This document provides an overview of metabolism and metabolic reactions. It begins by defining the key concepts of kinetic and potential energy. It then explains the laws of thermodynamics and how they apply to biological systems. Specifically, it states that energy cannot be created or destroyed, and that entropy increases with energy transfers. It introduces the idea of exergonic and endergonic reactions, and how cells harness energy from exergonic reactions through ATP. The document outlines metabolic pathways and explains how enzymes function as catalysts to lower the activation energy of reactions. It also discusses factors that regulate enzyme activity such as substrate concentration, temperature, pH, and cellular mechanisms like phosphorylation.
This document provides an overview of chapter 8 from Campbell Biology, 9th edition, which discusses metabolism. It covers several key topics in 3 paragraphs or less:
Metabolism transforms matter and energy according to the laws of thermodynamics through metabolic pathways mediated by enzymes. Catabolic pathways release energy by breaking down molecules, while anabolic pathways use energy to build molecules. ATP powers cellular work by coupling exergonic reactions to endergonic reactions.
Enzymes speed up metabolic reactions by lowering activation energy. Each enzyme has a specific substrate that binds at its active site, orienting the reactants in a way that facilitates the reaction. Environmental factors like temperature and pH can impact an enzyme's activity by influencing its
This document summarizes key concepts in bioenergetics and cellular respiration. It discusses how living organisms obtain and use energy through redox reactions and electron carriers like ATP. Photosynthesis and cellular respiration are introduced as the two main pathways of energy transformation. Photosynthesis uses energy from sunlight to synthesize glucose from carbon dioxide and water, while cellular respiration breaks down glucose to release energy through glycolysis, the Krebs cycle, and the electron transport chain. The document aims to explain the basic processes of how energy is transformed and utilized in living cells and organisms.
The Gaia Hypothesis & The Earth As A SystemPaul Wozney
The document discusses the Gaia Hypothesis, which proposes that all living things on Earth function together as a single superorganism to regulate conditions for life. The hypothesis views Earth as a closed system with four interacting spheres - the biosphere, hydrosphere, atmosphere, and lithosphere. These spheres work together to maintain surface temperature, atmospheric composition, and ocean salinity over time in ways that sustain life. The Earth is seen as a self-regulating system driven by energy from the sun, and disruption to its natural cycles could upset the balance required for life.
Cellular respiration introduction general for 9th grade biologyStephanie Beck
Cellular respiration is the process cells use to release energy from glucose and store it in ATP. It occurs in three stages:
1. Glycolysis breaks glucose into two pyruvate molecules, releasing a small amount of energy as ATP.
2. The citric acid cycle in the mitochondria further breaks down the pyruvate molecules, producing more ATP and electron carriers.
3. The electron transport chain uses oxygen to pump protons out of the mitochondria, powering ATP synthase to produce most of the cell's ATP through oxidative phosphorylation. Aerobic respiration produces 36 ATP while fermentation makes only 2 ATP without oxygen.
This document introduces key levels of biological organization from subatomic particles to ecosystems. It discusses the characteristics of living things including being complex, made of cells, obtaining energy and materials, responding to stimuli, growing, reproducing, and evolving over time. The scientific method and development of scientific theories are also outlined. Evolution is presented as the unifying theory of biology, with species adapting or going extinct based on environmental changes over millions of years.
Enzymes are protein catalysts that speed up biochemical reactions without being consumed. They work by lowering the activation energy of reactions. Enzymes have specific active sites that bind substrates and induce a conformational change through induced fit. This allows the enzyme to accelerate the reaction and produce products. The rate of enzyme reactions can be affected by environmental factors like temperature, pH, and concentrations of enzymes and substrates.
This document provides an overview of chapter 8 from Campbell Biology, 9th edition, which discusses metabolism. It covers several key topics in 3 paragraphs or less:
Metabolism transforms matter and energy according to the laws of thermodynamics through metabolic pathways mediated by enzymes. Catabolic pathways release energy by breaking down molecules, while anabolic pathways use energy to build molecules. ATP powers cellular work by coupling exergonic reactions to endergonic reactions.
Enzymes speed up metabolic reactions by lowering activation energy. Each enzyme has a specific substrate that binds at its active site, orienting the reactants in a way that facilitates the reaction. Environmental factors like temperature and pH can impact an enzyme's activity by influencing its
This document summarizes key concepts in bioenergetics and cellular respiration. It discusses how living organisms obtain and use energy through redox reactions and electron carriers like ATP. Photosynthesis and cellular respiration are introduced as the two main pathways of energy transformation. Photosynthesis uses energy from sunlight to synthesize glucose from carbon dioxide and water, while cellular respiration breaks down glucose to release energy through glycolysis, the Krebs cycle, and the electron transport chain. The document aims to explain the basic processes of how energy is transformed and utilized in living cells and organisms.
The Gaia Hypothesis & The Earth As A SystemPaul Wozney
The document discusses the Gaia Hypothesis, which proposes that all living things on Earth function together as a single superorganism to regulate conditions for life. The hypothesis views Earth as a closed system with four interacting spheres - the biosphere, hydrosphere, atmosphere, and lithosphere. These spheres work together to maintain surface temperature, atmospheric composition, and ocean salinity over time in ways that sustain life. The Earth is seen as a self-regulating system driven by energy from the sun, and disruption to its natural cycles could upset the balance required for life.
Cellular respiration introduction general for 9th grade biologyStephanie Beck
Cellular respiration is the process cells use to release energy from glucose and store it in ATP. It occurs in three stages:
1. Glycolysis breaks glucose into two pyruvate molecules, releasing a small amount of energy as ATP.
2. The citric acid cycle in the mitochondria further breaks down the pyruvate molecules, producing more ATP and electron carriers.
3. The electron transport chain uses oxygen to pump protons out of the mitochondria, powering ATP synthase to produce most of the cell's ATP through oxidative phosphorylation. Aerobic respiration produces 36 ATP while fermentation makes only 2 ATP without oxygen.
This document introduces key levels of biological organization from subatomic particles to ecosystems. It discusses the characteristics of living things including being complex, made of cells, obtaining energy and materials, responding to stimuli, growing, reproducing, and evolving over time. The scientific method and development of scientific theories are also outlined. Evolution is presented as the unifying theory of biology, with species adapting or going extinct based on environmental changes over millions of years.
Enzymes are protein catalysts that speed up biochemical reactions without being consumed. They work by lowering the activation energy of reactions. Enzymes have specific active sites that bind substrates and induce a conformational change through induced fit. This allows the enzyme to accelerate the reaction and produce products. The rate of enzyme reactions can be affected by environmental factors like temperature, pH, and concentrations of enzymes and substrates.
The study of energy in living systems (environments) and the organisms (plants and animals) that utilize them.
I'm a st.Xavier's student . i think this ppt will be helpful to the others. Because this is needed in our daily life.
https://www.deped.gov.ph/wp-content/uploads/2019/01/General-Chemistry-1-and-2.pdf
General Chemistry
GenChem
STEM
Science, Technology, Engineering, and Mathematics
K to 12 Senior High School STEM Specialized Subject – General Chemistry 1 and 2
Quarter 1 – General Chemistry 1
Matter and Its Properties
Measurements
Atoms, Molecules and Ions
Stoichiometry
Percent Composition and Chemical Formulas
Chemical reactions and chemical equations
Mass Relationships in Chemical Reactions
Gases
Dalton’s Law of partial pressures
Gas stoichiometry
Kinetic molecular theory of gases
Quarter 2 – General Chemistry 1
Electronic Structure of Atoms
Electronic Structure and Periodicity
Chemical Bonding
Organic compounds
Quarter 3 – General Chemistry 2
Intermolecular Forces and Liquids and Solids
Physical Properties of Solutions
Thermochemistry
Chemical Kinetics
Quarter 4 – General Chemistry 2
Chemical Thermodynamics
Chemical Equilibrium
Acid-Base Equilibria and Salt Equilibria
Electrochemistry
This document provides an overview of metabolism and enzymes for an AP Biology class. It discusses how chemical reactions in living things are facilitated by enzymes to transform energy and molecules. Enzymes are protein catalysts that reduce the activation energy of reactions and increase their rates. The functions of enzymes can be affected by factors like temperature, pH, and concentrations of enzymes and substrates. The document also explains inhibition of enzymes through competitive, noncompetitive, and irreversible mechanisms.
