This document describes a project by the Cochrane Tobacco Addiction Group (TAG) to prioritize future research areas on tobacco control and smoking cessation for their 20th anniversary. The project involved two surveys to gather uncertainties from stakeholders and rank identified research questions. The first survey identified 183 unanswered tobacco-related questions from 258 submissions. The second survey had 175 stakeholders rank the questions into 15 categories. A prioritization workshop with roundtable discussions then focused on Cochrane TAG's priorities moving forward. The project aims to raise awareness, identify further research needs, and set specific goals for Cochrane TAG.