The document summarizes cardiac physiology, including the cardiac cycle, electrical and mechanical events of the heart, ventricular structure and function, preload and afterload, cardiac output, the action potential, and neural control of cardiac function. Key points include a description of the cardiac cycle, how the electrocardiogram represents electrical events, factors that influence ventricular function like the Frank-Starling law, and how the autonomic nervous system regulates the heart through the sympathetic and parasympathetic pathways.
CVS physiology, all details with explanation easy to recall physiology of cardiovascular system. based on Ganong's Review of Medical Physiology. all the high-yield facts are there.
CVS physiology, all details with explanation easy to recall physiology of cardiovascular system. based on Ganong's Review of Medical Physiology. all the high-yield facts are there.
Useful for medical and biology students who want to study the cardiac cycle in a short time with big benefits !!
CVS physiology - Wigger Diagram - ECG of cardiac cycle - Heart sounds
Etiopathogenesis and pharmacotherapy of electrophysiology of heart
a. the pathophysiology of selected disease states and the rationale for drug therapy;
b. the therapeutic approach to management of these diseases;
c. the controversies in drug therapy;
d. the importance of preparation of individualised therapeutic plans based on diagnosis;
e. needs to identify the patient-specific parameters relevant in initiating drug therapy,
and monitoring therapy (including alternatives, time-course of clinical and laboratory
indices of therapeutic response and adverse effects);
f. describe the pathophysiology of selected disease states and explain the rationale for
drug therapy;
g. summarise the therapeutic approach to management of these diseases including
reference to the latest available evidence;
h. discuss the controversies in drug therapy;
i. discuss the preparation of individualised therapeutic plans based on diagnosis; and
j. identify the patient-specific parameters relevant in initiating drug therapy, and
monitoring therapy (including alternatives, time-course of clinical and laboratory indices of therapeutic response and adverse effects).
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
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In the DSM-5, all types of substance abuse and dependence have been
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the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Cardiac physiology
1. Cardiac physiology
Presented by - Mahtab Alam Ansari
Jr - Anaesthesia & ccm
Moderator - Dr. Satish kumar ( MD)
HOD Dept. Of Anaesthesia
2. • In 1628, English physician, William Harvey, first described the modern
concept of circulatory system .
• The basic anatomy of the heart consists of two atria and two ventricles that
provide two separate circulations in series.
• The pulmonary circulation, a low-resistance and high-capacitance vascular
bed, receives output from the right side of the heart, and its chief function is
bidirectional gas exchange.
• The left side of the heart provides output for the systemic circulation. It
functions to deliver oxygen (O2) and nutrients and to remove carbon dioxide
(CO2) and metabolites from various tissue beds.
3. CARDIAC CYCLE
• The cardiac cycle is the sequence of electrical and mechanical events
during the course of a single heartbeat.
• The cardiac cycle begins with the initiation of the heartbeat.
• Specialized cardiac pacemaker tissues have the property of
automaticity and rhythmicity.
• The sinoatrial (SA) node is usually the pacemaker; it can generate
impulses at the greatest frequency and is the natural pacemaker.
4. Electrical Events and the Electrocardiogram
• The ECG is the result of differences in electrical potential generated by the
heart at sites of the surface recording.
• The action potential initiated at the SA node is propagated to both atria by
specialized conduction tissue that leads to atrial systole (contraction) .
P wave of the ECG is produced due to atrial contraction
• At the junction of the interatrial and interventricular septa, specialized atrial
conduction tissue converges at the atrioventricular (AV) node, which is distally
connected to the His bundle.
• The AV node is an area of relatively slow conduction, and a delay between
atrial and ventricular contraction normally occurs at this site. The PR interval
represents the delay between atrial and ventricular contraction at the level of
the AV node.
5. • From the distal His bundle, an electrical impulse is propagated
through left ( larger ) and right bundle branches and finally to the
Purkinje system fibers, which are the smallest branches of the
specialized conduction system.
• Finally, electrical signals are transmitted from the Purkinje system to
individual ventricular cardiomyocytes. The spread of depolarization to
the ventricular myocardium is exhibited as the QRS complex on the
ECG.
• Depolarization is followed by ventricular repolarization which appears
asT wave on the ECG.
6. Mechanical Events
• The mechanical events of a cardiac cycle begin with the return of blood to the
right and left atria from the systemic and pulmonary circulation, respectively.
• As blood accumulates in the atria, atrial pressure increases until it exceeds the
pressure within the ventricle, the AV valve opens.
