui 1113, 1487
Liu, Jenny 342, 684, 1174
Liu, Jie 512, 1380
Liu, Kun 1464
Liu, Lucy 60
Liu, Mingli 313, 663
Liu, Mingshun 625
Liu, Shiping 23
Liu, Xia 175
Liu, Yunhua 23
Liu, Yue 1027
Livengood, Jill A. 619, 1013,
1014
Liyanage, Jayantha 410
Llanos, Fernando 446
Llanos, Fiorella 1341
Llanos-Cuentas, Alejandro 885,
887, 1270, 1341
Llergo, Jose L. 1320
Llewellyn, Martin S. 981
Llinás, Manuel 439
Lloyd, Bradley 790