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Delivery Methods and Dosing:
Making the most of your medicine
Medical Cannabis
and Harm Reduction
Presenter: Becky DeKeuster, M.Ed, Director of Education
Producer: Ben Gelassen, Digital Marketing Specialist
Potential for the treatment of addiction and
symptoms of withdrawal
What is harm reduction?
A public health philosophy and set of practices seeking
an overall decrease in the negative impacts of drug use
Harm reduction practices and policies seek to reduce
the harms associated with drug use*,
without requiring that consumption be reduced
*Harm reduction can be applied to non-drug-related aspects of life
LegalizationAbstinence
DRUG
POLICY
Assessing the impacts of use of various drugs
Self
Community
Society
Health
Social
Economic
General harm reduction strategies
Public health philosophy and set of practices seeking an overall
decrease in the negative impacts of drug use, including those
caused by drug control policies themselves
Other interventions
Advocacy for improved drug policies
HIV/AIDS-related interventions
Broader drug treatment options
Drug use management
Examples of harm reduction in history
Netherlands 1984: First needle exchange program
Late 50s-early 60s: Methadone programs begin in Canada, U.S.
1920s Britain: Rolleston Committee of physicians advocates for drug
maintenance programs for some problem drug users
Grew from the belief that the spread of HIV is more
harmful to individuals and society than is drug misuse
Today: Narcan for family members, friends, first responders
U.S. approaches to drug policy
Through most of our lifetimes, U.S.
stance on “illicit” drugs primarily
has been abstinence-based
Typically accomplished via
legislation, criminal penalties,
and stigmatizing consumers of
drugs considered illicit
Policies aim to reduce/eliminate
both supply and demand
Source: “CNN: The War on Drugs, 40 Years Later” (via YouTube)
Delivery Methods and Dosing:
Making the most of your medicineHow does cannabis fit into
a harm reduction approach
to the use of other
substances?
HR: So how does cannabis fit in?
Some would call for strategies (possibly including harm reduction
techniques) to reduce or eliminate marijuana supply and use.
Left: Nancy Reagan advocates for a “drug-free society” in the 1980s. Right: 2012 billboard in Portland, OR.
HR: So how does cannabis fit in?
Some would call medical and other cannabis laws part of a harm
reduction strategy for marijuana supply and use.
Source: Good to Know
Colorado, 2015
HR: So how does cannabis fit in?
Some would call medical and other cannabis laws part of a harm
reduction strategy for alcohol, opioid, and other drug supply and use.
2013 bus advertisement in Portland, ME.
Delivery Methods and Dosing:
Making the most of your medicine
What does modern
medicine and science say
about cannabis use as a
harm reduction tool?
NIDA on: Cannabis
Possible Health Effects
Short-term
Enhanced sensory perception and euphoria followed by drowsiness/relaxation;
slowed reaction time; problems with balance and coordination; increased heart
rate and appetite; problems with learning and memory; hallucinations; anxiety;
panic attacks; psychosis.
Long-term Mental health problems, chronic cough, frequent respiratory infections.
Other Health-related Issues
Youth: possible loss of IQ points when repeated use begins in adolescence.
Pregnancy: babies born with problems with attention, memory, and problem
solving.
In Combination with
Alcohol
Increased heart rate, blood pressure; further slowing of mental processing and
reaction time.
Withdrawal Symptoms Irritability, trouble sleeping, decreased appetite, anxiety.
Source: National Institute on Drug Abuse (NIDA) https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
NIDA on: Alcohol
“People drink to socialize, celebrate, and relax. Alcohol often has a strong effect on people—and throughout
history, people have struggled to understand and manage alcohol’s power. Why does alcohol cause people to
act and feel differently? How much is too much? Why do some people become addicted while others do not?
The National Institute on Alcohol Abuse and Alcoholism is researching the answers to these and many other
questions about alcohol. Here’s what is known:
• Alcohol’s effects vary from person to person, depending on a variety of factors, including:
How much you drink; how often you drink; your age; your health status; your family history
• While drinking alcohol is itself not necessarily a problem—drinking too much can cause a range of
consequences, and increase your risk for a variety of problems.
For more information on alcohol’s effects on the body, please see the National Institute on Alcohol Abuse and
Alcoholism’s related web page describing alcohol’s effects on the body.”
