This document discusses principles of antimicrobial therapy. It begins by classifying antimicrobials based on their source, mechanism of action, and spectrum. Narrow, extended, and broad spectrum antimicrobials are defined. The document emphasizes selecting the appropriate antimicrobial based on the infecting organism, patient factors, and pharmacokinetic properties. It stresses starting empiric therapy and then narrowing based on culture results. Monitoring treatment response and adjusting for toxicity or resistance is also highlighted. The goal of antimicrobial use is effective treatment of infection while limiting emergence of resistance.
Rational Use of Antibiotics. Infection was a major cause of morbidity and mortality, before the development of antibiotics.
The treatment of infections faced a great challenge during those periods.
Later in 1928, the discovery of Penicillin, a beta-lactam antibiotic, by Alexander Fleming opened up the golden era of antibiotics.
It marked a revolution in the treatment of infectious diseases and stimulated new efforts to synthesize newer antibiotics.
The period between the 1950s and 1970s is considered the golden era of discovery of novel antibiotic classes, with very few classes discovered since then.
12 PRINCIPLES OF ANTIBIOTIC THERAPY seminar 12.pptxsneha
This PowerPoint presentation offers a concise yet technical overview of antibiotic therapy. Dive into antibiotic mechanisms, classifications, indications, and prudent use. Master essential aspects of antibiotic therapy for informed clinical decision-making.
Rational Use of Antibiotics. Infection was a major cause of morbidity and mortality, before the development of antibiotics.
The treatment of infections faced a great challenge during those periods.
Later in 1928, the discovery of Penicillin, a beta-lactam antibiotic, by Alexander Fleming opened up the golden era of antibiotics.
It marked a revolution in the treatment of infectious diseases and stimulated new efforts to synthesize newer antibiotics.
The period between the 1950s and 1970s is considered the golden era of discovery of novel antibiotic classes, with very few classes discovered since then.
12 PRINCIPLES OF ANTIBIOTIC THERAPY seminar 12.pptxsneha
This PowerPoint presentation offers a concise yet technical overview of antibiotic therapy. Dive into antibiotic mechanisms, classifications, indications, and prudent use. Master essential aspects of antibiotic therapy for informed clinical decision-making.
Anti-microbials therapy and complications.pptxsushma kaphle
Antimicrobial drugs
Selection of microbial agents
Selection of routes
Determinants of rational dosing
Chemotherapeutic spectra
Combinations of Antimicrobials
Drug resistance
Prophylactic antibiotics
Complications
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Superbugs are strains of bacteria, viruses, parasites and fungi that are resistant to most of the antibiotics and other medications commonly used to treat the infections they cause. A few examples of superbugs include resistant bacteria that can cause pneumonia, urinary tract infections and skin infections.
Drug resistance (antimicrobial resistance) is a naturally occurring phenomenon that can be slowed, but not stopped. Over time, germs such as bacteria, viruses, parasites and fungi adapt to the drugs that are designed to kill them and change to ensure their survival. This makes previously standard treatments for some infections less effective, and sometimes ineffective. Researchers continue to evaluate how these germs develop resistance. They also study how to diagnose, treat and prevent antimicrobial resistance.
Certain actions may step up the appearance and spread of antimicrobial-resistant germs, such as:
Using or misusing antibiotics
Having poor infection prevention and control practices
Living or working in unclean conditions
Mishandling food
To protect yourself from harmful germs and lower the risk of illnesses:
Wash your hands often with soap and water, or use an alcohol-based hand sanitizer
Handle food properly, such as separating raw and cooked food, cooking food thoroughly, and using clean water
Avoid close contact with people who are ill
Make sure your vaccinations are up to date
You can also help tackle antibiotic resistance by:
Using antibiotics as directed and only when needed
Completing the full treatment course, even if you feel better
Not sharing antibiotics with others
Not using leftover prescriptions.
Anti-microbials therapy and complications.pptxsushma kaphle
Antimicrobial drugs
Selection of microbial agents
Selection of routes
Determinants of rational dosing
Chemotherapeutic spectra
Combinations of Antimicrobials
Drug resistance
Prophylactic antibiotics
Complications
Antibiotic selection /certified fixed orthodontic courses by Indian dental ...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
CONTACT: sayantand691@gmail.com
Superbugs are strains of bacteria, viruses, parasites and fungi that are resistant to most of the antibiotics and other medications commonly used to treat the infections they cause. A few examples of superbugs include resistant bacteria that can cause pneumonia, urinary tract infections and skin infections.