• Blood passively flows first into the ventricular chambers, and such flow
accounts for approximately 75% of the total ventricular filling. The remainder
of the blood flow is mediated by active atrial contraction or systole, known as
the atrial kick.
• The onset of atrial systole corresponds with depolarization of the sinus node
and the P wave.
7. • While the ventricles fill, the AV valves are displaced upward and ventricular
contraction (systole) begins with closure of the tricuspid and mitral valves,
which corresponds to the end of the R wave on the ECG.
• The first part of ventricular systole is known as isovolumic or isometric
contraction.
• the contraction of the ventricle leads to progressive increase in
intraventricular pressure. When intraventricular pressure exceeds pulmonary
artery and aortic pressure, the pulmonic and aortic valves open and
ventricular ejection occurs, which is the second part of ventricular systole.
8. • Ventricular ejection is divided into the rapid ejection phase and the
reduced ejection phase.
• During the rapid ejection phase, forward flow is maximal, and
pressure in pulmonary artery and aorta is maximally developed.
• During reduced ejection phase, flow and pressure of these two great
artery taper with progression of systole.
• Pressure in both ventricular chambers decreases as blood is ejected
from the heart, and ventricular diastole begins with closure of the
pulmonic and aortic valves.
• The initial period of ventricular diastole consists of the isovolumic
(isometric) relaxation phase.
9. • This phase is corresponds with repolarization of the ventricular
myocardium.
• The final portion of ventricular diastole involves a rapid decrease in
intraventricular pressure until it decreases to less than that of the
right and left atria, at which point the AV valve reopens, ventricular
filling occurs, and the cycle repeats itself.
10.
11.
12.
13. VENTRICULAR STRUCTURE AND FUNCTION
• Ventricular Structure
• The specific architectural order of the cardiac muscles provides the
basis for the heart to function as a pump.
• The ellipsoid shape of the left ventricle (LV) is a result of the laminar
layering of spiraling bundles of cardiac muscles
• The orientation of the muscle bundle is longitudinal in the
subepicardial myocardium and circumferential in the middle segment
and again becomes longitudinal in the subendocardial myocardium .
• this type of orientation allows the LV to eject blood in a corkscrew-
type motion beginning from the base and ending at the apex.
14.
15. • The architecturally complex structure of the LV thus allows maximal
shortening of myocytes, which results in increased wall thickness and
the generation of force during systole.
• Moreover, release of the twisted LV may provide a suction
mechanism for filling of the LV during diastole.
• The left ventricular free wall and the septum have similar muscle
bundle architecture. As a result, the septum moves inward during
systole in a normal heart.
• Regional wall thickness is a commonly used index of myocardial
performance that can be clinically assessed, by perioperative
echocardiography or magnetic resonance imaging.
16. • Unlike the LV, which pumps the blood against the higher-pressure
systemic circulation, the right ventricle (RV) pumps against a much
lower pressure pulmonary circulation. Consequently, wall thickness is
considerably less in the RV.
Ventricular Function
The traditional description of systolic function is usually limited to the
LV. Systolic performance of the heart is dependent on loading
conditions and contractility. Preload and afterload are two
interdependent factors extrinsic to the heart that govern cardiac
performance.
17. Systolic ventricular interaction involves the effect of the interventricular
septum on the function of both ventricles. Because the interventricular
septum is anatomically linked to both ventricles, it is part of the load
against which each ventricle has to work. Therefore, any changes in one
ventricle will also be present in the other.
In diastolic ventricular interaction, dilatation of either the LV or RV will
have an impact on effective filling of the contralateral ventricle and also
modify their function.
18. Preload and Afterload
Preload is defined as the ventricular load at the end of diastole, before
contraction has started.
First described by Starling, a linear relationship exists between
sarcomere length and myocardial force . In clinical practice it can be
assessd by pulmonary wedge pressure and central venous pressure .
With the development of transesophageal echocardiography, a more
direct measure of ventricular volume is available.
19. • Afterload is defined as systolic load on the LV after contraction has
begun.
• Aortic compliance is an additional determinant of afterload. Aortic
compliance is the ability of the aorta to give way to systolic forces
from the ventricle.
• Changes in the aortic wall (dilation or stiffness) can alter aortic
compliance and thus afterload.
• Examples of pathologic conditions that alter afterload are aortic
stenosis and chronic hypertension.
20. • Preload and afterload can be taken as the wall stress that is present at
the end of diastole and during left ventricular ejection, respectively.
• Wall stress is a useful concept because it includes preload, afterload,
and the energy required to generate contraction.