This document discusses limiting and excess reactants in chemical reactions. It defines a limiting reactant as the reactant that is consumed first or ends the reaction. It provides two methods to determine the limiting reactant: 1) converting reactants to moles and seeing which produces the fewest moles of product, and 2) comparing reactant ratios in the chemical equation and actual amounts. The excess reactant is any reactant other than the limiting one that remains after the reaction. It defines percent excess reactant as the moles in excess divided by the moles required to react with the limiting reactant.
This document discusses energy, ATP, and enzymes. It explains that ATP provides energy for cellular work by transferring energy from exergonic reactions to drive endergonic reactions. ATP is composed of adenine, ribose, and three phosphate groups. When ATP donates a phosphate group through hydrolysis, it is an exergonic reaction that releases energy that can be used to power cellular processes.
1. The document discusses the cell cycle and process of mitosis. It defines key terms like chromosomes, chromatids, chromatin and describes the main phases of the cell cycle - interphase and mitosis.
2. Interphase involves growth and DNA replication before cell division. Mitosis involves 5 phases - prophase, prometaphase, metaphase, anaphase, and telophase where the chromosomes are aligned and separated.
3. Cytokinesis then divides the cytoplasm, completing cell division and producing two identical daughter cells each with the same number and type of chromosomes as the original parent cell.
This document contains a collection of chemistry-themed jokes and puns. Each joke is one line long and followed by a one word answer playing on chemical elements, properties, or terminology. The jokes make use of wordplay and element symbols to playfully reference concepts in chemistry.
This document provides information about eukaryotic cells. It includes diagrams and descriptions of key structures in animal cells like the nucleus, cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and ribosomes. It compares prokaryotic and eukaryotic cells, highlights differences between plant and animal cells, and outlines two roles of extracellular components like bone matrix, basement membranes, and cell walls. The document contains links to additional resources for further information.
Ch06 lecture pathways that harvest and store chemical energyTia Hohler
The document summarizes pathways that cells use to harvest and store chemical energy. It discusses how ATP, reduced coenzymes, and chemiosmosis play important roles in energy metabolism. The aerobic breakdown of glucose is described in three stages: glycolysis, pyruvate oxidation, and the citric acid cycle. This releases a large amount of energy as ATP through oxidative phosphorylation. Under anaerobic conditions, fermentation is used to regenerate NAD+ from NADH, but yields much less ATP.
This document provides an introduction to the key concepts of ecology. It defines ecology as the study of interactions between organisms and their environment. It explains that the environment includes both abiotic (non-living) factors like temperature, water and soil as well as biotic (living) components like other organisms. The document also introduces several core ecological concepts, including populations, communities, ecosystems and the biosphere. It notes that ecology seeks to understand how these various environmental factors affect living populations. Finally, it briefly outlines some of the major terrestrial and aquatic biomes and the climatic and other environmental characteristics that define each one.
chemistry calculations percent yield and atom economyrei64
Percentage yield is a number between 0-100 that indicates how successful a chemical reaction was at producing the desired product. It is calculated by taking the mass of product actually produced and dividing it by the theoretical mass expected based on the limiting reactant.
Atom economy is also a number between 0-100 that indicates how efficiently a reaction uses reactants to produce the desired product. It is calculated by taking the mass of the desired product and dividing it by the total mass of all products.
Factors like incomplete reactions, losses during workup, and impure products can decrease the percentage yield of a reaction.
The document discusses energy transformations in living organisms. It explains that glucose is the main source of chemical energy for plants and animals. ATP is the energy currency of cells and is regenerated through cellular respiration. Cellular respiration can occur aerobically, using oxygen to produce more ATP, or anaerobically through fermentation without oxygen. Photosynthesis captures solar energy to convert carbon dioxide and water into glucose and oxygen. Plants have evolved C3, C4, and CAM pathways to photosynthesize that help conserve water in different environments.
Photosynthesis And Cellular Respiration Notes NewFred Phillips
1. Photosynthesis uses energy from sunlight, carbon dioxide, and water to produce glucose and oxygen through a two-phase process of light-dependent and light-independent reactions.
2. Cellular respiration breaks down glucose and other food molecules to produce ATP through three main stages: glycolysis, the citric acid cycle, and the electron transport chain.
3. Both processes are essential for life - photosynthesis provides energy for plants and produces oxygen and glucose as an energy source for cellular respiration in plants and animals.
Foundation and fundamentals of chemistry pptTejNarayan15
This document provides an introduction to general and physical chemistry presented by Tej Narayan Chapagain. It discusses key topics including:
- Chemistry is the study of the composition, structure, properties and transformations of matter. Chemists discover and apply principles for inventions and innovations.
- Chemistry contributes to understanding natural phenomena and traces out complications to provide solutions. It has played important roles in fields like clothing, shelter, pharmacy, agriculture and more.
- Chemistry is considered a central science as it links to other disciplines like biology, physics, geology and more. Nanotechnology has emerged guided by chemistry's basic principles.
- The document provides an overview of chemistry's importance, uses, and scope across various industries and
The document discusses reaction kinetics and rate laws. It defines key terms like rate law, order of reaction, and rate constant. The rate law expresses the relationship between the rate of a reaction and the concentrations of reactants raised to powers corresponding to their order. The order of a reaction with respect to a reactant is the exponent on its concentration term in the rate expression. The total order is the sum of all exponents. Examples are provided to demonstrate how to determine orders from rate laws and write rate expressions.
This presentation provides an outline on the topic of chemical kinetics. It introduces chemical kinetics and discusses reaction rates, examples of reaction rates, reaction rate laws, order of reaction, and activation energy. The presentation was given by MD Mehebu Easdani, a 3rd year chemistry student in the 6th semester of 2020-2021 at the Chemistry Department of Aliah University.
The document summarizes key concepts about the cell cycle and cell division. It discusses how cell division allows for reproduction, growth, and repair. There are two main types of cell division - mitosis, which produces genetically identical daughter cells, and meiosis, which produces gametes. The cell cycle consists of interphase and the mitotic phase. Interphase includes DNA replication in S phase. Mitosis separates duplicated chromosomes into two daughter cells. Cytokinesis then divides the cytoplasm. Prokaryotes divide by binary fission, with the chromosome replicating and daughter chromosomes moving apart.
Pressure, temperature and ‘rms’ related to kinetic modelMichael Marty
The macroscopic properties of a gas, pressure and temperature, are explained in terms of molecule movement of the Kinetic Theory. The derivation of formulas are shown in logical steps for pressure, temperature and KE.
This document provides an introduction to key concepts in ecology. It defines ecology as the study of the relationships between organisms and their environment. It describes the different levels of ecological organization from the biosphere down to individual organisms. It explains that all organisms interact with and depend on other living and non-living things in their environment. It also outlines biotic and abiotic factors that influence organisms, adaptations that help organisms survive, and mechanisms like acclimation, dormancy, and migration that aid survival. Finally, it defines niche and biogeography.
1. The document outlines key concepts and skills students should master in stoichiometry including calculating moles, mass, atoms, and molecules from balanced chemical equations and using these calculations to determine empirical formulas, molecular formulas, theoretical yields, and percent yields.
2. Example problems are provided to assess students' mastery of calculating moles from mass and vice versa, determining mass of products from reactants, calculating percent yields from experimental data, determining empirical and molecular formulas, and using balanced equations to calculate heat released.
