Chickenpox, also called varicella, is a highly contagious disease caused by the varicella-zoster virus. It presents with a red, itchy rash that initially resembles insect bites on the face, scalp, chest, and back. While chickenpox is usually mild and self-limiting in children, it can lead to complications in infants, adolescents, pregnant women, and older patients. Treatment focuses on relieving symptoms through cooling baths, calamine lotion, and acetaminophen. The varicella vaccine provides effective prevention against chickenpox.