• Wall stress and heart rate are probably the two most relevant indices
that account for changes in myocardial O2 demand.
• Laplace’s law states that wall stress (σ) is the product of pressure (P)
and radius (R) divided by wall thickness (h)
σ = P × R/2h
21. Frank starling law
The law states that the stroke volume of the heart increases in response to
an increase in the volume of blood in the ventricles, before contraction (the
end diastolic volume), when all other factors remain constant.
As a larger volume of blood flows into the ventricle, the blood stretches the
cardiac muscle fibers, leading to an increase in the force of contraction.
The Frank-Starling mechanism may remain intact even in a failing heart.
Factors that can modify contractility will create a family of Frank-Starling
curves with different contractility . those factors are exercise, adrenergic
stimulation, changes in pH, temperature, and drugs such as digitalis.
The ability of the LV to develop, generate, and sustain the necessary
pressure or the ejection of blood is the intrinsic inotropic state of the heart.
22.
23. • The pressure-volume loop represents an indirect measure of the
Frank-Starling relationship between force (pressure) and muscle
length (volume).
• Clinically, the most commonly used noninvasive index of ventricular
contractile function is the ejection fraction,
•
24.
25. Ejection fraction [ Ejection fraction = (LVEDV −
LVESV) /LVEDV]
• A percent measurement of how much blood the left
ventricle pumps out with each contraction.
• An ejection fraction of 60% means that 60% of the total
amount of blood in the left ventricle is pushed out with each
heartbeat.
• A normal ejection fraction is 50% to 70%.
• A measurement under 40% may be evidence of heart
failure or cardiomyopathy
26. • An EF from 41% to 49% may be considered “borderline” but does
not always indicate that a person is developing heart failure. It may
indicate damage, perhaps from a previous heart attack. In severe
cases, EF can be very low.
• EF higher than 75% may indicate a heart condition like hypertrophic
cardiomyopathy.
• Tests for measuring EF :
Echocardiogram (Echo) - most widely used test, MUGA scan
,Cardiac catheterization ,Nuclear stress test
27. Coronary Circulation
• 250 ml /min at rest and up to 1000ml/min during exercise
• Rt coronary artery ---- RA , RV , IVS , SA node , Conducting system
except left bundle branch
• Left coronary artery ----- LA , LV ,IVS ( majority ) and left bundle
branch
• Based on origine of posterior descending interventricular branch
, 90% population have rt dominant coronary circulation and 10%
have left dominance .
28.
29.
30.
31. CARDIAC OUTPUT
• Cardiac output is the amount of blood pumped by the heart per unit
of time (Q˙ ) and is determined by four factors:
• Two intrinsic factors—heart rate and myocardial contractility
• Two extrinsic factors —preload and afterload.
• Heart rate is defined as the number of beats per minute and is mainly
influenced by the autonomic nervous system.
• Increases in heart rate increases cardiac output as long as ventricular
filling is adequate during diastole.
• Blood supply to coronary circulation occurs mainly during diastole
and as the heart rate increase ,duration of diastole decreases which
can compromise the blood supply to heart .
32. • Cardiac output in a living organism can be measured with the Fick
principle and indicator dilution technique
• The Fick principle is based on the concept of conservation of mass
such that the O2 delivered from pulmonary venous blood (q3) is
equal to the total O2 delivered to pulmonary capillaries through the
pulmonary artery (q1) and the alveoli (q2).
• q1 + q2 = q3
• The indicator dilution technique is another method for determining
cardiac output also based on the law of conservation of mass. The
two most commonly used indicator dilution techniques are the dye
dilution and the thermodilution methods.
33. Action Potential
• Ion fluxes across plasma membranes result in depolarization (attaining a less
negative membrane potential) and repolarization (attaining a more negative
membrane potential).
• They are mediated by membrane proteins with ion-selective pores.
• Because these ion channel proteins open and close the pores in response to
changes in membrane potential, the channels are voltage gated.
• In the heart, sodium (Na+), potassium (K+), Ca2+, and chloride (Cl−) channels
contribute to the action potential.
34. • The electrochemical gradient for K+ across the plasma membrane is
the determinant for the resting membrane potential. Mostly as a
result of the influx of Na+, the membrane potential becomes
depolarized, which leads to an extremely rapid upstroke (phase 0). As
the membrane potential reaches a critical level (or threshold) during
depolarization, the action potential is propagated. The rapid upstroke
is followed by a transient repolarization (phase 1).
