Circadian rhythms influence physiology and disease states in a time-dependent manner. Chronopharmacology aims to optimize drug effects and minimize adverse reactions by timing medication administration relative to biological rhythms. Key aspects include chronopharmacokinetics, chronesthesy, and chronotherapy. Many disease states and drug effects vary over the 24-hour period, such as asthma exacerbations most common at night, and cardiovascular events peaking in the morning. Proper timing of drug administration can improve outcomes.
Introduction to chronology, chronotherapy, and chronopharmacology.
How chronopharmacology involved in asthma and helps to manage asthma?.
Biological rhythms in bronchial asthma.
Factors associated with nocturnal exacerbation of bronchial asthma.
Introduction to asthma and their symptoms.
Introduction to Antiasthmatic drugs like beta-blockers, leukotriene antagonists, steroids, etc.
Chronopharmacology division & their examples.
Advantages and disadvantages of chronopharmacology.
Marketed preparation and their images along with the price in India.
Its a about chrono-pharmacology of diabetes
The accurate and detail information about chrono- pharmacology its not available but this information is sufficient or useful.
Introduction to chronology, chronotherapy, and chronopharmacology.
How chronopharmacology involved in asthma and helps to manage asthma?.
Biological rhythms in bronchial asthma.
Factors associated with nocturnal exacerbation of bronchial asthma.
Introduction to asthma and their symptoms.
Introduction to Antiasthmatic drugs like beta-blockers, leukotriene antagonists, steroids, etc.
Chronopharmacology division & their examples.
Advantages and disadvantages of chronopharmacology.
Marketed preparation and their images along with the price in India.
Its a about chrono-pharmacology of diabetes
The accurate and detail information about chrono- pharmacology its not available but this information is sufficient or useful.
ChronoPharmacology in Body Functioning and in Cardiovascular Diseases.pptPayaamvohra1
This ppt gives one an idea about the chronopharmacology and its role i Pharmaceutics as well as Pharmacology.It describes the time dependent cellular processes of body for homeostasis
A brief introduction about Pharmacology of free radicals, generation of free radicals, Antioxidants, Free radicals causing disorders such as cancer diabetes, neuro degenerative disorders such as Parkisonism's Disease
Alternative methods to animals testing are the development and implementation of test method that avoid use of live animals or use of less animals in method.
The council directive on protection of animals used for experiments and scientific purpose in article 23
“The commission and member states should encourage
research into development and validation of alternative methods which could provide the same level of information as that obtained in experiment using animals but which involves less animal”.
Alternative methods able to do:
Reduce Refine Replace
collectively called as “The 3Rs Principle”.
Needs for alternative methods
Because in laboratory animals may be:
Poisoned.
Deprived of food water and sleep.
Applied with skin and eye irritants.
Subjected to psychological stress.
Deliberately infected with the infected disease.
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptxsakshinalkande
It's one of the topic of subject Principle Drug Discovery include in M pharm Pharmacology 2nd sem. It include introduction about rational and traditional drug design with types and methods. It'll be beneficial for M pharm Pharmacology students.
ChronoPharmacology in Body Functioning and in Cardiovascular Diseases.pptPayaamvohra1
This ppt gives one an idea about the chronopharmacology and its role i Pharmaceutics as well as Pharmacology.It describes the time dependent cellular processes of body for homeostasis
A brief introduction about Pharmacology of free radicals, generation of free radicals, Antioxidants, Free radicals causing disorders such as cancer diabetes, neuro degenerative disorders such as Parkisonism's Disease
Alternative methods to animals testing are the development and implementation of test method that avoid use of live animals or use of less animals in method.
The council directive on protection of animals used for experiments and scientific purpose in article 23
“The commission and member states should encourage
research into development and validation of alternative methods which could provide the same level of information as that obtained in experiment using animals but which involves less animal”.
Alternative methods able to do:
Reduce Refine Replace
collectively called as “The 3Rs Principle”.
Needs for alternative methods
Because in laboratory animals may be:
Poisoned.
Deprived of food water and sleep.
Applied with skin and eye irritants.
Subjected to psychological stress.
Deliberately infected with the infected disease.
RATIONAL AND TRADITIONAL DRUG DESIGN Drug Discovery.pptxsakshinalkande
It's one of the topic of subject Principle Drug Discovery include in M pharm Pharmacology 2nd sem. It include introduction about rational and traditional drug design with types and methods. It'll be beneficial for M pharm Pharmacology students.
Chronobiology is a field of biology that examines periodic phenomena in living organisms and their adaptation to solar- and lunar-related rhythms.
These cycles are known as biological rhythms.
Chronobiology comes from the ancient Greek word (chrónos, meaning "time"), and biology, which pertains to the study, or science, of life.
Chronobiology is the science of biological rhythms, more specifically the impact of the 24- hour light- dark cycle on our biochemistry and therefore behaviors.
It is defined as the periodic component of temporal series of biological data whose waveform profile has been analytically validated.
In other words, biological rhythm is a bio-signal whose period of oscillation has been validated by analytical models of periodic regression using one or more harmonic components.
Examples : Heart beat, breathing, hormone secretion, menstrual cycle, body temperature and sleep/wake cycle.
CHRONOTHERAPEUTICS: A NEW VISTA IN NOVEL DRUG DELIVERY SYSTEMSSarvan Mani
Chronotherapeutics is the delivery of medications in the
right concentration to the right targeted tissues at the
right time to meet biological rhythm-determined needs,
e.g., rhythms in the mechanisms of disease, symptom
intensity, and/ or patient tolerance, to optimize desired
and minimize and avert adverse effects.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
3. INTRODUCTION
Most facets of mammalian physiology and behavior vary according to time
of day, thanks to an endogenous “circadian” clock.
