The document discusses various approaches to cancer prevention, including reducing risk factors like tobacco use, excess sun exposure, obesity, physical inactivity, and infections. It outlines strategies to modify diet and environment as well as methods of chemoprevention. The leading causes of cancer are discussed and mechanisms by which risk factors contribute to oncogenesis are described.
Facts About Cancer and Alernative Cancer Treatmentspeterscharf
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. There are over 100 types of cancer. And any part of the body can be affected. There are many ways to cure this disease.Alternative treatments for cancer is also now available.
http://energyhealer.ca/
Facts About Cancer and Alernative Cancer Treatmentspeterscharf
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. There are over 100 types of cancer. And any part of the body can be affected. There are many ways to cure this disease.Alternative treatments for cancer is also now available.
http://energyhealer.ca/
Oncology nurses are registered nurses who take care of either cancer patients or those with the potential of developing cancer. Oncology nurses work with physicians and other medical professionals to prevent, diagnose, treat, and manage cancer symptoms, as well as provide palliative care.
#pinktober-#breast cancer awarness campaign #NBCAMDrDarshna Pandya
breast cancer awarness campaign from basics of breast cancer-right from ZERO TO SHE-RO
our social philanthropic activity for betterment of women,to make them aware against deadly diseases-------BREASTCANCER. We teach them when and how to do self examination of breast.we try to allviate fear of chemotherapy and radiotherapy and precautions to be taken during tretment.
Cancer Awareness - Kaplan University Dept. of Public Healthsmtibor
Cancer awareness, including general definitions, detection, prevention, treatment, and risk factors. Emphasis on skin and prostate cancers and at-risk populations.
Demonstrate the essential risk factors for developing cancer, and the predisposing factors for cancer.
Demonstrate a map of the prevalence of cancer throughout the world
Demonstrate how can we prevent the occurrence of cancer, by avoiding the predisposing risk factors.
Demonstrate the practical recommendation to avoid cancer
Nursing management of patients with oncological conditionsANILKUMAR BR
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells.
Cancer is caused by external factors and internal factors which may act together to initiate or promote carcinogenesis.
External Factors - chemicals, radiation, viruses, and lifestyle.
Internal Factors – hormones, immune condition, and inherited mutations.
Oncology branch of medicine deals with etiology, diagnosis, treatment and prevention of cancer.
Onco - is a Greek word meaning tumor .
Oncology nurses are registered nurses who take care of either cancer patients or those with the potential of developing cancer. Oncology nurses work with physicians and other medical professionals to prevent, diagnose, treat, and manage cancer symptoms, as well as provide palliative care.
#pinktober-#breast cancer awarness campaign #NBCAMDrDarshna Pandya
breast cancer awarness campaign from basics of breast cancer-right from ZERO TO SHE-RO
our social philanthropic activity for betterment of women,to make them aware against deadly diseases-------BREASTCANCER. We teach them when and how to do self examination of breast.we try to allviate fear of chemotherapy and radiotherapy and precautions to be taken during tretment.
Cancer Awareness - Kaplan University Dept. of Public Healthsmtibor
Cancer awareness, including general definitions, detection, prevention, treatment, and risk factors. Emphasis on skin and prostate cancers and at-risk populations.
Demonstrate the essential risk factors for developing cancer, and the predisposing factors for cancer.
Demonstrate a map of the prevalence of cancer throughout the world
Demonstrate how can we prevent the occurrence of cancer, by avoiding the predisposing risk factors.
Demonstrate the practical recommendation to avoid cancer
Nursing management of patients with oncological conditionsANILKUMAR BR
Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells.
Cancer is caused by external factors and internal factors which may act together to initiate or promote carcinogenesis.
External Factors - chemicals, radiation, viruses, and lifestyle.
Internal Factors – hormones, immune condition, and inherited mutations.
Oncology branch of medicine deals with etiology, diagnosis, treatment and prevention of cancer.
Onco - is a Greek word meaning tumor .