35. • Phase 1 is a period of brief and limited repolarization that is largely
attributable to the activation of a transient outward K+ current, ito.
• The plateau phase (phase 2) occurs with a net influx of Ca2+ through
• L-type Ca2+ channels and the efflux of K+ through several K+
channels—the inwardly rectifying ik, the delayed rectifier ik1, and ito.
36. • Repolarization (phase 3) is brought about when an efflux of K+ from
the three outward K+ currents exceeds the influx of Ca2+, thus
returning the membrane to the resting potential. Very little ionic flux
occurs during diastole (phase 4) in a fast-response action potential
• Pacemaker currents during phase 4 are the result of an increase in the
three inward currents and a decrease in the two outward currents.
37.
38. CONTROL OF CARDIAC FUNCTION
• NEURAL REGULATION OF CARDIAC FUNCTION
The two limbs of the autonomic nervous system provide opposing input to
regulate cardiac function. The neurotransmitter of the sympathetic nervous
system is norepinephrine, which provides positive chronotropic (heart rate),
inotropic (contractility), and lusitropic (relaxation) effects. The parasympathetic
nervous system has a more direct inhibitory effect in the atria and has a
negative modulatory effect in the ventricles.
The neurotransmitter of the parasympathetic nervous system is acetylcholine.
Both norepinephrine and acetylcholine bind to seven transmembrane–
spanning G protein–coupled receptors to transduce their intracellular signals
and affect their functional responses
39. • the major influence on the heart at rest is parasympathetic. During
exercise or stress, however, the sympathetic neural influence
becomes more prominent.
• Parasympathetic innervation of the heart is through the vagal nerve.
Supraventricular tissue receives significantly more intense vagal
innervation than do the ventricles. The principal parasympathetic
target neuroeffectors are the muscarinic receptors in the heart.
Activation of muscarinic receptors reduces pacemaker activity, slows
AV conduction, directly decreases atrial contractile force, and exerts
inhibitory modulation of ventricular contractile force.
40. • A total of five muscarinic receptors have been cloned. M2 receptors are the
predominant subtype found in the mammalian heart.
• In contrast to vagal innervation, sympathetic innervation of the heart is more
predominant in the ventricle than in the atrium. Norepinephrine released
from sympathetic nerve terminals stimulates adrenergic receptors
(adrenoreceptors [AdRs]) located in the heart. The two major classes of ARs
are α and β, both of which are G protein–coupled receptors that transduce
their intracellular signals by means of specific signaling cascades
• β-ARs can be further divided into subpopulations of β1, β2, and β3.Although
most mammalian hearts contain β1-ARs and β2-ARs, β3-ARs also exist in
many mammalian ventricular tissues.
41. • In humans, β1-ARs are the predominant subtype in both the atria and
ventricles, but a substantial proportion of β2-ARs are located in the atria, and
approximately 20% of β2-ARs are found in the LV.
• Both β1-ARs and β2-ARs activate a pathway that involves the stimulatory G
protein (Gs), activation of adenylyl cyclase, accumulation of cAMP, stimulation
of cAMP-dependent protein kinase A, and phosphorylation of key target
proteins, including L-type Ca2+ channels, phospholamban, and TnI.
• β2-ARs can couple to G protein–independent pathways to modulate cardiac
function. β-AR stimulation increases both contraction and relaxation,
42. • The two major subpopulations of α-ARs are α1 and α2.
• α1-ARs are G protein–coupled receptors and include the α1A, α1B,
and α1D subtypes.
• Both α1A-ARs and α1B-ARs mediate positive inotropic responses.
However, the positive inotropic effect mediated by α1-ARs is believed
to be of minor importance in the heart.
• α1-ARs are coupled to phospholipase C, phospholipase D, and
phospholipase A2; they increase iCa2+ and myofibrillar sensitivity to
Ca2+.
43. • Cardiac hypertrophy is primarily mediated by α1A receptors .
• Three subtypes of α2-ARs are recognized: α2A, α2B, and α2C. In the
mammalian heart, α2c-ARs in the atrium play a role in the
presynaptic inhibition of norepinephrine release.
44. HORMONES AFFECTING CARDIAC
FUNCTION
• Cardiac hormones are polypeptides secreted by cardiac tissues into the
circulation in the normal heart. Natriuretic peptides, aldosterone, and
adrenomedullin are hormones secreted by cardiomyocytes. Angiotensin II, the
effector hormone in the renin-angiotensin system, is also produced by
cardiomyocytes.