Source: National Institute on Drug Abuse (NIDA). https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
NIAAA on: Alcohol
Source: National Institute on Alcohol and Alcoholism (NIAAA). https://www.niaaa.nih.gov/alcohol-health/alcohols-effects-body
Brain:
Alcohol interferes with the brain’s communication pathways, and can affect the way the brain looks and
works. These disruptions can change mood and behavior, and make it harder to think clearly and move with
coordination.
Heart:
Drinking a lot over a long time or too much on a single occasion can damage the heart, causing problems
including:
•Cardiomyopathy – Stretching and drooping of heart muscle
•Arrhythmias – Irregular heart beat
•Stroke
•High blood pressure
Research also shows that drinking moderate amounts of alcohol may protect healthy adults
from developing coronary heart disease.
NIAAA on: Alcohol
Liver:
Heavy drinking takes a toll on the liver, and can
lead to a variety of problems and liver
inflammations including:
•Steatosis, or fatty liver
•Alcoholic hepatitis
•Fibrosis
•Cirrhosis
Pancreas:
Alcohol causes the pancreas to produce toxic substances that can eventually lead to pancreatitis, a dangerous
inflammation and swelling of the blood vessels in the pancreas that prevents proper digestion.
Source: National Institute on Alcohol and Alcoholism (NIAAA). https://www.niaaa.nih.gov/alcohol-health/alcohols-effects-body
Cancer:
Drinking too much alcohol can increase your
risk of developing certain cancers, including
cancers of the:
•Mouth
•Esophagus
•Throat
•Liver
•Breast
Immune System:
Drinking too much can weaken your immune system, making your body a much easier target for disease. Chronic
drinkers are more liable to contract diseases like pneumonia and tuberculosis than people who do not drink too
much. Drinking a lot on a single occasion slows your body’s ability to ward off infections – even up to 24 hours after
getting drunk.
NIDA on: Prescription Opioids
Possible Health Effects
Short-term
Pain relief, drowsiness, nausea, constipation, euphoria,
confusion, slowed breathing, death.
Long-term Unknown.
Other Health-related Issues
Pregnancy: Miscarriage, low birth weight, neonatal abstinence
syndrome.
Older adults: higher risk of accidental misuse or abuse because
many older adults have multiple prescriptions, increasing the
risk of drug-drug interactions, and breakdown of drugs slows
with age; also, many older adults are treated with prescription
medications for pain.
Risk of HIV, hepatitis, and other infectious diseases from shared
needles.
In Combination with Alcohol
Dangerous slowing of heart rate and breathing leading to coma
or death.
Source: National Institute on Drug Abuse (NIDA). https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
NIDA on: Prescription Opioids
Withdrawal Symptoms
Restlessness, muscle and bone pain, insomnia, diarrhea,
vomiting, cold flashes with goose bumps ("cold turkey"), leg
movements.
Treatment Options
Medications
•Methadone
•Buprenorphine
•Naltrexone (short- and long-acting)
Behavioral Therapies
Behavioral therapies that have helped treat addiction to heroin
may be useful in treating prescription opioid addiction.
Source: National Institute on Drug Abuse (NIDA). https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
Cannabis substitution for alcohol
“Substituting cannabis for prescription drugs, alcohol and other substances among
medical cannabis patients.” Lucas P, Walsh Z, et al. Drug and Alcohol Review, May 2016
“Substituting cannabis for one or more of alcohol, illicit drugs or
prescription drugs was reported by 87% (n = 410) of respondents, with
80.3% reporting substitution for prescription drugs, 51.7% for alcohol,
and 32.6% for illicit substances. Respondents who reported substituting
cannabis for prescription drugs were more likely to report difficulty
affording sufficient quantities of cannabis, and patients under 40 years of
age were more likely to substitute cannabis for all three classes of
substance than older patients.”
Cannabis substitution/supplement for opioids
“Prescribing cannabis for harm reduction.” Collen M, Harm Reduction Journal, 2005
“…a number of articles have reported on interactions between
cannabinoid and opioid receptors which may result in enhanced analgesia
and a synergistic effect when CC is added to opioids... This may translate
into patients being able to reduce their opioid intake with adjuvant
cannabinoid therapy...”
“There is sufficient evidence of safety and efficacy for the use of
(therapeutic cannabis) in the treatment of nerve pain relative to opioids
and as Carter et al write, "From a pharmacological prospective,
cannabinoids are considerably safer than opioids..."”
