This document discusses various approaches to computer-aided drug design (CADD), including ligand-based, target-based, de novo, and structure-based approaches. It describes the key steps and goals of CADD, which aim to accelerate drug discovery through rational drug design and testing compared to random screening. Specific methods discussed include quantitative structure-activity relationship analysis, pharmacophore modeling, molecular docking, and analyzing protein structures to inform lead optimization. The overall goal of CADD is to speed drug discovery and remove unsuccessful drug candidates earlier.