• renin-angiotensin system is one of the most important regulators of
cardiovascular physiology. It is a key modulator of cardiac growth and function.
Angiotensin II stimulates two separate receptor subtypes, AT1 and AT2, both of
which are present in the heart. AT1 receptors are the predominant subtype
expressed in the normal adult human heart. Stimulation of AT1 receptors induces
a positive chronotropic and inotropic effect. Angiotensin II also mediates cell
growth and proliferation in cardiomyocytes and fibroblasts and induces the
release of the growth factors aldosterone and catecholamines through the
stimulation of AT1 receptors.
45. • Activation of AT1 receptors is directly involved in the development of
cardiac hypertrophy and heart failure, as well as adverse remodeling
of the myocardium.
• AT2 receptor activation is counterregulatory and generally
antiproliferative.
• Expression of AT2 receptors, however, is relatively scant in the adult
heart because they are most abundant in the fetal heart and decline
with development.
• In response to injury and ischemia, AT2 receptors become
upregulated.
• The precise role of AT2 receptors in the heart remains to be defined.
46. • The beneficial effects of blockade of the renin-angiotensin system
with angiotensin-converting enzyme inhibitors in the treatment of
heart failure have been attributed to an inhibition of AT1-receptor
activity.
• In addition to the renin-angiotensin system, other cardiac hormones
that have been shown to play pathogenic roles in the promotion of
cardiomyocyte growth and cardiac fibrosis, development of cardiac
hypertrophy, and progression of congestive heart failure include
aldosterone, adrenomedullin, natriuretic peptides, angiotensin,
endothelin,and vasopressin.
47. • Increased stretch of the myocardium stimulates the release of atrial
natriuretic protein (ANP) and B-type natriuretic protein (BNP) from
the atria and ventricles, respectively.
• Both ANP and BNP bind to natriuretic peptide receptors to generate
the second messenger cyclic guanosine monophosphate and
represent part of the cardiac endocrine response to hemodynamic
changes caused by pressure or volume overload.
• They also participate in organogenesis of the embryonic heart and
cardiovascular system.
• In patients with chronic heart failure, increases of serum ANP and
BNP levels are a predictor of mortality.
48. • Adrenomedullin is a recently discovered cardiac hormone that was
originally isolated from pheochromocytoma tissue.
• It increases the accumulation of cAMP and has direct positive
chronotropic and inotropic effects.
• Adrenomedullin has also been shown to increase nitric oxide
production,and it functions as a potent vasodilator.
49. Sex Steroid Hormones and the Heart
• The most extensively studied sex steroid hormones are estradiol-17β
(E2) and its bioactive metabolites. They bind and act on the two
subtypes of estrogen receptors (ERs) in the heart: ERα and ERβ.
• Progesterone and testosterone bind and act on their respective
progesterone receptors and androgen receptors in the heart
• Cardiomyocytes are not only targets for the action of sex steroid
hormones, but they are also the source of synthesis and the site of
metabolism of these hormones.
50. • Sex steroid hormones can activate rapid signaling pathways without
changing gene expression .
• One such example is stimulation of vascular endothelial nitric oxide
synthase to mediate vascular dilatation.
• Estrogen’s vasodilatory effect might explain the lower systolic blood
pressures of premenopausal women when compared with age-
matched men.
51. • The modulatory actions of estrogen on Ca2+ channels might be
responsible for sex-based differences in repolarization of the heart,
such as the faster resting heart rate of women, as well as the
increased propensity of women to have prolonged QT syndrome.
• Estrogen, through the activation of ERβ, confers protection after
ischemia and reperfusion in murine models of myocardial infarction.
52. CARDIAC REFLEXES
• Cardiac receptors are linked to the CNS by myelinated or
unmyelinated afferent fibers that travel along the vagus nerve.
• Cardiac receptors are in the atria, ventricles, pericardium, and
coronary arteries
• Extracardiac receptors are located in the great vessels and carotid
artery.
• Sympathetic and parasympathetic nerve input is processed in the
CNS. After central processing, efferent fibers to the heart or the
systemic circulation will provoke a particular reaction.
53. Baroreceptor Reflex (Carotid Sinus Reflex)
• The baroreceptor reflex is responsible for the maintenance of arterial
blood pressure through a negative-feedback loop .
• Changes in arterial blood pressure are monitored by circumferential
and longitudinal stretch receptors located in the carotid sinus and
aortic arch. The nucleus solitarius, located in the cardiovascular
center of the medulla, receives impulses from these stretch receptors
through afferents of the glossopharyngeal and vagus nerves.