Drug resistance (antimicrobial resistance) is a naturally occurring phenomenon that can be slowed, but not stopped. Over time, germs such as bacteria, viruses, parasites and fungi adapt to the drugs that are designed to kill them and change to ensure their survival. This makes previously standard treatments for some infections less effective, and sometimes ineffective. Researchers continue to evaluate how these germs develop resistance. They also study how to diagnose, treat and prevent antimicrobial resistance.
Certain actions may step up the appearance and spread of antimicrobial-resistant germs, such as:
Using or misusing antibiotics
Having poor infection prevention and control practices
Living or working in unclean conditions
Mishandling food
To protect yourself from harmful germs and lower the risk of illnesses:
Wash your hands often with soap and water, or use an alcohol-based hand sanitizer
Handle food properly, such as separating raw and cooked food, cooking food thoroughly, and using clean water
Avoid close contact with people who are ill
Make sure your vaccinations are up to date
You can also help tackle antibiotic resistance by:
Using antibiotics as directed and only when needed
Completing the full treatment course, even if you feel better
Not sharing antibiotics with others
Not using leftover prescriptions.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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2 Case Reports of Gastric Ultrasound
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3. Objectives
1)Review the classification of antimicrobials
2)Define pharmacodynamic principles and their relationship to
effective antimicrobial therapy
3)Discuss patient and drug related factors that influence the
selection of the appropriate antimicrobial agent
4)Identify monitoring parameters to evaluate antimicrobial
therapy
4. What are Antimicrobials?
Antimicrobials are drugs that destroy microbes, prevent their
multiplication or growth, or prevent their pathogenic action
Differ in their physical, chemical, and pharmacological
properties
Differ in antibacterial spectrum of activity
Differ in their mechanism of action
5. Classification of Antimicrobials
A. According to source:
1.Natural compounds: e.g.penicillin, chloramphenicol.
2.Synthetic compounds: e.g.sulfonamides, quinolones.
3.Semisynthetic compounds: e.g.ampicillin.
6. B. Accordingto the effect on microorganisms:
1.Bactericidal agents: that kills the microorganism e.g.
penicillin.
2.Bacteriostatic agents: arrest growth of the microorganism
e.g. sulfonamides.
9. D. According to antimicrobial spectrum:
1. Narrow spectrum drugs:
Drugs affect mainly Gram +ve bacteria e.g. benzyl penicillin.
Drugs affect mainly Gram –ve bacteria e.g. aminoglycosides.
2. Extended spectrum drugs:
agents that affect Gram +ve & Gram –ve bacteria.
2.Broad spectrum drugs:
agents act on wide range of Gram +ve & Gram –ve bacteria
and others (protozoa) e.g. tetracyclines.
10. Antimicrobial therapy
Empiric
Infecting organism(s) not yet identified
More “broad spectrum”
Definitive
Organism(s) identified and specific therapy chosen
More “narrow” spectrum
Prophylactic or preventative
Prevent an initial infection or its recurrence after infection
12. I. Confirm the presence of an infection
CAREFUL history and physical exam including
relevant laboratory data and signs and symptoms
1) Fever:
o Is considered a hallmark of most infectious diseases.
o defined as elevated temperature >37.2◦C.
o May be present in absence of infection e.g. in
autoimmune disorders and several malignancies.
o May be absent in presence of infection if the immune
system is depressed.
13. 2) White blood cell count:
Normal WBC is 4000-10,000 cells/mm3.
Bacterial infections are associated with elevated granulocyte
counts (neutrophils, basophils, and eosinophils).
Viral, TB and fungal infections are associated with elevated
lymphocytic count.
Parasitic infections and allergic reactions are associated with
increased eosinophilic count.
3) Any swelling or erythema at a particular site
4) Purulent drainage from a visible site
5) Patient complaints
14. II. Selection of antimicrobial agents
1) Identification of the infecting organism:
Infected body materials (e.g., blood, sputum, urine, wound
drainage, etc.) must be sampled and cultured before initiating
treatment.