The future of cannabis for HR
Legal
status
Social
approval
Increasing legalization of
cannabis = expanded
acceptance
Residual resistance to
positives associated with
any cannabis use
Longer-term data on social
benefits & costs
Opponent messaging
focused on risks
Medical, legal, and
treatment barriers
Positive individual
experiences with cannabis
as substitute/treatment
Kennebec Journal, July 27, 2016
Sources & Resources
www.pubmed.comwww.drugpolicy.org www.harmreduction.org
Harm Reduction: National and International Perspectives. James A. Inciardi and Lana D. Harrison. SAGE
Publications, Oct 11, 1999.
Collen, Mark. Prescribing cannabis for harm reduction. Harm Reduction Journal 2012; 9: 1. Accessed July 5 2016
at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295721/
Video: Cannabis as Substitute for Other Drugs. Amanda Reiman, PhD MSW. Webinar presented
September 12, 2013, Center for Behavioral Health Policy at the University of California at Berkeley.
Accessed July 5, 2016 at https://www.youtube.com/watch?v=7FPyZhNtHss
Delivery Methods and Dosing:
Making the most of your medicine
Thank you for your
time and attention!
What are your remaining
questions & concerns?
www.mainewellness.org
@wellconnectme
www.facebook.com/mainewellness
Instagram: @mainewellness

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Cannabis for Harm Reduction

  • 1. Delivery Methods and Dosing: Making the most of your medicine Medical Cannabis and Harm Reduction Presenter: Becky DeKeuster, M.Ed, Director of Education Producer: Ben Gelassen, Digital Marketing Specialist Potential for the treatment of addiction and symptoms of withdrawal
  • 2. What is harm reduction? A public health philosophy and set of practices seeking an overall decrease in the negative impacts of drug use Harm reduction practices and policies seek to reduce the harms associated with drug use*, without requiring that consumption be reduced *Harm reduction can be applied to non-drug-related aspects of life LegalizationAbstinence DRUG POLICY
  • 3. Assessing the impacts of use of various drugs Self Community Society Health Social Economic
  • 4. General harm reduction strategies Public health philosophy and set of practices seeking an overall decrease in the negative impacts of drug use, including those caused by drug control policies themselves Other interventions Advocacy for improved drug policies HIV/AIDS-related interventions Broader drug treatment options Drug use management
  • 5. Examples of harm reduction in history Netherlands 1984: First needle exchange program Late 50s-early 60s: Methadone programs begin in Canada, U.S. 1920s Britain: Rolleston Committee of physicians advocates for drug maintenance programs for some problem drug users Grew from the belief that the spread of HIV is more harmful to individuals and society than is drug misuse Today: Narcan for family members, friends, first responders
  • 6. U.S. approaches to drug policy Through most of our lifetimes, U.S. stance on “illicit” drugs primarily has been abstinence-based Typically accomplished via legislation, criminal penalties, and stigmatizing consumers of drugs considered illicit Policies aim to reduce/eliminate both supply and demand Source: “CNN: The War on Drugs, 40 Years Later” (via YouTube)
  • 7. Delivery Methods and Dosing: Making the most of your medicineHow does cannabis fit into a harm reduction approach to the use of other substances?
  • 8. HR: So how does cannabis fit in? Some would call for strategies (possibly including harm reduction techniques) to reduce or eliminate marijuana supply and use. Left: Nancy Reagan advocates for a “drug-free society” in the 1980s. Right: 2012 billboard in Portland, OR.
  • 9. HR: So how does cannabis fit in? Some would call medical and other cannabis laws part of a harm reduction strategy for marijuana supply and use. Source: Good to Know Colorado, 2015
  • 10. HR: So how does cannabis fit in? Some would call medical and other cannabis laws part of a harm reduction strategy for alcohol, opioid, and other drug supply and use. 2013 bus advertisement in Portland, ME.
  • 11. Delivery Methods and Dosing: Making the most of your medicine What does modern medicine and science say about cannabis use as a harm reduction tool?