54. • Typically, stretch receptors are activated if systemic blood pressure is
greater than 170 mm Hg. The response of the depressor system
includes decreased sympathetic activity, leading to a decrease in
cardiac contractility, heart rate, and vascular tone.
• In addition, activation of the parasympathetic system further
decreases the heart rate and myocardial contractility.
• Reverse effects are elicited with the onset of hypotension.
• The baroreceptor reflex plays an important beneficial role during
acute blood loss and shock. However, the reflex arch loses its
functional capacity when arterial blood pressure is less than 50 mm
Hg.
55. • volatile anesthetics (particularly halothane) inhibit the heart rate
component of this reflex.
• Concomitant use of Ca2+-channel blockers, angiotensin-converting
enzyme inhibitors, or phosphodiesterase inhibitors will lessen the
cardiovascular response of raising blood pressure through the
baroreceptor reflex
56. Bainbridge Reflex
• The Bainbridge reflex is elicited by stretch receptors located in the
right atrial wall and the cavoatrial junction.
• An increase in right-sided filling pressure sends vagal afferent signals
to the cardiovascular center in the medulla. These afferent signals
inhibit parasympathetic activity, thereby increasing the heart rate.
• Acceleration of the heart rate also results from a direct effect on the
SA node by stretching the atrium.
• The changes in heart rate are depends on the underlying heart rate
before stimulation.
57. Marey's Law
• the haert rate is inversaly proportional to arterial blood pressure provided
that other that can affect the heart rate remains constant .
• incerase in arterial blood pressure ------> deceases heart rate or vice versa
• stimulus --- increase in arterial blood pressure
• receptors --- arterial baroreceptors in the wall of carotid sinus and aortic arch
• afferent ---- sinus nerve of hering ( branch of 9 th nerve ) and aortic nerve (
branch of 10 th nreve )
• centre --- vasomotor centre in medulla
• efferent --- vagus nerve stimulated ---- SA Node (- ) ---- HR decrease .
58. Bezold-Jarisch Reflex
Decrease in left ventricular volume ( ex ; decreased venous
return ) ------ sensed by receptors in ventricular wall -----The
activated receptors communicate via unmyelinated vagal
afferent type C fibers------- These fibers reflexively increases
parasympathetic tone ---- which produces bradycardia and
decreased contractility ( hypotension ) .
spinal and epidural anaesthesia
Natriuretic peptide receptors stimulated by endogenous ANP
or BNP may modulate the Bezold- Jarisch reflex. Thus the
Bezold-Jarisch reflex may be less pronounced in patients with
cardiac hypertrophy or atrial fibrillation.
59. Valsalva Maneuver
Forced expiration against a closed glottis produces increased intrathoracic
pressure, increased central venou pressure, and decreased venous return.
Cardiac output and blood pressure will be decreased after the Valsalva
maneuver. This decrease will be sensed by baroreceptors and will reflexively
result in an increase in heart rate and myocardial contractility through
sympathetic stimulation.
When the glottis opens, venous return increases and causes the heart to
respond by vigorous contraction and an increase in blood pressure. This
increase in arterial blood pressure will, in turn, be sensed by baroreceptors,
thereby stimulating the parasympathetic efferent pathway to the heart.
60. Cushing Reflex
• The Cushing reflex is a result of cerebral ischemia caused by increased
intracranial pressure.
• Cerebral ischemia at the medullary vasomotor center induces initial
activation of the sympathetic nervous system.
• Such activation will lead to an increase in heart rate, arterial blood
pressure, and myocardial contractility in an effort to improve cerebral
perfusion.
• As a result of the high vascular tone, reflex bradycardia mediated by
baroreceptors will take place .
• Triad of cushing reflex is HTN , bradycardia , and irregular respiration .
61. Oculocardiac Reflex
• The oculocardiac reflex begins when pressure applied to the globe of
the eye or traction on the surrounding structures.-------- Stretch
receptors located in the extraocular muscles ---- activated and send
afferent signals through the short- and long-ciliary nerves. The ciliary
nerves will merge with the ophthalmic division of the trigeminal
nerve at the ciliary ganglion.
• The trigeminal nerve will carry these impulses to the gasserian
ganglion, which ultimetly results in increased parasympathetic tone
and subsequent bradycardia.
• The incidence of this reflex during ophthalmic surgery ranges from
30% to 90%.
• Administration of an antimuscarinic drug such as glycopyrrolate or
atropine reduces the incidence of bradycardia during eye surgery.