Circadian clocks influence all major organ systems, and this influence
translates directly into disease pathology that also varies with time of day.
Franz Halberg coined the term ‘Circadian’ in 20th century.
(circa – about or approximately; dian-day, or about 24 hour).
Considered as one of the founders of “Modern Chronobiology”.
4. INTRODUCTION (contd)
Biological Rhythms
Circadian: Lasting for about 24 hours.
-Sleep wake cycles
Infradian: Cycles longer than 24 hours.
-Menstrual cycle
Ultradian: Cycles shorter than a day.
-Neuronal firing time
Seasonal: Seasonal affective disorders.
7. DEFINITIONS (contd)
Chronopharmacology
Science dealing with optimization of drug effects & minimization of
adverse effects by timing medications in relation to biological rhythm.
It is concerned with the effects of drugs upon the timing of biological
events and rhythms.
Subdivided into
- Chronopharmacokinetics
- Chronotoxicity
- Chronesthesy
- Chronotherapy
8. DEFINITION (contd)
Chronopharmacokinetics :
It deals with the study of the temporal changes in the pharmacokinetics of
the drugs with respective time.
Study of absorption, distribution, metabolism, and excretion of drug
according to the time of the day or year.
9. DEFINITION (contd)
Chronesthesy
The rhythmic changes in susceptibility or sensitivity of a target system to a
drug.
Chronergy
Rhythmic changes of both the desired [effectiveness] and undesired
[toxicity, tolerance] effects on the organism as a whole.
ChronoPharmaceutics
Branch which designs and develops a drug delivery system in accordance
with biological rhythm to optimize the treatment of disease.
10. CHRONOTHERAPEUTICS
Discipline of medical treatment which allows for the consideration of a
patient’s biological rhythm, changes in the severity of a disease state
during the day, and the synchronizing of dosing and delivery of a particular
drug to allow for the optimal efficacy in the patient.
Refers to concept of matching timing of treatment with intrinsic timing of
illness.
Advantages
Prevents over dosage
Appropriate usage of drug
Reduce side effects
12. CIRCADIAN RHYTHM
The basic unit of circadian time-keeping is the…
• Supra chiasmatic nucleus
• Clock genes
Zeitgeber
Circadian rhythms are driven by endogenous processes, are self-sustaining,
and rely upon circadian time cues (zeitgebers) to remain appropriately
oriented to the individual’s environment and desired routine.
13.
14. CLOCK GENES
Circadian rhythms are driven by a group of genes called clock genes.
In mammals, the core clock genes consist of Bmal1 (Brain and muscle aryl
hydrocarbon receptor nuclear translocator-like 1), CLOCK (Circadian
Locomotor Output Cycles Kaput), Per (Period), and Cry (Cryptochrome).
They form a tightly regulated system with interlocking feedback and
feedforward loops.
16. Respiratory System
Increased bronchoconstriction at night due to…
↑Parasympathetic tone
↓ Adrenaline
↓ Cortisol at midnight
↑Sensitivity to irritants and allergens at night
exacerbations of allergic rhinitis & asthma
17. Asthma
• Acute attack of asthma
- more common between midnight and 6 am.
• Rx - Theophylline and Beta 2 agonist is timed at evening
18. Cardiovascular Disorders
• Myocardial infarction
Sudden cardiac death
Angina pectoris
Transient ischemic attacks / Stroke
High incidence between 6am and 12 noon.
• ↑ Vascular tone
• ↑ Platelet aggregation
• ↓ Intrinsic thrombolytic activity.
19. Cardiovascular Drugs
• Aspirin – maximum antiplatelet effect in the morning.
•Thrombolytics and Heparin – ↓ benefit during early morning hours.
• Atenolol – more effective during day time.
• Labetalol – more effective in early morning hours.
• Enalapril - Peak effect in the afternoon after morning dose.
20. Endocrine System
Highest secretion of cortisol early morning.
Lowest at midnight.
GH peaks during sleep.
Testosterone peaks early morning.
TSH peaks at mid night.
Corticosteroids given as single morning dose cause less pituitary adrenal
suppression.
21. Gastrointestinal Tract
• Acid secretion peaks between 10 pm and 2 am.
• Ulcer pain is worst at this time.
• Ulcer healing is directly related to acid secretion inhibition at night.
• Evening dosage of H2 receptor antagonists or PPI.
22. Central Nervous System
Melatonin – secreted at night by pineal gland.
Function – synchronizes sleep wake cycle with circadian rhythm.
Melatonin agonist [Ramelteon] – hypnotic for sleep onset insomnia &
reduces jet lag symptoms.
Bedtime administration - more effective.
23. Musculoskeletal System
Rheumatoid Arthritis
Symptoms more severe - 8am & 11am.
Long acting NSAIDS at bed time.
Osteoarthritis
Pain more intense between 2 pm and 8 pm.
Morning dose for afternoon worsening, evening dose for night time
worsening.
25. Cancer
Cancer cells are considered to have lost internal time keeping mechanism.
Tumor cells and normal cells differ in their chronobiological cycles.
The basis for the chronopharmacotherapy of cancers...
Lymphoma
The DNA synthesis in the normal human bone marrow cells has a peak
around noon while the peak of DNA synthesis in lymphoma cells is near
midnight.
So, an s-phase active cytotoxic therapy at late nights should be more
advantageous.
26. Skin Disorders
Psoriasis: cell proliferation rate peaks between 9pm & 3am.
-Inflammatory activity highest at night, least in the morning.
Atopic dermatitis: sensitivity to histamine highest at night.
Topical corticosteroids: activity in the afternoon higher than that in the
morning.