  • 12. NIDA on: Cannabis Possible Health Effects Short-term Enhanced sensory perception and euphoria followed by drowsiness/relaxation; slowed reaction time; problems with balance and coordination; increased heart rate and appetite; problems with learning and memory; hallucinations; anxiety; panic attacks; psychosis. Long-term Mental health problems, chronic cough, frequent respiratory infections. Other Health-related Issues Youth: possible loss of IQ points when repeated use begins in adolescence. Pregnancy: babies born with problems with attention, memory, and problem solving. In Combination with Alcohol Increased heart rate, blood pressure; further slowing of mental processing and reaction time. Withdrawal Symptoms Irritability, trouble sleeping, decreased appetite, anxiety. Source: National Institute on Drug Abuse (NIDA) https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
  • 13. NIDA on: Alcohol “People drink to socialize, celebrate, and relax. Alcohol often has a strong effect on people—and throughout history, people have struggled to understand and manage alcohol’s power. Why does alcohol cause people to act and feel differently? How much is too much? Why do some people become addicted while others do not? The National Institute on Alcohol Abuse and Alcoholism is researching the answers to these and many other questions about alcohol. Here’s what is known: • Alcohol’s effects vary from person to person, depending on a variety of factors, including: How much you drink; how often you drink; your age; your health status; your family history • While drinking alcohol is itself not necessarily a problem—drinking too much can cause a range of consequences, and increase your risk for a variety of problems. For more information on alcohol’s effects on the body, please see the National Institute on Alcohol Abuse and Alcoholism’s related web page describing alcohol’s effects on the body.” Source: National Institute on Drug Abuse (NIDA). https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
  • 14. NIAAA on: Alcohol Source: National Institute on Alcohol and Alcoholism (NIAAA). https://www.niaaa.nih.gov/alcohol-health/alcohols-effects-body Brain: Alcohol interferes with the brain’s communication pathways, and can affect the way the brain looks and works. These disruptions can change mood and behavior, and make it harder to think clearly and move with coordination. Heart: Drinking a lot over a long time or too much on a single occasion can damage the heart, causing problems including: •Cardiomyopathy – Stretching and drooping of heart muscle •Arrhythmias – Irregular heart beat •Stroke •High blood pressure Research also shows that drinking moderate amounts of alcohol may protect healthy adults from developing coronary heart disease.
  • 15. NIAAA on: Alcohol Liver: Heavy drinking takes a toll on the liver, and can lead to a variety of problems and liver inflammations including: •Steatosis, or fatty liver •Alcoholic hepatitis •Fibrosis •Cirrhosis Pancreas: Alcohol causes the pancreas to produce toxic substances that can eventually lead to pancreatitis, a dangerous inflammation and swelling of the blood vessels in the pancreas that prevents proper digestion. Source: National Institute on Alcohol and Alcoholism (NIAAA). https://www.niaaa.nih.gov/alcohol-health/alcohols-effects-body Cancer: Drinking too much alcohol can increase your risk of developing certain cancers, including cancers of the: •Mouth •Esophagus •Throat •Liver •Breast Immune System: Drinking too much can weaken your immune system, making your body a much easier target for disease. Chronic drinkers are more liable to contract diseases like pneumonia and tuberculosis than people who do not drink too much. Drinking a lot on a single occasion slows your body’s ability to ward off infections – even up to 24 hours after getting drunk.
  • 16. NIDA on: Prescription Opioids Possible Health Effects Short-term Pain relief, drowsiness, nausea, constipation, euphoria, confusion, slowed breathing, death. Long-term Unknown. Other Health-related Issues Pregnancy: Miscarriage, low birth weight, neonatal abstinence syndrome. Older adults: higher risk of accidental misuse or abuse because many older adults have multiple prescriptions, increasing the risk of drug-drug interactions, and breakdown of drugs slows with age; also, many older adults are treated with prescription medications for pain. Risk of HIV, hepatitis, and other infectious diseases from shared needles. In Combination with Alcohol Dangerous slowing of heart rate and breathing leading to coma or death. Source: National Institute on Drug Abuse (NIDA). https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
  • 17. NIDA on: Prescription Opioids Withdrawal Symptoms Restlessness, muscle and bone pain, insomnia, diarrhea, vomiting, cold flashes with goose bumps ("cold turkey"), leg movements. Treatment Options Medications •Methadone •Buprenorphine •Naltrexone (short- and long-acting) Behavioral Therapies Behavioral therapies that have helped treat addiction to heroin may be useful in treating prescription opioid addiction. Source: National Institute on Drug Abuse (NIDA). https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts
  • 18. Cannabis substitution for alcohol “Substituting cannabis for prescription drugs, alcohol and other substances among medical cannabis patients.” Lucas P, Walsh Z, et al. Drug and Alcohol Review, May 2016 “Substituting cannabis for one or more of alcohol, illicit drugs or prescription drugs was reported by 87% (n = 410) of respondents, with 80.3% reporting substitution for prescription drugs, 51.7% for alcohol, and 32.6% for illicit substances. Respondents who reported substituting cannabis for prescription drugs were more likely to report difficulty affording sufficient quantities of cannabis, and patients under 40 years of age were more likely to substitute cannabis for all three classes of substance than older patients.”
