Celebrating Hope
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This document discusses Alzheimer's disease and contains information from Dr. Brian Appleby on several topics: 1) It compares hope and optimism and discusses celebrating life. 2) It shows graphs on the change in death rates from the top 10 causes of death from 1999-2010 and the #1 risk factor for Alzheimer's is age. 3) It provides estimated costs of care for Alzheimer's patients and calls for new disease models. 4) Graphs show increasing Google searches for "dementia" and Alzheimer's related publications over time.
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The document is a sermon about the God of hope from Romans 15:13. It discusses how humans often live in stress, fear and anxiety, but as creatures and children of God, our Father is the God of hope who wants us to face the future with hope. It encourages believers to have hope, which brings joy and patience, and is filled by the Holy Spirit through faith in God's promises and goodness. The sermon aims to convey that God wants to fill believers with hope, joy and peace through their belief in Jesus.
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1. Replace problem-focused thinking with solution-focused thinking by focusing on things that could make a situation better.
2. Lay out a daily 30-second "movie" of your life focusing on positive aspects.
3. Find any improvements in your current situation to think positively.
4. Limit distractions and avoid negative people or saboteurs.
5. Ask yourself daily what you've done well to reinforce optimism.
6. Figure out ways to avoid temptations that could lead you away from steady progress.
7. Smile more often as it is a natural response that shares happiness and can reduce stress while making you appear more
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Positive emotions include feelings of joy, happiness, love, and surprise. Positive emotions are beneficial as they help people make better decisions, focus attention on new opportunities, and reduce health risks. However, focusing too much on positive emotions can also have disadvantages. When people are too happy, they may jump to conclusions and disregard important details. Emphasizing happiness can also increase expectations and lead to greater disappointment when reality does not match high expectations. Pursuing happiness as a primary goal can paradoxically make people feel more lonely.
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2. It describes various tests and scales used to measure optimism and pessimism based on how permanent, pervasive, and personal individuals perceive causes of events to be. Lower scores indicate more optimism.
3. While pessimism can help with reality, excess pessimism is linked to depression, poorer health, lower achievement, and children doing worse when facing adversity. The document advocates learning to dispute pessimistic beliefs and develop a more optimistic explanatory style.
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- Experimental treatments for prion disease are discussed but evidence suggests they provide only temporary benefits at best, with no treatment stopping disease progression. Symptomatic treatments aim to manage symptoms like psychosis, myoclonus and seizures.
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Rapidly progressive dementia can be caused by many conditions, not just prion diseases. Prion diseases should not be the default diagnosis, as there are treatable and reversible causes that could be missed. While diagnostic tests like CSF 14-3-3, EEG, and brain MRI findings can support a prion disease diagnosis, they are not specific and can be present in other non-prion conditions as well. A thorough evaluation is needed to avoid misdiagnosis, and symptomatic treatment should still be considered even for prion diseases.
Georgetown University Hospital Dept of Medicine Grand Rounds
This document discusses Creutzfeldt-Jakob disease (CJD), a rare neurological prion disease. It covers the objectives of understanding diagnosis of CJD and managing patients with CJD. It describes the different etiologies of CJD including genetic, variant, and acquired forms. Diagnosis involves clinical signs, EEG, CSF tests, and MRI imaging. Experimental treatments including quinacrine, pentosan polysulphate, and doxycycline are summarized. Care and management of CJD involves education, communication, and symptom management, with the goals of caring for patients and supporting families during the disease course.
Determinants of-survival-time-in-human-prion-diseases-1233685082975925-3
This document summarizes a presentation on prion diseases given by Dr. Brian Appleby. It discusses the different types of prion diseases that affect animals and humans, including scrapie, bovine spongiform encephalopathy, chronic wasting disease, Creutzfeldt-Jakob disease, and variant CJD. It reviews the etiologies, symptoms, diagnostic criteria, survival times, and hypothesized phenotypes of human prion diseases. It also presents findings that serum LDL levels may predict survival time in sporadic CJD patients and proposes a hypothetical mechanism whereby lipid rafts could assist in prion protein conversion.
Talks what gçös new with cjd and related early onset
This document summarizes a presentation on recent developments in prion diseases such as Creutzfeldt-Jakob disease (CJD) given by Brian S. Appleby, M.D. on April 4th, 2009. The presentation covered the basic concepts of prion diseases, diagnostic strategies, and recent discoveries. New findings discussed included prognostic factors that can modify the incubation period of prion diseases, ongoing controversies around human transmission of prion diseases via blood, and several investigational therapies such as quinacrine, pentosan polysulfate, doxycycline, and simvastatin.
