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VolitionRx
MicroCapClub
Invitational
8 January 2014
Public Company Profile: VNRX

•
•
•
•
•
•

Market capitalization: ~22 million
Shares outstanding: 11.19 million
Insider ownership: 60%
Cash: ~$975,000 + outstanding grants
Debt: $0
Burn rate: $220,000/month
• Current CRC diagnostics:
– Colonoscopy
– FIT/FOBT
• Blood better:
– FIT compliance 30-60%
– PSA compliance at least 80%
– 95% of people would rather
take a blood test than a
colonoscopy or fecal test

Need for Better CRC Diagnosis

Need for Better CRC Diagnosis

3
– How It Works
•

The DNA in every cell is wound
around protein complexes in a
“beads on a string” structure.

•

Each individual “bead” is called a
nucleosome.

•

When a cell dies, the body breaks
the DNA string up into individual
nucleosomes which are released
into the blood to be naturally
“recycled”.

•

Cancer is characterized by
uncontrolled and rapid cell
turnover. As the body can’t recycle
such large amounts of cell
“debris”, the nucleosome level
rises in a cancer patient’s blood.

DNA String

Nucleosomes

Nucleosomes
Entering
Bloodstream

4

Nucleosomics® – How It Works

Nucleosomics®
– How It Works
•

•

Nucleosome
Showing
Histone
& DNA
Modifications

5

More than just a
biomarker – a new
army of biomarkers
VNRX holds IP
covering:
•
•
•
•
•

DNA modification
Histone modification
Histone variants
Adducts
Total nucleosomes

Nucleosomics® – How It Works

Nucleosomics®
6

Suite of Tests

Volition’s NuQ® Suite of Tests

Volition’s

NuQ®

• Two types of tests:
• Screening tests e.g. colonoscopy
• Diagnostic tests e.g. scan; biopsy
• Multiple NuQ assays
• “Panel” of assays = cancer test
• Patient has 1 small blood draw

A panel of
assays,
encompassing
the 4-5 best
assays for
identifying a
particular cancer,
is selected

The final cancer
test panel
7

• Results presented at Clinical Genomics and Informatics Europe, Dec 2013
• Preliminary findings from CHU Dinant Godinne | UCL Namur Hospital in Belgium.
• Colorectal cancer two-assay panel test
• 85% detection rates at 85% specificity
Colorectal Cancer
• 50% of precancerous polyps detected
1.5

1.0

• Results presented at CNAPS conference, Nov 2013:
• Colorectal cancer single-assay test:
• 75% of cancers detected, 70% specificity
(90 patients, one single assay); data
reconfirmed on further 113 patients

0.5

0.0

1

3

5

7

9 11 13 15 17 19 21 23 25

2

4

6

8 10 12 14 16 18 20 22 24

Healthy

Colon cancer

Breast Cancer
1.5

1.0

• Nov 2012: Preliminary results:
• Colon: 76% of cancers detected at 90% specificity
• Breast: 96% of cancers detected at 90% specificity
• Lung: 100% of cancers at 79% specificity

0.5

0.0

1

3

5

7

9 11 13 15 17 19 21 23 25

2

4

6

8 10 12 14 16 18 20 22 24

Healthy

Breast cancer

Lung Cancer
0.8
0.6
0.4
0.2
0.0

1

3

5

7

9 11 13 15 17 19 21 23

Healthy

1

3

5

7

9 11 13 15 17 19 21 23

Lung cancer

Results to Date

Results to Date
• First 1,000 or approx 16,000 samples from Denmark have been delivered; analysis
started end 2013

Clinical Trials

Clinical Trials

8
1.

2.

• ELISA platform very
stable: >30 years
old
• Nucleosomics is at
the cutting edge of
science
• NuQ® tests can be
adapted onto four
existing ELISA
diagnostic platforms

Volition’s manual ELISA format
(same as RUO kits)

3.

A machine similar to that which
could be used to run Volition’s pointof-care tests

The Abbott Architect – a machine of
a type which could be used for
Volition’s tests

4.

An example of the type of format
which Volition could use for its
disposable tests

Product Development: Clinical Kits

Product Development: Clinical Kits

9
Investment Highlights
• Blood-based tests are the future of
cancer diagnostics – higher compliance
rates than current tests
• VNRX is developing diagnostic and
screening blood tests for a range of
cancers, beginning with CRC
• Promising early results, shortly to begin
4,800 patient retrospective trial and
11,000 individual screening trial for
CRC
• Volition’s Nucleosomics® tests are
based on simple but cutting-edge
science and are inexpensive to produce
but with high potential selling cost with
little direct competition.
• Volition has strong patent protection
from applications in USA and Europe,
for all key technologies.