  • 19. Cannabis substitution/supplement for opioids “Prescribing cannabis for harm reduction.” Collen M, Harm Reduction Journal, 2005 “…a number of articles have reported on interactions between cannabinoid and opioid receptors which may result in enhanced analgesia and a synergistic effect when CC is added to opioids... This may translate into patients being able to reduce their opioid intake with adjuvant cannabinoid therapy...” “There is sufficient evidence of safety and efficacy for the use of (therapeutic cannabis) in the treatment of nerve pain relative to opioids and as Carter et al write, "From a pharmacological prospective, cannabinoids are considerably safer than opioids..."”
  • 20. The future of cannabis for HR Legal status Social approval Increasing legalization of cannabis = expanded acceptance Residual resistance to positives associated with any cannabis use Longer-term data on social benefits & costs Opponent messaging focused on risks Medical, legal, and treatment barriers Positive individual experiences with cannabis as substitute/treatment
  • 22. Sources & Resources www.pubmed.comwww.drugpolicy.org www.harmreduction.org Harm Reduction: National and International Perspectives. James A. Inciardi and Lana D. Harrison. SAGE Publications, Oct 11, 1999. Collen, Mark. Prescribing cannabis for harm reduction. Harm Reduction Journal 2012; 9: 1. Accessed July 5 2016 at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295721/ Video: Cannabis as Substitute for Other Drugs. Amanda Reiman, PhD MSW. Webinar presented September 12, 2013, Center for Behavioral Health Policy at the University of California at Berkeley. Accessed July 5, 2016 at https://www.youtube.com/watch?v=7FPyZhNtHss
  • 23. Delivery Methods and Dosing: Making the most of your medicine Thank you for your time and attention! What are your remaining questions & concerns? www.mainewellness.org @wellconnectme www.facebook.com/mainewellness Instagram: @mainewellness

Editor's Notes

  1. Introductions; how to submit questions. Also—HUGE topic, one hour = skimming the surface. But resources at the end to encourage your further research.
  2. Abstinence: Prohibition. Goal of zero supply, zero demand. Enforced by criminal penalties for suppliers and for those who do not or cannot abstain. Legalization: Full acceptance and support of commerce in and use of drugs.
  3. Crime; increase in transmission of disease; added health care costs; lost wages, etc. Also benefits – criminal justice system aside, do cannabis users require less law enforcement intervention? Have fewer episodes of domestic violence? In a legal adult-use framework, where cannabis users can safely access the product and education about it, and have safe spaces to consume, does teen use decline?
  4. Advocacy to change drug policies: decriminalization, legalization, changes in paraphernalia laws, creation of alternatives to incarceration. HIV/AIDS interventions = needle exchanges, condom distribution & education, free testing/counseling/case management. Broader treatment options: methadone, suboxone (maintenance medicines), cannabis substitution, access to experimental treatments like PREP. Drug use management = supervised injection sites, counseling and case management. Other = support groups, group homes, advocacy groups to give drug consumers a voice.
  5. This is in general—there are some harm reduction approaches used in the U.S., as we see in the increased availability of Narcan for example. But as we have seen in Maine, gaining approval for HR strategies may require intensive advocacy by stakeholders (substance users, law enforcement, treatment providers, the general public). Abstinence based = JUST SAY NO. Supply is people growing, producing and providing the substance; demand is people seeking to obtain the substance.
  6. Go back to NIDA on Cannabis to compare
  7. (Focused on treatment of neuropathic pain: Diabetic neuropathy, MS-related pain, post-stroke pain, phantom limb pain, HIV sensory neuropathy) Emphasis added
  8. Medical: Schedule I; NIDA mission. Legal: State laws that do not allow addiction as a condition; drug courts treat all use as abuse. Treatment: abstinence-only treatment focus in US
  9. Opioids effective for end of life care and post surgery pain, but are proven ineffective to treat chronic/intractable pain. Law goes into effect FRIDAY (tomorrow).