Each film coated tablet contains cefpodoxime proxetil equivalent to 200 mg of cefpodoxime and clavulanic acid equivalent to 125 mg. The document provides calculations to determine the amounts of cefpodoxime proxetil and potassium clavulanate required based on their molecular weights and assay percentages to achieve the label claim amounts. For potassium clavulanate with microcrystalline cellulose, 151.37 mg is required, and for potassium clavulanate with Syloid, 150.598 mg is required.

1. Label claim: Each Film coated tablets contains:
Cefpodoxime proxetil eq. to cefpodoxime 200 mg
Clavulanate potassium equivalent to clavulanic acid 125 mg
For cefpodoxime proxetil as per company Certificate of Analysis (COA)
738 µg/mg as on Anhydrous basis (As Cefpodoxime)
0.738 mg = 1 mg
200 mg = 1/0.738*200
= 271.0 mg (Cefpodoxime Proxetil)
For PotassiumClavulanate with MCC (1:1)
Potassium Clavulanate (C8H8KO5) = 237.25 (Molecular Weight)
Clavulanic acid (C8H8NO5) = 199.0 (Molecular Weight)
199 = 237.25
Now as per label claim: 125 mg we need.
=237.25/199*125
= 149.026 mg (Potassium Clavulanate)
For 100% , Potassium Clavulanate with MCC (1:1) , it should divide by assay
= 149.026/99.18*100
= 150.26 mg.
Now required to add water content also i.e. 0.74%
= 150.26 + 0.74
=151.37 mg required of potassium clavulanate with MCC.
Similarly,
For PotassiumClavulanate with Syloid (1:1)
For 100% Potassium Clavulanate with Syloid (1:1)
=149.026/99.59*100
=149.64mg + 0.64% (water content in %)
= 150.598 mg required of potassium clavulanate with syloid.