10
VolitionRX
OTCBB: VNRX

Contact
Centre Technologique
Rue du Séminaire, 20A
BE-5000 Namur
Belgium
www.volitionrx.com

This presentation is available for download
in the Investor Relations section of
VolitionRx’s website at:
http://volitionrx.com/investordownloads/category/3-presentations.html

CEO: Cameron
Reynolds
c.reynolds@volitionrx.com

CSO: Jake Micallef
j.micallef@volitionrx.com

Updated
January
2014

11

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MicroCapClub Invitational: VolitionRx (VNRX)

  • 2. Public Company Profile: VNRX • • • • • • Market capitalization: ~22 million Shares outstanding: 11.19 million Insider ownership: 60% Cash: ~$975,000 + outstanding grants Debt: $0 Burn rate: $220,000/month
  • 3. • Current CRC diagnostics: – Colonoscopy – FIT/FOBT • Blood better: – FIT compliance 30-60% – PSA compliance at least 80% – 95% of people would rather take a blood test than a colonoscopy or fecal test Need for Better CRC Diagnosis Need for Better CRC Diagnosis 3
  • 4. – How It Works • The DNA in every cell is wound around protein complexes in a “beads on a string” structure. • Each individual “bead” is called a nucleosome. • When a cell dies, the body breaks the DNA string up into individual nucleosomes which are released into the blood to be naturally “recycled”. • Cancer is characterized by uncontrolled and rapid cell turnover. As the body can’t recycle such large amounts of cell “debris”, the nucleosome level rises in a cancer patient’s blood. DNA String Nucleosomes Nucleosomes Entering Bloodstream 4 Nucleosomics® – How It Works Nucleosomics®
  • 5. – How It Works • • Nucleosome Showing Histone & DNA Modifications 5 More than just a biomarker – a new army of biomarkers VNRX holds IP covering: • • • • • DNA modification Histone modification Histone variants Adducts Total nucleosomes Nucleosomics® – How It Works Nucleosomics®
  • 6. 6 Suite of Tests Volition’s NuQ® Suite of Tests Volition’s NuQ® • Two types of tests: • Screening tests e.g. colonoscopy • Diagnostic tests e.g. scan; biopsy • Multiple NuQ assays • “Panel” of assays = cancer test • Patient has 1 small blood draw A panel of assays, encompassing the 4-5 best assays for identifying a particular cancer, is selected The final cancer test panel
  • 7. 7 • Results presented at Clinical Genomics and Informatics Europe, Dec 2013 • Preliminary findings from CHU Dinant Godinne | UCL Namur Hospital in Belgium. • Colorectal cancer two-assay panel test • 85% detection rates at 85% specificity Colorectal Cancer • 50% of precancerous polyps detected 1.5 1.0 • Results presented at CNAPS conference, Nov 2013: • Colorectal cancer single-assay test: • 75% of cancers detected, 70% specificity (90 patients, one single assay); data reconfirmed on further 113 patients 0.5 0.0 1 3 5 7 9 11 13 15 17 19 21 23 25 2 4 6 8 10 12 14 16 18 20 22 24 Healthy Colon cancer Breast Cancer 1.5 1.0 • Nov 2012: Preliminary results: • Colon: 76% of cancers detected at 90% specificity • Breast: 96% of cancers detected at 90% specificity • Lung: 100% of cancers at 79% specificity 0.5 0.0 1 3 5 7 9 11 13 15 17 19 21 23 25 2 4 6 8 10 12 14 16 18 20 22 24 Healthy Breast cancer Lung Cancer 0.8 0.6 0.4 0.2 0.0 1 3 5 7 9 11 13 15 17 19 21 23 Healthy 1 3 5 7 9 11 13 15 17 19 21 23 Lung cancer Results to Date Results to Date
  • 8. • First 1,000 or approx 16,000 samples from Denmark have been delivered; analysis started end 2013 Clinical Trials Clinical Trials 8
  • 9. 1. 2. • ELISA platform very stable: >30 years old • Nucleosomics is at the cutting edge of science • NuQ® tests can be adapted onto four existing ELISA diagnostic platforms Volition’s manual ELISA format (same as RUO kits) 3. A machine similar to that which could be used to run Volition’s pointof-care tests The Abbott Architect – a machine of a type which could be used for Volition’s tests 4. An example of the type of format which Volition could use for its disposable tests Product Development: Clinical Kits Product Development: Clinical Kits 9
  • 10. Investment Highlights • Blood-based tests are the future of cancer diagnostics – higher compliance rates than current tests • VNRX is developing diagnostic and screening blood tests for a range of cancers, beginning with CRC • Promising early results, shortly to begin 4,800 patient retrospective trial and 11,000 individual screening trial for CRC • Volition’s Nucleosomics® tests are based on simple but cutting-edge science and are inexpensive to produce but with high potential selling cost with little direct competition. • Volition has strong patent protection from applications in USA and Europe, for all key technologies. 10
  • 11. VolitionRX OTCBB: VNRX Contact Centre Technologique Rue du Séminaire, 20A BE-5000 Namur Belgium www.volitionrx.com This presentation is available for download in the Investor Relations section of VolitionRx’s website at: http://volitionrx.com/investordownloads/category/3-presentations.html CEO: Cameron Reynolds c.reynolds@volitionrx.com CSO: Jake Micallef j.micallef@volitionrx.com Updated January 2014 11