This study investigated hormone levels in 31 boys with autism and 28 healthy controls between ages 3-8. It found that boys with autism had significantly lower levels of acyl ghrelin (AG), des-acyl ghrelin (DG), and growth hormone (GH) compared to controls. However, boys with autism had significantly higher levels of total testosterone (TT), free testosterone (FT), and leptin. Lower AG and DG levels in autistic boys were a novel finding that suggests ghrelin may play a role in autism pathogenesis given its effects on neuroinflammation, apoptosis, and other processes implicated in autism. Correlation analyses also found several significant relationships between hormone levels.
- Shenzhen Leveking bio-engineering Co. Ltd produces phytase enzymes for use in animal feed to improve nutrient utilization.
- Phytate in feed binds phosphorus and other minerals, reducing their availability to animals. Leveking's phytase is added to feed to break down phytate, releasing nutrients and improving growth performance.
- A study found that adding Leveking phytase to broiler diets improved final weight, feed intake, and feed conversion ratio in a dose-dependent manner compared to controls.
The study of energy in living systems (environments) and the organisms (plants and animals) that utilize them.
I'm a st.Xavier's student . i think this ppt will be helpful to the others. Because this is needed in our daily life.
https://www.deped.gov.ph/wp-content/uploads/2019/01/General-Chemistry-1-and-2.pdf
General Chemistry
GenChem
STEM
Science, Technology, Engineering, and Mathematics
K to 12 Senior High School STEM Specialized Subject – General Chemistry 1 and 2
Quarter 1 – General Chemistry 1
Matter and Its Properties
Measurements
Atoms, Molecules and Ions
Stoichiometry
Percent Composition and Chemical Formulas
Chemical reactions and chemical equations
Mass Relationships in Chemical Reactions
Gases
Dalton’s Law of partial pressures
Gas stoichiometry
Kinetic molecular theory of gases
Quarter 2 – General Chemistry 1
Electronic Structure of Atoms
Electronic Structure and Periodicity
Chemical Bonding
Organic compounds
Quarter 3 – General Chemistry 2
Intermolecular Forces and Liquids and Solids
Physical Properties of Solutions
Thermochemistry
Chemical Kinetics
Quarter 4 – General Chemistry 2
Chemical Thermodynamics
Chemical Equilibrium
Acid-Base Equilibria and Salt Equilibria
Electrochemistry
This document provides an overview of metabolism and enzymes for an AP Biology class. It discusses how chemical reactions in living things are facilitated by enzymes to transform energy and molecules. Enzymes are protein catalysts that reduce the activation energy of reactions and increase their rates. The functions of enzymes can be affected by factors like temperature, pH, and concentrations of enzymes and substrates. The document also explains inhibition of enzymes through competitive, noncompetitive, and irreversible mechanisms.
This document discusses limiting and excess reactants in chemical reactions. It defines a limiting reactant as the reactant that is consumed first or ends the reaction. It provides two methods to determine the limiting reactant: 1) converting reactants to moles and seeing which produces the fewest moles of product, and 2) comparing reactant ratios in the chemical equation and actual amounts. The excess reactant is any reactant other than the limiting one that remains after the reaction. It defines percent excess reactant as the moles in excess divided by the moles required to react with the limiting reactant.
This document discusses energy, ATP, and enzymes. It explains that ATP provides energy for cellular work by transferring energy from exergonic reactions to drive endergonic reactions. ATP is composed of adenine, ribose, and three phosphate groups. When ATP donates a phosphate group through hydrolysis, it is an exergonic reaction that releases energy that can be used to power cellular processes.
1. The document discusses the cell cycle and process of mitosis. It defines key terms like chromosomes, chromatids, chromatin and describes the main phases of the cell cycle - interphase and mitosis.
2. Interphase involves growth and DNA replication before cell division. Mitosis involves 5 phases - prophase, prometaphase, metaphase, anaphase, and telophase where the chromosomes are aligned and separated.
3. Cytokinesis then divides the cytoplasm, completing cell division and producing two identical daughter cells each with the same number and type of chromosomes as the original parent cell.
This document contains a collection of chemistry-themed jokes and puns. Each joke is one line long and followed by a one word answer playing on chemical elements, properties, or terminology. The jokes make use of wordplay and element symbols to playfully reference concepts in chemistry.
This document provides information about eukaryotic cells. It includes diagrams and descriptions of key structures in animal cells like the nucleus, cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and ribosomes. It compares prokaryotic and eukaryotic cells, highlights differences between plant and animal cells, and outlines two roles of extracellular components like bone matrix, basement membranes, and cell walls. The document contains links to additional resources for further information.
Ch06 lecture pathways that harvest and store chemical energyTia Hohler
The document summarizes pathways that cells use to harvest and store chemical energy. It discusses how ATP, reduced coenzymes, and chemiosmosis play important roles in energy metabolism. The aerobic breakdown of glucose is described in three stages: glycolysis, pyruvate oxidation, and the citric acid cycle. This releases a large amount of energy as ATP through oxidative phosphorylation. Under anaerobic conditions, fermentation is used to regenerate NAD+ from NADH, but yields much less ATP.
This document provides an introduction to the key concepts of ecology. It defines ecology as the study of interactions between organisms and their environment. It explains that the environment includes both abiotic (non-living) factors like temperature, water and soil as well as biotic (living) components like other organisms. The document also introduces several core ecological concepts, including populations, communities, ecosystems and the biosphere. It notes that ecology seeks to understand how these various environmental factors affect living populations. Finally, it briefly outlines some of the major terrestrial and aquatic biomes and the climatic and other environmental characteristics that define each one.
chemistry calculations percent yield and atom economyrei64
Percentage yield is a number between 0-100 that indicates how successful a chemical reaction was at producing the desired product. It is calculated by taking the mass of product actually produced and dividing it by the theoretical mass expected based on the limiting reactant.
Atom economy is also a number between 0-100 that indicates how efficiently a reaction uses reactants to produce the desired product. It is calculated by taking the mass of the desired product and dividing it by the total mass of all products.
Factors like incomplete reactions, losses during workup, and impure products can decrease the percentage yield of a reaction.
The document discusses energy transformations in living organisms. It explains that glucose is the main source of chemical energy for plants and animals. ATP is the energy currency of cells and is regenerated through cellular respiration. Cellular respiration can occur aerobically, using oxygen to produce more ATP, or anaerobically through fermentation without oxygen. Photosynthesis captures solar energy to convert carbon dioxide and water into glucose and oxygen. Plants have evolved C3, C4, and CAM pathways to photosynthesize that help conserve water in different environments.
Photosynthesis And Cellular Respiration Notes NewFred Phillips
1. Photosynthesis uses energy from sunlight, carbon dioxide, and water to produce glucose and oxygen through a two-phase process of light-dependent and light-independent reactions.
2. Cellular respiration breaks down glucose and other food molecules to produce ATP through three main stages: glycolysis, the citric acid cycle, and the electron transport chain.
3. Both processes are essential for life - photosynthesis provides energy for plants and produces oxygen and glucose as an energy source for cellular respiration in plants and animals.
Foundation and fundamentals of chemistry pptTejNarayan15
This document provides an introduction to general and physical chemistry presented by Tej Narayan Chapagain. It discusses key topics including:
- Chemistry is the study of the composition, structure, properties and transformations of matter. Chemists discover and apply principles for inventions and innovations.
- Chemistry contributes to understanding natural phenomena and traces out complications to provide solutions. It has played important roles in fields like clothing, shelter, pharmacy, agriculture and more.
- Chemistry is considered a central science as it links to other disciplines like biology, physics, geology and more. Nanotechnology has emerged guided by chemistry's basic principles.