Empirical therapy before identification of the organism is
necessary in the following conditions:
o In all acutely ill patients with infections of unknown origin.
o Infection in a neutropenic patient, or a patient with meningitis.
15. Culture Results
Minimum inhibitory concentration (MIC)
o The lowest concentration of drug that prevents visible bacterial growth
after 24 hours of incubation in a specified growth medium
o Organism and antimicrobial specific
Report organism(s) and susceptibilities to antimicrobials
o Susceptible (S)
o Intermediate (I)
o Resistant (R)
17. 2) Patient factors:
In neonates
- The use of chloramphenicol can lead to shock and
cardiovascular collapse(gray baby syndrome).
- The use of sulfonamides may lead to kernicterus (brain
damage)
In growing children:
- the use of fluoiroquinolones can lead to arthropathy
-the use of tetracyclines can bind to growing bones and teeth
resulting in abnormal teeth and bone formation.
18. In old age(>65years)
- The incidence of renal toxicity with aminoglycosides is
greater than in younger patients.
In immunocompromised patients
- The use of bactericidal agents is necessary , as the host’s
immune system is not capable of final elimination of the
bacteria.
Pregnancy:
- Many antibiotics cross the placenta and cause adverse
effects to the fetus e.g. aminoglycosides and tetracyclines.
19. Genetic or metabolic abnormalities
o Glucose-6-phosphate dehydrogenase (G6PD) deficiency
Renal and hepatic function
o Accumulation of drug metabolized and/or excreted by these
routes with impaired function
o risk of drug toxicity unless doses adjusted accordingly
o Renal excretion is the most important route of elimination
for the majority of antimicrobials
20. 3) Tissue penetration:
The capillary lining in some tissues e.g. brain form natural barriers to
drug delivery due to presence of tight junctions of the capillary wall.
Lipid soluble antibiotics e.g. chloramphenicol and metronidazole can
cross these barriers in normal conditions. Penicillin is ionized at
physiologic pH and cannot cross these barriers unless inflammation
is present.
Poor perfusion of some area
- e.g. diabetic foot, reduces the amount of antibiotic reaching this area,
making treatment is difficult.
21. III. Determinants of the rational dosing
Minimum inhibitory concentration (MIC):
o The MIC is the lowest concentration of antibiotic in body tissues
and fluids that inhibits bacterial growth.
Concentration-dependent killing:
o Certain antibiotics(e.g.aminoglycosides) show enhanced bacterial
killing in concentration above the MIC.
o Giving these antibiotics by a single large dose per day achieves
high peak levels and cause rapid killing of bacteria.
22. Time-dependent killing:
o depends on the time of the drug concentration to remain above
the MIC. So, preparations with long duration kill more bacteria.
o e.g.β-lactam antibiotics, macrolides, clindamycin, and linezolid
Post-antibiotic effect (PAE):
o The PAE is a persistent bacterial suppression after levels of
antibiotic fall below the MIC.
o Antimicrobials with long PAE(e.g. aminoglycosides and
fluoroquinolones) usually require one dose per day.
23. IV. Monitoring
Efficacy and toxicity of antimicrobials
Clinical assessment
o Improvement in signs and symptoms
• Fever curve, WBC
• erythema, pain, cough, drainage, etc.
Antimicrobial regimen
o Serum levels
o Renal and/or hepatic function
o Other lab tests as needed
o Consider IV to PO switch
Microbiology reports
o Modify antimicrobial regimen to susceptibility results if necessary
o “Narrow” spectrum of antimicrobial if appropriate
24. Other Drug Factors
Adverse effect profile and potential toxicity
Cost
Acquisition cost + storage + preparation + distribution + administration
Monitoring
Length of hospitalization + readmissions
Patient quality of life
Resistance
Effects of the drug on the potential for the development of resistant
bacteria in the patient, on the ward, and throughout the institution
Drug – Drug interactions
26. I. General adverse effects:
Hypersensitivity or allergic reactions: In form of fever, skin
rash, arthralgia, cholestatic jaundice or hemolysis. More
serious reactions are agranulocytosis, bone marrow aplasia or
anaphylactic reaction.