Cjdfgrcincinnati2009 7-19-090722141427-phpapp02
This document summarizes research on prion diseases like Creutzfeldt-Jakob disease (CJD). It discusses the causes of prion diseases including genetic mutations and spontaneous misfolding. The document outlines the clinical diagnosis and tests used to diagnose CJD. It also describes recent investigational treatments for CJD like quinacrine, pentosan polysulfate, and doxycycline. Finally, it provides an overview of resources for patients and their families dealing with prion diseases.
Biomarkersinpriondisease2010 4-5-100405151856-phpapp02
The document discusses the historical significance of biomarkers in prion diseases. It covers: (1) how spongiform encephalopathy and transmissibility served as early biomarkers, (2) how PrPres became a key biomarker for detecting prion disease, and (3) how biomarkers can vary depending on the specific type of prion disease. The document provides examples of different prion diseases and how their biomarkers, clinical presentations, and neuropathologies may differ based on strain and host genotype.
Aus 2011 dealing with a loved one with cjd
This document discusses dealing with a loved one who has Creutzfeldt-Jakob disease (CJD) and provides resources for support. It notes that CJD may require significant changes to one's assumptions about life, as described in stages of grief models. The document lists several international support organizations that can help those dealing with CJD and notes that perceptions shape experiences with healthcare systems, so support groups exist to assist people impacted by CJD.
Healthy Brain Aging
- Healthy brain aging is important due to the rising prevalence of age-related cognitive disorders like Alzheimer's disease.
- Brain aging is influenced by both modifiable and non-modifiable risk factors. Engaging in heart-healthy habits, cognitive activities, and social interaction may help promote healthy brain aging.
- When discussing brain health with older patients, physicians should evaluate risk factors and encourage lifestyle changes like exercise, a healthy diet, cognitive stimulation, and social engagement.
Diagnosis of Creutzfeldt-Jakob Disease
This document provides information on diagnosing Creutzfeldt-Jakob Disease (CJD). It discusses the importance of considering other treatable causes of rapidly progressive dementias before diagnosing CJD. It outlines the diagnostic criteria for probable sporadic CJD, including having at least two clinical signs and one positive diagnostic test result. The document discusses various diagnostic tests used for CJD like CSF 14-3-3, EEG, and brain MRI findings. It notes that conditions other than CJD can produce positive 14-3-3 results and that genetic mutations may have unknown or age-related penetrance. Finally, it provides a case report example of a patient initially responding to psychiatric treatment before being found to have a
Frontotemporal Dementia: An Overview
The document describes frontotemporal lobar degeneration (FTLD), which includes frontotemporal dementia, primary progressive aphasia, and semantic dementia, and characterizes the clinical features and treatment approaches for each. Case examples are presented to illustrate the diverse presentations of FTLD.
Cc cjdf gr 2012 8-13
Creutzfeldt-Jakob Disease (CJD) is a rare and fatal brain disorder. The document discusses diagnosing and managing CJD, providing strategies for each stage of the disease. It outlines the diagnostic criteria for probable CJD and describes imaging and biomarker tests. Managing patients involves educating family, assessing symptoms, limiting exposure, and providing hospice care. The CJD Foundation and specialized centers provide resources and support for patients and caregivers.
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Celebrating Hope
- 1. May 8, 2013 Brian S. Appleby, M.D. Cleveland Clinic Lou Ruvo Center for Brain Health
- 2. Hope vs Optimism Hope (verb, noun): “to desire with expectation of fulfillment” Optimism (noun)/Optimistic (adjective) Celebrate (verb): “to perform publicly”
- 3. Trainee: “Why do you do this, you always have bad news to give?” • Quality vs Quantity of Life (psychiatry) • Comprehensive Model (geriatric psych) • Caregiver/Family dyad (dementia care) • Unmet Need (CJD, young-onset dementia) • 5 days/week (Cleveland Clinic)
- 4. -80 -60 -40 -20 0 20 Heart Disease Cancer Stroke Lung disease Accidents Diabetes Influenza Alzheimer’s Kidney disease Septicemia Change in Death Rate (1999 vs 2010) of Top 10 Causes of Death in U.S.A. Does NOT take age into account
- 5. #1 Risk for Alzheimer’s? AGE Thies W, Alzheimers Dement 2013
- 6. Thies W, Alzheimers Dement 2013
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- 8. Thies W, Alzheimers Dement 2013
- 9. “I'm Givin' Her All She's Got Captain! If I Push It Any Harder the Whole Thing's Gonna' Blow”
- 10. New and Better Disease Models Aguzzi A, Nature 2009
- 11. A B C Google searches for “dementia” over time
- 12. Appleby BS, Prion 2012 U.S. Alzheimer’s Related Publications Over Time
- 13. What IS Alzheimer’s Disease?
- 14. What is the Best Way to Treat/ Prevent Alzheimer’s Disease? LIVE!