- The document provides an overview of chemistry's importance, uses, and scope across various industries and
The document discusses reaction kinetics and rate laws. It defines key terms like rate law, order of reaction, and rate constant. The rate law expresses the relationship between the rate of a reaction and the concentrations of reactants raised to powers corresponding to their order. The order of a reaction with respect to a reactant is the exponent on its concentration term in the rate expression. The total order is the sum of all exponents. Examples are provided to demonstrate how to determine orders from rate laws and write rate expressions.
This presentation provides an outline on the topic of chemical kinetics. It introduces chemical kinetics and discusses reaction rates, examples of reaction rates, reaction rate laws, order of reaction, and activation energy. The presentation was given by MD Mehebu Easdani, a 3rd year chemistry student in the 6th semester of 2020-2021 at the Chemistry Department of Aliah University.
The document summarizes key concepts about the cell cycle and cell division. It discusses how cell division allows for reproduction, growth, and repair. There are two main types of cell division - mitosis, which produces genetically identical daughter cells, and meiosis, which produces gametes. The cell cycle consists of interphase and the mitotic phase. Interphase includes DNA replication in S phase. Mitosis separates duplicated chromosomes into two daughter cells. Cytokinesis then divides the cytoplasm. Prokaryotes divide by binary fission, with the chromosome replicating and daughter chromosomes moving apart.
Pressure, temperature and ‘rms’ related to kinetic modelMichael Marty
The macroscopic properties of a gas, pressure and temperature, are explained in terms of molecule movement of the Kinetic Theory. The derivation of formulas are shown in logical steps for pressure, temperature and KE.
This document provides an introduction to key concepts in ecology. It defines ecology as the study of the relationships between organisms and their environment. It describes the different levels of ecological organization from the biosphere down to individual organisms. It explains that all organisms interact with and depend on other living and non-living things in their environment. It also outlines biotic and abiotic factors that influence organisms, adaptations that help organisms survive, and mechanisms like acclimation, dormancy, and migration that aid survival. Finally, it defines niche and biogeography.
1. The document outlines key concepts and skills students should master in stoichiometry including calculating moles, mass, atoms, and molecules from balanced chemical equations and using these calculations to determine empirical formulas, molecular formulas, theoretical yields, and percent yields.
2. Example problems are provided to assess students' mastery of calculating moles from mass and vice versa, determining mass of products from reactants, calculating percent yields from experimental data, determining empirical and molecular formulas, and using balanced equations to calculate heat released.
This study investigated hormone levels in 31 boys with autism and 28 healthy controls between ages 3-8. It found that boys with autism had significantly lower levels of acyl ghrelin (AG), des-acyl ghrelin (DG), and growth hormone (GH) compared to controls. However, boys with autism had significantly higher levels of total testosterone (TT), free testosterone (FT), and leptin. Lower AG and DG levels in autistic boys were a novel finding that suggests ghrelin may play a role in autism pathogenesis given its effects on neuroinflammation, apoptosis, and other processes implicated in autism. Correlation analyses also found several significant relationships between hormone levels.
- Shenzhen Leveking bio-engineering Co. Ltd produces phytase enzymes for use in animal feed to improve nutrient utilization.
- Phytate in feed binds phosphorus and other minerals, reducing their availability to animals. Leveking's phytase is added to feed to break down phytate, releasing nutrients and improving growth performance.
- A study found that adding Leveking phytase to broiler diets improved final weight, feed intake, and feed conversion ratio in a dose-dependent manner compared to controls.
This document summarizes a study on screening, optimizing, and producing phytase from Aspergillus species isolated from environmental samples. Key findings include:
1) Several Aspergillus isolates (A. niger, A. fumigatus, A. tamari) were able to produce high levels of phytase when grown in media containing organic substrates like orange peel, sesame, and watermelon seeds.
2) Culture conditions like pH, carbon and nitrogen sources, inoculum age, and substrates were optimized to improve phytase production. Maximum yields were obtained at pH 5.5 using glucose and (NH4)2SO4 and an inoculum age of 72 hours
This study investigated the effects of a phytase enzyme from C. braakii on phosphorus digestibility and phytate degradation in soybean meal, rapeseed meal, corn, and wheat for broiler chickens. Ten male broilers per treatment were fed one of nine diets, including a nitrogen-free synthetic diet and semi-purified diets with or without 1000 U/kg of phytase added, from days 20-24. True ileal phosphorus digestibility and phytate phosphorus disappearance were measured. The phytase significantly improved the hydrolysis of phytate phosphorus and total phosphorus digestibility of soybean meal, rapeseed meal, wheat, and corn.
Leptin is a hormone secreted by adipose tissue that regulates food intake and energy expenditure. It works through the hypothalamus, stimulating neurons that reduce appetite and increase metabolism, while inhibiting neurons that induce feeding. Conditions like lesions in the hypothalamus or leptin resistance can disrupt this system and lead to obesity or anorexia. Obese individuals often have high leptin levels but are resistant to its effects, causing further weight gain despite the body's attempts to reduce food intake through leptin signaling.
1. Ghrelin is a hormone produced mainly in the stomach that stimulates appetite and food intake. It is increased during fasting and decreased after eating.
2. Ghrelin acts in the hypothalamus to increase appetite by stimulating orexigenic neurons and inhibiting anorexigenic neurons. It also decreases gastric emptying to prolong the feeling of fullness.
3. Ghrelin levels are regulated by nutritional factors like food intake, nutrients, insulin, and leptin in order to maintain energy homeostasis and body weight.
1. An ischemic stroke occurs when a blood clot or fat deposit blocks an artery in the brain, cutting off blood flow and oxygen to brain cells.
2. There are two main types - arterial thrombosis where a clot forms in the brain artery, and cerebral embolism where a clot forms elsewhere and travels to the brain.
3. Risk factors include age, gender, medical conditions like high blood pressure, smoking, high cholesterol, prior transient ischemic attacks, and family history.
This document provides an overview of nutrition and metabolism. It discusses the main macronutrients (carbohydrates, lipids, proteins) and micronutrients (vitamins, minerals) required by the human body. For each nutrient, it describes sources, digestion, uses, and dietary requirements. The document also covers energy expenditure, balance between intake and output, and factors that influence desirable weight.
This document summarizes the management of acute ischemic stroke patients. It discusses the types of strokes, prehospital identification and scales used to identify strokes, the evaluation process in the emergency department, differential diagnosis, and management strategies. The key points are:
1) Prehospital scales like the Los Angeles Prehospital Stroke Screen and Cincinnati Prehospital Stroke Scale are used by EMS to rapidly identify acute strokes.
2) In the emergency department, patients receive an evaluation including vital signs, glucose testing, neurological exam using the NIH Stroke Scale, and non-contrast head CT to identify the type and location of stroke.
3) Differential diagnosis for acute neurological symptoms includes conditions like seizures, intrac
The document discusses ischemic stroke, including its epidemiology, classification, risk factors, and etiopathogenesis. Some key points:
- Stroke occurs every 5 seconds worldwide and is a leading cause of death and disability globally. Incidence and prevalence varies significantly between countries and regions.
- Strokes are classified based on their underlying cause (ischemic vs hemorrhagic) and further subtyped based on etiology (large vessel atherosclerosis, cardioembolism, small vessel disease, etc).
- Major risk factors for ischemic stroke include hypertension, atrial fibrillation, diabetes, smoking, obesity, high cholesterol, lack of physical activity, and a family history of stroke.
This document discusses energy transformations in biology. It begins by explaining that energy transformations are linked to chemical reactions in cells, and the laws of thermodynamics apply. ATP plays a key role by capturing free energy from exergonic reactions and transferring it to power endergonic reactions. Enzymes lower the activation energy of reactions and are highly specific biological catalysts that use several mechanisms to facilitate chemical transformations in living systems. Enzyme activity can be regulated by inhibitors binding to the active site.
