This document discusses ventilator-associated pneumonia (VAP), which is a common nosocomial infection in critically ill patients that leads to poor outcomes. It reviews guidelines for preventing VAP, including using orotracheal intubation, limiting circuit changes, and closed suctioning systems. It also describes the Ventilator Bundle, a set of evidence-based practices including elevating the head of the bed, daily sedation vacations, and DVT and stress ulcer prophylaxis that have been shown to reduce VAP rates more than individual measures. While effective, the bundle may not include all strategies recommended in guidelines, so modifying it or creating a specific VAP bundle is suggested.