This document discusses reconstructing cancer progression models from bulk and single-cell data using TRaIT. It provides an overview of TRaIT, which is part of the TRONCO library and can infer mutational trees from individual tumor data. TRaIT supports both multi-region and single-cell sequencing data within a unified statistical framework. The document also presents examples of TRaIT analyzing multi-region colorectal cancer data and single-cell triple-negative breast cancer data to reconstruct progression models.