This document discusses bioenergetics, which is the study of energy transformations that occur in living organisms. It notes that all organisms need energy for physical activities, which involve chemical reactions that obey the laws of thermodynamics. Specifically, it examines human bioenergetics and how the study of cellular and metabolic processes leads to the production and use of energy in the form of ATP. Metabolism represents the chemical changes that convert nutrients into energy and complex cell products, and involves both catabolism and anabolism. Catabolism breaks down molecules to release energy or for use in anabolism, while anabolism uses energy to construct new bonds. The pathways are in equilibrium, with catabolism providing energy and
This document discusses biomolecules and bioenergetics. It defines biomolecules as proteins and amino acids. It then discusses bioenergetics, including the concepts of free energy, endergonic and exergonic reactions. It explains how ATP is an important energy currency for cells and is regenerated through coupled reactions like substrate-level phosphorylation and oxidative phosphorylation in the mitochondria. These coupled reactions involve the exergonic hydrolysis of ATP being linked to endergonic processes like dehydration through the transfer of a phosphate group.
This document provides an overview of metabolism and oxidative phosphorylation. It defines oxidative phosphorylation as the formation of ATP using energy released by electron transfer through electron carriers in the mitochondrial inner membrane. A proton gradient couples ATP formation to electron transfer. Catabolic pathways break down molecules and release energy, while anabolic pathways use energy to build molecules. ATP powers cellular work by coupling exergonic reactions that release energy to endergonic reactions that require energy. Enzymes lower the activation energy of reactions and increase their rates.
B.sc. biochemistry sem 1 introduction to biochemistry unit 4 metabolism and b...Rai University
The document discusses metabolic concepts and bioenergetics. It explains that metabolism occurs through enzyme-catalyzed reactions in metabolic pathways. Catabolic pathways break down nutrients into smaller molecules and release energy as ATP or electron carriers, while anabolic pathways use this energy to build larger molecules. The two laws of thermodynamics state that energy is conserved but tends towards increased entropy. Mitochondria allow catabolism of glucose to release energy through three main stages - glycolysis outside the mitochondria yields some ATP, the Krebs cycle in the matrix yields more ATP, and electron transport inside the cristae yields the most ATP by pumping protons and producing ATP synthase. Overall, breaking down one glucose molecule yields about 36 ATP.
This document discusses bioenergetics, which describes how living organisms capture, transform, store, and utilize energy. It defines endergonic and exergonic reactions, and explains that ATP is used to transport energy in cells. When ATP is hydrolyzed, energy is released to power cellular work in an exergonic reaction. This hydrolysis is coupled to endergonic reactions through common intermediates like ATP to drive biochemical pathways.
The document summarizes key concepts about chemical reactions, energy in reactions, enzymes, and enzyme action from a biology textbook chapter on chemistry of life. It defines chemical reactions as processes that transform chemicals, with reactants entering and products forming. Reactions can release or absorb energy depending on differences in bond energies between reactants and products. Enzymes are protein catalysts that lower the activation energy of reactions, speeding up rates immensely and allowing life-sustaining reactions to occur efficiently. They achieve catalysis by creating an ideal microenvironment where substrates precisely bind at active sites.
The document discusses key concepts related to cellular energy and metabolism. It covers forms of energy, the laws of thermodynamics, ATP as a carrier of chemical energy, metabolic pathways, enzymes, and the processes of photosynthesis and cellular respiration. ATP is constantly regenerated from ADP through coupled reactions, where exergonic reactions capture energy to drive endergonic reactions like cellular work functions. Enzymes lower the activation energy of reactions and catalyze metabolic pathways by binding substrates in their active sites.
The document provides an overview of metabolism and energy transformations in cells. It discusses how (1) cells extract and use energy to perform work through thousands of chemical reactions organized into metabolic pathways, (2) the laws of thermodynamics govern energy transformations with energy being conserved but entropy increasing, and (3) ATP powers cellular work by coupling exergonic reactions like its hydrolysis to endergonic reactions like transport or synthesis through energy transfer.
This presentation was prepared in order to take Lecture of students in a summarised way and to provide them with the short, sweet and concise notes. It is based on PCI syllabus and is meant for B. Pharm. Second Semester...
- Metabolism involves chemical reactions that build up or break down molecules, organized into metabolic pathways with multiple enzyme-catalyzed steps.
- Catabolic pathways break down molecules and release energy, while anabolic pathways use energy to build molecules.
- ATP powers cellular work by coupling exergonic reactions, which release energy, to endergonic reactions like transport and synthesis that require energy. ATP is regenerated through catabolic pathways.
Enzymes are biological catalysts that are usually proteins. They increase the rate of chemical reactions by lowering the activation energy required. Enzymes have a specific 3D shape that substrates fit into, forming an enzyme-substrate complex. The rate of enzyme-catalyzed reactions depends on factors like temperature, pH, substrate and product concentration, and the presence of cofactors. Energy from exergonic reactions is used to drive endergonic reactions in cells by coupling them to ATP synthesis and hydrolysis.
Enzymes are biological catalysts that are usually proteins. They increase the rate of chemical reactions by lowering the activation energy required. Enzymes have a specific 3D shape that substrates fit into, forming an enzyme-substrate complex. The rate of enzyme-catalyzed reactions depends on factors like temperature, pH, substrate and product concentrations, and the presence of cofactors. Energy from exergonic reactions is used to drive endergonic reactions in cells by coupling them to ATP synthesis and hydrolysis.
UNIT1.2 bioenergetic in introduction of biochemistrypayalpilaji
The document discusses bioenergetics, which is the study of energy changes that occur during biochemical reactions in living organisms. It covers several key topics:
- Adenosine triphosphate (ATP) acts as the main "energy currency" in organisms and is produced through catabolic processes to be used for biological work.
- Reactions can be exergonic (releasing energy) or endergonic (requiring energy input). Exergonic reactions like cellular respiration break ATP to power biological processes.
- Activation energy is the minimum energy needed to start a chemical reaction. Enzymes and catalysts lower this barrier to speed up reactions.
- High-energy compounds like
Reference Harper Illustrated book of Biochemistry
Applying laws of Thermodynamics to Biochemistry.
Diferent types of Reactions, exergonic and edergonic,
Illustrated explain of Role of ATP in our body,
Brief concept on ATP production and high energy phosphate,
ATP/ADP cycle and about Creatine Kinase
Biology 12 - Powerpoint - Energy Transformation - Section 5-1JEmmons
This document outlines chapters and sections from a biology textbook covering cell biology topics. It focuses on Chapter 5 Section 5.1 which discusses cellular metabolism and energy transformations. The key points are:
1) Cellular metabolism involves catabolic reactions that break down molecules and anabolic reactions that build them up.
2) Exergonic reactions release energy while endergonic reactions require energy input. ATP is used to power endergonic reactions in cells.
3) ATP is the energy currency of cells and is regenerated through reactions involving the breakdown of nutrients.
The document provides an overview of key concepts in metabolism. It defines the first and second laws of thermodynamics, and discusses how cells use ATP to do work through energy coupling. Enzymes lower the activation energy of reactions and work with specificity on substrates. Regulation allows cells to control metabolic pathways and switch enzyme activity on and off through mechanisms like feedback inhibition and allosteric regulation.
The document discusses key concepts in bioenergetics including:
1) Bioenergetics concerns the energy involved in making and breaking chemical bonds in molecules, which is fundamental to biological processes like growth that depend on energy transformations.
2) The first law of thermodynamics states that energy is conserved, while the second law states that entropy increases, reducing the available free energy.
3) Free energy (G) expresses the energy available to do work and depends on enthalpy (H) and entropy (S) changes. Exergonic reactions release free energy while endergonic reactions absorb it.
1. Metabolism transforms matter and energy through chemical reactions within organisms, subject to the laws of thermodynamics. 2. Metabolic pathways are organized into catabolic pathways that break down molecules and release energy, and anabolic pathways that use energy to build molecules. 3. ATP powers cellular work by coupling exergonic reactions like its own hydrolysis to drive endergonic reactions like protein synthesis.
