Sinus tymapni shape and depth can influence surgical approach in cholesteatoma surgery. In the case of a shallower ST, an exclusive endoscopic exploration is chosen; while in the case of a deeper ST, a retrofacial approach is usually preferred.
Mastoid surgery is a commonly performed surgery by ENT surgeons. Although lots of modifications have been made in the techniques of mastoid surgery, the basic is cortical and modified radical mastoid surgery. In this lecture, I shall be discussing about different techniques of performing mastoid surgery, their advantages and disadvantages and complications of mastoid surgery.
Sinus tymapni shape and depth can influence surgical approach in cholesteatoma surgery. In the case of a shallower ST, an exclusive endoscopic exploration is chosen; while in the case of a deeper ST, a retrofacial approach is usually preferred.
Mastoid surgery is a commonly performed surgery by ENT surgeons. Although lots of modifications have been made in the techniques of mastoid surgery, the basic is cortical and modified radical mastoid surgery. In this lecture, I shall be discussing about different techniques of performing mastoid surgery, their advantages and disadvantages and complications of mastoid surgery.
Cavity obliteration is a procedure done at the end of Mastoidectomy to get a cavity-less mastoid cavity thus solving the problem of discharging post-operative cavity.
Sino-nasal cancers are not uncommon. However, treatment is always challenging because of surrounding critical normal structures.
Skilled surgical procedure and high end radiation therapy (IMRT, IGRT, SBRT) can definitely treat these difficult cancers.
Cavity obliteration is a procedure done at the end of Mastoidectomy to get a cavity-less mastoid cavity thus solving the problem of discharging post-operative cavity.
Sino-nasal cancers are not uncommon. However, treatment is always challenging because of surrounding critical normal structures.
Skilled surgical procedure and high end radiation therapy (IMRT, IGRT, SBRT) can definitely treat these difficult cancers.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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3. Introduction
Rare, rapidly progressive disease with limited
therapeutic success
Female predominance
Malignant temporal bone tumors < 0.2% of all
head and neck tumors
Most common (80%) of all primary Temporal bone
tumors – SCC
9. Examination
Ulcerated lesion or granular
mass or polypoid mass
Cranial nerve examination
Neck examination including
parotid gland
10. Differential
Diagnosis
Skull base osteomyelitis
CSOM
Other tumors of temporal bone
Melanoma
Adenocarcinoma
Adenoid cystic carcinoma
Lymphoma
Metastsis
11. Investigations
Deep biopsy – CT guided biopsy
CT
MRI
PTA
Angiography & Balloon Occlusion Test
Systemic workup (for GA fitness)
12.
13.
14. Staging
(Pittsburgh
Classification)
Stage Description
T1 Tumour limited to EAC
T2 Tumour with limited erosion of EAC or <0.5cm
involvement of soft tissue on radiological
assessment
T3 Tumour eroding the osseous EAC (full
thickness) with limited (<0.5cm) soft tissue
involvement or middle ear and/or mastoid
T4 Tumour eroding the cochlear, petrous apex,
medial wall of middle ear, carotid canal, jugular
foramen or dura or extensive soft tissue
involvement (>0.5cm). Facial paralysis at
presentation
15. N Status
N0 No nodal metastasis
N1 Metastasis to regional lymph nodes
M Status
M0 No distant metastasis
M1 Distance metastasis present
Stage
Stage I T1,N0,M0
Stage II T2,N0,M0
Stage III T3,N0,M0 T1,N1,M0
Stage IV T4,N0,M0 T2-4, N1,M0 any T, any N M1
16. Treatment
Lateral Temporal bone resection
T1, T2
Lesion lateral to Tympanic membrane
Extended temporal bone resection
T3, T4
Adjuvant therapy
17. Lateral
temporalbone
resection
Incision
Pinna excised partially or completely
Cortical Mastoidectomy
Posterior Tympanotomy – extended facial recess
Anterosuperior extension into
Temporomandibular Joint (TMJ)
Resection of TMJ and Mandible (condyle)
Superficial Parotidectomy
Neck dissection
Reconstruction
24. Sleeve resection of the external auditory canal (solid line) - small lesions of the EAC.
Lateral temporal bone resection (dotted line)
Total temporal bone resection (dashed line)
27. Adjuvant
therapy
Radiotherapy
Primary treatment – Lesion limited to pinna,
limited EAC tumour by Silva et all
Post- op radiotherapy (60-70 Gy)
Chemotherapy
Debulking and chemotherapy (5FU) by knegt et all
28. Intracranial
extension
Poor prognostic factor
Dura and brain involved – resected
Frozen section of resection margins
Dural defect repair with Fascia Lata
29. Carotid
involvement
Poor prognosis
Adventitia involvement – tumor dissected of
artery
Gross involvement – ligation and resection of
artery
Neurological consequences
30. Palliativecare
o Distant metastasis
o ICA involvement, petrous apex involvement and
extensive Dural or brain parenchymal
involvement
Palliative surgical resection + post op
Radiotherapy
32. Post Op Care
Hearing Aids – BAHA
Facial reanimation
Feeding tube
Speech therapy
Follow UP –
2 monthly – first 2 years
6 monthly – 3rd-5th years
Yearly – after 5 years
CT & MRI – 6monthly (first 2 years) and then yearly
33. Recurrence
Recurrence without distant metastasis – surgical
resection and post op radiotherapy
Recurrent disease with metastasis – palliative
care
34. Outcome
80-100% 5 year survival rates in stage I & II
50% - stage III
15-42% - stage IV
Lymphatic and hematologic spread is rare
Intraparotid lymph nodes are echelon nodes
Chronic inflammation and irritation
NPC and other intracranial (7 yrs after radiation, another histologic type than the cancer previously radiated for)
UVR (pinna)
More than 70%
Exophytic mass within left EAC
Metastatic workup (in adenocarcinoma, lymphoma etc)
Gadolinium DTPA - MRI
Incision – post auricular, pre auricular, extended into neck for ND
AS – along line of middle fossa plate curving along sup wall of EAC
Complete mastoidectomy – exposure of incus long process, facial canal V seg and lat SCC
Extended facial recess
FN from geniculate ganglion to SM foramen
Corda sacrificed, IS joint disarticulated
( a ) intact facial nerve from second genu to periphery, ( b ) sino-dural angle, ( c ) glenoid fossa, ( d ) cut end of the neck of mandible, ( e ) posterior belly of digastric with removal of mastoid tip, and ( f ) remaining deep lobe of parotid
Kutz jr et all in 2015 advocated a LTBR with TMJ excision (glenoid fossa and condyle), total parotidectomy and neck dissection for T3 and T4 lesions of Lateral temporal bone
Includind condyle, glenoid fossa,coronoid
NTTBR petrous apex not included
TTBR petrous air cells, sigmoid sinus even petrous ICA
Subtotal temporal bone resection. Incisions include a central external auditory canal core, which is sutured closed. Note the tragus can be preserved for better cosmesis. Temporal craniotomy for subtotal temporal bone resection is smaller than for a total temporal bone resection. Parotid gland with main trunk of facial nerve has been elevated from masseter muscle.
Subtotal temporal bone resection. A, Bird’s-eye view of proposed resection. Note the facial nerve can be exposed for clean sectioning in the labyrinthine segment. B,Osteotome at carotid canal first genu directed at internal auditory canal fundus. C, Specimen removed showing remaining petrous apex and otic capsule. Roman numerals denote cranial nerves.
Superficial parotidectomy at least in LTBR, total in TTBR
First echelon nodes
Pedicled flaps (more durable) suitable for smoker, diabetic, vascular disease
Free flaps- greater versatility – gold standard