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Cancer prevention
1. The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt
-Bertrand Russell
INTRODUCTION
● 2nd most common cause of death in US
● Many malignancies are preventable
● Survival rates are improving
● Prevention is better than cure
● 2 approaches
○ Risk factor reduction
■ Tobacco
■ Alcohol
■ Obesity
■ Inactivity
■ Unsafe sex
■ Urban air pollution
■ Contaminated injections
○ Screening of high risk population
TOBACCO USE
● Most easily preventable cause of cancer
● Accounts for 20 % of all cancer related deaths
● A/W malignancies of
○ Lung
○ Oral cavity
○ Pharynx
○ Larynx
○ Leukemia
○ Esophagus
○ Pancreas
○ Liver
○ Stomach
○ Bladder
● Mechanism of oncogenesis
○ Delivers carcinogens directly to tissues
○ Causes irritation and inflammation
- Created with love
by Dr. Eashan Srivastava
2. The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt
-Bertrand Russell
○ Interferes with the body's natural protective barriers
ENVIRONMENTAL EXPOSURES
1. Excess sun exposure, artificial ultraviolet radiation
a. Risk factors for BCC, SCC, Melanoma
b. Mechanism
i. Ultraviolet radiation causes genetic mutations
ii. Interferes with the cutaneous immune system
c. Recommendations for sun/ultraviolet protection
i. Applicable to high-risk characteristics such as
1. Fair skin
2. Large number of nevi
3. Positive family history
ii. Limit the time spent in the sun 10 AM to 4 PM
iii. Wear hats/sunglasses
iv. Use sunscreen
2. Air pollution
a. Diesel exhaust
b. Particulate matter
c. A/w CA Lung
d. Radon = Component of indoor air pollution
e. Arsenic
i. In drinking water
ii. A/w CA Bladder
PHYSICAL ACTIVITY
● Physical activity is protective in
○ CA Breast
○ CA colon
○ Endometrial and prostate cancer
● Mechanisms
○ Reduction in circulating levels of insulin, hormones, and other growth factors
- Created with love
by Dr. Eashan Srivastava
3. The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt
-Bertrand Russell
○ Improved immune function
OBESITY
● Esophageal adenocarcinoma
● Gastric CA
● Colorectal CA
● HCC
● CA endometrial
● Ovarian CA
● Breast cancers
● Meningioma
● Thyroid CA
● Bladder CA
● Mechanism
○ Obesity creates an inflammatory environment
DIET
1. Dietary fat
a. No clear link between total fat intake and colon or breast cancer
b. Reports suggest that a diet low in animal fat may be protective against colorectal
cancer
2. Red meat
a. Increased risk of colon cancer
3. Fruits and vegetables
a. a/w reduction in cancer
b. Weak association
4. Dairy
a. Association with ovarian cancer is uncertain
5. Fiber
a. A/w reduced colorectal cancer risk
6. Omega-3 fatty acids and dietary fish
a. A/w decreased incidence of colorectal cancer
- Created with love
by Dr. Eashan Srivastava
4. The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt
-Bertrand Russell
7. Dietary patterns
a. Mediterranean diet (ie, high intake of fruits, vegetables, nuts, legumes, whole
wheat bread, fish, and olive oil)= Lower risk of cancer
b. Western diet (Ultra-processed foods) = A/w colorectal CA
8. VITAMINS AND MICRONUTRIENTS
a. In theory, antioxidants should reduces CA risk
b. Vitamin A, C, D, E = No evidence of benefit
c. Selenium = No evidence
d. Calcium
i. Linked to reduced risk of colorectal cancer
ii. a/w an increased risk of prostate cancer
e. Folate and other B vitamins
i. Widely present in green, leafy vegetables, fruits, cereals and grains
ii. Role is uncertain
ALCOHOL
● A/w CA
○ Oropharynx
○ Esophagus
○ Larynx
○ Rectum
○ Breast
○ HCC
INFECTIONS
● HPV
○ CA cervix
○ Other anogenital cancers
○ SCC of the head and neck
● HBV and HCV
○ HCC
● HTLV-I
- Created with love
by Dr. Eashan Srivastava
5. The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt
-Bertrand Russell
○ Adult T-cell leukemia
● HIV
○ Kaposi sarcoma
○ non-Hodgkin lymphoma
● HHV-8
○ Kaposi sarcoma
○ Primary effusion lymphoma
● EBV
○ Burkitt lymphoma
● H pylori
○ CA stomach
○ MALT lymphomas
● Liver flukes
○ Cholangiocarcinoma
○ HCC
● Strategies to prevent transmission
○ Screening of blood products
○ ANC screening
○ Use of sterile disposable needles
○ Regulation of tattooing
○ HPV vaccination
○ ART has been shown to reduce the incidence of AIDS-related lymphoma
○ HepB vaccination
CHEMOPREVENTION
1. Breast cancer
a. Tamoxifen
i. Selective estrogen receptor modulator (SERM)
ii. Estrogen agonist and antagonist properties
iii. ER+ breast cancer
iv. Risk
1. Endometrial cancer
2. Thromboembolic events
b. Raloxifene
- Created with love
by Dr. Eashan Srivastava
6. The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt
-Bertrand Russell
i. Alternative to tamoxfene
c. Aromatase inhibitors
i. Anastrozole, letrozole, and exemestane
ii. Inactivating aromatase
2. Prostate cancer and 5-alpha reductase inhibitors
a. Finasteride
i. Reduces incidence of CA prostate
ii. But do not have a favorable risk-benefit profile for the chemoprevention of
prostate cancer in healthy men
3. Aspirin
a. Effective in reducing colorectal cancer risk
b. Decreases the synthesis of prostaglandins
4. Metformin
a. a/w reduced incidence of several types of cancer in patients with type 2 diabetes
b. Pancreatic, liver, breast, colon and prostate
5. Statins
a. No convincing evidence
- Created with love
by Dr. Eashan Srivastava