Similar to Chapter 08 An Introduction to Metabolism (20)
1. Cellular respiration involves the breakdown of glucose to extract energy through redox reactions in the mitochondria.
2. Glucose is broken down through glycolysis, the citric acid cycle, and the electron transport chain. This releases energy that is used to synthesize ATP.
3. Glycolysis occurs in the cytoplasm and yields 2 ATP per glucose. The citric acid cycle and electron transport chain occur in the mitochondria and yield 34 more ATP. Overall, cellular respiration generates around 36 ATP from one glucose molecule.
The document discusses chapters 2 and 3 of a chemistry and water textbook. Chapter 2 covers chemical elements, atomic symbols, the periodic table, atomic structure including the Bohr model, chemical bonding including ionic and covalent bonds, and polarity. Chapter 3 discusses the properties of water, acids and bases, and hydrogen bonding. The learning objectives are to understand subatomic particles, electron configurations, ionic and covalent bonds, polar compounds, pH, and buffer interactions.
The document discusses several key properties of water including its high heat capacity, heat of vaporization, and heat of fusion due to hydrogen bonding. This hydrogen bonding gives water thermal inertia and allows it to absorb large amounts of heat before changing temperature or phase. Buffers in the body also help maintain homeostasis by resisting changes in pH when acids or bases are introduced. The polarity and hydrogen bonding of water enables it to act as an important transport medium in plants and animals.
Macromolecules are large molecules composed of repeating subunits called monomers. There are four main classes of macromolecules: carbohydrates, lipids, proteins, and nucleic acids. Carbohydrates include sugars such as glucose and complex carbohydrates like starch and cellulose. Lipids are nonpolar molecules including fatty acids, triglycerides, phospholipids, and steroids. Proteins are polymers of amino acids with functions like structure, enzymes, transport, and motion. Nucleic acids DNA and RNA are polymers of nucleotides that serve genetic and protein synthesis functions.
This document discusses macromolecules and their structure and function. It outlines the four major classes of macromolecules - carbohydrates, lipids, proteins, and nucleic acids. It explains that organic molecules contain carbon and are associated with living systems, while inorganic molecules do not contain carbon and are associated with nonliving matter. The document discusses carbon atoms and their ability to form chains and rings, as well as isomers and important functional groups that determine molecular polarity and reactivity.
This chapter introduces key concepts in biology including defining properties of life, levels of biological organization, classification systems, and the scientific method. It explores the eight properties used to define living things, such as cellular structure, metabolism, response to stimuli, and reproduction. It also describes the hierarchical organization of the biosphere from populations to ecosystems. The chapter establishes taxonomy as the classification of organisms based on evolutionary relationships and outlines the steps of the scientific method including hypothesis formation and controlled experimentation.
- The plasma membrane is made up of a phospholipid bilayer with embedded and peripheral proteins. It separates the cell's interior from its external environment.
- Diffusion and osmosis allow for the passive movement of solutes and water across the membrane down their concentration gradients. Active transport uses protein pumps to move solutes against their gradients.
- The fluid mosaic model describes the plasma membrane as a fluid structure with proteins embedded and floating within the phospholipid bilayer. Membrane proteins have many important functions including transport, signaling, and cell adhesion.
This document provides an overview of cell structure and function. It begins with an introduction to cell theory and sizes of living things. It then describes principles limiting cell size and differences between prokaryotic and eukaryotic cells. Organelles of animal and plant cells are outlined, including the endomembrane system, energy-related organelles like mitochondria and chloroplasts, and other structures. Microscopy techniques for viewing cells are also summarized.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
How to Manage Your Lost Opportunities in Odoo 17 CRMCeline George
Odoo 17 CRM allows us to track why we lose sales opportunities with "Lost Reasons." This helps analyze our sales process and identify areas for improvement. Here's how to configure lost reasons in Odoo 17 CRM
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In Odoo, the chatter is like a chat tool that helps you work together on records. You can leave notes and track things, making it easier to talk with your team and partners. Inside chatter, all communication history, activity, and changes will be displayed.
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
Assessment and Planning in Educational technology.pptxKavitha Krishnan
In an education system, it is understood that assessment is only for the students, but on the other hand, the Assessment of teachers is also an important aspect of the education system that ensures teachers are providing high-quality instruction to students. The assessment process can be used to provide feedback and support for professional development, to inform decisions about teacher retention or promotion, or to evaluate teacher effectiveness for accountability purposes.
The simplified electron and muon model, Oscillating Spacetime: The Foundation...RitikBhardwaj56
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
2. MetabolismMetabolism
Chapter 8
Learning ObjectivesLearning Objectives
• Apply fundamental laws of physics toApply fundamental laws of physics to
biological metabolismbiological metabolism
• Describe with chemical equations howDescribe with chemical equations how
chemical potential energy is stored andchemical potential energy is stored and
utilized in catabolic and anabolic reactionsutilized in catabolic and anabolic reactions
using appropriate vocabulary (endergonic,using appropriate vocabulary (endergonic,
exergonic, free energy)exergonic, free energy)
• Describe how enzymes work as catalysts toDescribe how enzymes work as catalysts to
lower activation energy.lower activation energy.
• Describe with examples how enzymes areDescribe with examples how enzymes are
regulated by physical and cellularregulated by physical and cellular
mechanisms.mechanisms.
3. MetabolismMetabolism
Chapter 8
OutlineOutline
A.A. Forms of EnergyForms of Energy
B.B. Laws of ThermodynamicsLaws of Thermodynamics
C. Metabolic ReactionsC. Metabolic Reactions
D. ATPD. ATP
E. Metabolic PathwaysE. Metabolic Pathways
Energy of ActivationEnergy of Activation
EnzymesEnzymes
PhotosynthesisPhotosynthesis
Cellular Respiration.Cellular Respiration.
- Kinectic verses Potential
- Total energy is constant
- Entropy (disorder) increases
-exergonic versus endergonic reactions
- the intermediate form of chemical energy for most metabolic reactions
- an energy barrier
- catalysts: cells way of overcoming energy barriers
- using solar energy to create chemical bonds
-using the energy from photosynthesis
to create other chemical bonds
6. MetabolismMetabolism
Chapter 8
A. Two Forms of EnergyA. Two Forms of Energy
a. Kinetic Energya. Kinetic Energy = Energy of motion= Energy of motion
Examples: ?Examples: ?
b. Potentialb. Potential EnergyEnergy = Stored Energy= Stored Energy(can create motion(can create motion))
Examples: ?Examples: ?
- falling water, rolling bycicle ………..
- water behind a dam, stretch elastic, drawn bow….ect
** Important (biology) type of potential energy = Chemical E.
Examples: oil, gasoline = fossil fuels
(notes: write a chemical equation that depicts combustion
of a hydrocarbon [C16H32SO4]
Know these two definitions.
7. MetabolismMetabolism
Chapter 8
B. Laws of ThermodynamicsB. Laws of Thermodynamics
First law:First law: Conservation of energyConservation of energy
Energy cannot be created or destroyed, butEnergy cannot be created or destroyed, but
can only be changed from one type to anothercan only be changed from one type to another
Example: Think of the changes in forms of energy in the combustion reaction
you just diagramed
Know these two laws !
8. MetabolismMetabolism
Chapter 8
Second law:Second law:
Law of increasing entropyLaw of increasing entropy (disorder)(disorder)
When energy is changed from one form toWhen energy is changed from one form to
another, there is aanother, there is a loss of usable energyloss of usable energy thatthat
goes to increase disordergoes to increase disorder
Example: The energy of combustion is largely dissipated as heat (Enthalpy) to
molecules in the “air” etc. as they begin to vibrate faster, spread out and expand.
(Entropy)
9. Energy flow in biosystems:
Carbohydrate metabolism
YOU MUST KNOW THIS EQUATION !
(and its reverse!)
