It is a calculation idea of different A.R. No.

1. When Active required from 3 A.R. Number
Eg: Levamisole
Label Claim: 75 mg/tab
Quantity required = 77.25 mg/tab (7.725 kg) (with 3.0 % Overage)
Case 1: Ist A.R. Number.
L.O.D = 0.15%, Assay = 99.73%
To Maintain 100 % = 0.15% + (100-99.73)% = 0.42% i.e. 100.42 % required from this A.R. No.
Therefore for 100.42 % = 100/100.42*1.843
= 1.835 kg (we have 1.843 kg of this A.R No. available)
= 18.35 mg/tab is required
Case 2: 2nd A.R. No.
L.O.D = 0.18%, Assay = 99.89%
To maintain 100% = 0.18% + (100 – 99.89)% = 0.29% i.e. 100.29 % required from this A.R. No.
Therefore 100.29% = 100/100.29*0.442
= 0.440 kg ( we have 0.442 kg of this A.R. no. is available)
= 4.4 mg/tab
Case 3: 3rd A.R. No.
L.O.D: 0.06%, Assay: 99.02%
Here, Our Standard mg/tab including 3% Overage = 77.25 mg/tab
Now, 77.25 – 18.35(from Ist A.R. No.) – 4.4 (from 2nd A.R. No.) = 54.5 mg/tab
Now, Remaining Quantity from 3rd A.R. No.
=54.5*100/99.02*100/99.94
= 55.07 mg/tab
= 5.507 kg is required.
Therefore total quantity of Levamisole HCL will be: (1.843 + 0.442 + 5.507) kg
= 7.792 kg is required for 100 % dissolution.
A.R. No. Qty. Available Expiry Report
QC/RM/429/075 1.843 kg 02/08/2021
QC/RM/649/074 0.442 kg 17/06/2021
QC/RM/213/075 399.99 kg 14/08/2021