This document discusses cerebral blood flow and stroke. It provides details on the anatomy and blood supply of the brain, different types of strokes including causes and locations. It describes the effects of infarctions in different arterial territories, focusing on deficits that can result from damage to areas supplied by the middle cerebral, anterior cerebral, and posterior cerebral arteries. Treatment options are also summarized, including both pharmacological interventions and surgeries.
Slideshow is from the University of Michigan Medical School's M1 Cardiovascular / Respiratory sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Cardio
oxygen requrement cmr and cerebral circulationBRAJENDRA VERMA
this titel for knowlage abt cerebral blood flow and effect for intrensic and extensic factor for control the ICP and CBF..this topic cover all about cerebral blood circulation and cmro2
I am a Neurosurgeon with advanced training in Interventional vascular Neurosurgery(FINR) from Zurich, Switzerland, and FMINS-Fellowship in minimally invasive and Endoscopic Neurosurgery from Germany.
I am presently working in Columbia asia hospitals, Bangalore.
My areas of interest are Vascular Neurosurgery, Stroke specialist, interventional neuroradiology, Endoscopic and minimally invasive Neurosurgery, Endoscopic spine surgery.
Slideshow is from the University of Michigan Medical School's M1 Cardiovascular / Respiratory sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Cardio
oxygen requrement cmr and cerebral circulationBRAJENDRA VERMA
this titel for knowlage abt cerebral blood flow and effect for intrensic and extensic factor for control the ICP and CBF..this topic cover all about cerebral blood circulation and cmro2
I am a Neurosurgeon with advanced training in Interventional vascular Neurosurgery(FINR) from Zurich, Switzerland, and FMINS-Fellowship in minimally invasive and Endoscopic Neurosurgery from Germany.
I am presently working in Columbia asia hospitals, Bangalore.
My areas of interest are Vascular Neurosurgery, Stroke specialist, interventional neuroradiology, Endoscopic and minimally invasive Neurosurgery, Endoscopic spine surgery.
Clinical syndromes of vascular disease of the nervousaditya romadhon
The middle cerebral artery is the largest branch of the internal carotid artery and supllies the largest area of the cerebral cortex
Supplying the motor and sensory cortices, also supplies the areas of the cortex pertaining to the comprehension Wernicke’s area and expresion brocca’s area (left hemisphere)
The blood supply to the central nervous system (CNS), including the brain and spinal cord, is crucial for maintaining the metabolic needs of neural tissues.
Neurosurgical interventions related to the blood supply of the CNS are often aimed at addressing vascular abnormalities, preventing strokes, and managing conditions affecting blood vessels in the brain.
Cavernous Sinus Thrombosis.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
6. Types of CVAs
Occlusive CVA:
due to the closure of a blood vessel
-
usually due to atherosclerosis &
thrombosis.
Hemorrhagic CVA:
due to bleeding from a blood vessel
usually due to either hypertension or
an aneurysm. ~
7. Stroke: Ischemia
Insufficiency of blood supply
Glucose & O2 deprivation, build-up
of wastes
NOT synonymous Anoxia:
O2 deprivation only
Few seconds: little or no damage
6-8 minutes ---> Infarction
neurons & other cells die ~
8. Blood Supply of Brain
Arises from aortic arch
2 common carotid arteries
(extracranial)
give rise to external & internal carotid
2 vertebral arteries ~
11. Anterior Cerebral Arteries
Surface branches
supply cortex and white matter of :
inferior frontal lobe
medial surface of the frontal and
parietal lobes
anterior corpus callosum ~
12. Anterior Cerebral Arteries
Penetrating branches supply:
deeper cerebrum
diencephalon
limbic structures
head of caudate
anterior limb of internal capsule ~
13. Middle Cerebral Arteries
Surface branches supply
cortex & white matter of
hemispheric convexity
(all four lobes and insula).
Penetrating branches
deep white matter
some diencephalic structures ~
15. Vertebral Arteries
Rise from subclavian artery
Branches
anterior spinal arteries &
posterior inferior cerebellar arteries.
2 vertebral arteries join at the junction of
the pons and medulla
form basilar artery
basilar divides into 2 posterior
cerebral arteries. ~
16. Posterior Cerebral Arteries
Surface branches supply
cortex and white matter of medial
occipital lobes
inferior temporal lobes
posterior corpus callosum
Penetrating branches supply:
parts of the thalamus
parts of the midbrain ~
20. Frontal lobe
Prefrontal lobes
anterior to motor cortex
weigh consequences of future action
and plan accordingly (an executive
function);
performance of delayed responses
Inferior frontal lobes
emotional responding ~
21. Frontal lobe
Precentral gyri
control contalateral movement
Broca's area (L. Hemi.)
language production
R. Hemi.: may be more involved in
music production. ~
22. Parietal lobe
Postcentral gyrus
Anterior parietal lobe
primary somatosensory cortex (S1)
Posterior parietal cortex (PPC)
higher-order sensory areas
convergence from other sensory systems
left parietal lobe: reading and writing
right parietal lobe: spatial information. ~
23. Temporal lobe
Language & object recognition
memory
L. Hemi.: verbal information
R. Hemi.: nonverbal information
Inferior temporal lobes
higher-order visual perception ~
24. Temporal lobe
Superior temporal gyrus
primary auditory cortex (A1)
Superior temporal lobe
L. Hemi.: language comprehension
R. Hemi.: music comprehension
except trained musicians ~
25. Occipital Lobe
Analysis of visual information.
Primary visual cortex (V1)
Visual association cortex
color
movement
shape ~
27. Middle cerebral artery
Most common stroke syndrome.
contralateral weakness
face, arm, and hand more than legs
contralateral sensory loss
face, arm, and hand more than legs
visual field cut
damage to optic radiations
28. Middle Cerebral Artery
Aphasia: language disturbances
more likely with L. Hemi. damage
especially men
Broca's: production
Wernicke's: comprehension ~
29. Middle Cerebral Artery
Impaired spatial perception
more likely after R. Hemi. damage
spatial neglect
dressing apraxia
constructional apraxia
topographagnosia ~
30. Anterior cerebral artery
Motor distrubance contralateral
distal leg
urinary incontinence
speech disturbance (may be more of
a motor problem)
apraxia of left arm (sympathetic
apraxia) if anterior corpus callosum
is affected
If bilateral may cause apathy, motor
inertia, and muteness ~
31. Posterior Cerebral Artery
Visual disturbances
contralateral homonymous hemianopsia
(central vision is often spared)
L. Hemi: lesions alexia
(with or without agraphia)
Bilateral lesions: cortical blindness
patients unaware they cannot see
(Anton's syndrome)
Memory impairment if temporal lobe is
affected ~
32. Posterior Cerebral Artery
Proximal occlusion
contralateral hemisensory loss,
spontaneous pain and dysesthesia if
thalamus affected
(thalamic pain syndrome)
contralateral severe proximal chorea
(hemiballism) ~
34. Treatment
Surgery
remove aneurysms
remove pressure following
hemorrhage
Radiation to treat AVMs
Embolization therapy to
plug vessels of an AVM
or to treat an aneurysm
(direct surgery usually preferable)
35. Stroke Rescue?
Cell transplant - experimental
Inject immature nerve cells
grown from human cancer cells
Cells mature ---> bridge damaged areas
Rats: function restored
Human: June 23, 1998
no ill effects
no recovery yet ~