A. Carbohydrate synthesis
B. Carbohydrate Metabolism
(Oxidative Respiration)
O2
These molecules are
More disordered than
glucose = increased
entropy
(reference p162)
10. Cells and Energy & Entropy
Stored
potential
energy
Increased
EntropyA
B
Both of these means of releasing energy result in an increased entropy
Electrogenic
Pumps
11. MetabolismMetabolism
Chapter 8
Free energyFree energy
In biology,In biology, Free energyFree energy is considered insteadis considered instead
of entropyof entropy..
Definition:Definition:
Free Energy: “Gibb’s Free Energy”Free Energy: “Gibb’s Free Energy” (( G)G)
The amount of energy available to do workThe amount of energy available to do work
after a chemical reaction has occurred:after a chemical reaction has occurred:
the potential energy difference betweenthe potential energy difference between
reactants and products.reactants and products.
12. MetabolismMetabolism
Chapter 8
Types of Reactions:Types of Reactions:
There are two types of reactions:There are two types of reactions:
1.1. Exergonic ReactionsExergonic Reactions - Products have- Products have lessless
free energyfree energy than reactants.than reactants.
2.2. Endergonic ReactionsEndergonic Reactions - Products have- Products have
moremore free energy than reactants.free energy than reactants.
TheseThese do not require energy inputdo not require energy input and generally proceedand generally proceed
(are sped up) simply with the help of an enzyme.(are sped up) simply with the help of an enzyme.
These reactionsThese reactions require energy inputrequire energy input, usually in the, usually in the
form high energy bonds from ATP, and also require theform high energy bonds from ATP, and also require the
actions of enzymesactions of enzymes..
15. MetabolismMetabolism
Chapter 8
Metabolic Reactions andMetabolic Reactions and
Energy TransformationsEnergy Transformations
MetabolismMetabolism:: The total of all the reactions within aThe total of all the reactions within a
cell.cell.
A + BA + B C + DC + D
(Reactants) (Products)
OR
b. Require energy input
= Endergonic reaction
a. Release energy to surroundings
= Exergonic reaction
16. MetabolismMetabolism
Chapter 8
Free Energy Defined:Free Energy Defined:
Endergonic versus ExergonicEndergonic versus Exergonic
A. B.
Exergonic reaction:
G is said
to be negative
Endergonic reaction:
G is positive
= the energy difference between reactants and products, and is therefore
available (free) after the reaction has occurred. Reaction A- has more
available (positive), Reaction B – has less available (negative)
Require energy input
= Endergonic reaction
Release energy to surroundings
= Exergonic reaction
17. MetabolismMetabolism
Chapter 8
How is this “Free Energy” used?How is this “Free Energy” used?
Metabolic reactions areMetabolic reactions are coupledcoupled to the generationto the generation
and release of a high energy intermediate:and release of a high energy intermediate:
Adenosine triphosphateAdenosine triphosphate ((ATPATP))
Energy released by anEnergy released by an exergonicexergonic reaction captured inreaction captured in
ATPATP
That ATP used to drive anThat ATP used to drive an endergonicendergonic reactionreaction
18. The ATP Cycle
Mechanical work
Chemical work
H2O
H2O
** ATP is “coupled
To virtually all
Metabolic reactions
19. Energy
summary:
• Photo synthesis captures energy from the sun an transfers it to
chemical bond.
• Cellular respiration (an exergonic reaction) releases the energy from
these bonds and couples it to one of two processes:
1. High energy phosphate bonds of ATP (“substrate level phosphorylation”)
2. Proton gradient – followed by ATP production
• Synthesis reactions are endergonic and require an input of energy
from ATP produced in exergonic reactions.
• Other endergonic reactions include muscular movement, and also
require an energy input from ATP (and other high energy phosphate
containing molecules. Ex: phosphocreatine)
20. MetabolismMetabolism
Chapter 8
Work-Related FunctionsWork-Related Functions
of ATPof ATP
Primarily to perform cellular workPrimarily to perform cellular work
1.1. Chemical Work - Energy needed toChemical Work - Energy needed to
synthesize macromoleculessynthesize macromolecules
2.2. Transport Work - Energy needed to pumpTransport Work - Energy needed to pump
substances across plasma membranesubstances across plasma membrane
3.3. Mechanical Work - Energy needed toMechanical Work - Energy needed to
contract muscles, beat flagella, etccontract muscles, beat flagella, etc
Know 3 forms of work coupled to ATP
22. MetabolismMetabolism
Chapter 8
Metabolic PathwaysMetabolic Pathways
Reactions usually occur in a sequenceReactions usually occur in a sequence
Products of an earlier reaction become reactants of a laterProducts of an earlier reaction become reactants of a later
reactionreaction
Such linked reactions form aSuch linked reactions form a metabolic pathwaymetabolic pathway
Begins with a particularBegins with a particular reactantreactant,,
Proceeds through severalProceeds through several intermediatesintermediates, and, and
Terminates with a particularTerminates with a particular end productend productis required at each step……
“A” is Initial
Reactant
“D” is End
Product
Intermediates
23. MetabolismMetabolism
Chapter 8
What is an enzyme?What is an enzyme?
EnzymesEnzymes
Protein molecules thatProtein molecules that function as catalystsfunction as catalysts
CatalystCatalyst = any molecule that speeds up a reaction= any molecule that speeds up a reaction
but is itself not used up in that reaction.but is itself not used up in that reaction.
The things it acts on are calledThe things it acts on are called substratessubstrates
Each enzyme accelerates a specific reactionEach enzyme accelerates a specific reaction
Each reaction in a metabolic pathway requires aEach reaction in a metabolic pathway requires a
unique and specific enzymeunique and specific enzyme
End product will not appear unless ALL enzymes areEnd product will not appear unless ALL enzymes are
present and functionalpresent and functional
E1 E2 E3 E4 E5 E6
A B C D E F G
Definition:
24. MetabolismMetabolism
Chapter 8
Enzymes:Enzymes:
How do they function.How do they function.
There is usually an input of energy requiredThere is usually an input of energy required
for two substrates to “meet” in anfor two substrates to “meet” in an
orientation that favors a reaction.orientation that favors a reaction.
This energy requirement is called:This energy requirement is called: Energy ofEnergy of
Activation.Activation.
Enzymes operate byEnzymes operate by lowering the energy oflowering the energy of
activationactivation (1)(1)
They do this by bringing the substrates intoThey do this by bringing the substrates into
contact with one another in the correctcontact with one another in the correct
orientation.orientation.
Energy of Activation
27. MetabolismMetabolism
Chapter 8
2. Enzyme-Substrate Complex2. Enzyme-Substrate Complex
TheThe Induced fit model.Induced fit model.
• The enzyme and the substrate form a short livedThe enzyme and the substrate form a short lived
intermediate called theintermediate called the enzyme-substrate complex.enzyme-substrate complex.
• The substrates are bound inThe substrates are bound in the active sitethe active site. Binding. Binding
of the substrateof the substrate inducesinduces the active site tothe active site to changechange
conformationconformation, energetically aligning the substrates, energetically aligning the substrates
reactive sites.reactive sites.