Reactions related to alterations in normal body flora,
superinfection or vitamin B deficiency may follow the use of
broad-spectrum antimicrobials. It is due to inhibition of
bacterial flora that suppresses commensal micro-organisms
which present in gut or that forms these vitamins, respectively.
Resistance
27. II. Direct toxic reactions:
resulting from high doses or drug interactions, on liver,
kidney, GIT, nervous system or CVS.
29. Administration of antimicrobials usually alter bacterial flora but with no
ill effect in most cases however, broad-spectrum antibiotics if used for
long time may alter or kill bacterial flora. So, the bacteria and fungi that
are normally inhibited by bacterial flora will multiply leading to
superinfection (its early manifestation may by diarrhea).
caused by staphylococci, Pseudomonas, proteus, Candida albicans or
Clostridia difficile.
30. Cont..
Superinfection may be vaginal, oral, pharyngeal or even systemic
infection e.g. staphylococcal enterocolitis, candidiasis or
Pseudomembranous colitis(=antibiotic-associated diarrhea).
Treatment:
Stop the causative agent and give drug, which kill the organisms
responsible for super infection e.g. staphylococcal enterocolitis,
which is treated by metronidazole or vancomycin orally, antifungal
nystatin for candidiasis.
32. I. Innate resistance:
Is a feature of a particular species of bacteria e.g Pseudomonas.
The gene(s)of resistance can be transferred between bacteria by
transfer of naked DNA(transformation),by conjugation with direct
cell-to-cellt transfer of extrachromosomal DNA(plasmids), or
through bacteriophage(transduction)..
33. II. Acquired resistance:
Occurs when bacteria that were sensitive to certain antibiotic
become resistant with time.
Mechanisms responsible :
i. Production of enzymes that inactivate the drug.
ii. Alteration of drug binding site.
iii. Reduction in drug uptake by the organism.
iv. Development of altered metabolic pathways.
35. Drug-Drug interactions
Influences the selection of appropriate drug therapy, the dosage, and
necessary monitoring
Drug interactions
risk of toxicity or potential for efficacy of antimicrobial
May affect the patient and/or the organisms
Pharmacokinetic interactions
o Alter drug absorption, distribution, metabolism, or excretion
Pharmacodynamic interactions
o Alter pharmacologic response of a drug
o Selection of combination antimicrobial therapy ( 2 agents) requires
understanding of the interaction potential
36. COMBINATION OF ANTIBIOTICS
Indications:
1. To obtain broader spectrum e.g. amoxicillin+clavulanic acid→ co-
amoxiclav.
2. To obtain synergism e.g. sulfonamides + trimethoprim → co-
trimoxazole.
3. In mixed bacterial infections e.g. diabetic foot or peritonitis.
4. In serious bacterial infections e.g. bacterial meningitis or septicemia.
5. To overcome bacterial resistance e.g.TB and pseudomonas infection.
6. To reduce toxicity of one drug by using smaller doses of two drugs.
37. Cont.
Results:
i. Bactericidal+bactericidal → synergism :
e.g. penicillin with aminoglycosides.
ii. Bacteriostatic+bacteriostatic → addition:
e.g. tetracyclines with sulfonamides.
iii. Bactericidal+bacteriostatic →
a. Antagonism: e.g. penicillin with erythromycin
b. Synergism: e.g. sulfadiazine with penicillin
39. 1. Antimicrobials should only be given when necessary and after antimicrobials
susceptibility test whenever possible.
2. The pharmacokinetics of the drug should be taken into consideration e.g.
the state of hepatic and renal functions of the patient.
3. In serious infection it is better to start with a parenteral loading of a
bactericidal agent to avoid emergence of resistant strains by giving
adequate dosage for sufficient duration and adapting proper combination
regimens.
4. Antimicrobials should be continued for 3 days after apparent cure is
40. Summary
Antimicrobials are essential components to treating infections
Appropriate selection of antimicrobials is more complicated than matching a drug to a
bug
While a number of antimicrobials potentially can be considered, clinical efficacy, adverse
effect profile, pharmacokinetic disposition, and cost ultimately guide therapy
Once an agent has been chosen, the dosage must be based upon the size of the patient,
site of infection, route of elimination, and other factors
Optimize therapy for each patient and try to avoid patient harm
Use antimicrobials only when needed for as short a time period as needed to treat the
infection in order to limit the emergence of bacterial resistance