Caris Life Sciences provides comprehensive molecular profiling services to help guide cancer treatment decisions. They have a large laboratory campus in Arizona that offers multiple technology platforms to analyze tumor biology. Caris also has a network of cancer centers that collaborate to profile patients, track outcomes, publish research, and establish guidelines for integrating molecular testing into care. The goal is to illuminate treatment options and match patients to therapies or clinical trials through their molecular intelligence reports.

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Caris Life Sciences®

2. ©2015 Caris Life Sciences
Comprehensive Molecular Profiling Services
Ensuring high quality, accurate and reliable molecular data
Collaborative Network for Research & Clinical Trials
Access to large scale annotated biospecimens and accelerated
clinical trial enrollment
Aggregated Clinical & Molecular Data and Analytics
Robust outcomes tracking and bioinformatic analytic tools
Unbiased Biomarker & Target Discovery Technology
Highly multiplexed platform to characterize
biological systems in their native state (s)
Using informatics and
technologies at the vanguard of
medical science to enable the
most comprehensive molecular
understanding of cancer
Headquarters: Irving, Texas
Laboratory: Phoenix, Arizona
• 66,000 sq. ft. oncology-focused
• ISO 15189, CLIA, CAP, NY State
and CE Mark approved/certified
Fulfilling the Promise of Precision Medicine

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• Technology agnostic panOmic solid
tumor profiling service (i.e., NGS, IHC,
FISH, CISH, PCR, Pyro, Sanger, Fragment
Analysis, CNV, Fusion, Translocations)
• Proprietary methods, bioinformatic
algorithms and analytics to assess
drug-biomarker associations
• Extensive clinical literature
assessment for drug/biomarker
associations (120,000+ reviewed papers)
• Clinical assays and technologies for
testing menu endorsed by COE
Steering Committee
Demonstrated Clinical Utility
• Rapid turnaround time (2014 average 8.1 days)
• 60 Actionable FDA approved Drug / Target Associations
• 30+ manuscripts published
• 130+ accepted and published abstracts
Caris Molecular Intelligence® – Tumor Profiling Leader
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• Tumor profiling is the information bridge between tumor biology and cancer
treatments
– Helps guide therapy decisions when there is little to no medical treatment consensus or
guideline
• Caris Molecular Intelligence uses multiple technology platforms to provide a more
comprehensive analysis of the tumor biology
• The report helps physicians:
– Navigate among therapies with potential benefit
– Identify therapies that may not have been considered
– Detect drugs with potential lack of benefit
(avoiding unnecessary toxicities and costs)
– Match patients to clinical trial opportunities
• Caris Molecular Intelligence helps illuminate a clearer path in personalized treatment
selection for physicians and their patients.
Caris Molecular Intelligenceis Designed to Help
Oncologists Make More Informed Therapy Choices
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Centers of Excellence for Precision Medicine Network™
Established in January 2015, the COE Network comprises leading academic and community
cancer care centers together serving ~100k new US cancer patients annually.
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The Network is committed to:
• Profile cancer patients using the industry
leading comprehensive molecular profiling
service, Caris Molecular Intelligence®
• Track longitudinal outcomes and contribute
data to Caris C.O.D.E.™
• Leverage Caris C.O.D.E.™ to publish novel
research and clinical data
• Establish guidelines to integrate molecular
tumor profiling into cancer care and patient
treatment management
• Participate in research studies and clinical
trials (prospective & retrospective)
• Collaborate in Virtual Molecular Tumor
Boards to advance the industry’s
understanding of cancer and the clinical
utility of profiling in clinical care
Access to Large Scale Clinical Samples
Molecular
Tumor
Profiling
ADAPT
Exosomal
Profiling
(plasma)
Capture
and Share
Outcomes