29. MetabolismMetabolism
Chapter 8
Enzymes:Enzymes:
A summary…………A summary…………
MECHANISMS
1. Catalysts (speed up reaction without being consumed)
They do this by “Lowering the Energy of Activation” (Ea)
- Decreased Ea results from….
a. Substrates are aligned to optimize new bond formation
b. Enzyme undergoes a conformational change (Induced fit)
e. Lower energy intermediates are formed. “Enzyme-substrate complex”
- (to be continued)
30. MetabolismMetabolism
Chapter 8
Degradation vs. SynthesisDegradation vs. Synthesis
Degradation:Degradation:
EnzymeEnzyme complexes with a singlecomplexes with a single substratesubstrate
moleculemolecule
Substrate is broken apart into two productSubstrate is broken apart into two product
moleculesmolecules
Synthesis:Synthesis:
EnzymeEnzyme complexes with twocomplexes with two substratesubstrate
moleculesmolecules
Substrates are joined together and releasedSubstrates are joined together and released
as single product moleculeas single product molecule
32. MetabolismMetabolism
Chapter 8
Factors Affecting Enzyme Activity (1)Factors Affecting Enzyme Activity (1)
a) Substrate concentrationa) Substrate concentration
Enzyme activity increases with substrateEnzyme activity increases with substrate
concentrationconcentration
More collisions between substrate moleculesMore collisions between substrate molecules
and the enzymeand the enzyme
b) Temperatureb) Temperature
Enzyme activity increases with temperatureEnzyme activity increases with temperature
Warmer temperatures cause more effectiveWarmer temperatures cause more effective
collisions between enzyme and substratecollisions between enzyme and substrate
However, hot temperatures destroy enzymeHowever, hot temperatures destroy enzyme
C pHC pH
Most enzymes are optimized for a particularMost enzymes are optimized for a particular
pHpH
35. MetabolismMetabolism
Chapter 8
Enzymes:Enzymes:
A summary…………A summary…………
A. MECHANISMS
1. Catalysts (speed up reaction)
Lower energy of activation
a) Align substrates
b) Undergo a conformational change (Induced fit)
c) Active site participates in the reaction
B. ACTIVITY
1. Synthesis and degradation: 2 substrates for synthesis, 1 for
degradation
2. Activity is affected by substrate conc. , Temperature, pH
- -
36. MetabolismMetabolism
Chapter 8
Cellular Factors Affecting Enzyme ActivityCellular Factors Affecting Enzyme Activity
Cells can affect presence/absence of enzymeCells can affect presence/absence of enzyme
Cells can affect concentration of enzymeCells can affect concentration of enzyme
Cells can activate or deactivate enzymeCells can activate or deactivate enzyme
Molecules required to activate enzymeMolecules required to activate enzyme
EnzymeEnzyme CofactorsCofactors areare inorganicinorganic elements andelements and
compounds. Ex. = Calcium, Magnesium, Zinccompounds. Ex. = Calcium, Magnesium, Zinc
CoenzymesCoenzymes are organic cofactors, like someare organic cofactors, like some
vitaminsvitamins
PhosphorylationPhosphorylation – some enzymes require– some enzymes require
addition of a phosphateaddition of a phosphate
41. MetabolismMetabolism
Chapter 8
Enzyme Inhibition.Enzyme Inhibition.
ReversibleReversible enzyme inhibitionenzyme inhibition
When a substance known as an inhibitor
binds to an enzyme and decreases its activity
-Competitive inhibitioninhibition – substrate and the– substrate and the
inhibitor are both able toinhibitor are both able to bind tobind to active siteactive site
- Noncompetitive inhibitionNoncompetitive inhibition – the inhibitor binds– the inhibitor binds
not at the active site, but atnot at the active site, but at thethe allosteric siteallosteric site
Feedback inhibitionFeedback inhibition – The– The end productend product of aof a
pathway inhibits the pathway’s first enzymepathway inhibits the pathway’s first enzyme
47. MetabolismMetabolism
Chapter 8
Irreversible InhibitionIrreversible Inhibition
Materials that irreversibly inhibit an enzymeMaterials that irreversibly inhibit an enzyme
are known asare known as poisonspoisons
CyanidesCyanides inhibit enzymes resulting in all ATPinhibit enzymes resulting in all ATP
productionproduction
PenicillinPenicillin inhibits an enzyme unique to certaininhibits an enzyme unique to certain
bacteriabacteria
Heavy metalsHeavy metals irreversibly bind with manyirreversibly bind with many
enzymesenzymes
Nerve gasNerve gas irreversibly inhibits enzymesirreversibly inhibits enzymes
required by nervous systemrequired by nervous system
48. MetabolismMetabolism
Chapter 8
A. MECHANISMS
-Catalysts (speed up reaction)
- Lower energy of activation
-Form intermediate “Enzyme-substrate complex”
- Undergo a conformational change (Induced fit)
- Active site participates in the reaction
B. ACTIVITY
- Synthesis and degradation: 2 substrates for synthesis, 1 for degredation
-Activity is affected by substrate conc. , Temperature, Ph
C. REGULATION
- Production and activation is regulated by cells (inducable enzymes)
-May require co-enzymes OR co-factors from a nutrient source
-May be regulated by other enzymes (phosphorylation turns off or on)
-Are subject to reversible and irreversible inhibition.
-Reversible: Competitive, Non-competitive, Feedback inhibition.
- Poisons such as cyanide are irreversible inhibitors
49. MetabolismMetabolism
Chapter 8
How is all this energy (ATP) generated ?How is all this energy (ATP) generated ?
Oxidation-ReductionOxidation-Reduction
Oxidation-reductionOxidation-reduction ((redoxredox)) reactions:reactions:
Electrons pass from one molecule to anotherElectrons pass from one molecule to another
- The molecule that loses an electron isThe molecule that loses an electron is oxidizedoxidized
- The molecule that gains an electron isThe molecule that gains an electron is reducedreduced
Both take place at same timeBoth take place at same time
One molecule accepts the electron given upOne molecule accepts the electron given up
by the otherby the other
LEO (the lion) says GER
“Loss of Electrons = Oxidation”
“Gain of Electrons = Reduction”
Redox reactions
50. PhotosynthesisPhotosynthesis
andand
Cellular RespirationCellular Respiration
Carbon dioxideCarbon dioxide
+water+water
+solar energy+solar energy
GlucoseGlucose
+oxygen+oxygen
6CO6CO22 + 6H+ 6H22OO
energyenergy
CC66HH1212OO66 + 6O+ 6O22
Carbon dioxideCarbon dioxide
+water+water
+chemical energy+chemical energy
GlucoseGlucose
+oxygen+oxygen
6CO6CO22 + 6H+ 6H22O + energyO + energyCC66HH1212OO66 + 6O+ 6O22
Cellular Respiration:Cellular Respiration:
Photosynthesis:Photosynthesis:
Both are coupled to a redox chain that passes energy on to ATP synthesis
51. MetabolismMetabolism
Chapter 8
Electron Transport ChainElectron Transport Chain
Membrane-bound carrier proteins found inMembrane-bound carrier proteins found in
mitochondria and chloroplastsmitochondria and chloroplasts
Physically arranged in an ordered seriesPhysically arranged in an ordered series
Starts with high-energy electrons and low-energyStarts with high-energy electrons and low-energy
ADPADP
Pass electrons from one carrier to anotherPass electrons from one carrier to another
- Electron energy used to pump hydrogen ions (HElectron energy used to pump hydrogen ions (H++
) to one) to one
side of membraneside of membrane
- Establishes electrical gradient across membraneEstablishes electrical gradient across membrane
- Electrical gradient used to make ATP from ADP –Electrical gradient used to make ATP from ADP –
ChemiosmosisChemiosmosis
Ends with low-energy electrons and high-energy ATPEnds with low-energy electrons and high-energy ATP
54. MetabolismMetabolism
Chapter 8
OutlineOutline
A.A. Forms of EnergyForms of Energy
B.B. Laws of ThermodynamicsLaws of Thermodynamics
C. Metabolic ReactionsC. Metabolic Reactions
D. ATPD. ATP
E. Metabolic PathwaysE. Metabolic Pathways
Energy of ActivationEnergy of Activation
EnzymesEnzymes
PhotosynthesisPhotosynthesis
Cellular RespirationCellular Respiration
- Kinectic verses Potential
- Total energy is constant
- Entropy (disorder) increases
-exergonic versus endergonic reactions
- the intermediate form of chemical energy for most metabolic reactions
- an energy barrier
- catalysts: cells way of overcoming energy barriers
- using solar energy to create chemical bonds
-using the energy from photosynthesis
to create other chemical bonds