Clinical research (literature, protocol elements)
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This document provides an overview of clinical research basics and medical literature. It discusses the importance of conducting literature reviews to avoid duplicating previous work and inform the research methodology. It describes the differences between journals, textbooks, and databases. Several common medical databases and research engines are listed, including PubMed, Google Scholar, Web of Science, Scopus, and Cochrane. PubMed is described in more detail, outlining how to access and search it using keywords, filters, Boolean operators, and truncation. Steps for developing a strong research proposal are also outlined.
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This document provides an overview of resources available through the Welch Library, including over 1.8 million online resources such as databases, journals, e-books and videos. It describes several important databases for literature searching such as PubMed, Embase, CINAHL, PsycINFO and Scopus. Finally, it outlines the steps for effective literature searching, including developing search strategies using controlled vocabularies, keywords, Boolean operators and evaluating search results.
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The document discusses the process of researching, publishing, and searching for medical literature. It begins by outlining the steps from developing a research protocol through publication and indexing in databases. It then provides basic search tips for using Boolean operators, phrasal searches, and truncation. Examples are given for searching PubMed and the Egyptian Knowledge Bank (EKB) database. Finally, it briefly outlines some options for obtaining full-text articles.
How to search the medical litterature on the net?
This document provides guidance on how to search the medical literature using online resources like PubMed. It discusses formulating answerable clinical questions using the PICO framework. Key strategies for searching PubMed are described, including using Medical Subject Headings (MeSH) terms and Boolean operators. The importance of appraising the level of evidence of search results is also highlighted.
Overview of Scientific literature
Scientific literature began with the earliest science journal in 1665 called The Philosophical Transactions of the Royal Society. This journal was significant because it published papers by famous scientists like Newton and Darwin and began the practice of peer review. A key part of scientific research articles is that they are published in peer-reviewed journals and have distinguishable sections like the abstract, introduction, methods, results, and discussion. Databases like Academic Search Complete and CINAHL provide access to scientific research articles and tips for effective searching.
Search for evidence
The document provides guidance on selecting evidence-based medicine tools and resources for clinicians. It recommends keeping resources simple, focusing on those that are free or accessible at the point of care. Primary research sites like PubMed and specialized databases like Cochrane and National Guideline Clearinghouse are suggested as starting places. When formulating questions, a systematic search process including guidelines, reviews and primary studies is outlined.
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Clinical research (literature, protocol elements)
- 1. 1 Clinical Research Basics Mohamed Fahmy Doheim M.B.B.Ch Candidate
- 2. Previous Session 1- Introduction Medical Research Types! Science? Research? Why do research?
- 4. Medical Literature : What, where and how?
- 5. What? • Medical literature is the scientific literature of medicine: articles in journals and texts in books devoted to the field of medicine
- 6. 6 Literature review • It prevents the duplication of work that has been done before. • It helps the researchers to find out what others have found and reported on the problem. • It helps the researcher to become more familiar with the various types of methodology that could be used in the study. • It should provide convincing arguments why this particular research project is needed.
- 7. What’s the difference? • Journals ( Peer reviewed vs. not?) • Text books • Databases • Publishers?
- 8. Common databases/ Research engines • PubMed (website) from Medline! • Google scholar • Web of science (ISI) (Via EKB) • Scopus (Via EKB) • Embase ( No free access) • Cochrane • WHO Global Health Library (GHL)
- 9. PubMed Free resource developed and maintained by the National Center for Biotechnology Information (NCBI), at the U.S. National Library of Medicine (NLM), located at the National Institutes of Health (NIH). More than 5,400 worldwide journals in 60 languages. Covers 1947 to the present with some older material.
- 10. PubMed • How to open PubMed? In your browser, type http://www.ncbi.nlm.nih.gov/pubmed
- 11. PubMed interface
- 13. PubMed filters
- 16. Boolean operators • George Boole (1815 –1864) was an English mathematician and philosopher. Invented Boolean logic which is the basis of modern digital computers. • -AND • -OR • -NOT
- 17. AND
- 18. OR
- 19. NOT
- 20. TRUNCTION • Truncation is a searchable shortened form of a word. • Example: – adolescen* will include • adolescence • adolescent • adolescents, etc…
- 21. Example • We seach about Articles which mention The safety and efficacy of the combination of daclatasvir, asunaprevir, and beclabuvir in the treatment of chronic hepatitis C virus (Daclatasvir OR BMS-790052 OR Daklinza OR DCV) AND (Asunaprevir OR BMS-650032 OR Sunvepra OR ASV) AND (Beclabuvir OR BMS-791325 OR BCV).
- 22. Try yourself • We want to know the effects of eicosapentaenoic acid (EPA) in depression. What's your proposed search strategy?
- 23. 23 Steps of developing a research proposal • Title of the research • Background information and statement of the research problem (scientific justification for the study) • Research objectives • Research hypothesis • Methodology • Work plan • Plan for utilization and dissemination of research results • References • Budget preparation • Annexes