This document discusses Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), an acquired immune-mediated disorder of the peripheral nervous system. It causes damage to the protective myelin sheath surrounding nerves. CIDP symptoms include progressive or relapsing limb weakness and sensory disturbances. Diagnosis involves electrodiagnostic tests, bloodwork, lumbar puncture and nerve biopsy. Treatment focuses on slowing the immune system through corticosteroids, intravenous immunoglobulin, plasma exchange or immunotherapy. The goal is to prevent nerve damage and stop symptoms from becoming severe.
AUTOIMMUNE DISORDERS OF NERVOUS SYSTEMANILKUMAR BR
Autoimmune disorders of the nervous system can attack the central nervous system (CNS), Autoimmune disorders affecting both the central and peripheral nervous system.) which includes the brain and spinal cord, or the peripheral nervous system, consisting of nerves that connect the CNS with the limbs and organs.
The most common disorders are multiple sclerosis and myasthenia gravis.
Autoimmune nervous system disorders include:
Multiple sclerosis
Myasthenia gravis
Guillain-Barré syndrome. (GB Syndrome)
AUTOIMMUNE DISORDERS OF NERVOUS SYSTEMANILKUMAR BR
Autoimmune disorders of the nervous system can attack the central nervous system (CNS), Autoimmune disorders affecting both the central and peripheral nervous system.) which includes the brain and spinal cord, or the peripheral nervous system, consisting of nerves that connect the CNS with the limbs and organs.
The most common disorders are multiple sclerosis and myasthenia gravis.
Autoimmune nervous system disorders include:
Multiple sclerosis
Myasthenia gravis
Guillain-Barré syndrome. (GB Syndrome)
GBS means Guillain Barre syndrome a disease of neurological system. It often begins with tingling sensation and weakens from the legs and radiating to upper body and arms. there is no known cure for GBS, but treatments can improve symptoms and shorten its duration.
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.Dr. Kiran Dhamak
Central Nervous System is one of the unit in Pharmacotherapeutics Subject which is for Second Year Diploma in Pharmacy. The unit covers diseases like Epilepsy, Parkinson, Alzheimer, Stroke and Migraine. The presentation includes the point as per diploma in pharmacy students may understand very easily. The syllabus is framed by Pharmacy Council of India which is implemented by MSBTE ER 2020-2021
Neurocognitive disorders includes : Delirium and Dementia.
This presentation focuses on causes, risk factors, management and how to prevent its complication
GBS means Guillain Barre syndrome a disease of neurological system. It often begins with tingling sensation and weakens from the legs and radiating to upper body and arms. there is no known cure for GBS, but treatments can improve symptoms and shorten its duration.
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.Dr. Kiran Dhamak
Central Nervous System is one of the unit in Pharmacotherapeutics Subject which is for Second Year Diploma in Pharmacy. The unit covers diseases like Epilepsy, Parkinson, Alzheimer, Stroke and Migraine. The presentation includes the point as per diploma in pharmacy students may understand very easily. The syllabus is framed by Pharmacy Council of India which is implemented by MSBTE ER 2020-2021
Neurocognitive disorders includes : Delirium and Dementia.
This presentation focuses on causes, risk factors, management and how to prevent its complication
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
2. Learning Objectives
By the end of this presentation, learners will be able to:
• Define the term Chronic inflammatory demyelinating polyneuropathy
• Enlist its causes and risk factors
• Enumerate the clinical manifestations
• Elaborate its management
3. Chronic inflammatory demyelinating
polyneuropathy (CIDP)
• It is an acquired immune-mediated
inflammatory disorder of the peripheral
nervous system.
• The disorder is sometimes called chronic
relapsing polyneuropathy (CRP) or chronic
inflammatory demyelinating poly
radiculoneuropathy (because it involves the
nerve roots).
4. Etiology
• Chronic inflammatory demyelinating polyneuropathy (or
polyradiculoneuropathy) is considered an autoimmune disorder
destroying myelin, the protective covering of the nerves.
• CIDP is closely related to Guillain-Barre syndrome (GBS).
• With GBS, once treated, most people recover fairly quickly.
• CIDP, on the other hand, tends to be a longer-term problem. In rare
cases, people who don’t recover from GBS may develop CIDP.
5. Signs and Symptoms
• CIDP typically starts insidiously and evolves slowly, in either a slowly
progressive or a relapsing manner, with partial or complete recovery
between recurrences; periods of worsening and improvement usually
last weeks or months.
• Most experts consider the necessary duration of symptoms to be
greater than 8 weeks for the diagnosis of CIDP to be made.
• Symptoms reported include the following:
• Preceding infection (infrequent)
• Initial limb weakness, both proximal and distal
• Sensory symptoms (eg, tingling and numbness of hands and feet)
6. Signs and Symptoms
• Motor symptoms (usually predominant) muscle
fasciculations, "vibration" feelings, loss of balance,
general muscle cramping and nerve pain
• In children, usually a more quick onset of symptoms
• Symptoms of autonomic system dysfunction (eg,
orthostatic dizziness)
• Pertinent physical findings are limited to the nervous
system, except when the condition is associated with
other diseases.
7. Signs and Symptoms
• Such findings may include the following.
• Signs of cranial nerve (CN) involvement (eg, facial muscle paralysis or
diplopia)
• Gait abnormalities
• Motor deficits (eg, symmetric weakness of both proximal and distal
muscles in upper and lower extremities)
• Diminished or absent deep tendon reflexes
• Sensory deficits (typically in stocking-glove distribution)
• Impaired coordination
8. Typical diagnostic tests include:
• Electrodiagnostics – electromyography (EMG) and nerve conduction study.
• Serum test to exclude other autoimmune diseases.
• Lumbar puncture .
• Sural nerve biopsy; biopsy is considered for those patients in whom the
diagnosis is not completely clear, when other causes of neuropathy (e.g.,
hereditary, vasculitic) cannot be excluded, or when
profound axonal involvement is observed on EMG.
• Ultrasound of the peripheral nerves may show swelling of the affected
nerves.
• MRI can also be used in the diagnosic workup
9.
10. Treatment
• Early treatment is key. It can help prevent nerve damage. That can
help stop symptoms from becoming severe.
Treatment may include:
• Corticosteroids. These medications bring down inflammation and
slow the immune system.
• Intravenous immunoglobulin (IVIG). Your doctor may give you
injections of concentrated antibodies from healthy people to slow
your body’s immune response.
11. Treatment
• Plasma exchange (PE). This treatment involves receiving a part of
blood called plasma through an IV to slow down your immune
system.
• Immunotherapy. These drugs interrupt your immune system to help
stop it from attacking the myelin.
• Stem cell transplant. In rare cases, your doctor may inject healthy
stem cells (either yours or donated by someone else) to "reset" your
immune system.
12. Treatment
• Your doctor may also recommend physical therapy.
• Moderate exercise may give you more energy.
• You may recover entirely from CIDP. Some people do, but they may
have symptoms from nerve damage, such as numbness and
weakness, for the rest of their lives.